Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS |
| Enrichment Score (ES) | -0.612004 |
| Normalized Enrichment Score (NES) | -1.5842277 |
| Nominal p-value | 0.03125 |
| FDR q-value | 0.10790411 |
| FWER p-Value | 0.395 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | DHDDS | NA | DHDDS Entrez, Source | dehydrodolichyl diphosphate synthase | 1699 | 1.735 | -0.0081 | No |
| 2 | PMVK | NA | PMVK Entrez, Source | phosphomevalonate kinase | 3153 | 1.100 | -0.0341 | No |
| 3 | HMGCS2 | NA | HMGCS2 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | 3548 | 0.986 | -0.0069 | No |
| 4 | GGPS1 | NA | GGPS1 Entrez, Source | geranylgeranyl diphosphate synthase 1 | 3676 | 0.948 | 0.0333 | No |
| 5 | ACAT1 | NA | ACAT1 Entrez, Source | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 9186 | 0.080 | -0.2694 | No |
| 6 | IDI2 | NA | IDI2 Entrez, Source | isopentenyl-diphosphate delta isomerase 2 | 13835 | -0.460 | -0.5052 | No |
| 7 | PDSS1 | NA | PDSS1 Entrez, Source | prenyl (decaprenyl) diphosphate synthase, subunit 1 | 15755 | -0.953 | -0.5645 | Yes |
| 8 | PDSS2 | NA | PDSS2 Entrez, Source | prenyl (decaprenyl) diphosphate synthase, subunit 2 | 16381 | -1.236 | -0.5377 | Yes |
| 9 | IDI1 | NA | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 16384 | -1.239 | -0.4761 | Yes |
| 10 | ACAT2 | NA | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 16675 | -1.410 | -0.4219 | Yes |
| 11 | FDPS | NA | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 16721 | -1.448 | -0.3522 | Yes |
| 12 | MVK | NA | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 17142 | -1.834 | -0.2842 | Yes |
| 13 | HMGCR | NA | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 17292 | -2.029 | -0.1913 | Yes |
| 14 | MVD | NA | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 17431 | -2.287 | -0.0850 | Yes |
| 15 | HMGCS1 | NA | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 17448 | -2.317 | 0.0296 | Yes |
