Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS |
| Enrichment Score (ES) | 0.4251459 |
| Normalized Enrichment Score (NES) | 1.4474881 |
| Nominal p-value | 0.008588957 |
| FDR q-value | 0.21369737 |
| FWER p-Value | 0.968 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | HLA-DRA | NA | HLA-DRA Entrez, Source | major histocompatibility complex, class II, DR alpha | 83 | 4.582 | 0.0380 | Yes |
| 2 | HLA-DRB1 | NA | HLA-DRB1 Entrez, Source | major histocompatibility complex, class II, DR beta 1 | 235 | 3.969 | 0.0665 | Yes |
| 3 | HLA-DPA1 | NA | HLA-DPA1 Entrez, Source | major histocompatibility complex, class II, DP alpha 1 | 345 | 3.598 | 0.0939 | Yes |
| 4 | HIST1H2AC | NA | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 349 | 3.593 | 0.1272 | Yes |
| 5 | HIST1H2BD | NA | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 412 | 3.429 | 0.1556 | Yes |
| 6 | HIST2H2AA3 | NA | HIST2H2AA3 Entrez, Source | histone cluster 2, H2aa3 | 518 | 3.106 | 0.1787 | Yes |
| 7 | HIST1H2BJ | NA | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 550 | 3.037 | 0.2052 | Yes |
| 8 | HLA-DMA | NA | HLA-DMA Entrez, Source | major histocompatibility complex, class II, DM alpha | 556 | 3.030 | 0.2331 | Yes |
| 9 | HLA-DRB5 | NA | HLA-DRB5 Entrez, Source | major histocompatibility complex, class II, DR beta 5 | 611 | 2.898 | 0.2571 | Yes |
| 10 | HIST1H2BK | NA | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 615 | 2.890 | 0.2838 | Yes |
| 11 | HIST1H4H | NA | HIST1H4H Entrez, Source | histone cluster 1, H4h | 676 | 2.799 | 0.3065 | Yes |
| 12 | HIST1H2BN | NA | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 745 | 2.656 | 0.3274 | Yes |
| 13 | HIST1H2BC | NA | HIST1H2BC Entrez, Source | histone cluster 1, H2bc | 874 | 2.485 | 0.3434 | Yes |
| 14 | HIST2H2BE | NA | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 896 | 2.460 | 0.3651 | Yes |
| 15 | HLA-DRB3 | NA | HLA-DRB3 Entrez, Source | major histocompatibility complex, class II, DR beta 3 | 916 | 2.438 | 0.3868 | Yes |
| 16 | HLA-DMB | NA | HLA-DMB Entrez, Source | major histocompatibility complex, class II, DM beta | 1107 | 2.215 | 0.3967 | Yes |
| 17 | HLA-DRB4 | NA | HLA-DRB4 Entrez, Source | major histocompatibility complex, class II, DR beta 4 | 1321 | 2.023 | 0.4036 | Yes |
| 18 | HLA-DOB | NA | HLA-DOB Entrez, Source | major histocompatibility complex, class II, DO beta | 1477 | 1.892 | 0.4126 | Yes |
| 19 | C2 | NA | C2 Entrez, Source | complement component 2 | 1559 | 1.836 | 0.4251 | Yes |
| 20 | HIST1H2AB | NA | HIST1H2AB Entrez, Source | histone cluster 1, H2ab | 2613 | 1.276 | 0.3781 | No |
| 21 | SSB | NA | SSB Entrez, Source | Sjogren syndrome antigen B (autoantigen La) | 2964 | 1.160 | 0.3693 | No |
| 22 | HIST1H3A | NA | HIST1H3A Entrez, Source | histone cluster 1, H3a | 3234 | 1.079 | 0.3643 | No |
| 23 | HIST2H4B | NA | HIST2H4B Entrez, Source | histone cluster 2, H4b | 3273 | 1.068 | 0.3721 | No |
| 24 | HIST1H3B | NA | HIST1H3B Entrez, Source | histone cluster 1, H3b | 3324 | 1.049 | 0.3791 | No |
| 25 | HIST1H2AM | NA | HIST1H2AM Entrez, Source | histone cluster 1, H2am | 3376 | 1.035 | 0.3859 | No |
| 26 | HIST1H2AJ | NA | HIST1H2AJ Entrez, Source | histone cluster 1, H2aj | 3444 | 1.017 | 0.3916 | No |
| 27 | HIST2H2BF | NA | HIST2H2BF Entrez, Source | histone cluster 2, H2bf | 3500 | 0.999 | 0.3978 | No |
| 28 | HIST1H3H | NA | HIST1H3H Entrez, Source | histone cluster 1, H3h | 3690 | 0.944 | 0.3960 | No |
| 29 | C1R | NA | C1R Entrez, Source | complement component 1, r subcomponent | 3774 | 0.922 | 0.4000 | No |
| 30 | FCGR2A | NA | FCGR2A Entrez, Source | Fc fragment of IgG, low affinity IIa, receptor (CD32) | 3846 | 0.906 | 0.4044 | No |
| 31 | HIST1H2BL | NA | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 3997 | 0.868 | 0.4041 | No |
| 32 | HIST1H2AK | NA | HIST1H2AK Entrez, Source | histone cluster 1, H2ak | 4229 | 0.809 | 0.3987 | No |
| 33 | HIST1H4B | NA | HIST1H4B Entrez, Source | histone cluster 1, H4b | 4405 | 0.772 | 0.3961 | No |
| 34 | HIST1H2AG | NA | HIST1H2AG Entrez, Source | histone cluster 1, H2ag | 4583 | 0.730 | 0.3930 | No |
| 35 | HIST1H4C | NA | HIST1H4C Entrez, Source | histone cluster 1, H4c | 4696 | 0.704 | 0.3933 | No |
| 36 | H2AFY | NA | H2AFY Entrez, Source | H2A histone family, member Y | 4708 | 0.701 | 0.3992 | No |
| 37 | H2AFJ | NA | H2AFJ Entrez, Source | H2A histone family, member J | 4934 | 0.654 | 0.3927 | No |
| 38 | HIST1H3C | NA | HIST1H3C Entrez, Source | histone cluster 1, H3c | 5070 | 0.629 | 0.3910 | No |
| 39 | HLA-DPB1 | NA | HLA-DPB1 Entrez, Source | major histocompatibility complex, class II, DP beta 1 | 5159 | 0.612 | 0.3918 | No |
| 40 | FCGR1A | NA | FCGR1A Entrez, Source | Fc fragment of IgG, high affinity Ia, receptor (CD64) | 5231 | 0.599 | 0.3934 | No |
| 41 | HIST3H3 | NA | HIST3H3 Entrez, Source | histone cluster 3, H3 | 5705 | 0.515 | 0.3717 | No |
| 42 | HIST2H2AC | NA | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 5806 | 0.499 | 0.3707 | No |
| 43 | TRIM21 | NA | TRIM21 Entrez, Source | tripartite motif-containing 21 | 5910 | 0.485 | 0.3695 | No |
| 44 | CD80 | NA | CD80 Entrez, Source | CD80 molecule | 6065 | 0.457 | 0.3651 | No |
| 45 | H2AFZ | NA | H2AFZ Entrez, Source | H2A histone family, member Z | 6124 | 0.445 | 0.3660 | No |
| 46 | HIST1H2AE | NA | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 6172 | 0.435 | 0.3674 | No |
| 47 | HIST1H4I | NA | HIST1H4I Entrez, Source | histone cluster 1, H4i | 6524 | 0.382 | 0.3513 | No |
| 48 | HIST1H2BE | NA | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 6630 | 0.368 | 0.3489 | No |
| 49 | HIST1H2AI | NA | HIST1H2AI Entrez, Source | histone cluster 1, H2ai | 6653 | 0.364 | 0.3510 | No |
| 50 | HIST1H2BO | NA | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 6681 | 0.360 | 0.3529 | No |
| 51 | SNRPB | NA | SNRPB Entrez, Source | small nuclear ribonucleoprotein polypeptides B and B1 | 6855 | 0.335 | 0.3463 | No |
| 52 | H2AFY2 | NA | H2AFY2 Entrez, Source | H2A histone family, member Y2 | 6939 | 0.324 | 0.3447 | No |
| 53 | HIST1H4K | NA | HIST1H4K Entrez, Source | histone cluster 1, H4k | 7058 | 0.309 | 0.3410 | No |
| 54 | HLA-DQB1 | NA | HLA-DQB1 Entrez, Source | major histocompatibility complex, class II, DQ beta 1 | 7133 | 0.297 | 0.3396 | No |
| 55 | ACTN4 | NA | ACTN4 Entrez, Source | actinin, alpha 4 | 7282 | 0.276 | 0.3339 | No |
| 56 | HIST1H2BI | NA | HIST1H2BI Entrez, Source | histone cluster 1, H2bi | 7339 | 0.269 | 0.3332 | No |
| 57 | HIST1H3F | NA | HIST1H3F Entrez, Source | histone cluster 1, H3f | 7375 | 0.264 | 0.3337 | No |
| 58 | CD40LG | NA | CD40LG Entrez, Source | CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome) | 7609 | 0.242 | 0.3229 | No |
| 59 | HIST2H3D | NA | HIST2H3D Entrez, Source | histone cluster 2, H3d | 7722 | 0.232 | 0.3188 | No |
| 60 | HLA-DQA1 | NA | HLA-DQA1 Entrez, Source | major histocompatibility complex, class II, DQ alpha 1 | 7724 | 0.232 | 0.3209 | No |
| 61 | C4B | NA | C4B Entrez, Source | complement component 4B (Childo blood group) | 7863 | 0.218 | 0.3153 | No |
| 62 | C8A | NA | C8A Entrez, Source | complement component 8, alpha polypeptide | 7878 | 0.216 | 0.3165 | No |
| 63 | HIST1H4A | NA | HIST1H4A Entrez, Source | histone cluster 1, H4a | 8011 | 0.201 | 0.3110 | No |
| 64 | HIST1H3D | NA | HIST1H3D Entrez, Source | histone cluster 1, H3d | 8252 | 0.173 | 0.2991 | No |
| 65 | HIST1H2AH | NA | HIST1H2AH Entrez, Source | histone cluster 1, H2ah | 8361 | 0.164 | 0.2946 | No |
| 66 | HLA-DOA | NA | HLA-DOA Entrez, Source | major histocompatibility complex, class II, DO alpha | 8378 | 0.164 | 0.2953 | No |
| 67 | C8B | NA | C8B Entrez, Source | complement component 8, beta polypeptide | 8400 | 0.162 | 0.2956 | No |
| 68 | TROVE2 | NA | TROVE2 Entrez, Source | TROVE domain family, member 2 | 8594 | 0.143 | 0.2861 | No |
| 69 | C9 | NA | C9 Entrez, Source | complement component 9 | 8604 | 0.143 | 0.2869 | No |
| 70 | H2AFV | NA | H2AFV Entrez, Source | H2A histone family, member V | 8743 | 0.128 | 0.2804 | No |
| 71 | C7 | NA | C7 Entrez, Source | complement component 7 | 8761 | 0.125 | 0.2806 | No |
| 72 | HIST1H2BB | NA | HIST1H2BB Entrez, Source | histone cluster 1, H2bb | 9150 | 0.084 | 0.2597 | No |
| 73 | C4A | NA | C4A Entrez, Source | complement component 4A (Rodgers blood group) | 9277 | 0.073 | 0.2533 | No |
| 74 | C6 | NA | C6 Entrez, Source | complement component 6 | 9328 | 0.067 | 0.2511 | No |
| 75 | IL10 | NA | IL10 Entrez, Source | interleukin 10 | 9803 | 0.010 | 0.2247 | No |
| 76 | HIST1H3I | NA | HIST1H3I Entrez, Source | histone cluster 1, H3i | 9898 | 0.000 | 0.2195 | No |
| 77 | FCGR3A | NA | FCGR3A Entrez, Source | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | 9919 | 0.000 | 0.2183 | No |
| 78 | FCGR3B | NA | FCGR3B Entrez, Source | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | 9920 | 0.000 | 0.2183 | No |
| 79 | HIST1H2BM | NA | HIST1H2BM Entrez, Source | histone cluster 1, H2bm | 10031 | 0.000 | 0.2122 | No |
| 80 | H2AFB2 | NA | H2AFB2 Entrez, Source | H2A histone family, member B2 | 10097 | 0.000 | 0.2085 | No |
| 81 | HIST3H2BB | NA | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 10125 | 0.000 | 0.2070 | No |
| 82 | HLA-DQA2 | NA | HLA-DQA2 Entrez, Source | major histocompatibility complex, class II, DQ alpha 2 | 10636 | -0.045 | 0.1789 | No |
| 83 | GRIN2B | NA | GRIN2B Entrez, Source | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 10737 | -0.054 | 0.1738 | No |
| 84 | C8G | NA | C8G Entrez, Source | complement component 8, gamma polypeptide | 10761 | -0.054 | 0.1730 | No |
| 85 | H2AFX | NA | H2AFX Entrez, Source | H2A histone family, member X | 10835 | -0.062 | 0.1695 | No |
| 86 | H3F3C | NA | 11009 | -0.082 | 0.1606 | No | ||
| 87 | C5 | NA | C5 Entrez, Source | complement component 5 | 11052 | -0.086 | 0.1591 | No |
| 88 | CD86 | NA | CD86 Entrez, Source | CD86 molecule | 11217 | -0.106 | 0.1509 | No |
| 89 | IFNG | NA | IFNG Entrez, Source | interferon, gamma | 11661 | -0.150 | 0.1275 | No |
| 90 | HIST1H3J | NA | HIST1H3J Entrez, Source | histone cluster 1, H3j | 11900 | -0.180 | 0.1158 | No |
| 91 | FCGR2B | NA | FCGR2B Entrez, Source | Fc fragment of IgG, low affinity IIb, receptor (CD32) | 11980 | -0.188 | 0.1132 | No |
| 92 | HIST2H2AB | NA | HIST2H2AB Entrez, Source | histone cluster 2, H2ab | 12531 | -0.256 | 0.0848 | No |
| 93 | TNF | NA | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 12645 | -0.269 | 0.0809 | No |
| 94 | HIST1H4J | NA | HIST1H4J Entrez, Source | histone cluster 1, H4j | 12652 | -0.270 | 0.0831 | No |
| 95 | HIST1H2BG | NA | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 12735 | -0.282 | 0.0812 | No |
| 96 | HIST4H4 | NA | HIST4H4 Entrez, Source | histone cluster 4, H4 | 12968 | -0.314 | 0.0711 | No |
| 97 | H2BFWT | NA | H2BFWT Entrez, Source | H2B histone family, member W, testis-specific | 14371 | -0.567 | -0.0021 | No |
| 98 | SNRPD1 | NA | SNRPD1 Entrez, Source | small nuclear ribonucleoprotein D1 polypeptide 16kDa | 14580 | -0.613 | -0.0080 | No |
| 99 | SNRPD3 | NA | SNRPD3 Entrez, Source | small nuclear ribonucleoprotein D3 polypeptide 18kDa | 14717 | -0.647 | -0.0096 | No |
| 100 | H2BFM | NA | H2BFM Entrez, Source | H2B histone family, member M | 14887 | -0.692 | -0.0126 | No |
| 101 | H3F3B | NA | H3F3B Entrez, Source | H3 histone, family 3B (H3.3B) | 15097 | -0.746 | -0.0174 | No |
| 102 | ACTN3 | NA | ACTN3 Entrez, Source | actinin, alpha 3 | 15102 | -0.747 | -0.0106 | No |
| 103 | GRIN2A | NA | GRIN2A Entrez, Source | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 15409 | -0.837 | -0.0200 | No |
| 104 | H3F3A | NA | H3F3A Entrez, Source | H3 histone, family 3A | 15500 | -0.862 | -0.0170 | No |
| 105 | HIST2H3A | NA | HIST2H3A Entrez, Source | histone cluster 2, H3a | 15503 | -0.863 | -0.0091 | No |
| 106 | CTSG | NA | CTSG Entrez, Source | cathepsin G | 15560 | -0.884 | -0.0040 | No |
| 107 | CD28 | NA | CD28 Entrez, Source | CD28 molecule | 16374 | -1.233 | -0.0380 | No |
| 108 | ACTN1 | NA | ACTN1 Entrez, Source | actinin, alpha 1 | 16729 | -1.453 | -0.0443 | No |
| 109 | ACTN2 | NA | ACTN2 Entrez, Source | actinin, alpha 2 | 17447 | -2.317 | -0.0628 | No |
| 110 | C1S | NA | C1S Entrez, Source | complement component 1, s subcomponent | 17464 | -2.349 | -0.0419 | No |
| 111 | CD40 | NA | CD40 Entrez, Source | CD40 molecule, TNF receptor superfamily member 5 | 17681 | -3.081 | -0.0253 | No |
| 112 | C3 | NA | C3 Entrez, Source | complement component 3 | 17907 | -4.505 | 0.0041 | No |
