Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_STEROID_BIOSYNTHESIS |
| Enrichment Score (ES) | -0.5325581 |
| Normalized Enrichment Score (NES) | -1.4223673 |
| Nominal p-value | 0.07887324 |
| FDR q-value | 0.20578359 |
| FWER p-Value | 0.841 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | TM7SF2 | NA | TM7SF2 Entrez, Source | transmembrane 7 superfamily member 2 | 1048 | 2.272 | 0.0485 | No |
| 2 | CEL | NA | CEL Entrez, Source | carboxyl ester lipase (bile salt-stimulated lipase) | 2131 | 1.479 | 0.0578 | No |
| 3 | SOAT1 | NA | SOAT1 Entrez, Source | sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 | 4516 | 0.745 | -0.0398 | No |
| 4 | LIPA | NA | LIPA Entrez, Source | lipase A, lysosomal acid, cholesterol esterase (Wolman disease) | 5214 | 0.601 | -0.0504 | No |
| 5 | SOAT2 | NA | SOAT2 Entrez, Source | sterol O-acyltransferase 2 | 6221 | 0.425 | -0.0864 | No |
| 6 | NSDHL | NA | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 13603 | -0.416 | -0.4777 | No |
| 7 | EBP | NA | EBP Entrez, Source | emopamil binding protein (sterol isomerase) | 14287 | -0.549 | -0.4899 | No |
| 8 | CYP51A1 | NA | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 15055 | -0.735 | -0.4980 | Yes |
| 9 | LSS | NA | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 15280 | -0.797 | -0.4730 | Yes |
| 10 | FDFT1 | NA | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 15889 | -1.003 | -0.4597 | Yes |
| 11 | HSD17B7 | NA | HSD17B7 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 7 | 16440 | -1.265 | -0.4308 | Yes |
| 12 | DHCR7 | NA | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 16843 | -1.541 | -0.3807 | Yes |
| 13 | SQLE | NA | SQLE Entrez, Source | squalene epoxidase | 17023 | -1.704 | -0.3105 | Yes |
| 14 | MSMO1 | NA | 17045 | -1.727 | -0.2304 | Yes | ||
| 15 | CYP27B1 | NA | CYP27B1 Entrez, Source | cytochrome P450, family 27, subfamily B, polypeptide 1 | 17626 | -2.801 | -0.1310 | Yes |
| 16 | DHCR24 | NA | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 17715 | -3.203 | 0.0148 | Yes |
