Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_PRION_DISEASES |
| Enrichment Score (ES) | -0.34448263 |
| Normalized Enrichment Score (NES) | -1.1179429 |
| Nominal p-value | 0.2428115 |
| FDR q-value | 0.62717557 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 690 | 2.778 | 0.0723 | No |
| 2 | HSPA1A | NA | HSPA1A Entrez, Source | heat shock 70kDa protein 1A | 1411 | 1.945 | 0.1097 | No |
| 3 | LAMC1 | NA | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 2513 | 1.318 | 0.1008 | No |
| 4 | PRNP | NA | PRNP Entrez, Source | prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) | 3123 | 1.110 | 0.1111 | No |
| 5 | HSPA5 | NA | HSPA5 Entrez, Source | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 3934 | 0.884 | 0.1012 | No |
| 6 | MAP2K2 | NA | MAP2K2 Entrez, Source | mitogen-activated protein kinase kinase 2 | 3949 | 0.881 | 0.1356 | No |
| 7 | CCL5 | NA | CCL5 Entrez, Source | chemokine (C-C motif) ligand 5 | 5108 | 0.622 | 0.0958 | No |
| 8 | SOD1 | NA | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 6092 | 0.452 | 0.0591 | No |
| 9 | NOTCH1 | NA | NOTCH1 Entrez, Source | Notch homolog 1, translocation-associated (Drosophila) | 6392 | 0.398 | 0.0583 | No |
| 10 | PRKX | NA | PRKX Entrez, Source | protein kinase, X-linked | 6692 | 0.358 | 0.0559 | No |
| 11 | C8A | NA | C8A Entrez, Source | complement component 8, alpha polypeptide | 7878 | 0.216 | -0.0015 | No |
| 12 | EGR1 | NA | EGR1 Entrez, Source | early growth response 1 | 7953 | 0.209 | 0.0027 | No |
| 13 | C8B | NA | C8B Entrez, Source | complement component 8, beta polypeptide | 8400 | 0.162 | -0.0157 | No |
| 14 | C9 | NA | C9 Entrez, Source | complement component 9 | 8604 | 0.143 | -0.0214 | No |
| 15 | C7 | NA | C7 Entrez, Source | complement component 7 | 8761 | 0.125 | -0.0251 | No |
| 16 | FYN | NA | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 8943 | 0.105 | -0.0310 | No |
| 17 | BAX | NA | BAX Entrez, Source | BCL2-associated X protein | 8966 | 0.102 | -0.0281 | No |
| 18 | NCAM1 | NA | NCAM1 Entrez, Source | neural cell adhesion molecule 1 | 9191 | 0.079 | -0.0375 | No |
| 19 | C6 | NA | C6 Entrez, Source | complement component 6 | 9328 | 0.067 | -0.0424 | No |
| 20 | ELK1 | NA | ELK1 Entrez, Source | ELK1, member of ETS oncogene family | 9664 | 0.029 | -0.0599 | No |
| 21 | PRKACA | NA | PRKACA Entrez, Source | protein kinase, cAMP-dependent, catalytic, alpha | 10652 | -0.045 | -0.1131 | No |
| 22 | C8G | NA | C8G Entrez, Source | complement component 8, gamma polypeptide | 10761 | -0.054 | -0.1169 | No |
| 23 | C5 | NA | C5 Entrez, Source | complement component 5 | 11052 | -0.086 | -0.1296 | No |
| 24 | PRKACG | NA | PRKACG Entrez, Source | protein kinase, cAMP-dependent, catalytic, gamma | 11122 | -0.095 | -0.1297 | No |
| 25 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 12360 | -0.233 | -0.1894 | No |
| 26 | STIP1 | NA | STIP1 Entrez, Source | stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) | 12695 | -0.274 | -0.1970 | No |
| 27 | NCAM2 | NA | NCAM2 Entrez, Source | neural cell adhesion molecule 2 | 14821 | -0.675 | -0.2885 | No |
| 28 | PRKACB | NA | PRKACB Entrez, Source | protein kinase, cAMP-dependent, catalytic, beta | 15440 | -0.844 | -0.2893 | No |
| 29 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 16431 | -1.263 | -0.2942 | Yes |
| 30 | MAP2K1 | NA | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 16504 | -1.300 | -0.2464 | Yes |
| 31 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 17833 | -3.984 | -0.1616 | Yes |
| 32 | IL1A | NA | IL1A Entrez, Source | interleukin 1, alpha | 17880 | -4.259 | 0.0056 | Yes |
