Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS |
| Enrichment Score (ES) | 0.63104415 |
| Normalized Enrichment Score (NES) | 1.5283806 |
| Nominal p-value | 0.037383176 |
| FDR q-value | 0.1355322 |
| FWER p-Value | 0.793 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CH25H | NA | CH25H Entrez, Source | cholesterol 25-hydroxylase | 138 | 4.378 | 0.2266 | Yes |
| 2 | HSD3B7 | NA | HSD3B7 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 260 | 3.872 | 0.4271 | Yes |
| 3 | CYP39A1 | NA | CYP39A1 Entrez, Source | cytochrome P450, family 39, subfamily A, polypeptide 1 | 275 | 3.824 | 0.6310 | Yes |
| 4 | HSD17B4 | NA | HSD17B4 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 4 | 2732 | 1.233 | 0.5603 | No |
| 5 | AMACR | NA | AMACR Entrez, Source | alpha-methylacyl-CoA racemase | 3995 | 0.868 | 0.5366 | No |
| 6 | SCP2 | NA | SCP2 Entrez, Source | sterol carrier protein 2 | 5068 | 0.629 | 0.5106 | No |
| 7 | BAAT | NA | BAAT Entrez, Source | bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase) | 5448 | 0.557 | 0.5193 | No |
| 8 | AKR1C4 | NA | AKR1C4 Entrez, Source | aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) | 9370 | 0.065 | 0.3045 | No |
| 9 | CYP46A1 | NA | CYP46A1 Entrez, Source | cytochrome P450, family 46, subfamily A, polypeptide 1 | 9478 | 0.055 | 0.3016 | No |
| 10 | CYP7A1 | NA | CYP7A1 Entrez, Source | cytochrome P450, family 7, subfamily A, polypeptide 1 | 10825 | -0.061 | 0.2299 | No |
| 11 | AKR1D1 | NA | AKR1D1 Entrez, Source | aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | 10876 | -0.066 | 0.2306 | No |
| 12 | SLC27A5 | NA | SLC27A5 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 5 | 11293 | -0.113 | 0.2135 | No |
| 13 | CYP8B1 | NA | CYP8B1 Entrez, Source | cytochrome P450, family 8, subfamily B, polypeptide 1 | 11756 | -0.162 | 0.1965 | No |
| 14 | CYP7B1 | NA | CYP7B1 Entrez, Source | cytochrome P450, family 7, subfamily B, polypeptide 1 | 11985 | -0.189 | 0.1939 | No |
| 15 | ACOX2 | NA | ACOX2 Entrez, Source | acyl-Coenzyme A oxidase 2, branched chain | 15200 | -0.773 | 0.0564 | No |
| 16 | CYP27A1 | NA | CYP27A1 Entrez, Source | cytochrome P450, family 27, subfamily A, polypeptide 1 | 17146 | -1.837 | 0.0464 | No |
