Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 |
| Enrichment Score (ES) | 0.566436 |
| Normalized Enrichment Score (NES) | 1.770676 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.035837747 |
| FWER p-Value | 0.073 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | ALDH3A1 | NA | ALDH3A1 Entrez, Source | aldehyde dehydrogenase 3 family, memberA1 | 7 | 4.949 | 0.0665 | Yes |
| 2 | AKR1C1 | NA | AKR1C1 Entrez, Source | aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) | 9 | 4.939 | 0.1332 | Yes |
| 3 | CYP1B1 | NA | CYP1B1 Entrez, Source | cytochrome P450, family 1, subfamily B, polypeptide 1 | 13 | 4.923 | 0.1996 | Yes |
| 4 | AKR1C2 | NA | AKR1C2 Entrez, Source | aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) | 37 | 4.782 | 0.2630 | Yes |
| 5 | AKR1C3 | NA | AKR1C3 Entrez, Source | aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) | 47 | 4.758 | 0.3268 | Yes |
| 6 | CYP1A1 | NA | CYP1A1 Entrez, Source | cytochrome P450, family 1, subfamily A, polypeptide 1 | 57 | 4.715 | 0.3901 | Yes |
| 7 | EPHX1 | NA | EPHX1 Entrez, Source | epoxide hydrolase 1, microsomal (xenobiotic) | 310 | 3.714 | 0.4262 | Yes |
| 8 | CYP2S1 | NA | CYP2S1 Entrez, Source | cytochrome P450, family 2, subfamily S, polypeptide 1 | 634 | 2.858 | 0.4468 | Yes |
| 9 | ADH6 | NA | ADH6 Entrez, Source | alcohol dehydrogenase 6 (class V) | 707 | 2.746 | 0.4799 | Yes |
| 10 | MGST1 | NA | MGST1 Entrez, Source | microsomal glutathione S-transferase 1 | 866 | 2.497 | 0.5049 | Yes |
| 11 | ALDH3B1 | NA | ALDH3B1 Entrez, Source | aldehyde dehydrogenase 3 family, member B1 | 1522 | 1.862 | 0.4935 | Yes |
| 12 | GSTM2 | NA | GSTM2 Entrez, Source | glutathione S-transferase M2 (muscle) | 1567 | 1.832 | 0.5158 | Yes |
| 13 | MGST3 | NA | MGST3 Entrez, Source | microsomal glutathione S-transferase 3 | 1787 | 1.675 | 0.5262 | Yes |
| 14 | CYP2E1 | NA | CYP2E1 Entrez, Source | cytochrome P450, family 2, subfamily E, polypeptide 1 | 1849 | 1.641 | 0.5450 | Yes |
| 15 | ADH1A | NA | ADH1A Entrez, Source | alcohol dehydrogenase 1A (class I), alpha polypeptide | 1862 | 1.634 | 0.5664 | Yes |
| 16 | ADH5 | NA | ADH5 Entrez, Source | alcohol dehydrogenase 5 (class III), chi polypeptide | 2719 | 1.237 | 0.5354 | No |
| 17 | CYP2F1 | NA | CYP2F1 Entrez, Source | cytochrome P450, family 2, subfamily F, polypeptide 1 | 3182 | 1.093 | 0.5244 | No |
| 18 | GSTA4 | NA | GSTA4 Entrez, Source | glutathione S-transferase A4 | 3896 | 0.892 | 0.4967 | No |
| 19 | UGT2B15 | NA | UGT2B15 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B15 | 4307 | 0.792 | 0.4845 | No |
| 20 | ADH1C | NA | ADH1C Entrez, Source | alcohol dehydrogenase 1C (class I), gamma polypeptide | 4486 | 0.751 | 0.4847 | No |
| 21 | ADH7 | NA | ADH7 Entrez, Source | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide | 5337 | 0.579 | 0.4451 | No |
| 22 | CYP1A2 | NA | CYP1A2 Entrez, Source | cytochrome P450, family 1, subfamily A, polypeptide 2 | 5521 | 0.546 | 0.4423 | No |
| 23 | CYP2C18 | NA | CYP2C18 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 18 | 5636 | 0.528 | 0.4430 | No |
| 24 | DHDH | NA | DHDH Entrez, Source | dihydrodiol dehydrogenase (dimeric) | 5803 | 0.500 | 0.4405 | No |
| 25 | UGT2A3 | NA | UGT2A3 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide A3 | 6188 | 0.433 | 0.4250 | No |
| 26 | UGT2B7 | NA | UGT2B7 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B7 | 6196 | 0.430 | 0.4304 | No |
| 27 | CYP2B6 | NA | CYP2B6 Entrez, Source | cytochrome P450, family 2, subfamily B, polypeptide 6 | 6578 | 0.374 | 0.4142 | No |
| 28 | ADH1B | NA | ADH1B Entrez, Source | alcohol dehydrogenase IB (class I), beta polypeptide | 6654 | 0.364 | 0.4149 | No |
| 29 | UGT2B4 | NA | UGT2B4 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B4 | 8151 | 0.182 | 0.3339 | No |
| 30 | GSTT2 | NA | GSTT2 Entrez, Source | glutathione S-transferase theta 2 | 8488 | 0.154 | 0.3172 | No |
| 31 | GSTK1 | NA | GSTK1 Entrez, Source | glutathione S-transferase kappa 1 | 8680 | 0.135 | 0.3084 | No |
| 32 | CYP2C9 | NA | CYP2C9 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 9 | 9009 | 0.098 | 0.2914 | No |
| 33 | UGT1A1 | NA | UGT1A1 Entrez, Source | UDP glucuronosyltransferase 1 family, polypeptide A1 | 9145 | 0.085 | 0.2850 | No |
| 34 | UGT1A6 | NA | UGT1A6 Entrez, Source | UDP glucuronosyltransferase 1 family, polypeptide A6 | 9215 | 0.077 | 0.2822 | No |
| 35 | AKR1C4 | NA | AKR1C4 Entrez, Source | aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) | 9370 | 0.065 | 0.2745 | No |
| 36 | GSTM1 | NA | GSTM1 Entrez, Source | glutathione S-transferase M1 | 9490 | 0.054 | 0.2686 | No |
| 37 | UGT2B10 | NA | UGT2B10 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B10 | 9943 | 0.000 | 0.2434 | No |
| 38 | UGT1A7 | NA | UGT1A7 Entrez, Source | UDP glucuronosyltransferase 1 family, polypeptide A7 | 10139 | 0.000 | 0.2325 | No |
| 39 | UGT1A10 | NA | UGT1A10 Entrez, Source | UDP glucuronosyltransferase 1 family, polypeptide A10 | 10274 | -0.012 | 0.2252 | No |
| 40 | ADH4 | NA | ADH4 Entrez, Source | alcohol dehydrogenase 4 (class II), pi polypeptide | 10599 | -0.042 | 0.2077 | No |
| 41 | CYP3A43 | NA | CYP3A43 Entrez, Source | cytochrome P450, family 3, subfamily A, polypeptide 43 | 10614 | -0.045 | 0.2075 | No |
| 42 | UGT2A1 | NA | UGT2A1 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide A1 | 11040 | -0.085 | 0.1849 | No |
| 43 | UGT1A9 | NA | UGT1A9 Entrez, Source | UDP glucuronosyltransferase 1 family, polypeptide A9 | 11115 | -0.094 | 0.1821 | No |
| 44 | UGT2B11 | NA | UGT2B11 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B11 | 11309 | -0.115 | 0.1729 | No |
| 45 | CYP2C19 | NA | CYP2C19 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 19 | 11744 | -0.161 | 0.1508 | No |
| 46 | CYP3A7 | NA | CYP3A7 Entrez, Source | cytochrome P450, family 3, subfamily A, polypeptide 7 | 12020 | -0.193 | 0.1381 | No |
| 47 | MGST2 | NA | MGST2 Entrez, Source | microsomal glutathione S-transferase 2 | 12137 | -0.205 | 0.1344 | No |
| 48 | ALDH3B2 | NA | ALDH3B2 Entrez, Source | aldehyde dehydrogenase 3 family, member B2 | 12442 | -0.242 | 0.1207 | No |
| 49 | CYP3A4 | NA | CYP3A4 Entrez, Source | cytochrome P450, family 3, subfamily A, polypeptide 4 | 12472 | -0.246 | 0.1224 | No |
| 50 | GSTA2 | NA | GSTA2 Entrez, Source | glutathione S-transferase A2 | 13238 | -0.354 | 0.0845 | No |
| 51 | GSTA5 | NA | GSTA5 Entrez, Source | glutathione S-transferase A5 | 13480 | -0.396 | 0.0764 | No |
| 52 | GSTM4 | NA | GSTM4 Entrez, Source | glutathione S-transferase M4 | 14384 | -0.569 | 0.0337 | No |
| 53 | GSTM3 | NA | GSTM3 Entrez, Source | glutathione S-transferase M3 (brain) | 14435 | -0.580 | 0.0388 | No |
| 54 | CYP2C8 | NA | CYP2C8 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 8 | 15013 | -0.724 | 0.0164 | No |
| 55 | GSTO1 | NA | GSTO1 Entrez, Source | glutathione S-transferase omega 1 | 15319 | -0.811 | 0.0103 | No |
| 56 | GSTM5 | NA | GSTM5 Entrez, Source | glutathione S-transferase M5 | 16078 | -1.076 | -0.0174 | No |
| 57 | CYP3A5 | NA | CYP3A5 Entrez, Source | cytochrome P450, family 3, subfamily A, polypeptide 5 | 17254 | -1.979 | -0.0563 | No |
| 58 | GSTP1 | NA | GSTP1 Entrez, Source | glutathione S-transferase pi | 17386 | -2.197 | -0.0339 | No |
| 59 | ALDH1A3 | NA | ALDH1A3 Entrez, Source | aldehyde dehydrogenase 1 family, member A3 | 17463 | -2.345 | -0.0064 | No |
| 60 | GSTO2 | NA | GSTO2 Entrez, Source | glutathione S-transferase omega 2 | 17561 | -2.604 | 0.0234 | No |
