Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_LYSOSOME |
| Enrichment Score (ES) | 0.43716443 |
| Normalized Enrichment Score (NES) | 1.4843192 |
| Nominal p-value | 0.0024420025 |
| FDR q-value | 0.17295942 |
| FWER p-Value | 0.919 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | ATP6V0D2 | NA | ATP6V0D2 Entrez, Source | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 | 341 | 3.613 | 0.0077 | Yes |
| 2 | ASAH1 | NA | ASAH1 Entrez, Source | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | 377 | 3.514 | 0.0318 | Yes |
| 3 | FUCA1 | NA | FUCA1 Entrez, Source | fucosidase, alpha-L- 1, tissue | 378 | 3.513 | 0.0579 | Yes |
| 4 | AP1S3 | NA | AP1S3 Entrez, Source | adaptor-related protein complex 1, sigma 3 subunit | 389 | 3.475 | 0.0831 | Yes |
| 5 | CTSD | NA | CTSD Entrez, Source | cathepsin D (lysosomal aspartyl peptidase) | 390 | 3.474 | 0.1089 | Yes |
| 6 | ATP6AP1 | NA | ATP6AP1 Entrez, Source | ATPase, H+ transporting, lysosomal accessory protein 1 | 491 | 3.163 | 0.1268 | Yes |
| 7 | NEU1 | NA | NEU1 Entrez, Source | sialidase 1 (lysosomal sialidase) | 527 | 3.087 | 0.1477 | Yes |
| 8 | GLA | NA | GLA Entrez, Source | galactosidase, alpha | 653 | 2.829 | 0.1617 | Yes |
| 9 | CTSB | NA | CTSB Entrez, Source | cathepsin B | 721 | 2.715 | 0.1781 | Yes |
| 10 | ATP6V0A4 | NA | ATP6V0A4 Entrez, Source | ATPase, H+ transporting, lysosomal V0 subunit a4 | 827 | 2.546 | 0.1911 | Yes |
| 11 | MANBA | NA | MANBA Entrez, Source | mannosidase, beta A, lysosomal | 1091 | 2.231 | 0.1929 | Yes |
| 12 | GM2A | NA | GM2A Entrez, Source | GM2 ganglioside activator | 1148 | 2.169 | 0.2059 | Yes |
| 13 | NPC1 | NA | NPC1 Entrez, Source | Niemann-Pick disease, type C1 | 1166 | 2.154 | 0.2209 | Yes |
| 14 | PPT2 | NA | PPT2 Entrez, Source | palmitoyl-protein thioesterase 2 | 1301 | 2.043 | 0.2286 | Yes |
| 15 | SCARB2 | NA | SCARB2 Entrez, Source | scavenger receptor class B, member 2 | 1310 | 2.034 | 0.2432 | Yes |
| 16 | SMPD1 | NA | SMPD1 Entrez, Source | sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) | 1399 | 1.950 | 0.2527 | Yes |
| 17 | LAMP3 | NA | LAMP3 Entrez, Source | lysosomal-associated membrane protein 3 | 1401 | 1.950 | 0.2671 | Yes |
| 18 | SLC17A5 | NA | SLC17A5 Entrez, Source | solute carrier family 17 (anion/sugar transporter), member 5 | 1438 | 1.923 | 0.2794 | Yes |
| 19 | GNS | NA | GNS Entrez, Source | glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) | 1503 | 1.882 | 0.2898 | Yes |
| 20 | IDS | NA | IDS Entrez, Source | iduronate 2-sulfatase (Hunter syndrome) | 1506 | 1.880 | 0.3036 | Yes |
| 21 | AP3M2 | NA | AP3M2 Entrez, Source | adaptor-related protein complex 3, mu 2 subunit | 1562 | 1.835 | 0.3141 | Yes |
| 22 | CTSF | NA | CTSF Entrez, Source | cathepsin F | 1632 | 1.782 | 0.3235 | Yes |
| 23 | DNASE2 | NA | DNASE2 Entrez, Source | deoxyribonuclease II, lysosomal | 1677 | 1.750 | 0.3340 | Yes |
| 24 | ARSA | NA | ARSA Entrez, Source | arylsulfatase A | 1684 | 1.746 | 0.3466 | Yes |
| 25 | CLN3 | NA | CLN3 Entrez, Source | ceroid-lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease) | 1717 | 1.725 | 0.3577 | Yes |
| 26 | CLTCL1 | NA | CLTCL1 Entrez, Source | clathrin, heavy chain-like 1 | 1909 | 1.609 | 0.3589 | Yes |
| 27 | ENTPD4 | NA | ENTPD4 Entrez, Source | ectonucleoside triphosphate diphosphohydrolase 4 | 1934 | 1.595 | 0.3694 | Yes |
| 28 | PLA2G15 | NA | 2148 | 1.471 | 0.3684 | Yes | ||
| 29 | SGSH | NA | SGSH Entrez, Source | N-sulfoglucosamine sulfohydrolase (sulfamidase) | 2174 | 1.461 | 0.3778 | Yes |
| 30 | HGSNAT | NA | HGSNAT Entrez, Source | heparan-alpha-glucosaminide N-acetyltransferase | 2464 | 1.339 | 0.3716 | Yes |
| 31 | MCOLN1 | NA | MCOLN1 Entrez, Source | mucolipin 1 | 2687 | 1.249 | 0.3684 | Yes |
| 32 | NPC2 | NA | NPC2 Entrez, Source | Niemann-Pick disease, type C2 | 2694 | 1.247 | 0.3773 | Yes |
| 33 | AP3S2 | NA | AP3S2 Entrez, Source | adaptor-related protein complex 3, sigma 2 subunit | 2714 | 1.239 | 0.3855 | Yes |
| 34 | ATP6V0A1 | NA | ATP6V0A1 Entrez, Source | ATPase, H+ transporting, lysosomal V0 subunit a1 | 2828 | 1.205 | 0.3881 | Yes |
| 35 | SORT1 | NA | SORT1 Entrez, Source | sortilin 1 | 2882 | 1.187 | 0.3939 | Yes |
| 36 | AP3S1 | NA | AP3S1 Entrez, Source | adaptor-related protein complex 3, sigma 1 subunit | 3033 | 1.137 | 0.3939 | Yes |
| 37 | ARSB | NA | ARSB Entrez, Source | arylsulfatase B | 3079 | 1.122 | 0.3998 | Yes |
| 38 | GBA | NA | GBA Entrez, Source | glucosidase, beta; acid (includes glucosylceramidase) | 3114 | 1.114 | 0.4061 | Yes |
| 39 | CTSO | NA | CTSO Entrez, Source | cathepsin O | 3308 | 1.054 | 0.4031 | Yes |
| 40 | ATP6V0B | NA | ATP6V0B Entrez, Source | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | 3328 | 1.048 | 0.4098 | Yes |
| 41 | LGMN | NA | LGMN Entrez, Source | legumain | 3465 | 1.012 | 0.4097 | Yes |
| 42 | ACP2 | NA | ACP2 Entrez, Source | acid phosphatase 2, lysosomal | 3625 | 0.961 | 0.4080 | Yes |
| 43 | AGA | NA | AGA Entrez, Source | aspartylglucosaminidase | 3700 | 0.940 | 0.4108 | Yes |
| 44 | CTSA | NA | 3702 | 0.940 | 0.4177 | Yes | ||
| 45 | CTSZ | NA | CTSZ Entrez, Source | cathepsin Z | 3955 | 0.878 | 0.4101 | Yes |
| 46 | GNPTAB | NA | GNPTAB Entrez, Source | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | 3978 | 0.872 | 0.4154 | Yes |
| 47 | CTNS | NA | CTNS Entrez, Source | cystinosis, nephropathic | 4000 | 0.868 | 0.4206 | Yes |
| 48 | GALC | NA | GALC Entrez, Source | galactosylceramidase | 4125 | 0.835 | 0.4199 | Yes |
| 49 | CLTB | NA | CLTB Entrez, Source | clathrin, light chain (Lcb) | 4192 | 0.818 | 0.4223 | Yes |
| 50 | ABCB9 | NA | ABCB9 Entrez, Source | ATP-binding cassette, sub-family B (MDR/TAP), member 9 | 4201 | 0.816 | 0.4279 | Yes |
| 51 | MAN2B1 | NA | MAN2B1 Entrez, Source | mannosidase, alpha, class 2B, member 1 | 4212 | 0.813 | 0.4333 | Yes |
| 52 | IDUA | NA | IDUA Entrez, Source | iduronidase, alpha-L- | 4251 | 0.803 | 0.4372 | Yes |
| 53 | PSAP | NA | PSAP Entrez, Source | prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) | 4431 | 0.767 | 0.4328 | No |
| 54 | CTSK | NA | CTSK Entrez, Source | cathepsin K (pycnodysostosis) | 4477 | 0.753 | 0.4359 | No |
| 55 | CLTC | NA | CLTC Entrez, Source | clathrin, heavy chain (Hc) | 4924 | 0.656 | 0.4158 | No |
| 56 | CD63 | NA | CD63 Entrez, Source | CD63 molecule | 5019 | 0.637 | 0.4153 | No |
| 57 | GALNS | NA | GALNS Entrez, Source | galactosamine (N-acetyl)-6-sulfate sulfatase (Morquio syndrome, mucopolysaccharidosis type IVA) | 5072 | 0.629 | 0.4170 | No |
| 58 | LIPA | NA | LIPA Entrez, Source | lipase A, lysosomal acid, cholesterol esterase (Wolman disease) | 5214 | 0.601 | 0.4136 | No |
| 59 | CD68 | NA | CD68 Entrez, Source | CD68 molecule | 5672 | 0.522 | 0.3919 | No |
| 60 | AP4S1 | NA | AP4S1 Entrez, Source | adaptor-related protein complex 4, sigma 1 subunit | 6028 | 0.462 | 0.3754 | No |
| 61 | ATP6V0C | NA | ATP6V0C Entrez, Source | ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c | 6336 | 0.406 | 0.3613 | No |
| 62 | GGA1 | NA | GGA1 Entrez, Source | golgi associated, gamma adaptin ear containing, ARF binding protein 1 | 6460 | 0.390 | 0.3573 | No |
| 63 | AP4E1 | NA | AP4E1 Entrez, Source | adaptor-related protein complex 4, epsilon 1 subunit | 6593 | 0.372 | 0.3526 | No |
| 64 | DNASE2B | NA | DNASE2B Entrez, Source | deoxyribonuclease II beta | 6708 | 0.355 | 0.3489 | No |
| 65 | HEXB | NA | HEXB Entrez, Source | hexosaminidase B (beta polypeptide) | 6755 | 0.347 | 0.3489 | No |
| 66 | LAPTM4A | NA | LAPTM4A Entrez, Source | lysosomal-associated protein transmembrane 4 alpha | 7005 | 0.315 | 0.3373 | No |
| 67 | ATP6V1H | NA | ATP6V1H Entrez, Source | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H | 7144 | 0.295 | 0.3317 | No |
| 68 | GGA3 | NA | GGA3 Entrez, Source | golgi associated, gamma adaptin ear containing, ARF binding protein 3 | 7710 | 0.233 | 0.3018 | No |
| 69 | AP3M1 | NA | AP3M1 Entrez, Source | adaptor-related protein complex 3, mu 1 subunit | 7917 | 0.213 | 0.2919 | No |
| 70 | IGF2R | NA | IGF2R Entrez, Source | insulin-like growth factor 2 receptor | 8178 | 0.179 | 0.2787 | No |
| 71 | SLC11A2 | NA | SLC11A2 Entrez, Source | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | 8280 | 0.171 | 0.2743 | No |
| 72 | SUMF1 | NA | SUMF1 Entrez, Source | sulfatase modifying factor 1 | 8684 | 0.135 | 0.2527 | No |
| 73 | ATP6V0D1 | NA | ATP6V0D1 Entrez, Source | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 | 8712 | 0.131 | 0.2522 | No |
| 74 | ATP6V0A2 | NA | ATP6V0A2 Entrez, Source | ATPase, H+ transporting, lysosomal V0 subunit a2 | 8985 | 0.100 | 0.2377 | No |
| 75 | AP1M1 | NA | AP1M1 Entrez, Source | adaptor-related protein complex 1, mu 1 subunit | 9149 | 0.085 | 0.2292 | No |
| 76 | GNPTG | NA | GNPTG Entrez, Source | N-acetylglucosamine-1-phosphate transferase, gamma subunit | 9383 | 0.064 | 0.2166 | No |
| 77 | AP1S2 | NA | AP1S2 Entrez, Source | adaptor-related protein complex 1, sigma 2 subunit | 9491 | 0.054 | 0.2110 | No |
| 78 | MFSD8 | NA | 9773 | 0.015 | 0.1954 | No | ||
| 79 | AP1G1 | NA | AP1G1 Entrez, Source | adaptor-related protein complex 1, gamma 1 subunit | 9787 | 0.014 | 0.1948 | No |
| 80 | CLTA | NA | CLTA Entrez, Source | clathrin, light chain (Lca) | 10222 | -0.008 | 0.1705 | No |
| 81 | NAGLU | NA | NAGLU Entrez, Source | N-acetylglucosaminidase, alpha- (Sanfilippo disease IIIB) | 10513 | -0.032 | 0.1546 | No |
| 82 | NAGPA | NA | NAGPA Entrez, Source | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase | 10531 | -0.035 | 0.1539 | No |
| 83 | AP3D1 | NA | AP3D1 Entrez, Source | adaptor-related protein complex 3, delta 1 subunit | 10562 | -0.037 | 0.1525 | No |
| 84 | LAPTM4B | NA | LAPTM4B Entrez, Source | lysosomal associated protein transmembrane 4 beta | 11039 | -0.085 | 0.1264 | No |
| 85 | TCIRG1 | NA | TCIRG1 Entrez, Source | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | 11257 | -0.110 | 0.1151 | No |
| 86 | CTSC | NA | CTSC Entrez, Source | cathepsin C | 11401 | -0.124 | 0.1080 | No |
| 87 | GLB1 | NA | GLB1 Entrez, Source | galactosidase, beta 1 | 11427 | -0.127 | 0.1076 | No |
| 88 | M6PR | NA | M6PR Entrez, Source | mannose-6-phosphate receptor (cation dependent) | 11437 | -0.127 | 0.1080 | No |
| 89 | SLC11A1 | NA | SLC11A1 Entrez, Source | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 | 12186 | -0.212 | 0.0677 | No |
| 90 | LAMP2 | NA | LAMP2 Entrez, Source | lysosomal-associated membrane protein 2 | 12603 | -0.264 | 0.0464 | No |
| 91 | AP3B2 | NA | AP3B2 Entrez, Source | adaptor-related protein complex 3, beta 2 subunit | 12915 | -0.304 | 0.0312 | No |
| 92 | TPP1 | NA | TPP1 Entrez, Source | tripeptidyl peptidase I | 13153 | -0.341 | 0.0205 | No |
| 93 | GGA2 | NA | GGA2 Entrez, Source | golgi associated, gamma adaptin ear containing, ARF binding protein 2 | 13244 | -0.355 | 0.0181 | No |
| 94 | AP1S1 | NA | AP1S1 Entrez, Source | adaptor-related protein complex 1, sigma 1 subunit | 13507 | -0.400 | 0.0064 | No |
| 95 | ACP5 | NA | ACP5 Entrez, Source | acid phosphatase 5, tartrate resistant | 13951 | -0.480 | -0.0149 | No |
| 96 | NAPSA | NA | NAPSA Entrez, Source | napsin A aspartic peptidase | 13953 | -0.481 | -0.0113 | No |
| 97 | ABCA2 | NA | ABCA2 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 2 | 14180 | -0.527 | -0.0201 | No |
| 98 | AP4B1 | NA | AP4B1 Entrez, Source | adaptor-related protein complex 4, beta 1 subunit | 14258 | -0.543 | -0.0204 | No |
| 99 | LAMP1 | NA | LAMP1 Entrez, Source | lysosomal-associated membrane protein 1 | 14270 | -0.545 | -0.0169 | No |
| 100 | CD164 | NA | CD164 Entrez, Source | CD164 molecule, sialomucin | 14293 | -0.550 | -0.0141 | No |
| 101 | AP4M1 | NA | AP4M1 Entrez, Source | adaptor-related protein complex 4, mu 1 subunit | 14326 | -0.556 | -0.0118 | No |
| 102 | AP1B1 | NA | AP1B1 Entrez, Source | adaptor-related protein complex 1, beta 1 subunit | 14351 | -0.563 | -0.0089 | No |
| 103 | CLN5 | NA | CLN5 Entrez, Source | ceroid-lipofuscinosis, neuronal 5 | 14588 | -0.614 | -0.0176 | No |
| 104 | AP3B1 | NA | AP3B1 Entrez, Source | adaptor-related protein complex 3, beta 1 subunit | 14658 | -0.632 | -0.0168 | No |
| 105 | PPT1 | NA | PPT1 Entrez, Source | palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) | 15446 | -0.845 | -0.0545 | No |
| 106 | CTSG | NA | CTSG Entrez, Source | cathepsin G | 15560 | -0.884 | -0.0543 | No |
| 107 | ARSG | NA | ARSG Entrez, Source | arylsulfatase G | 15849 | -0.987 | -0.0631 | No |
| 108 | PSAPL1 | NA | PSAPL1 Entrez, Source | prosaposin-like 1 | 15859 | -0.991 | -0.0563 | No |
| 109 | NAGA | NA | NAGA Entrez, Source | N-acetylgalactosaminidase, alpha- | 16459 | -1.274 | -0.0803 | No |
| 110 | GUSB | NA | GUSB Entrez, Source | glucuronidase, beta | 16663 | -1.403 | -0.0813 | No |
| 111 | GAA | NA | GAA Entrez, Source | glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II) | 16678 | -1.412 | -0.0716 | No |
| 112 | CTSH | NA | CTSH Entrez, Source | cathepsin H | 16852 | -1.551 | -0.0698 | No |
| 113 | CTSW | NA | CTSW Entrez, Source | cathepsin W (lymphopain) | 17361 | -2.149 | -0.0823 | No |
| 114 | HEXA | NA | HEXA Entrez, Source | hexosaminidase A (alpha polypeptide) | 17383 | -2.194 | -0.0672 | No |
| 115 | AP1M2 | NA | AP1M2 Entrez, Source | adaptor-related protein complex 1, mu 2 subunit | 17539 | -2.526 | -0.0571 | No |
| 116 | LAPTM5 | NA | LAPTM5 Entrez, Source | lysosomal associated multispanning membrane protein 5 | 17716 | -3.205 | -0.0432 | No |
| 117 | CTSE | NA | CTSE Entrez, Source | cathepsin E | 17795 | -3.692 | -0.0202 | No |
| 118 | CTSS | NA | CTSS Entrez, Source | cathepsin S | 17858 | -4.107 | 0.0068 | No |
