Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_ERBB_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.50186515 |
| Normalized Enrichment Score (NES) | 1.6312332 |
| Nominal p-value | 0.0037688443 |
| FDR q-value | 0.06155352 |
| FWER p-Value | 0.386 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | EREG | NA | EREG Entrez, Source | epiregulin | 53 | 4.731 | 0.0459 | Yes |
| 2 | AREG | NA | AREG Entrez, Source | amphiregulin (schwannoma-derived growth factor) | 100 | 4.528 | 0.0900 | Yes |
| 3 | TGFA | NA | TGFA Entrez, Source | transforming growth factor, alpha | 103 | 4.515 | 0.1365 | Yes |
| 4 | ERBB3 | NA | ERBB3 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 143 | 4.355 | 0.1793 | Yes |
| 5 | NRG1 | NA | NRG1 Entrez, Source | neuregulin 1 | 150 | 4.326 | 0.2236 | Yes |
| 6 | BTC | NA | BTC Entrez, Source | betacellulin | 369 | 3.537 | 0.2479 | Yes |
| 7 | CAMK2B | NA | CAMK2B Entrez, Source | calcium/calmodulin-dependent protein kinase (CaM kinase) II beta | 506 | 3.124 | 0.2726 | Yes |
| 8 | CDKN1A | NA | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 522 | 3.100 | 0.3037 | Yes |
| 9 | SHC3 | NA | SHC3 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 3 | 635 | 2.856 | 0.3270 | Yes |
| 10 | EGF | NA | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 734 | 2.677 | 0.3491 | Yes |
| 11 | PIK3CA | NA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 749 | 2.649 | 0.3757 | Yes |
| 12 | CAMK2D | NA | CAMK2D Entrez, Source | calcium/calmodulin-dependent protein kinase (CaM kinase) II delta | 868 | 2.495 | 0.3948 | Yes |
| 13 | MTOR | NA | 1024 | 2.302 | 0.4099 | Yes | ||
| 14 | PRKCG | NA | PRKCG Entrez, Source | protein kinase C, gamma | 1098 | 2.222 | 0.4288 | Yes |
| 15 | CBLB | NA | CBLB Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | 1384 | 1.967 | 0.4332 | Yes |
| 16 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 1410 | 1.946 | 0.4518 | Yes |
| 17 | PRKCA | NA | PRKCA Entrez, Source | protein kinase C, alpha | 1595 | 1.810 | 0.4602 | Yes |
| 18 | PIK3R1 | NA | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 2108 | 1.493 | 0.4470 | Yes |
| 19 | EIF4EBP1 | NA | EIF4EBP1 Entrez, Source | eukaryotic translation initiation factor 4E binding protein 1 | 2287 | 1.419 | 0.4517 | Yes |
| 20 | CDKN1B | NA | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 2680 | 1.253 | 0.4428 | Yes |
| 21 | SHC2 | NA | SHC2 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 2 | 2820 | 1.207 | 0.4475 | Yes |
| 22 | ERBB2 | NA | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 2851 | 1.197 | 0.4581 | Yes |
| 23 | SOS2 | NA | SOS2 Entrez, Source | son of sevenless homolog 2 (Drosophila) | 2927 | 1.172 | 0.4660 | Yes |
| 24 | ERBB4 | NA | ERBB4 Entrez, Source | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) | 3021 | 1.142 | 0.4726 | Yes |
| 25 | SHC4 | NA | SHC4 Entrez, Source | SHC (Src homology 2 domain containing) family, member 4 | 3135 | 1.107 | 0.4777 | Yes |
| 26 | HBEGF | NA | HBEGF Entrez, Source | heparin-binding EGF-like growth factor | 3371 | 1.037 | 0.4753 | Yes |
| 27 | EGFR | NA | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 3428 | 1.020 | 0.4827 | Yes |
| 28 | PAK2 | NA | PAK2 Entrez, Source | p21 (CDKN1A)-activated kinase 2 | 3570 | 0.979 | 0.4849 | Yes |
| 29 | ABL2 | NA | ABL2 Entrez, Source | v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) | 3631 | 0.959 | 0.4915 | Yes |
| 30 | CBL | NA | CBL Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 3786 | 0.920 | 0.4924 | Yes |
| 31 | SOS1 | NA | SOS1 Entrez, Source | son of sevenless homolog 1 (Drosophila) | 3824 | 0.911 | 0.4997 | Yes |
| 32 | MAP2K2 | NA | MAP2K2 Entrez, Source | mitogen-activated protein kinase kinase 2 | 3949 | 0.881 | 0.5019 | Yes |
| 33 | CAMK2A | NA | CAMK2A Entrez, Source | calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha | 4559 | 0.735 | 0.4754 | No |
| 34 | SRC | NA | SRC Entrez, Source | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 4827 | 0.676 | 0.4675 | No |
| 35 | HRAS | NA | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 4840 | 0.674 | 0.4738 | No |
| 36 | PAK6 | NA | PAK6 Entrez, Source | p21(CDKN1A)-activated kinase 6 | 5063 | 0.630 | 0.4679 | No |
| 37 | MAPK9 | NA | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 6268 | 0.418 | 0.4049 | No |
| 38 | NCK2 | NA | NCK2 Entrez, Source | NCK adaptor protein 2 | 6277 | 0.416 | 0.4087 | No |
| 39 | AKT2 | NA | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 6498 | 0.385 | 0.4004 | No |
| 40 | GAB1 | NA | GAB1 Entrez, Source | GRB2-associated binding protein 1 | 6501 | 0.384 | 0.4043 | No |
| 41 | PLCG2 | NA | PLCG2 Entrez, Source | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 6737 | 0.350 | 0.3948 | No |
| 42 | JUN | NA | JUN Entrez, Source | jun oncogene | 7042 | 0.310 | 0.3810 | No |
| 43 | BAD | NA | BAD Entrez, Source | BCL2-antagonist of cell death | 7106 | 0.300 | 0.3806 | No |
| 44 | KRAS | NA | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 7514 | 0.251 | 0.3604 | No |
| 45 | PIK3CB | NA | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 7635 | 0.240 | 0.3562 | No |
| 46 | RPS6KB1 | NA | RPS6KB1 Entrez, Source | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 8058 | 0.195 | 0.3346 | No |
| 47 | PRKCB | NA | 8131 | 0.185 | 0.3325 | No | ||
| 48 | MAP2K4 | NA | MAP2K4 Entrez, Source | mitogen-activated protein kinase kinase 4 | 8145 | 0.182 | 0.3336 | No |
| 49 | PAK3 | NA | PAK3 Entrez, Source | p21 (CDKN1A)-activated kinase 3 | 8610 | 0.142 | 0.3092 | No |
| 50 | ARAF | NA | ARAF Entrez, Source | v-raf murine sarcoma 3611 viral oncogene homolog | 8641 | 0.139 | 0.3089 | No |
| 51 | CRKL | NA | CRKL Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 8717 | 0.130 | 0.3061 | No |
| 52 | PTK2 | NA | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 8777 | 0.123 | 0.3041 | No |
| 53 | MAP2K7 | NA | MAP2K7 Entrez, Source | mitogen-activated protein kinase kinase 7 | 8797 | 0.121 | 0.3043 | No |
| 54 | CBLC | NA | CBLC Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence c | 8864 | 0.114 | 0.3017 | No |
| 55 | MAPK10 | NA | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 9003 | 0.098 | 0.2950 | No |
| 56 | ABL1 | NA | ABL1 Entrez, Source | v-abl Abelson murine leukemia viral oncogene homolog 1 | 9168 | 0.083 | 0.2867 | No |
| 57 | ELK1 | NA | ELK1 Entrez, Source | ELK1, member of ETS oncogene family | 9664 | 0.029 | 0.2594 | No |
| 58 | MAPK8 | NA | MAPK8 Entrez, Source | mitogen-activated protein kinase 8 | 9814 | 0.009 | 0.2511 | No |
| 59 | PIK3R5 | NA | PIK3R5 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 5, p101 | 9845 | 0.004 | 0.2495 | No |
| 60 | CRK | NA | CRK Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian) | 9877 | 0.000 | 0.2478 | No |
| 61 | CAMK2G | NA | CAMK2G Entrez, Source | calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma | 10885 | -0.067 | 0.1922 | No |
| 62 | PAK4 | NA | PAK4 Entrez, Source | p21(CDKN1A)-activated kinase 4 | 11589 | -0.143 | 0.1544 | No |
| 63 | GRB2 | NA | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 12056 | -0.196 | 0.1304 | No |
| 64 | NRAS | NA | NRAS Entrez, Source | neuroblastoma RAS viral (v-ras) oncogene homolog | 12151 | -0.207 | 0.1273 | No |
| 65 | STAT5B | NA | STAT5B Entrez, Source | signal transducer and activator of transcription 5B | 12285 | -0.224 | 0.1221 | No |
| 66 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 12360 | -0.233 | 0.1204 | No |
| 67 | PIK3R2 | NA | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 12508 | -0.252 | 0.1148 | No |
| 68 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 12596 | -0.262 | 0.1126 | No |
| 69 | NRG2 | NA | NRG2 Entrez, Source | neuregulin 2 | 12714 | -0.278 | 0.1090 | No |
| 70 | NCK1 | NA | NCK1 Entrez, Source | NCK adaptor protein 1 | 12903 | -0.302 | 0.1016 | No |
| 71 | RPS6KB2 | NA | RPS6KB2 Entrez, Source | ribosomal protein S6 kinase, 70kDa, polypeptide 2 | 13732 | -0.442 | 0.0599 | No |
| 72 | RAF1 | NA | RAF1 Entrez, Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 13760 | -0.446 | 0.0630 | No |
| 73 | PLCG1 | NA | PLCG1 Entrez, Source | phospholipase C, gamma 1 | 13897 | -0.470 | 0.0602 | No |
| 74 | NRG3 | NA | NRG3 Entrez, Source | neuregulin 3 | 14737 | -0.656 | 0.0201 | No |
| 75 | NRG4 | NA | NRG4 Entrez, Source | neuregulin 4 | 14911 | -0.698 | 0.0176 | No |
| 76 | AKT3 | NA | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 14929 | -0.703 | 0.0239 | No |
| 77 | PAK1 | NA | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 15023 | -0.727 | 0.0262 | No |
| 78 | BRAF | NA | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 15145 | -0.758 | 0.0273 | No |
| 79 | MYC | NA | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 15151 | -0.760 | 0.0349 | No |
| 80 | AKT1 | NA | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 15339 | -0.816 | 0.0328 | No |
| 81 | STAT5A | NA | STAT5A Entrez, Source | signal transducer and activator of transcription 5A | 15688 | -0.923 | 0.0229 | No |
| 82 | GSK3B | NA | GSK3B Entrez, Source | glycogen synthase kinase 3 beta | 15818 | -0.977 | 0.0258 | No |
| 83 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 16431 | -1.263 | 0.0046 | No |
| 84 | MAP2K1 | NA | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 16504 | -1.300 | 0.0140 | No |
| 85 | SHC1 | NA | SHC1 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 1 | 17055 | -1.738 | 0.0012 | No |
| 86 | PIK3CG | NA | PIK3CG Entrez, Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 17957 | -4.885 | 0.0013 | No |
