Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_DNA_REPLICATION |
| Enrichment Score (ES) | -0.4707066 |
| Normalized Enrichment Score (NES) | -1.5325333 |
| Nominal p-value | 0.012903226 |
| FDR q-value | 0.13643399 |
| FWER p-Value | 0.546 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | RFC4 | NA | RFC4 Entrez, Source | replication factor C (activator 1) 4, 37kDa | 853 | 2.505 | 0.0527 | No |
| 2 | RPA4 | NA | RPA4 Entrez, Source | replication protein A4, 34kDa | 2651 | 1.263 | 0.0031 | No |
| 3 | PRIM2 | NA | 5111 | 0.621 | -0.1091 | No | ||
| 4 | RFC1 | NA | RFC1 Entrez, Source | replication factor C (activator 1) 1, 145kDa | 5564 | 0.539 | -0.1127 | No |
| 5 | RNASEH2C | NA | RNASEH2C Entrez, Source | ribonuclease H2, subunit C | 5940 | 0.478 | -0.1144 | No |
| 6 | RPA2 | NA | RPA2 Entrez, Source | replication protein A2, 32kDa | 7584 | 0.245 | -0.1962 | No |
| 7 | PCNA | NA | PCNA Entrez, Source | proliferating cell nuclear antigen | 8603 | 0.143 | -0.2472 | No |
| 8 | MCM3 | NA | MCM3 Entrez, Source | MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) | 9190 | 0.079 | -0.2767 | No |
| 9 | POLE2 | NA | POLE2 Entrez, Source | polymerase (DNA directed), epsilon 2 (p59 subunit) | 9465 | 0.056 | -0.2897 | No |
| 10 | POLE | NA | POLE Entrez, Source | polymerase (DNA directed), epsilon | 10242 | -0.010 | -0.3326 | No |
| 11 | RNASEH2A | NA | RNASEH2A Entrez, Source | ribonuclease H2, subunit A | 10243 | -0.010 | -0.3322 | No |
| 12 | RNASEH1 | NA | RNASEH1 Entrez, Source | ribonuclease H1 | 10689 | -0.049 | -0.3550 | No |
| 13 | MCM6 | NA | MCM6 Entrez, Source | MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) | 10954 | -0.076 | -0.3667 | No |
| 14 | RPA1 | NA | RPA1 Entrez, Source | replication protein A1, 70kDa | 10991 | -0.080 | -0.3654 | No |
| 15 | RPA3 | NA | RPA3 Entrez, Source | replication protein A3, 14kDa | 11617 | -0.146 | -0.3945 | No |
| 16 | POLD4 | NA | POLD4 Entrez, Source | polymerase (DNA-directed), delta 4 | 12128 | -0.204 | -0.4147 | No |
| 17 | RFC2 | NA | RFC2 Entrez, Source | replication factor C (activator 1) 2, 40kDa | 12780 | -0.287 | -0.4395 | No |
| 18 | POLE3 | NA | POLE3 Entrez, Source | polymerase (DNA directed), epsilon 3 (p17 subunit) | 13002 | -0.319 | -0.4390 | No |
| 19 | PRIM1 | NA | PRIM1 Entrez, Source | primase, polypeptide 1, 49kDa | 13189 | -0.347 | -0.4355 | No |
| 20 | POLD1 | NA | POLD1 Entrez, Source | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 13347 | -0.374 | -0.4293 | No |
| 21 | POLA2 | NA | POLA2 Entrez, Source | polymerase (DNA directed), alpha 2 (70kD subunit) | 14091 | -0.507 | -0.4504 | Yes |
| 22 | POLD3 | NA | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 14094 | -0.508 | -0.4302 | Yes |
| 23 | DNA2 | NA | 14684 | -0.638 | -0.4375 | Yes | ||
| 24 | SSBP1 | NA | SSBP1 Entrez, Source | single-stranded DNA binding protein 1 | 14935 | -0.704 | -0.4233 | Yes |
| 25 | MCM7 | NA | MCM7 Entrez, Source | MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) | 15124 | -0.752 | -0.4037 | Yes |
| 26 | MCM4 | NA | MCM4 Entrez, Source | MCM4 minichromosome maintenance deficient 4 (S. cerevisiae) | 15270 | -0.795 | -0.3799 | Yes |
| 27 | LIG1 | NA | LIG1 Entrez, Source | ligase I, DNA, ATP-dependent | 15395 | -0.833 | -0.3535 | Yes |
| 28 | FEN1 | NA | FEN1 Entrez, Source | flap structure-specific endonuclease 1 | 15451 | -0.848 | -0.3227 | Yes |
| 29 | RFC5 | NA | RFC5 Entrez, Source | replication factor C (activator 1) 5, 36.5kDa | 15582 | -0.889 | -0.2943 | Yes |
| 30 | POLD2 | NA | POLD2 Entrez, Source | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | 15846 | -0.985 | -0.2696 | Yes |
| 31 | POLA1 | NA | POLA1 Entrez, Source | polymerase (DNA directed), alpha 1 | 16027 | -1.056 | -0.2374 | Yes |
| 32 | MCM5 | NA | MCM5 Entrez, Source | MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) | 16100 | -1.089 | -0.1978 | Yes |
| 33 | RFC3 | NA | RFC3 Entrez, Source | replication factor C (activator 1) 3, 38kDa | 16669 | -1.404 | -0.1733 | Yes |
| 34 | MCM2 | NA | MCM2 Entrez, Source | MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) | 17118 | -1.808 | -0.1259 | Yes |
| 35 | POLE4 | NA | POLE4 Entrez, Source | polymerase (DNA-directed), epsilon 4 (p12 subunit) | 17350 | -2.135 | -0.0533 | Yes |
| 36 | RNASEH2B | NA | RNASEH2B Entrez, Source | ribonuclease H2, subunit B | 17389 | -2.209 | 0.0329 | Yes |
