Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY |
| Enrichment Score (ES) | 0.52981645 |
| Normalized Enrichment Score (NES) | 1.5318834 |
| Nominal p-value | 0.022988506 |
| FDR q-value | 0.14183293 |
| FWER p-Value | 0.785 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | PYCARD | NA | PYCARD Entrez, Source | PYD and CARD domain containing | 97 | 4.535 | 0.0825 | Yes |
| 2 | AIM2 | NA | AIM2 Entrez, Source | absent in melanoma 2 | 222 | 4.021 | 0.1536 | Yes |
| 3 | IL18 | NA | IL18 Entrez, Source | interleukin 18 (interferon-gamma-inducing factor) | 338 | 3.623 | 0.2174 | Yes |
| 4 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 690 | 2.778 | 0.2517 | Yes |
| 5 | IKBKG | NA | IKBKG Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 818 | 2.562 | 0.2943 | Yes |
| 6 | CASP1 | NA | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 1001 | 2.338 | 0.3295 | Yes |
| 7 | CXCL10 | NA | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 1224 | 2.107 | 0.3579 | Yes |
| 8 | IKBKB | NA | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 1288 | 2.052 | 0.3942 | Yes |
| 9 | IRF7 | NA | IRF7 Entrez, Source | interferon regulatory factor 7 | 1322 | 2.023 | 0.4316 | Yes |
| 10 | POLR3D | NA | POLR3D Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide D, 44kDa | 1396 | 1.953 | 0.4654 | Yes |
| 11 | DDX58 | NA | DDX58 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 1531 | 1.858 | 0.4939 | Yes |
| 12 | RIPK3 | NA | RIPK3 Entrez, Source | receptor-interacting serine-threonine kinase 3 | 1534 | 1.857 | 0.5298 | Yes |
| 13 | MAVS | NA | 2137 | 1.477 | 0.5249 | No | ||
| 14 | IRF3 | NA | IRF3 Entrez, Source | interferon regulatory factor 3 | 3905 | 0.890 | 0.4436 | No |
| 15 | POLR3F | NA | POLR3F Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa | 4334 | 0.785 | 0.4350 | No |
| 16 | POLR3G | NA | POLR3G Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide G (32kD) | 4397 | 0.773 | 0.4465 | No |
| 17 | CCL5 | NA | CCL5 Entrez, Source | chemokine (C-C motif) ligand 5 | 5108 | 0.622 | 0.4190 | No |
| 18 | POLR1C | NA | POLR1C Entrez, Source | polymerase (RNA) I polypeptide C, 30kDa | 5150 | 0.614 | 0.4286 | No |
| 19 | IL33 | NA | 6309 | 0.410 | 0.3720 | No | ||
| 20 | IFNB1 | NA | IFNB1 Entrez, Source | interferon, beta 1, fibroblast | 6591 | 0.372 | 0.3636 | No |
| 21 | CCL4 | NA | CCL4 Entrez, Source | chemokine (C-C motif) ligand 4 | 7022 | 0.312 | 0.3457 | No |
| 22 | POLR3H | NA | POLR3H Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) | 7854 | 0.219 | 0.3036 | No |
| 23 | TMEM173 | NA | TMEM173 Entrez, Source | transmembrane protein 173 | 9042 | 0.095 | 0.2392 | No |
| 24 | POLR3GL | NA | POLR3GL Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide G (32kD) like | 9396 | 0.062 | 0.2208 | No |
| 25 | ADAR | NA | ADAR Entrez, Source | adenosine deaminase, RNA-specific | 9569 | 0.045 | 0.2121 | No |
| 26 | POLR3A | NA | POLR3A Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide A, 155kDa | 9713 | 0.024 | 0.2045 | No |
| 27 | NFKBIA | NA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 9793 | 0.012 | 0.2004 | No |
| 28 | CHUK | NA | CHUK Entrez, Source | conserved helix-loop-helix ubiquitous kinase | 9794 | 0.012 | 0.2006 | No |
| 29 | POLR3C | NA | POLR3C Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide C (62kD) | 9840 | 0.005 | 0.1982 | No |
| 30 | CCL4L2 | NA | CCL4L2 Entrez, Source | chemokine (C-C motif) ligand 4-like 2 | 10030 | 0.000 | 0.1877 | No |
| 31 | RELA | NA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 10834 | -0.062 | 0.1441 | No |
| 32 | RIPK1 | NA | RIPK1 Entrez, Source | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 10998 | -0.081 | 0.1366 | No |
| 33 | IFNA21 | NA | IFNA21 Entrez, Source | interferon, alpha 21 | 11800 | -0.169 | 0.0952 | No |
| 34 | TBK1 | NA | TBK1 Entrez, Source | TANK-binding kinase 1 | 11968 | -0.187 | 0.0895 | No |
| 35 | IFNA8 | NA | IFNA8 Entrez, Source | interferon, alpha 8 | 12884 | -0.299 | 0.0443 | No |
| 36 | POLR3B | NA | POLR3B Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide B | 13392 | -0.380 | 0.0234 | No |
| 37 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 15399 | -0.833 | -0.0722 | No |
| 38 | POLR3K | NA | POLR3K Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa | 15886 | -1.002 | -0.0799 | No |
| 39 | ZBP1 | NA | ZBP1 Entrez, Source | Z-DNA binding protein 1 | 15914 | -1.012 | -0.0618 | No |
| 40 | TREX1 | NA | TREX1 Entrez, Source | three prime repair exonuclease 1 | 16419 | -1.259 | -0.0655 | No |
| 41 | POLR1D | NA | POLR1D Entrez, Source | polymerase (RNA) I polypeptide D, 16kDa | 16713 | -1.443 | -0.0538 | No |
| 42 | IKBKE | NA | IKBKE Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 17503 | -2.430 | -0.0507 | No |
| 43 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 17833 | -3.984 | 0.0082 | No |
