Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_COMPLEMENT_AND_COAGULATION_CASCADES |
| Enrichment Score (ES) | 0.51606506 |
| Normalized Enrichment Score (NES) | 1.6384863 |
| Nominal p-value | 0.0013297872 |
| FDR q-value | 0.06456277 |
| FWER p-Value | 0.366 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | C4BPB | NA | C4BPB Entrez, Source | complement component 4 binding protein, beta | 8 | 4.945 | 0.0573 | Yes |
| 2 | MASP2 | NA | MASP2 Entrez, Source | mannan-binding lectin serine peptidase 2 | 212 | 4.055 | 0.0932 | Yes |
| 3 | CD55 | NA | CD55 Entrez, Source | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 344 | 3.599 | 0.1279 | Yes |
| 4 | THBD | NA | THBD Entrez, Source | thrombomodulin | 406 | 3.436 | 0.1646 | Yes |
| 5 | SERPIND1 | NA | SERPIND1 Entrez, Source | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 | 445 | 3.318 | 0.2012 | Yes |
| 6 | CFH | NA | CFH Entrez, Source | complement factor H | 492 | 3.160 | 0.2355 | Yes |
| 7 | F2R | NA | F2R Entrez, Source | coagulation factor II (thrombin) receptor | 515 | 3.112 | 0.2706 | Yes |
| 8 | PLAT | NA | PLAT Entrez, Source | plasminogen activator, tissue | 520 | 3.103 | 0.3066 | Yes |
| 9 | F3 | NA | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 576 | 2.979 | 0.3383 | Yes |
| 10 | PLAU | NA | PLAU Entrez, Source | plasminogen activator, urokinase | 691 | 2.777 | 0.3643 | Yes |
| 11 | CR2 | NA | CR2 Entrez, Source | complement component (3d/Epstein Barr virus) receptor 2 | 693 | 2.769 | 0.3966 | Yes |
| 12 | SERPINE1 | NA | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 1051 | 2.268 | 0.4031 | Yes |
| 13 | CFB | NA | CFB Entrez, Source | complement factor B | 1225 | 2.107 | 0.4181 | Yes |
| 14 | PLG | NA | PLG Entrez, Source | plasminogen | 1315 | 2.029 | 0.4368 | Yes |
| 15 | CFD | NA | CFD Entrez, Source | complement factor D (adipsin) | 1445 | 1.919 | 0.4520 | Yes |
| 16 | C2 | NA | C2 Entrez, Source | complement component 2 | 1559 | 1.836 | 0.4671 | Yes |
| 17 | CR1 | NA | CR1 Entrez, Source | complement component (3b/4b) receptor 1 (Knops blood group) | 1693 | 1.741 | 0.4800 | Yes |
| 18 | TFPI | NA | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 1721 | 1.722 | 0.4986 | Yes |
| 19 | KLKB1 | NA | KLKB1 Entrez, Source | kallikrein B, plasma (Fletcher factor) 1 | 1761 | 1.687 | 0.5161 | Yes |
| 20 | FGB | NA | FGB Entrez, Source | fibrinogen beta chain | 2400 | 1.371 | 0.4965 | No |
| 21 | F10 | NA | F10 Entrez, Source | coagulation factor X | 3502 | 0.999 | 0.4466 | No |
| 22 | C1R | NA | C1R Entrez, Source | complement component 1, r subcomponent | 3774 | 0.922 | 0.4423 | No |
| 23 | F5 | NA | F5 Entrez, Source | coagulation factor V (proaccelerin, labile factor) | 5099 | 0.623 | 0.3756 | No |
| 24 | CD46 | NA | CD46 Entrez, Source | CD46 molecule, complement regulatory protein | 5114 | 0.621 | 0.3821 | No |
| 25 | CFI | NA | CFI Entrez, Source | complement factor I | 5379 | 0.571 | 0.3740 | No |
| 26 | PROC | NA | PROC Entrez, Source | protein C (inactivator of coagulation factors Va and VIIIa) | 5748 | 0.508 | 0.3594 | No |
| 27 | PLAUR | NA | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 6352 | 0.402 | 0.3305 | No |
| 28 | PROS1 | NA | PROS1 Entrez, Source | protein S (alpha) | 6635 | 0.367 | 0.3190 | No |
| 29 | C5AR1 | NA | C5AR1 Entrez, Source | complement component 5a receptor 1 | 6716 | 0.353 | 0.3187 | No |
| 30 | BDKRB2 | NA | BDKRB2 Entrez, Source | bradykinin receptor B2 | 6854 | 0.335 | 0.3149 | No |
| 31 | CD59 | NA | CD59 Entrez, Source | CD59 molecule, complement regulatory protein | 6984 | 0.318 | 0.3114 | No |
| 32 | F13B | NA | F13B Entrez, Source | coagulation factor XIII, B polypeptide | 7678 | 0.235 | 0.2755 | No |
| 33 | C4B | NA | C4B Entrez, Source | complement component 4B (Childo blood group) | 7863 | 0.218 | 0.2678 | No |
| 34 | C8A | NA | C8A Entrez, Source | complement component 8, alpha polypeptide | 7878 | 0.216 | 0.2695 | No |
| 35 | C8B | NA | C8B Entrez, Source | complement component 8, beta polypeptide | 8400 | 0.162 | 0.2423 | No |
| 36 | C9 | NA | C9 Entrez, Source | complement component 9 | 8604 | 0.143 | 0.2326 | No |
| 37 | FGG | NA | FGG Entrez, Source | fibrinogen gamma chain | 8607 | 0.142 | 0.2342 | No |
| 38 | BDKRB1 | NA | BDKRB1 Entrez, Source | bradykinin receptor B1 | 8667 | 0.137 | 0.2325 | No |
| 39 | C7 | NA | C7 Entrez, Source | complement component 7 | 8761 | 0.125 | 0.2288 | No |
| 40 | F8 | NA | F8 Entrez, Source | coagulation factor VIII, procoagulant component (hemophilia A) | 8850 | 0.116 | 0.2252 | No |
| 41 | SERPING1 | NA | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 8994 | 0.099 | 0.2184 | No |
| 42 | C4A | NA | C4A Entrez, Source | complement component 4A (Rodgers blood group) | 9277 | 0.073 | 0.2035 | No |
| 43 | C6 | NA | C6 Entrez, Source | complement component 6 | 9328 | 0.067 | 0.2015 | No |
| 44 | FGA | NA | FGA Entrez, Source | fibrinogen alpha chain | 9903 | 0.000 | 0.1695 | No |
| 45 | C8G | NA | C8G Entrez, Source | complement component 8, gamma polypeptide | 10761 | -0.054 | 0.1222 | No |
| 46 | C5 | NA | C5 Entrez, Source | complement component 5 | 11052 | -0.086 | 0.1071 | No |
| 47 | F9 | NA | F9 Entrez, Source | coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B) | 11505 | -0.134 | 0.0834 | No |
| 48 | A2M | NA | A2M Entrez, Source | alpha-2-macroglobulin | 11895 | -0.180 | 0.0638 | No |
| 49 | F11 | NA | F11 Entrez, Source | coagulation factor XI (plasma thromboplastin antecedent) | 12536 | -0.256 | 0.0310 | No |
| 50 | C4BPA | NA | C4BPA Entrez, Source | complement component 4 binding protein, alpha | 12556 | -0.257 | 0.0330 | No |
| 51 | F7 | NA | F7 Entrez, Source | coagulation factor VII (serum prothrombin conversion accelerator) | 12930 | -0.307 | 0.0157 | No |
| 52 | CPB2 | NA | CPB2 Entrez, Source | carboxypeptidase B2 (plasma, carboxypeptidase U) | 12985 | -0.317 | 0.0164 | No |
| 53 | F2 | NA | F2 Entrez, Source | coagulation factor II (thrombin) | 13096 | -0.334 | 0.0142 | No |
| 54 | MBL2 | NA | MBL2 Entrez, Source | mannose-binding lectin (protein C) 2, soluble (opsonic defect) | 13389 | -0.380 | 0.0023 | No |
| 55 | KNG1 | NA | KNG1 Entrez, Source | kininogen 1 | 13678 | -0.431 | -0.0087 | No |
| 56 | SERPINF2 | NA | SERPINF2 Entrez, Source | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 | 13709 | -0.437 | -0.0053 | No |
| 57 | VWF | NA | VWF Entrez, Source | von Willebrand factor | 14741 | -0.657 | -0.0552 | No |
| 58 | MASP1 | NA | MASP1 Entrez, Source | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | 15752 | -0.952 | -0.1005 | No |
| 59 | C3AR1 | NA | C3AR1 Entrez, Source | complement component 3a receptor 1 | 16179 | -1.127 | -0.1111 | No |
| 60 | F12 | NA | F12 Entrez, Source | coagulation factor XII (Hageman factor) | 16749 | -1.471 | -0.1257 | No |
| 61 | SERPINC1 | NA | SERPINC1 Entrez, Source | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 16829 | -1.529 | -0.1123 | No |
| 62 | F13A1 | NA | F13A1 Entrez, Source | coagulation factor XIII, A1 polypeptide | 17085 | -1.773 | -0.1058 | No |
| 63 | SERPINA5 | NA | SERPINA5 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | 17155 | -1.847 | -0.0881 | No |
| 64 | C1S | NA | C1S Entrez, Source | complement component 1, s subcomponent | 17464 | -2.349 | -0.0779 | No |
| 65 | C3 | NA | C3 Entrez, Source | complement component 3 | 17907 | -4.505 | -0.0500 | No |
| 66 | SERPINA1 | NA | SERPINA1 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 17926 | -4.627 | 0.0030 | No |
