Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_COLORECTAL_CANCER |
| Enrichment Score (ES) | -0.3290789 |
| Normalized Enrichment Score (NES) | -1.1876091 |
| Nominal p-value | 0.140625 |
| FDR q-value | 0.6232689 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | TCF7 | NA | TCF7 Entrez, Source | transcription factor 7 (T-cell specific, HMG-box) | 189 | 4.141 | 0.0641 | No |
| 2 | PIK3CA | NA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 749 | 2.649 | 0.0807 | No |
| 3 | CASP9 | NA | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 841 | 2.527 | 0.1212 | No |
| 4 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 1410 | 1.946 | 0.1246 | No |
| 5 | TGFBR1 | NA | TGFBR1 Entrez, Source | transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) | 1654 | 1.765 | 0.1428 | No |
| 6 | PIK3R1 | NA | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 2108 | 1.493 | 0.1445 | No |
| 7 | TGFB3 | NA | TGFB3 Entrez, Source | transforming growth factor, beta 3 | 2274 | 1.422 | 0.1609 | No |
| 8 | TGFB2 | NA | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 2302 | 1.414 | 0.1849 | No |
| 9 | AXIN2 | NA | AXIN2 Entrez, Source | axin 2 (conductin, axil) | 4028 | 0.861 | 0.1042 | No |
| 10 | BCL2 | NA | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 4064 | 0.851 | 0.1176 | No |
| 11 | CCND1 | NA | CCND1 Entrez, Source | cyclin D1 | 5252 | 0.595 | 0.0621 | No |
| 12 | MAPK9 | NA | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 6268 | 0.418 | 0.0129 | No |
| 13 | AKT2 | NA | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 6498 | 0.385 | 0.0071 | No |
| 14 | TGFB1 | NA | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 6816 | 0.341 | -0.0044 | No |
| 15 | JUN | NA | JUN Entrez, Source | jun oncogene | 7042 | 0.310 | -0.0114 | No |
| 16 | BAD | NA | BAD Entrez, Source | BCL2-antagonist of cell death | 7106 | 0.300 | -0.0095 | No |
| 17 | KRAS | NA | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 7514 | 0.251 | -0.0277 | No |
| 18 | PIK3CB | NA | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 7635 | 0.240 | -0.0301 | No |
| 19 | SMAD2 | NA | SMAD2 Entrez, Source | SMAD, mothers against DPP homolog 2 (Drosophila) | 8235 | 0.174 | -0.0604 | No |
| 20 | RAC3 | NA | RAC3 Entrez, Source | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) | 8286 | 0.170 | -0.0601 | No |
| 21 | ARAF | NA | ARAF Entrez, Source | v-raf murine sarcoma 3611 viral oncogene homolog | 8641 | 0.139 | -0.0773 | No |
| 22 | BAX | NA | BAX Entrez, Source | BCL2-associated X protein | 8966 | 0.102 | -0.0936 | No |
| 23 | MAPK10 | NA | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 9003 | 0.098 | -0.0938 | No |
| 24 | MSH2 | NA | MSH2 Entrez, Source | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | 9025 | 0.096 | -0.0932 | No |
| 25 | APC | NA | APC Entrez, Source | adenomatosis polyposis coli | 9129 | 0.086 | -0.0974 | No |
| 26 | APC2 | NA | APC2 Entrez, Source | adenomatosis polyposis coli 2 | 9505 | 0.052 | -0.1174 | No |
| 27 | MAPK8 | NA | MAPK8 Entrez, Source | mitogen-activated protein kinase 8 | 9814 | 0.009 | -0.1345 | No |
| 28 | PIK3R5 | NA | PIK3R5 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 5, p101 | 9845 | 0.004 | -0.1361 | No |
| 29 | FOS | NA | FOS Entrez, Source | v-fos FBJ murine osteosarcoma viral oncogene homolog | 11142 | -0.098 | -0.2066 | No |
| 30 | SMAD3 | NA | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 12320 | -0.229 | -0.2682 | No |
| 31 | RAC2 | NA | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 12326 | -0.230 | -0.2643 | No |
| 32 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 12360 | -0.233 | -0.2619 | No |
| 33 | PIK3R2 | NA | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 12508 | -0.252 | -0.2656 | No |
| 34 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 12596 | -0.262 | -0.2657 | No |
| 35 | AXIN1 | NA | AXIN1 Entrez, Source | axin 1 | 12933 | -0.308 | -0.2789 | No |
| 36 | RAC1 | NA | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 13101 | -0.334 | -0.2822 | No |
| 37 | CYCS | NA | CYCS Entrez, Source | cytochrome c, somatic | 13185 | -0.346 | -0.2806 | No |
| 38 | TCF7L2 | NA | TCF7L2 Entrez, Source | transcription factor 7-like 2 (T-cell specific, HMG-box) | 13312 | -0.370 | -0.2810 | No |
| 39 | MSH6 | NA | MSH6 Entrez, Source | mutS homolog 6 (E. coli) | 13449 | -0.390 | -0.2815 | No |
| 40 | SMAD4 | NA | SMAD4 Entrez, Source | SMAD, mothers against DPP homolog 4 (Drosophila) | 13708 | -0.437 | -0.2880 | No |
| 41 | RAF1 | NA | RAF1 Entrez, Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 13760 | -0.446 | -0.2828 | No |
| 42 | BIRC5 | NA | BIRC5 Entrez, Source | baculoviral IAP repeat-containing 5 (survivin) | 13772 | -0.448 | -0.2754 | No |
| 43 | RALGDS | NA | RALGDS Entrez, Source | ral guanine nucleotide dissociation stimulator | 14010 | -0.492 | -0.2797 | No |
| 44 | CTNNB1 | NA | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 14895 | -0.694 | -0.3166 | Yes |
| 45 | AKT3 | NA | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 14929 | -0.703 | -0.3057 | Yes |
| 46 | BRAF | NA | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 15145 | -0.758 | -0.3041 | Yes |
| 47 | MYC | NA | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 15151 | -0.760 | -0.2906 | Yes |
| 48 | MLH1 | NA | MLH1 Entrez, Source | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | 15190 | -0.771 | -0.2789 | Yes |
| 49 | AKT1 | NA | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 15339 | -0.816 | -0.2724 | Yes |
| 50 | RHOA | NA | RHOA Entrez, Source | ras homolog gene family, member A | 15597 | -0.894 | -0.2706 | Yes |
| 51 | MSH3 | NA | MSH3 Entrez, Source | mutS homolog 3 (E. coli) | 15603 | -0.896 | -0.2547 | Yes |
| 52 | GSK3B | NA | GSK3B Entrez, Source | glycogen synthase kinase 3 beta | 15818 | -0.977 | -0.2491 | Yes |
| 53 | LEF1 | NA | LEF1 Entrez, Source | lymphoid enhancer-binding factor 1 | 16125 | -1.101 | -0.2463 | Yes |
| 54 | APPL1 | NA | 16236 | -1.163 | -0.2315 | Yes | ||
| 55 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 16431 | -1.263 | -0.2195 | Yes |
| 56 | MAP2K1 | NA | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 16504 | -1.300 | -0.2001 | Yes |
| 57 | TGFBR2 | NA | TGFBR2 Entrez, Source | transforming growth factor, beta receptor II (70/80kDa) | 16903 | -1.592 | -0.1936 | Yes |
| 58 | CASP3 | NA | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 17337 | -2.106 | -0.1798 | Yes |
| 59 | TP53 | NA | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 17352 | -2.136 | -0.1420 | Yes |
| 60 | DCC | NA | DCC Entrez, Source | deleted in colorectal carcinoma | 17418 | -2.268 | -0.1048 | Yes |
| 61 | TCF7L1 | NA | TCF7L1 Entrez, Source | transcription factor 7-like 1 (T-cell specific, HMG-box) | 17581 | -2.658 | -0.0659 | Yes |
| 62 | PIK3CG | NA | PIK3CG Entrez, Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 17957 | -4.885 | 0.0013 | Yes |
