Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_CITRATE_CYCLE_TCA_CYCLE |
| Enrichment Score (ES) | -0.40267605 |
| Normalized Enrichment Score (NES) | -1.2086769 |
| Nominal p-value | 0.22910216 |
| FDR q-value | 0.59539574 |
| FWER p-Value | 0.999 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | OGDHL | NA | OGDHL Entrez, Source | oxoglutarate dehydrogenase-like | 681 | 2.795 | 0.0621 | No |
| 2 | IDH1 | NA | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 2150 | 1.471 | 0.0330 | No |
| 3 | IDH3G | NA | IDH3G Entrez, Source | isocitrate dehydrogenase 3 (NAD+) gamma | 2548 | 1.300 | 0.0575 | No |
| 4 | PC | NA | PC Entrez, Source | pyruvate carboxylase | 2777 | 1.219 | 0.0884 | No |
| 5 | OGDH | NA | OGDH Entrez, Source | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 2907 | 1.180 | 0.1235 | No |
| 6 | SDHB | NA | SDHB Entrez, Source | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | 4218 | 0.812 | 0.0796 | No |
| 7 | ACO2 | NA | ACO2 Entrez, Source | aconitase 2, mitochondrial | 6531 | 0.381 | -0.0356 | No |
| 8 | PCK1 | NA | PCK1 Entrez, Source | phosphoenolpyruvate carboxykinase 1 (soluble) | 6650 | 0.364 | -0.0291 | No |
| 9 | CS | NA | CS Entrez, Source | citrate synthase | 6743 | 0.349 | -0.0217 | No |
| 10 | DLST | NA | DLST Entrez, Source | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | 8924 | 0.107 | -0.1394 | No |
| 11 | MDH2 | NA | MDH2 Entrez, Source | malate dehydrogenase 2, NAD (mitochondrial) | 9270 | 0.074 | -0.1559 | No |
| 12 | SDHA | NA | SDHA Entrez, Source | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 11220 | -0.106 | -0.2607 | No |
| 13 | SDHC | NA | SDHC Entrez, Source | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa | 11956 | -0.186 | -0.2950 | No |
| 14 | PDHA1 | NA | PDHA1 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 1 | 12505 | -0.252 | -0.3165 | No |
| 15 | DLAT | NA | DLAT Entrez, Source | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | 13919 | -0.474 | -0.3782 | No |
| 16 | PDHB | NA | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 14359 | -0.565 | -0.3824 | Yes |
| 17 | FH | NA | FH Entrez, Source | fumarate hydratase | 14511 | -0.594 | -0.3696 | Yes |
| 18 | IDH3A | NA | IDH3A Entrez, Source | isocitrate dehydrogenase 3 (NAD+) alpha | 14626 | -0.624 | -0.3536 | Yes |
| 19 | DLD | NA | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 14871 | -0.688 | -0.3426 | Yes |
| 20 | SDHD | NA | SDHD Entrez, Source | succinate dehydrogenase complex, subunit D, integral membrane protein | 15214 | -0.778 | -0.3338 | Yes |
| 21 | PCK2 | NA | PCK2 Entrez, Source | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 15546 | -0.878 | -0.3207 | Yes |
| 22 | ACLY | NA | ACLY Entrez, Source | ATP citrate lyase | 15722 | -0.939 | -0.2969 | Yes |
| 23 | SUCLG2 | NA | SUCLG2 Entrez, Source | succinate-CoA ligase, GDP-forming, beta subunit | 15843 | -0.984 | -0.2683 | Yes |
| 24 | ACO1 | NA | ACO1 Entrez, Source | aconitase 1, soluble | 16261 | -1.176 | -0.2494 | Yes |
| 25 | SUCLA2 | NA | SUCLA2 Entrez, Source | succinate-CoA ligase, ADP-forming, beta subunit | 16719 | -1.447 | -0.2231 | Yes |
| 26 | MDH1 | NA | MDH1 Entrez, Source | malate dehydrogenase 1, NAD (soluble) | 16977 | -1.662 | -0.1779 | Yes |
| 27 | SUCLG1 | NA | SUCLG1 Entrez, Source | succinate-CoA ligase, GDP-forming, alpha subunit | 17652 | -2.929 | -0.1106 | Yes |
| 28 | IDH2 | NA | IDH2 Entrez, Source | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 17775 | -3.598 | 0.0114 | Yes |
