Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetKEGG_CHEMOKINE_SIGNALING_PATHWAY
Enrichment Score (ES)-0.2702805
Normalized Enrichment Score (NES)-1.1500894
Nominal p-value0.09558824
FDR q-value0.58788925
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: KEGG_CHEMOKINE_SIGNALING_PATHWAY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DOCK2NADOCK2
Entrez,  Source
dedicator of cytokinesis 22034.0740.0157No
2CCL26NACCL26
Entrez,  Source
chemokine (C-C motif) ligand 266282.8720.0111No
3SHC3NASHC3
Entrez,  Source
SHC (Src homology 2 domain containing) transforming protein 36352.8560.0298No
4PIK3CANAPIK3CA
Entrez,  Source
phosphoinositide-3-kinase, catalytic, alpha polypeptide7492.6490.0411No
5IKBKGNAIKBKG
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma8182.5620.0543No
6CXCL16NACXCL16
Entrez,  Source
chemokine (C-X-C motif) ligand 168702.4890.0680No
7CCL28NACCL28
Entrez,  Source
chemokine (C-C motif) ligand 288912.4700.0834No
8GRK4NAGRK4
Entrez,  Source
G protein-coupled receptor kinase 49402.4140.0968No
9GNB4NAGNB4
Entrez,  Source
guanine nucleotide binding protein (G protein), beta polypeptide 410582.2650.1053No
10CXCL10NACXCL10
Entrez,  Source
chemokine (C-X-C motif) ligand 1012242.1070.1101No
11IKBKBNAIKBKB
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta12882.0520.1202No
12CXCL11NACXCL11
Entrez,  Source
chemokine (C-X-C motif) ligand 1113981.9500.1271No
13PIK3R3NAPIK3R3
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)14101.9460.1394No
14CXCR4NACXCR4
Entrez,  Source
chemokine (C-X-C motif) receptor 415611.8360.1432No
15STAT1NASTAT1
Entrez,  Source
signal transducer and activator of transcription 1, 91kDa20251.5430.1275No
16GNG13NAGNG13
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma 1320881.5040.1341No
17PIK3R1NAPIK3R1
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)21081.4930.1429No
18PLCB4NAPLCB4
Entrez,  Source
phospholipase C, beta 422731.4220.1432No
19CXCL2NACXCL2
Entrez,  Source
chemokine (C-X-C motif) ligand 224901.3280.1399No
20VAV1NAVAV1
Entrez,  Source
vav 1 oncogene25591.2970.1447No
21GNAI1NAGNAI1
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 126541.2620.1479No
22ARRB2NAARRB2
Entrez,  Source
arrestin, beta 227371.2320.1515No
23SHC2NASHC2
Entrez,  Source
SHC (Src homology 2 domain containing) transforming protein 228201.2070.1549No
24SOS2NASOS2
Entrez,  Source
son of sevenless homolog 2 (Drosophila)29271.1720.1568No
25STAT2NASTAT2
Entrez,  Source
signal transducer and activator of transcription 2, 113kDa29471.1660.1635No
26CCR7NACCR7
Entrez,  Source
chemokine (C-C motif) receptor 730931.1180.1628No
27SHC4NASHC4
Entrez,  Source
SHC (Src homology 2 domain containing) family, member 431351.1070.1679No
28SOS1NASOS1
Entrez,  Source
son of sevenless homolog 1 (Drosophila)38240.9110.1353No
29NCF1NANCF1
Entrez,  Source
neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1)38780.8970.1383No
30JAK2NAJAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)40580.8520.1339No
31CCR6NACCR6
Entrez,  Source
chemokine (C-C motif) receptor 641010.8420.1372No
32BCAR1NABCAR1
Entrez,  Source
breast cancer anti-estrogen resistance 141490.8290.1401No
33CDC42NACDC42
Entrez,  Source
cell division cycle 42 (GTP binding protein, 25kDa)43240.7880.1355No
34CXCL14NACXCL14
Entrez,  Source
chemokine (C-X-C motif) ligand 1445250.7430.1293No
35CCL8NACCL8
Entrez,  Source
chemokine (C-C motif) ligand 845570.7360.1324No
36ADCY9NAADCY9
Entrez,  Source
adenylate cyclase 946060.7240.1345No
37PLCB3NAPLCB3
Entrez,  Source
phospholipase C, beta 3 (phosphatidylinositol-specific)48000.6830.1283No
38HRASNAHRAS
Entrez,  Source
v-Ha-ras Harvey rat sarcoma viral oncogene homolog48400.6740.1306No
39CCR5NACCR5
Entrez,  Source
chemokine (C-C motif) receptor 549190.6570.1306No
40VAV2NAVAV2
Entrez,  Source
vav 2 oncogene50300.6360.1286No
41CCL5NACCL5
Entrez,  Source
chemokine (C-C motif) ligand 551080.6220.1284No
42ARRB1NAARRB1
Entrez,  Source
arrestin, beta 151390.6160.1309No
43PF4NAPF4
Entrez,  Source
platelet factor 4 (chemokine (C-X-C motif) ligand 4)52000.6050.1315No
44JAK3NAJAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)52070.6030.1352No
45GNB5NAGNB5
Entrez,  Source
guanine nucleotide binding protein (G protein), beta 553120.5830.1333No
46RASGRP2NARASGRP2
Entrez,  Source
RAS guanyl releasing protein 2 (calcium and DAG-regulated)56160.5310.1198No
47GNG3NAGNG3
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma 357380.5100.1164No
48GSK3ANAGSK3A
Entrez,  Source
glycogen synthase kinase 3 alpha57890.5010.1169No
49GNB1NAGNB1
Entrez,  Source
guanine nucleotide binding protein (G protein), beta polypeptide 160260.4630.1067No
50WASLNAWASL
Entrez,  Source
Wiskott-Aldrich syndrome-like61050.4490.1054No
51AKT2NAAKT2
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 264980.3850.0859No
52GRK1NAGRK1
Entrez,  Source
G protein-coupled receptor kinase 165220.3820.0872No
53CCR9NACCR9
Entrez,  Source
chemokine (C-C motif) receptor 966060.3700.0850No
54PRKXNAPRKX
Entrez,  Source
protein kinase, X-linked66920.3580.0826No
55GNAI3NAGNAI3
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 369120.3270.0725No
56CCL17NACCL17
Entrez,  Source
chemokine (C-C motif) ligand 1769360.3240.0733No
57CCL4NACCL4
Entrez,  Source
chemokine (C-C motif) ligand 470220.3120.0706No
58PREX1NAPREX1
Entrez,  Source
-70830.3050.0693No
59CCL7NACCL7
Entrez,  Source
chemokine (C-C motif) ligand 772260.2840.0632No
60GNG5NAGNG5
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma 574290.2590.0536No
61ROCK2NAROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 274970.2520.0515No
62KRASNAKRAS
Entrez,  Source
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog75140.2510.0523No
63CCR8NACCR8
Entrez,  Source
chemokine (C-C motif) receptor 875550.2480.0517No
64PIK3CBNAPIK3CB
Entrez,  Source
phosphoinositide-3-kinase, catalytic, beta polypeptide76350.2400.0488No
65ADCY4NAADCY4
Entrez,  Source
adenylate cyclase 476500.2380.0496No
66CCL1NACCL1
Entrez,  Source
chemokine (C-C motif) ligand 178940.2150.0374No
67ADCY6NAADCY6
Entrez,  Source
adenylate cyclase 679680.2070.0347No
68PF4V1NAPF4V1
Entrez,  Source
platelet factor 4 variant 180490.1960.0315No
69WASNAWAS
Entrez,  Source
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)80820.1910.0310No
70PRKCBNA81310.1850.0295No
71CXCL9NACXCL9
Entrez,  Source
chemokine (C-X-C motif) ligand 981560.1810.0294No
72ADCY1NAADCY1
Entrez,  Source
adenylate cyclase 1 (brain)81590.1810.0305No
73ROCK1NAROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 184630.1560.0145No
74CRKLNACRKL
Entrez,  Source
v-crk sarcoma virus CT10 oncogene homolog (avian)-like87170.1300.0012No
75XCR1NAXCR1
Entrez,  Source
chemokine (C motif) receptor 187350.1290.0011No
76CCL20NACCL20
Entrez,  Source
chemokine (C-C motif) ligand 2087460.1270.0014No
77PTK2NAPTK2
Entrez,  Source
PTK2 protein tyrosine kinase 287770.1230.0005No
78ADCY2NAADCY2
Entrez,  Source
adenylate cyclase 2 (brain)88130.120-0.0007No
79CXCR3NACXCR3
Entrez,  Source
chemokine (C-X-C motif) receptor 389570.103-0.0080No
80CXCR6NACXCR6
Entrez,  Source
chemokine (C-X-C motif) receptor 691560.084-0.0186No
81ELMO1NAELMO1
Entrez,  Source
engulfment and cell motility 192990.071-0.0261No
82CCL24NACCL24
Entrez,  Source
chemokine (C-C motif) ligand 2493570.066-0.0288No
83CXCL12NACXCL12
Entrez,  Source
chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)94240.058-0.0322No
84LYNNALYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog94980.053-0.0359No
85NFKBIANANFKBIA
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha97930.012-0.0523No
86CHUKNACHUK
Entrez,  Source
conserved helix-loop-helix ubiquitous kinase97940.012-0.0523No
87PIK3R5NAPIK3R5
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 5, p10198450.004-0.0550No
88CRKNACRK
Entrez,  Source
v-crk sarcoma virus CT10 oncogene homolog (avian)98770.000-0.0568No
89GNGT1NAGNGT1
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 198940.000-0.0577No
90CCL14NACCL14
Entrez,  Source
chemokine (C-C motif) ligand 14100060.000-0.0639No
91CCL18NACCL18
Entrez,  Source
chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)100070.000-0.0639No
92CCL4L2NACCL4L2
Entrez,  Source
chemokine (C-C motif) ligand 4-like 2100300.000-0.0651No
93CCL22NACCL22
Entrez,  Source
chemokine (C-C motif) ligand 2210385-0.022-0.0849No
94VAV3NAVAV3
Entrez,  Source
vav 3 oncogene10409-0.025-0.0860No
95GNG4NAGNG4
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma 410515-0.033-0.0917No
96CCL27NACCL27
Entrez,  Source
chemokine (C-C motif) ligand 2710532-0.036-0.0923No
97CX3CL1NACX3CL1
Entrez,  Source
chemokine (C-X3-C motif) ligand 110558-0.036-0.0935No
98CXCR2NA10598-0.042-0.0954No
99HCKNAHCK
Entrez,  Source
hemopoietic cell kinase10615-0.045-0.0960No
100PRKACANAPRKACA
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, alpha10652-0.045-0.0977No
101ADCY7NAADCY7
Entrez,  Source
adenylate cyclase 710682-0.049-0.0990No
102RELANARELA
Entrez,  Source
v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)10834-0.062-0.1071No
103PRKACGNAPRKACG
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, gamma11122-0.095-0.1226No
104CCL16NACCL16
Entrez,  Source
chemokine (C-C motif) ligand 1611205-0.105-0.1265No
105PARD3NAPARD3
Entrez,  Source
par-3 partitioning defective 3 homolog (C. elegans)11281-0.112-0.1300No
106CCR3NACCR3
Entrez,  Source
chemokine (C-C motif) receptor 311333-0.118-0.1320No
107CXCL6NACXCL6
Entrez,  Source
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)11409-0.125-0.1354No
108STAT3NASTAT3
Entrez,  Source
signal transducer and activator of transcription 3 (acute-phase response factor)11455-0.129-0.1371No
109CCL25NACCL25
Entrez,  Source
chemokine (C-C motif) ligand 2511603-0.144-0.1444No
110RAP1BNARAP1B
Entrez,  Source
RAP1B, member of RAS oncogene family11823-0.172-0.1555No
111GNG10NAGNG10
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma 1011940-0.184-0.1608No
112GRK6NAGRK6
Entrez,  Source
G protein-coupled receptor kinase 611943-0.185-0.1597No
113CXCR1NA12007-0.191-0.1620No
114GRB2NAGRB2
Entrez,  Source
growth factor receptor-bound protein 212056-0.196-0.1634No
115CCL3NACCL3
Entrez,  Source
chemokine (C-C motif) ligand 312099-0.201-0.1644No
116NRASNANRAS
Entrez,  Source
neuroblastoma RAS viral (v-ras) oncogene homolog12151-0.207-0.1659No
117STAT5BNASTAT5B
Entrez,  Source
signal transducer and activator of transcription 5B12285-0.224-0.1718No
118RAC2NARAC2
Entrez,  Source
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)12326-0.230-0.1726No
119XCL1NAXCL1
Entrez,  Source
chemokine (C motif) ligand 112341-0.231-0.1718No
120MAPK1NAMAPK1
Entrez,  Source
mitogen-activated protein kinase 112360-0.233-0.1713No
121PIK3R2NAPIK3R2
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)12508-0.252-0.1778No
122PIK3CDNAPIK3CD
Entrez,  Source
phosphoinositide-3-kinase, catalytic, delta polypeptide12596-0.262-0.1810No
123FGRNAFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog12675-0.273-0.1835No
124CX3CR1NACX3CR1
Entrez,  Source
chemokine (C-X3-C motif) receptor 112701-0.275-0.1831No
125CXCL13NACXCL13
Entrez,  Source
chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)12929-0.307-0.1938No
126RAC1NARAC1
Entrez,  Source
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)13101-0.334-0.2012No
127ADCY5NAADCY5
Entrez,  Source
adenylate cyclase 513236-0.354-0.2063No
128CCR2NACCR2
Entrez,  Source
chemokine (C-C motif) receptor 213275-0.361-0.2061No
129CCL15NACCL15
Entrez,  Source
chemokine (C-C motif) ligand 1513276-0.362-0.2037No
130PPBPNAPPBP
Entrez,  Source
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)13324-0.371-0.2038No
131RAF1NARAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 113760-0.446-0.2253No
132RAP1ANARAP1A
Entrez,  Source
RAP1A, member of RAS oncogene family13883-0.468-0.2290No
133GNB2NAGNB2
Entrez,  Source
guanine nucleotide binding protein (G protein), beta polypeptide 213939-0.478-0.2289No
134GRK7NAGRK7
Entrez,  Source
G protein-coupled receptor kinase 714137-0.517-0.2365No
135ADCY8NAADCY8
Entrez,  Source
adenylate cyclase 8 (brain)14346-0.562-0.2445No
136CCL2NACCL2
Entrez,  Source
chemokine (C-C motif) ligand 214501-0.592-0.2492No
137PLCB1NAPLCB1
Entrez,  Source
phospholipase C, beta 1 (phosphoinositide-specific)14805-0.670-0.2617No
138AKT3NAAKT3
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)14929-0.703-0.2640No
139PAK1NAPAK1
Entrez,  Source
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)15023-0.727-0.2643No
140CCR4NACCR4
Entrez,  Source
chemokine (C-C motif) receptor 415125-0.752-0.2650Yes
141BRAFNABRAF
Entrez,  Source
v-raf murine sarcoma viral oncogene homolog B115145-0.758-0.2610Yes
142PXNNAPXN
Entrez,  Source
paxillin15311-0.807-0.2649Yes
143GNG12NAGNG12
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma 1215316-0.810-0.2597Yes
144AKT1NAAKT1
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 115339-0.816-0.2555Yes
145NFKB1NANFKB1
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)15399-0.833-0.2533Yes
146FOXO3NA15433-0.842-0.2495Yes
147PRKACBNAPRKACB
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, beta15440-0.844-0.2442Yes
148CCR1NACCR1
Entrez,  Source
chemokine (C-C motif) receptor 115496-0.861-0.2416Yes
149RHOANARHOA
Entrez,  Source
ras homolog gene family, member A15597-0.894-0.2413Yes
150CXCL3NACXCL3
Entrez,  Source
chemokine (C-X-C motif) ligand 315611-0.898-0.2360Yes
151GNAI2NAGNAI2
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 215665-0.914-0.2329Yes
152GSK3BNAGSK3B
Entrez,  Source
glycogen synthase kinase 3 beta15818-0.977-0.2349Yes
153ADCY3NAADCY3
Entrez,  Source
adenylate cyclase 316173-1.126-0.2473Yes
154MAPK3NAMAPK3
Entrez,  Source
mitogen-activated protein kinase 316431-1.263-0.2533Yes
155MAP2K1NAMAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 116504-1.300-0.2487Yes
156PTK2BNAPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta16569-1.348-0.2433Yes
157TIAM2NATIAM2
Entrez,  Source
T-cell lymphoma invasion and metastasis 216639-1.387-0.2379Yes
158GRK5NAGRK5
Entrez,  Source
G protein-coupled receptor kinase 516762-1.478-0.2349Yes
159CCR10NACCR10
Entrez,  Source
chemokine (C-C motif) receptor 1016763-1.478-0.2251Yes
160SHC1NASHC1
Entrez,  Source
SHC (Src homology 2 domain containing) transforming protein 117055-1.738-0.2298Yes
161GNG11NAGNG11
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma 1117066-1.755-0.2187Yes
162GNG7NAGNG7
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma 717191-1.902-0.2130Yes
163PRKCDNAPRKCD
Entrez,  Source
protein kinase C, delta17310-2.062-0.2059Yes
164PRKCZNAPRKCZ
Entrez,  Source
protein kinase C, zeta17333-2.098-0.1931Yes
165CSKNACSK
Entrez,  Source
c-src tyrosine kinase17372-2.166-0.1808Yes
166CXCL5NACXCL5
Entrez,  Source
chemokine (C-X-C motif) ligand 517596-2.718-0.1753Yes
167GNB3NAGNB3
Entrez,  Source
guanine nucleotide binding protein (G protein), beta polypeptide 317620-2.776-0.1580Yes
168TIAM1NATIAM1
Entrez,  Source
T-cell lymphoma invasion and metastasis 117655-2.958-0.1402Yes
169CXCL1NACXCL1
Entrez,  Source
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)17669-3.027-0.1208Yes
170PLCB2NAPLCB2
Entrez,  Source
phospholipase C, beta 217672-3.047-0.1006Yes
171GNG2NAGNG2
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma 217811-3.820-0.0829Yes
172ITKNAITK
Entrez,  Source
IL2-inducible T-cell kinase17842-4.008-0.0579Yes
173PIK3CGNAPIK3CG
Entrez,  Source
phosphoinositide-3-kinase, catalytic, gamma polypeptide17957-4.885-0.0317Yes
174GNGT2NAGNGT2
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 217971-4.9480.0005Yes
Table: GSEA details [plain text format]



Fig 2: KEGG_CHEMOKINE_SIGNALING_PATHWAY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: KEGG_CHEMOKINE_SIGNALING_PATHWAY: Random ES distribution   
Gene set null distribution of ES for KEGG_CHEMOKINE_SIGNALING_PATHWAY