Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_BASE_EXCISION_REPAIR |
| Enrichment Score (ES) | -0.46434292 |
| Normalized Enrichment Score (NES) | -1.470283 |
| Nominal p-value | 0.03076923 |
| FDR q-value | 0.18464181 |
| FWER p-Value | 0.715 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | POLB | NA | POLB Entrez, Source | polymerase (DNA directed), beta | 617 | 2.887 | 0.0702 | No |
| 2 | APEX2 | NA | APEX2 Entrez, Source | APEX nuclease (apurinic/apyrimidinic endonuclease) 2 | 1959 | 1.579 | 0.0527 | No |
| 3 | POLL | NA | POLL Entrez, Source | polymerase (DNA directed), lambda | 5587 | 0.536 | -0.1299 | No |
| 4 | LIG3 | NA | LIG3 Entrez, Source | ligase III, DNA, ATP-dependent | 5962 | 0.474 | -0.1336 | No |
| 5 | NEIL2 | NA | NEIL2 Entrez, Source | nei like 2 (E. coli) | 6032 | 0.462 | -0.1207 | No |
| 6 | SMUG1 | NA | SMUG1 Entrez, Source | single-strand-selective monofunctional uracil-DNA glycosylase 1 | 6704 | 0.355 | -0.1452 | No |
| 7 | NEIL3 | NA | NEIL3 Entrez, Source | nei endonuclease VIII-like 3 (E. coli) | 6986 | 0.318 | -0.1493 | No |
| 8 | PCNA | NA | PCNA Entrez, Source | proliferating cell nuclear antigen | 8603 | 0.143 | -0.2342 | No |
| 9 | TDG | NA | TDG Entrez, Source | thymine-DNA glycosylase | 8918 | 0.107 | -0.2478 | No |
| 10 | POLE2 | NA | POLE2 Entrez, Source | polymerase (DNA directed), epsilon 2 (p59 subunit) | 9465 | 0.056 | -0.2762 | No |
| 11 | POLE | NA | POLE Entrez, Source | polymerase (DNA directed), epsilon | 10242 | -0.010 | -0.3191 | No |
| 12 | POLD4 | NA | POLD4 Entrez, Source | polymerase (DNA-directed), delta 4 | 12128 | -0.204 | -0.4167 | No |
| 13 | NTHL1 | NA | NTHL1 Entrez, Source | nth endonuclease III-like 1 (E. coli) | 12751 | -0.284 | -0.4411 | No |
| 14 | POLE3 | NA | POLE3 Entrez, Source | polymerase (DNA directed), epsilon 3 (p17 subunit) | 13002 | -0.319 | -0.4434 | No |
| 15 | POLD1 | NA | POLD1 Entrez, Source | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 13347 | -0.374 | -0.4490 | Yes |
| 16 | NEIL1 | NA | NEIL1 Entrez, Source | nei endonuclease VIII-like 1 (E. coli) | 13369 | -0.377 | -0.4365 | Yes |
| 17 | OGG1 | NA | OGG1 Entrez, Source | 8-oxoguanine DNA glycosylase | 13869 | -0.467 | -0.4474 | Yes |
| 18 | POLD3 | NA | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 14094 | -0.508 | -0.4415 | Yes |
| 19 | UNG | NA | UNG Entrez, Source | uracil-DNA glycosylase | 14205 | -0.533 | -0.4283 | Yes |
| 20 | MPG | NA | MPG Entrez, Source | N-methylpurine-DNA glycosylase | 14407 | -0.575 | -0.4186 | Yes |
| 21 | MBD4 | NA | MBD4 Entrez, Source | methyl-CpG binding domain protein 4 | 14740 | -0.656 | -0.4134 | Yes |
| 22 | LIG1 | NA | LIG1 Entrez, Source | ligase I, DNA, ATP-dependent | 15395 | -0.833 | -0.4196 | Yes |
| 23 | XRCC1 | NA | XRCC1 Entrez, Source | X-ray repair complementing defective repair in Chinese hamster cells 1 | 15431 | -0.842 | -0.3911 | Yes |
| 24 | FEN1 | NA | FEN1 Entrez, Source | flap structure-specific endonuclease 1 | 15451 | -0.848 | -0.3614 | Yes |
| 25 | POLD2 | NA | POLD2 Entrez, Source | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | 15846 | -0.985 | -0.3477 | Yes |
| 26 | PARP4 | NA | PARP4 Entrez, Source | poly (ADP-ribose) polymerase family, member 4 | 15871 | -0.995 | -0.3130 | Yes |
| 27 | APEX1 | NA | APEX1 Entrez, Source | APEX nuclease (multifunctional DNA repair enzyme) 1 | 16321 | -1.201 | -0.2945 | Yes |
| 28 | MUTYH | NA | MUTYH Entrez, Source | mutY homolog (E. coli) | 16417 | -1.257 | -0.2542 | Yes |
| 29 | PARP1 | NA | PARP1 Entrez, Source | poly (ADP-ribose) polymerase family, member 1 | 16710 | -1.438 | -0.2184 | Yes |
| 30 | PARP2 | NA | PARP2 Entrez, Source | poly (ADP-ribose) polymerase family, member 2 | 16823 | -1.525 | -0.1693 | Yes |
| 31 | PARP3 | NA | PARP3 Entrez, Source | poly (ADP-ribose) polymerase family, member 3 | 17267 | -1.996 | -0.1217 | Yes |
| 32 | POLE4 | NA | POLE4 Entrez, Source | polymerase (DNA-directed), epsilon 4 (p12 subunit) | 17350 | -2.135 | -0.0489 | Yes |
| 33 | HMGB1 | NA | HMGB1 Entrez, Source | high-mobility group box 1 | 17446 | -2.316 | 0.0298 | Yes |
