Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_AXON_GUIDANCE |
| Enrichment Score (ES) | 0.42673758 |
| Normalized Enrichment Score (NES) | 1.4741923 |
| Nominal p-value | 0.0072202166 |
| FDR q-value | 0.17741336 |
| FWER p-Value | 0.931 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | NTN4 | NA | NTN4 Entrez, Source | netrin 4 | 40 | 4.774 | 0.0291 | Yes |
| 2 | EPHA4 | NA | EPHA4 Entrez, Source | EPH receptor A4 | 147 | 4.334 | 0.0517 | Yes |
| 3 | NGEF | NA | NGEF Entrez, Source | neuronal guanine nucleotide exchange factor | 258 | 3.876 | 0.0710 | Yes |
| 4 | DPYSL2 | NA | DPYSL2 Entrez, Source | dihydropyrimidinase-like 2 | 307 | 3.718 | 0.0927 | Yes |
| 5 | PLXNA3 | NA | PLXNA3 Entrez, Source | plexin A3 | 312 | 3.705 | 0.1168 | Yes |
| 6 | NFATC2 | NA | NFATC2 Entrez, Source | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 380 | 3.507 | 0.1361 | Yes |
| 7 | SEMA3B | NA | SEMA3B Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 395 | 3.468 | 0.1581 | Yes |
| 8 | EPHA2 | NA | EPHA2 Entrez, Source | EPH receptor A2 | 546 | 3.043 | 0.1697 | Yes |
| 9 | RND1 | NA | RND1 Entrez, Source | Rho family GTPase 1 | 577 | 2.976 | 0.1876 | Yes |
| 10 | SEMA3C | NA | SEMA3C Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 683 | 2.794 | 0.2000 | Yes |
| 11 | EPHA7 | NA | EPHA7 Entrez, Source | EPH receptor A7 | 739 | 2.668 | 0.2145 | Yes |
| 12 | SEMA3D | NA | SEMA3D Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | 748 | 2.650 | 0.2315 | Yes |
| 13 | UNC5C | NA | UNC5C Entrez, Source | unc-5 homolog C (C. elegans) | 771 | 2.623 | 0.2475 | Yes |
| 14 | SEMA6A | NA | SEMA6A Entrez, Source | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | 807 | 2.574 | 0.2624 | Yes |
| 15 | EPHB2 | NA | EPHB2 Entrez, Source | EPH receptor B2 | 809 | 2.569 | 0.2792 | Yes |
| 16 | RHOD | NA | RHOD Entrez, Source | ras homolog gene family, member D | 1002 | 2.337 | 0.2838 | Yes |
| 17 | SLIT2 | NA | SLIT2 Entrez, Source | slit homolog 2 (Drosophila) | 1006 | 2.329 | 0.2990 | Yes |
| 18 | PLXNA1 | NA | PLXNA1 Entrez, Source | plexin A1 | 1043 | 2.279 | 0.3119 | Yes |
| 19 | MET | NA | MET Entrez, Source | met proto-oncogene (hepatocyte growth factor receptor) | 1052 | 2.268 | 0.3264 | Yes |
| 20 | EFNB2 | NA | EFNB2 Entrez, Source | ephrin-B2 | 1144 | 2.174 | 0.3356 | Yes |
| 21 | EFNA5 | NA | EFNA5 Entrez, Source | ephrin-A5 | 1286 | 2.053 | 0.3411 | Yes |
| 22 | EPHA5 | NA | EPHA5 Entrez, Source | EPH receptor A5 | 1342 | 2.000 | 0.3512 | Yes |
| 23 | EPHA6 | NA | EPHA6 Entrez, Source | EPH receptor A6 | 1463 | 1.901 | 0.3570 | Yes |
| 24 | PPP3CC | NA | PPP3CC Entrez, Source | protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma) | 1480 | 1.891 | 0.3685 | Yes |
| 25 | CXCR4 | NA | CXCR4 Entrez, Source | chemokine (C-X-C motif) receptor 4 | 1561 | 1.836 | 0.3761 | Yes |
| 26 | EPHB3 | NA | EPHB3 Entrez, Source | EPH receptor B3 | 1852 | 1.639 | 0.3706 | Yes |
| 27 | EFNB1 | NA | EFNB1 Entrez, Source | ephrin-B1 | 1857 | 1.635 | 0.3811 | Yes |
| 28 | NRP1 | NA | NRP1 Entrez, Source | neuropilin 1 | 1861 | 1.634 | 0.3917 | Yes |
| 29 | ABLIM2 | NA | ABLIM2 Entrez, Source | actin binding LIM protein family, member 2 | 2067 | 1.516 | 0.3902 | Yes |
| 30 | CFL2 | NA | CFL2 Entrez, Source | cofilin 2 (muscle) | 2119 | 1.487 | 0.3971 | Yes |
| 31 | LIMK1 | NA | LIMK1 Entrez, Source | LIM domain kinase 1 | 2346 | 1.396 | 0.3936 | Yes |
| 32 | EFNA2 | NA | EFNA2 Entrez, Source | ephrin-A2 | 2355 | 1.392 | 0.4023 | Yes |
| 33 | EFNB3 | NA | EFNB3 Entrez, Source | ephrin-B3 | 2392 | 1.376 | 0.4093 | Yes |
| 34 | ROBO2 | NA | ROBO2 Entrez, Source | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 2558 | 1.297 | 0.4086 | Yes |
| 35 | RASA1 | NA | RASA1 Entrez, Source | RAS p21 protein activator (GTPase activating protein) 1 | 2649 | 1.264 | 0.4119 | Yes |
| 36 | GNAI1 | NA | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 2654 | 1.262 | 0.4199 | Yes |
| 37 | PLXNA2 | NA | PLXNA2 Entrez, Source | plexin A2 | 2782 | 1.218 | 0.4208 | Yes |
| 38 | SEMA6D | NA | SEMA6D Entrez, Source | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D | 2819 | 1.207 | 0.4267 | Yes |
| 39 | ABLIM1 | NA | ABLIM1 Entrez, Source | actin binding LIM protein 1 | 3133 | 1.108 | 0.4165 | No |
| 40 | EPHA3 | NA | EPHA3 Entrez, Source | EPH receptor A3 | 3192 | 1.089 | 0.4204 | No |
| 41 | DPYSL5 | NA | DPYSL5 Entrez, Source | dihydropyrimidinase-like 5 | 3364 | 1.039 | 0.4176 | No |
| 42 | NFAT5 | NA | NFAT5 Entrez, Source | nuclear factor of activated T-cells 5, tonicity-responsive | 3544 | 0.987 | 0.4141 | No |
| 43 | PAK2 | NA | PAK2 Entrez, Source | p21 (CDKN1A)-activated kinase 2 | 3570 | 0.979 | 0.4191 | No |
| 44 | SEMA4D | NA | SEMA4D Entrez, Source | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | 3613 | 0.964 | 0.4231 | No |
| 45 | SRGAP1 | NA | SRGAP1 Entrez, Source | SLIT-ROBO Rho GTPase activating protein 1 | 3664 | 0.951 | 0.4266 | No |
| 46 | CDC42 | NA | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 4324 | 0.788 | 0.3948 | No |
| 47 | PPP3CA | NA | PPP3CA Entrez, Source | protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha) | 4436 | 0.766 | 0.3936 | No |
| 48 | SRGAP3 | NA | SRGAP3 Entrez, Source | SLIT-ROBO Rho GTPase activating protein 3 | 4476 | 0.753 | 0.3964 | No |
| 49 | CDK5 | NA | CDK5 Entrez, Source | cyclin-dependent kinase 5 | 4633 | 0.717 | 0.3924 | No |
| 50 | HRAS | NA | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 4840 | 0.674 | 0.3853 | No |
| 51 | PAK6 | NA | PAK6 Entrez, Source | p21(CDKN1A)-activated kinase 6 | 5063 | 0.630 | 0.3770 | No |
| 52 | EPHB6 | NA | EPHB6 Entrez, Source | EPH receptor B6 | 5164 | 0.611 | 0.3754 | No |
| 53 | EPHB4 | NA | EPHB4 Entrez, Source | EPH receptor B4 | 5226 | 0.600 | 0.3759 | No |
| 54 | LRRC4C | NA | LRRC4C Entrez, Source | leucine rich repeat containing 4C | 5309 | 0.583 | 0.3751 | No |
| 55 | UNC5D | NA | UNC5D Entrez, Source | unc-5 homolog D (C. elegans) | 5341 | 0.578 | 0.3772 | No |
| 56 | ABLIM3 | NA | ABLIM3 Entrez, Source | actin binding LIM protein family, member 3 | 5367 | 0.572 | 0.3796 | No |
| 57 | SEMA3F | NA | SEMA3F Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F | 5478 | 0.553 | 0.3770 | No |
| 58 | SEMA6C | NA | SEMA6C Entrez, Source | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C | 5942 | 0.478 | 0.3542 | No |
| 59 | SEMA4G | NA | SEMA4G Entrez, Source | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G | 5986 | 0.469 | 0.3549 | No |
| 60 | PLXNB2 | NA | PLXNB2 Entrez, Source | plexin B2 | 6152 | 0.438 | 0.3486 | No |
| 61 | NCK2 | NA | NCK2 Entrez, Source | NCK adaptor protein 2 | 6277 | 0.416 | 0.3443 | No |
| 62 | SEMA4A | NA | SEMA4A Entrez, Source | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 6291 | 0.413 | 0.3463 | No |
| 63 | ITGB1 | NA | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 6495 | 0.386 | 0.3375 | No |
| 64 | ARHGEF12 | NA | ARHGEF12 Entrez, Source | Rho guanine nucleotide exchange factor (GEF) 12 | 6582 | 0.374 | 0.3351 | No |
| 65 | ROBO1 | NA | ROBO1 Entrez, Source | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 6598 | 0.371 | 0.3367 | No |
| 66 | GNAI3 | NA | GNAI3 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 6912 | 0.327 | 0.3214 | No |
| 67 | NTN3 | NA | 7041 | 0.310 | 0.3162 | No | ||
| 68 | CHP2 | NA | 7298 | 0.275 | 0.3037 | No | ||
| 69 | ROCK2 | NA | ROCK2 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 2 | 7497 | 0.252 | 0.2943 | No |
| 70 | KRAS | NA | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 7514 | 0.251 | 0.2950 | No |
| 71 | SEMA3E | NA | SEMA3E Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | 7798 | 0.224 | 0.2806 | No |
| 72 | EPHA8 | NA | EPHA8 Entrez, Source | EPH receptor A8 | 8038 | 0.198 | 0.2685 | No |
| 73 | EFNA4 | NA | EFNA4 Entrez, Source | ephrin-A4 | 8083 | 0.191 | 0.2673 | No |
| 74 | EFNA1 | NA | EFNA1 Entrez, Source | ephrin-A1 | 8276 | 0.171 | 0.2577 | No |
| 75 | RAC3 | NA | RAC3 Entrez, Source | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) | 8286 | 0.170 | 0.2583 | No |
| 76 | PPP3CB | NA | PPP3CB Entrez, Source | protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta) | 8335 | 0.166 | 0.2567 | No |
| 77 | ROCK1 | NA | ROCK1 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 1 | 8463 | 0.156 | 0.2506 | No |
| 78 | PAK3 | NA | PAK3 Entrez, Source | p21 (CDKN1A)-activated kinase 3 | 8610 | 0.142 | 0.2434 | No |
| 79 | PTK2 | NA | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 8777 | 0.123 | 0.2349 | No |
| 80 | SRGAP2 | NA | SRGAP2 Entrez, Source | SLIT-ROBO Rho GTPase activating protein 2 | 8836 | 0.117 | 0.2324 | No |
| 81 | FYN | NA | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 8943 | 0.105 | 0.2272 | No |
| 82 | NFATC3 | NA | NFATC3 Entrez, Source | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 9078 | 0.091 | 0.2203 | No |
| 83 | ABL1 | NA | ABL1 Entrez, Source | v-abl Abelson murine leukemia viral oncogene homolog 1 | 9168 | 0.083 | 0.2158 | No |
| 84 | SEMA4B | NA | SEMA4B Entrez, Source | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 9256 | 0.075 | 0.2114 | No |
| 85 | CXCL12 | NA | CXCL12 Entrez, Source | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | 9424 | 0.058 | 0.2025 | No |
| 86 | EPHB1 | NA | EPHB1 Entrez, Source | EPH receptor B1 | 10753 | -0.054 | 0.1284 | No |
| 87 | UNC5B | NA | UNC5B Entrez, Source | unc-5 homolog B (C. elegans) | 11216 | -0.106 | 0.1033 | No |
| 88 | PAK4 | NA | PAK4 Entrez, Source | p21(CDKN1A)-activated kinase 4 | 11589 | -0.143 | 0.0834 | No |
| 89 | NRAS | NA | NRAS Entrez, Source | neuroblastoma RAS viral (v-ras) oncogene homolog | 12151 | -0.207 | 0.0533 | No |
| 90 | PPP3R2 | NA | PPP3R2 Entrez, Source | protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, beta isoform (calcineurin B, type II) | 12175 | -0.210 | 0.0534 | No |
| 91 | RAC2 | NA | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 12326 | -0.230 | 0.0465 | No |
| 92 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 12360 | -0.233 | 0.0462 | No |
| 93 | CFL1 | NA | CFL1 Entrez, Source | cofilin 1 (non-muscle) | 12813 | -0.292 | 0.0228 | No |
| 94 | NCK1 | NA | NCK1 Entrez, Source | NCK adaptor protein 1 | 12903 | -0.302 | 0.0198 | No |
| 95 | SEMA7A | NA | SEMA7A Entrez, Source | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | 13013 | -0.321 | 0.0158 | No |
| 96 | RAC1 | NA | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 13101 | -0.334 | 0.0131 | No |
| 97 | NTN1 | NA | NTN1 Entrez, Source | netrin 1 | 13128 | -0.338 | 0.0139 | No |
| 98 | SEMA3G | NA | SEMA3G Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G | 13187 | -0.347 | 0.0129 | No |
| 99 | SLIT3 | NA | SLIT3 Entrez, Source | slit homolog 3 (Drosophila) | 13271 | -0.361 | 0.0106 | No |
| 100 | PLXNC1 | NA | PLXNC1 Entrez, Source | plexin C1 | 13339 | -0.373 | 0.0093 | No |
| 101 | SLIT1 | NA | SLIT1 Entrez, Source | slit homolog 1 (Drosophila) | 13806 | -0.454 | -0.0138 | No |
| 102 | SEMA5B | NA | SEMA5B Entrez, Source | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B | 13947 | -0.479 | -0.0185 | No |
| 103 | RGS3 | NA | RGS3 Entrez, Source | regulator of G-protein signalling 3 | 14109 | -0.511 | -0.0241 | No |
| 104 | PLXNB3 | NA | PLXNB3 Entrez, Source | plexin B3 | 14319 | -0.554 | -0.0322 | No |
| 105 | EPHA1 | NA | EPHA1 Entrez, Source | EPH receptor A1 | 14474 | -0.588 | -0.0370 | No |
| 106 | SEMA3A | NA | SEMA3A Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 14696 | -0.640 | -0.0451 | No |
| 107 | SEMA4C | NA | SEMA4C Entrez, Source | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C | 14901 | -0.696 | -0.0520 | No |
| 108 | PAK1 | NA | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 15023 | -0.727 | -0.0540 | No |
| 109 | RHOA | NA | RHOA Entrez, Source | ras homolog gene family, member A | 15597 | -0.894 | -0.0802 | No |
| 110 | GNAI2 | NA | GNAI2 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 15665 | -0.914 | -0.0780 | No |
| 111 | GSK3B | NA | GSK3B Entrez, Source | glycogen synthase kinase 3 beta | 15818 | -0.977 | -0.0801 | No |
| 112 | NTNG1 | NA | NTNG1 Entrez, Source | netrin G1 | 16411 | -1.255 | -0.1050 | No |
| 113 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 16431 | -1.263 | -0.0978 | No |
| 114 | PPP3R1 | NA | PPP3R1 Entrez, Source | protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) | 16468 | -1.277 | -0.0914 | No |
| 115 | LIMK2 | NA | LIMK2 Entrez, Source | LIM domain kinase 2 | 16568 | -1.348 | -0.0881 | No |
| 116 | FES | NA | FES Entrez, Source | feline sarcoma oncogene | 16896 | -1.587 | -0.0960 | No |
| 117 | PLXNB1 | NA | PLXNB1 Entrez, Source | plexin B1 | 16946 | -1.629 | -0.0880 | No |
| 118 | SEMA4F | NA | SEMA4F Entrez, Source | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F | 17052 | -1.734 | -0.0825 | No |
| 119 | L1CAM | NA | L1CAM Entrez, Source | L1 cell adhesion molecule | 17100 | -1.790 | -0.0734 | No |
| 120 | EFNA3 | NA | EFNA3 Entrez, Source | ephrin-A3 | 17103 | -1.792 | -0.0617 | No |
| 121 | NFATC1 | NA | NFATC1 Entrez, Source | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 | 17116 | -1.805 | -0.0505 | No |
| 122 | SEMA6B | NA | SEMA6B Entrez, Source | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | 17160 | -1.858 | -0.0407 | No |
| 123 | SEMA5A | NA | SEMA5A Entrez, Source | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 17275 | -2.002 | -0.0339 | No |
| 124 | ROBO3 | NA | ROBO3 Entrez, Source | roundabout, axon guidance receptor, homolog 3 (Drosophila) | 17303 | -2.050 | -0.0220 | No |
| 125 | DCC | NA | DCC Entrez, Source | deleted in colorectal carcinoma | 17418 | -2.268 | -0.0135 | No |
| 126 | NFATC4 | NA | NFATC4 Entrez, Source | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 17739 | -3.339 | -0.0095 | No |
| 127 | UNC5A | NA | UNC5A Entrez, Source | unc-5 homolog A (C. elegans) | 17758 | -3.486 | 0.0124 | No |
