Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_AUTOIMMUNE_THYROID_DISEASE |
| Enrichment Score (ES) | 0.5922139 |
| Normalized Enrichment Score (NES) | 1.7213672 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.037486862 |
| FWER p-Value | 0.143 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | HLA-DRA | NA | HLA-DRA Entrez, Source | major histocompatibility complex, class II, DR alpha | 83 | 4.582 | 0.1007 | Yes |
| 2 | HLA-DRB1 | NA | HLA-DRB1 Entrez, Source | major histocompatibility complex, class II, DR beta 1 | 235 | 3.969 | 0.1835 | Yes |
| 3 | HLA-DPA1 | NA | HLA-DPA1 Entrez, Source | major histocompatibility complex, class II, DP alpha 1 | 345 | 3.598 | 0.2601 | Yes |
| 4 | HLA-DMA | NA | HLA-DMA Entrez, Source | major histocompatibility complex, class II, DM alpha | 556 | 3.030 | 0.3181 | Yes |
| 5 | HLA-DRB5 | NA | HLA-DRB5 Entrez, Source | major histocompatibility complex, class II, DR beta 5 | 611 | 2.898 | 0.3817 | Yes |
| 6 | FAS | NA | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 733 | 2.679 | 0.4365 | Yes |
| 7 | HLA-DRB3 | NA | HLA-DRB3 Entrez, Source | major histocompatibility complex, class II, DR beta 3 | 916 | 2.438 | 0.4824 | Yes |
| 8 | HLA-DMB | NA | HLA-DMB Entrez, Source | major histocompatibility complex, class II, DM beta | 1107 | 2.215 | 0.5227 | Yes |
| 9 | HLA-DRB4 | NA | HLA-DRB4 Entrez, Source | major histocompatibility complex, class II, DR beta 4 | 1321 | 2.023 | 0.5574 | Yes |
| 10 | HLA-DOB | NA | HLA-DOB Entrez, Source | major histocompatibility complex, class II, DO beta | 1477 | 1.892 | 0.5922 | Yes |
| 11 | HLA-E | NA | HLA-E Entrez, Source | major histocompatibility complex, class I, E | 2705 | 1.243 | 0.5524 | No |
| 12 | PRF1 | NA | PRF1 Entrez, Source | perforin 1 (pore forming protein) | 3267 | 1.069 | 0.5457 | No |
| 13 | HLA-A | NA | HLA-A Entrez, Source | major histocompatibility complex, class I, A | 4503 | 0.747 | 0.4940 | No |
| 14 | FASLG | NA | FASLG Entrez, Source | Fas ligand (TNF superfamily, member 6) | 4608 | 0.723 | 0.5049 | No |
| 15 | HLA-C | NA | HLA-C Entrez, Source | major histocompatibility complex, class I, C | 4653 | 0.713 | 0.5188 | No |
| 16 | HLA-DPB1 | NA | HLA-DPB1 Entrez, Source | major histocompatibility complex, class II, DP beta 1 | 5159 | 0.612 | 0.5047 | No |
| 17 | HLA-F | NA | HLA-F Entrez, Source | major histocompatibility complex, class I, F | 5915 | 0.484 | 0.4738 | No |
| 18 | CD80 | NA | CD80 Entrez, Source | CD80 molecule | 6065 | 0.457 | 0.4760 | No |
| 19 | HLA-DQB1 | NA | HLA-DQB1 Entrez, Source | major histocompatibility complex, class II, DQ beta 1 | 7133 | 0.297 | 0.4233 | No |
| 20 | CD40LG | NA | CD40LG Entrez, Source | CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome) | 7609 | 0.242 | 0.4024 | No |
| 21 | HLA-DQA1 | NA | HLA-DQA1 Entrez, Source | major histocompatibility complex, class II, DQ alpha 1 | 7724 | 0.232 | 0.4014 | No |
| 22 | TPO | NA | TPO Entrez, Source | thyroid peroxidase | 7890 | 0.215 | 0.3971 | No |
| 23 | IL2 | NA | IL2 Entrez, Source | interleukin 2 | 8119 | 0.187 | 0.3887 | No |
| 24 | HLA-DOA | NA | HLA-DOA Entrez, Source | major histocompatibility complex, class II, DO alpha | 8378 | 0.164 | 0.3781 | No |
| 25 | CTLA4 | NA | CTLA4 Entrez, Source | cytotoxic T-lymphocyte-associated protein 4 | 9358 | 0.066 | 0.3250 | No |
| 26 | CGA | NA | CGA Entrez, Source | glycoprotein hormones, alpha polypeptide | 9668 | 0.029 | 0.3085 | No |
| 27 | IL10 | NA | IL10 Entrez, Source | interleukin 10 | 9803 | 0.010 | 0.3012 | No |
| 28 | IL4 | NA | IL4 Entrez, Source | interleukin 4 | 9924 | 0.000 | 0.2946 | No |
| 29 | HLA-DQA2 | NA | HLA-DQA2 Entrez, Source | major histocompatibility complex, class II, DQ alpha 2 | 10636 | -0.045 | 0.2560 | No |
| 30 | CD86 | NA | CD86 Entrez, Source | CD86 molecule | 11217 | -0.106 | 0.2261 | No |
| 31 | IFNA21 | NA | IFNA21 Entrez, Source | interferon, alpha 21 | 11800 | -0.169 | 0.1975 | No |
| 32 | TG | NA | TG Entrez, Source | thyroglobulin | 12062 | -0.197 | 0.1875 | No |
| 33 | TSHB | NA | TSHB Entrez, Source | thyroid stimulating hormone, beta | 12191 | -0.212 | 0.1852 | No |
| 34 | TSHR | NA | TSHR Entrez, Source | thyroid stimulating hormone receptor | 12565 | -0.258 | 0.1704 | No |
| 35 | IFNA8 | NA | IFNA8 Entrez, Source | interferon, alpha 8 | 12884 | -0.299 | 0.1595 | No |
| 36 | HLA-B | NA | HLA-B Entrez, Source | major histocompatibility complex, class I, B | 14110 | -0.511 | 0.1030 | No |
| 37 | HLA-G | NA | HLA-G Entrez, Source | HLA-G histocompatibility antigen, class I, G | 14436 | -0.581 | 0.0983 | No |
| 38 | CD28 | NA | CD28 Entrez, Source | CD28 molecule | 16374 | -1.233 | 0.0186 | No |
| 39 | CD40 | NA | CD40 Entrez, Source | CD40 molecule, TNF receptor superfamily member 5 | 17681 | -3.081 | 0.0167 | No |
