Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_ARACHIDONIC_ACID_METABOLISM |
| Enrichment Score (ES) | 0.5519399 |
| Normalized Enrichment Score (NES) | 1.6718671 |
| Nominal p-value | 0.001344086 |
| FDR q-value | 0.050927136 |
| FWER p-Value | 0.267 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | GPX3 | NA | GPX3 Entrez, Source | glutathione peroxidase 3 (plasma) | 4 | 4.960 | 0.0900 | Yes |
| 2 | GGT5 | NA | 14 | 4.923 | 0.1789 | Yes | ||
| 3 | AKR1C3 | NA | AKR1C3 Entrez, Source | aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) | 47 | 4.758 | 0.2637 | Yes |
| 4 | TBXAS1 | NA | TBXAS1 Entrez, Source | thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) | 335 | 3.633 | 0.3137 | Yes |
| 5 | CYP2J2 | NA | CYP2J2 Entrez, Source | cytochrome P450, family 2, subfamily J, polypeptide 2 | 403 | 3.454 | 0.3728 | Yes |
| 6 | PTGS1 | NA | PTGS1 Entrez, Source | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | 622 | 2.881 | 0.4130 | Yes |
| 7 | CYP4F3 | NA | CYP4F3 Entrez, Source | cytochrome P450, family 4, subfamily F, polypeptide 3 | 747 | 2.651 | 0.4543 | Yes |
| 8 | PLA2G12A | NA | PLA2G12A Entrez, Source | phospholipase A2, group XIIA | 810 | 2.569 | 0.4975 | Yes |
| 9 | PTGS2 | NA | PTGS2 Entrez, Source | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 1611 | 1.797 | 0.4856 | Yes |
| 10 | CYP2U1 | NA | CYP2U1 Entrez, Source | cytochrome P450, family 2, subfamily U, polypeptide 1 | 1724 | 1.721 | 0.5106 | Yes |
| 11 | CYP2E1 | NA | CYP2E1 Entrez, Source | cytochrome P450, family 2, subfamily E, polypeptide 1 | 1849 | 1.641 | 0.5335 | Yes |
| 12 | PTGES | NA | PTGES Entrez, Source | prostaglandin E synthase | 2023 | 1.544 | 0.5519 | Yes |
| 13 | CBR1 | NA | CBR1 Entrez, Source | carbonyl reductase 1 | 2518 | 1.316 | 0.5483 | No |
| 14 | GGT6 | NA | GGT6 Entrez, Source | gamma-glutamyltransferase 6 homolog (rat) | 3750 | 0.926 | 0.4965 | No |
| 15 | GPX4 | NA | GPX4 Entrez, Source | glutathione peroxidase 4 (phospholipid hydroperoxidase) | 4221 | 0.812 | 0.4850 | No |
| 16 | ALOX12B | NA | ALOX12B Entrez, Source | arachidonate 12-lipoxygenase, 12R type | 4556 | 0.736 | 0.4798 | No |
| 17 | PTGES2 | NA | PTGES2 Entrez, Source | prostaglandin E synthase 2 | 4705 | 0.703 | 0.4843 | No |
| 18 | PTGIS | NA | PTGIS Entrez, Source | prostaglandin I2 (prostacyclin) synthase | 4706 | 0.702 | 0.4971 | No |
| 19 | CYP4F2 | NA | CYP4F2 Entrez, Source | cytochrome P450, family 4, subfamily F, polypeptide 2 | 4921 | 0.657 | 0.4971 | No |
| 20 | CYP2C18 | NA | CYP2C18 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 18 | 5636 | 0.528 | 0.4669 | No |
| 21 | PLA2G4E | NA | PLA2G4E Entrez, Source | phospholipase A2, group IVE | 5737 | 0.510 | 0.4706 | No |
| 22 | CBR3 | NA | CBR3 Entrez, Source | carbonyl reductase 3 | 5943 | 0.477 | 0.4678 | No |
| 23 | PLA2G10 | NA | PLA2G10 Entrez, Source | phospholipase A2, group X | 6199 | 0.429 | 0.4614 | No |
| 24 | CYP2B6 | NA | CYP2B6 Entrez, Source | cytochrome P450, family 2, subfamily B, polypeptide 6 | 6578 | 0.374 | 0.4471 | No |
| 25 | ALOX15 | NA | ALOX15 Entrez, Source | arachidonate 15-lipoxygenase | 7168 | 0.291 | 0.4195 | No |
| 26 | EPHX2 | NA | EPHX2 Entrez, Source | epoxide hydrolase 2, cytoplasmic | 7232 | 0.283 | 0.4212 | No |
| 27 | ALOX5 | NA | ALOX5 Entrez, Source | arachidonate 5-lipoxygenase | 7394 | 0.263 | 0.4170 | No |
| 28 | PLA2G12B | NA | PLA2G12B Entrez, Source | phospholipase A2, group XIIB | 7442 | 0.257 | 0.4190 | No |
| 29 | LTA4H | NA | LTA4H Entrez, Source | leukotriene A4 hydrolase | 7586 | 0.244 | 0.4155 | No |
| 30 | PLA2G2F | NA | PLA2G2F Entrez, Source | phospholipase A2, group IIF | 8002 | 0.203 | 0.3960 | No |
| 31 | CYP4A11 | NA | CYP4A11 Entrez, Source | cytochrome P450, family 4, subfamily A, polypeptide 11 | 8117 | 0.187 | 0.3931 | No |
| 32 | PTGDS | NA | PTGDS Entrez, Source | prostaglandin D2 synthase 21kDa (brain) | 8134 | 0.185 | 0.3955 | No |
| 33 | PLA2G4A | NA | PLA2G4A Entrez, Source | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 8419 | 0.160 | 0.3826 | No |
| 34 | PLA2G4B | NA | PLA2G4B Entrez, Source | phospholipase A2, group IVB (cytosolic) | 8578 | 0.145 | 0.3764 | No |
| 35 | PLA2G2D | NA | PLA2G2D Entrez, Source | phospholipase A2, group IID | 8879 | 0.112 | 0.3617 | No |
| 36 | CYP2C9 | NA | CYP2C9 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 9 | 9009 | 0.098 | 0.3563 | No |
| 37 | PLA2G5 | NA | PLA2G5 Entrez, Source | phospholipase A2, group V | 9020 | 0.097 | 0.3575 | No |
| 38 | JMJD7-PLA2G4B | NA | 9398 | 0.062 | 0.3376 | No | ||
| 39 | GPX5 | NA | GPX5 Entrez, Source | glutathione peroxidase 5 (epididymal androgen-related protein) | 9446 | 0.057 | 0.3360 | No |
| 40 | PLA2G3 | NA | PLA2G3 Entrez, Source | phospholipase A2, group III | 9670 | 0.029 | 0.3241 | No |
| 41 | GPX1 | NA | GPX1 Entrez, Source | glutathione peroxidase 1 | 9742 | 0.020 | 0.3205 | No |
| 42 | ALOX15B | NA | ALOX15B Entrez, Source | arachidonate 15-lipoxygenase, type B | 10777 | -0.056 | 0.2639 | No |
| 43 | CYP2C19 | NA | CYP2C19 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 19 | 11744 | -0.161 | 0.2129 | No |
| 44 | PLA2G2A | NA | PLA2G2A Entrez, Source | phospholipase A2, group IIA (platelets, synovial fluid) | 11827 | -0.172 | 0.2115 | No |
| 45 | LTC4S | NA | LTC4S Entrez, Source | leukotriene C4 synthase | 11936 | -0.184 | 0.2088 | No |
| 46 | PLA2G6 | NA | PLA2G6 Entrez, Source | phospholipase A2, group VI (cytosolic, calcium-independent) | 12316 | -0.229 | 0.1918 | No |
| 47 | HPGDS | NA | 12725 | -0.279 | 0.1741 | No | ||
| 48 | GPX2 | NA | GPX2 Entrez, Source | glutathione peroxidase 2 (gastrointestinal) | 13820 | -0.456 | 0.1214 | No |
| 49 | PLA2G1B | NA | PLA2G1B Entrez, Source | phospholipase A2, group IB (pancreas) | 14136 | -0.517 | 0.1132 | No |
| 50 | ALOX12 | NA | ALOX12 Entrez, Source | arachidonate 12-lipoxygenase | 14775 | -0.664 | 0.0897 | No |
| 51 | CYP2C8 | NA | CYP2C8 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 8 | 15013 | -0.724 | 0.0896 | No |
| 52 | GPX7 | NA | GPX7 Entrez, Source | glutathione peroxidase 7 | 16600 | -1.369 | 0.0261 | No |
| 53 | GGT7 | NA | 17624 | -2.797 | 0.0199 | No |
