Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION |
| Enrichment Score (ES) | 0.507752 |
| Normalized Enrichment Score (NES) | 1.611468 |
| Nominal p-value | 0.0040431265 |
| FDR q-value | 0.06975716 |
| FWER p-Value | 0.452 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CD74 | NA | CD74 Entrez, Source | CD74 molecule, major histocompatibility complex, class II invariant chain | 3 | 4.961 | 0.0656 | Yes |
| 2 | HLA-DRA | NA | HLA-DRA Entrez, Source | major histocompatibility complex, class II, DR alpha | 83 | 4.582 | 0.1220 | Yes |
| 3 | CIITA | NA | CIITA Entrez, Source | class II, major histocompatibility complex, transactivator | 226 | 4.001 | 0.1671 | Yes |
| 4 | HLA-DRB1 | NA | HLA-DRB1 Entrez, Source | major histocompatibility complex, class II, DR beta 1 | 235 | 3.969 | 0.2193 | Yes |
| 5 | HLA-DPA1 | NA | HLA-DPA1 Entrez, Source | major histocompatibility complex, class II, DP alpha 1 | 345 | 3.598 | 0.2609 | Yes |
| 6 | HLA-DMA | NA | HLA-DMA Entrez, Source | major histocompatibility complex, class II, DM alpha | 556 | 3.030 | 0.2894 | Yes |
| 7 | HLA-DRB5 | NA | HLA-DRB5 Entrez, Source | major histocompatibility complex, class II, DR beta 5 | 611 | 2.898 | 0.3248 | Yes |
| 8 | CTSB | NA | CTSB Entrez, Source | cathepsin B | 721 | 2.715 | 0.3548 | Yes |
| 9 | HLA-DRB3 | NA | HLA-DRB3 Entrez, Source | major histocompatibility complex, class II, DR beta 3 | 916 | 2.438 | 0.3763 | Yes |
| 10 | HLA-DMB | NA | HLA-DMB Entrez, Source | major histocompatibility complex, class II, DM beta | 1107 | 2.215 | 0.3950 | Yes |
| 11 | HLA-DRB4 | NA | HLA-DRB4 Entrez, Source | major histocompatibility complex, class II, DR beta 4 | 1321 | 2.023 | 0.4100 | Yes |
| 12 | HSPA1A | NA | HSPA1A Entrez, Source | heat shock 70kDa protein 1A | 1411 | 1.945 | 0.4308 | Yes |
| 13 | HLA-DOB | NA | HLA-DOB Entrez, Source | major histocompatibility complex, class II, DO beta | 1477 | 1.892 | 0.4523 | Yes |
| 14 | KLRC1 | NA | KLRC1 Entrez, Source | killer cell lectin-like receptor subfamily C, member 1 | 1591 | 1.814 | 0.4700 | Yes |
| 15 | TAPBP | NA | TAPBP Entrez, Source | TAP binding protein (tapasin) | 2139 | 1.475 | 0.4591 | Yes |
| 16 | HLA-E | NA | HLA-E Entrez, Source | major histocompatibility complex, class I, E | 2705 | 1.243 | 0.4440 | Yes |
| 17 | HSPA1B | NA | HSPA1B Entrez, Source | heat shock 70kDa protein 1B | 2713 | 1.240 | 0.4601 | Yes |
| 18 | PSME1 | NA | PSME1 Entrez, Source | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 2769 | 1.222 | 0.4732 | Yes |
| 19 | NFYA | NA | NFYA Entrez, Source | nuclear transcription factor Y, alpha | 2795 | 1.214 | 0.4879 | Yes |
| 20 | IFI30 | NA | IFI30 Entrez, Source | interferon, gamma-inducible protein 30 | 2977 | 1.155 | 0.4931 | Yes |
| 21 | LGMN | NA | LGMN Entrez, Source | legumain | 3465 | 1.012 | 0.4794 | Yes |
| 22 | HSPA5 | NA | HSPA5 Entrez, Source | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 3934 | 0.884 | 0.4650 | Yes |
| 23 | KLRC3 | NA | KLRC3 Entrez, Source | killer cell lectin-like receptor subfamily C, member 3 | 3986 | 0.871 | 0.4737 | Yes |
| 24 | HSPA4 | NA | HSPA4 Entrez, Source | heat shock 70kDa protein 4 | 4204 | 0.815 | 0.4723 | Yes |
| 25 | KLRC2 | NA | KLRC2 Entrez, Source | killer cell lectin-like receptor subfamily C, member 2 | 4263 | 0.801 | 0.4797 | Yes |
| 26 | PSME2 | NA | PSME2 Entrez, Source | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | 4336 | 0.785 | 0.4861 | Yes |
| 27 | CREB1 | NA | CREB1 Entrez, Source | cAMP responsive element binding protein 1 | 4407 | 0.771 | 0.4924 | Yes |
| 28 | HLA-A | NA | HLA-A Entrez, Source | major histocompatibility complex, class I, A | 4503 | 0.747 | 0.4971 | Yes |
| 29 | HSPA1L | NA | HSPA1L Entrez, Source | heat shock 70kDa protein 1-like | 4638 | 0.716 | 0.4991 | Yes |
| 30 | HLA-C | NA | HLA-C Entrez, Source | major histocompatibility complex, class I, C | 4653 | 0.713 | 0.5078 | Yes |
| 31 | HLA-DPB1 | NA | HLA-DPB1 Entrez, Source | major histocompatibility complex, class II, DP beta 1 | 5159 | 0.612 | 0.4877 | No |
| 32 | HSPA8 | NA | HSPA8 Entrez, Source | heat shock 70kDa protein 8 | 5216 | 0.601 | 0.4925 | No |
| 33 | LTA | NA | LTA Entrez, Source | lymphotoxin alpha (TNF superfamily, member 1) | 5480 | 0.553 | 0.4852 | No |
| 34 | HLA-F | NA | HLA-F Entrez, Source | major histocompatibility complex, class I, F | 5915 | 0.484 | 0.4674 | No |
| 35 | KLRD1 | NA | KLRD1 Entrez, Source | killer cell lectin-like receptor subfamily D, member 1 | 6128 | 0.445 | 0.4614 | No |
| 36 | HSP90AB1 | NA | HSP90AB1 Entrez, Source | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 6586 | 0.373 | 0.4409 | No |
| 37 | HLA-DQB1 | NA | HLA-DQB1 Entrez, Source | major histocompatibility complex, class II, DQ beta 1 | 7133 | 0.297 | 0.4143 | No |
| 38 | HLA-DQA1 | NA | HLA-DQA1 Entrez, Source | major histocompatibility complex, class II, DQ alpha 1 | 7724 | 0.232 | 0.3845 | No |
| 39 | TAP1 | NA | TAP1 Entrez, Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 8046 | 0.197 | 0.3692 | No |
| 40 | HLA-DOA | NA | HLA-DOA Entrez, Source | major histocompatibility complex, class II, DO alpha | 8378 | 0.164 | 0.3529 | No |
| 41 | CANX | NA | CANX Entrez, Source | calnexin | 9695 | 0.027 | 0.2798 | No |
| 42 | KLRC4 | NA | KLRC4 Entrez, Source | killer cell lectin-like receptor subfamily C, member 4 | 9974 | 0.000 | 0.2643 | No |
| 43 | RFX5 | NA | RFX5 Entrez, Source | regulatory factor X, 5 (influences HLA class II expression) | 10166 | -0.001 | 0.2536 | No |
| 44 | CALR | NA | CALR Entrez, Source | calreticulin | 10233 | -0.009 | 0.2501 | No |
| 45 | HLA-DQA2 | NA | HLA-DQA2 Entrez, Source | major histocompatibility complex, class II, DQ alpha 2 | 10636 | -0.045 | 0.2282 | No |
| 46 | NFYC | NA | NFYC Entrez, Source | nuclear transcription factor Y, gamma | 10669 | -0.046 | 0.2270 | No |
| 47 | KIR3DL1 | NA | KIR3DL1 Entrez, Source | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 | 11210 | -0.105 | 0.1983 | No |
| 48 | HSPA6 | NA | HSPA6 Entrez, Source | heat shock 70kDa protein 6 (HSP70B') | 11611 | -0.145 | 0.1779 | No |
| 49 | RFXANK | NA | RFXANK Entrez, Source | regulatory factor X-associated ankyrin-containing protein | 11660 | -0.150 | 0.1772 | No |
| 50 | IFNA21 | NA | IFNA21 Entrez, Source | interferon, alpha 21 | 11800 | -0.169 | 0.1717 | No |
| 51 | B2M | NA | B2M Entrez, Source | beta-2-microglobulin | 11935 | -0.184 | 0.1667 | No |
| 52 | CD4 | NA | CD4 Entrez, Source | CD4 molecule | 12053 | -0.196 | 0.1627 | No |
| 53 | TAP2 | NA | TAP2 Entrez, Source | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | 12227 | -0.218 | 0.1560 | No |
| 54 | IFNA8 | NA | IFNA8 Entrez, Source | interferon, alpha 8 | 12884 | -0.299 | 0.1233 | No |
| 55 | HLA-B | NA | HLA-B Entrez, Source | major histocompatibility complex, class I, B | 14110 | -0.511 | 0.0617 | No |
| 56 | PDIA3 | NA | PDIA3 Entrez, Source | protein disulfide isomerase family A, member 3 | 14171 | -0.525 | 0.0653 | No |
| 57 | HLA-G | NA | HLA-G Entrez, Source | HLA-G histocompatibility antigen, class I, G | 14436 | -0.581 | 0.0583 | No |
| 58 | HSP90AA1 | NA | HSP90AA1 Entrez, Source | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 15288 | -0.799 | 0.0214 | No |
| 59 | RFXAP | NA | RFXAP Entrez, Source | regulatory factor X-associated protein | 15769 | -0.955 | 0.0073 | No |
| 60 | PSME3 | NA | PSME3 Entrez, Source | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) | 15786 | -0.965 | 0.0192 | No |
| 61 | HSPA2 | NA | HSPA2 Entrez, Source | heat shock 70kDa protein 2 | 15823 | -0.979 | 0.0302 | No |
| 62 | CD8A | NA | CD8A Entrez, Source | CD8a molecule | 16382 | -1.236 | 0.0154 | No |
| 63 | NFYB | NA | NFYB Entrez, Source | nuclear transcription factor Y, beta | 16718 | -1.446 | 0.0159 | No |
| 64 | CTSS | NA | CTSS Entrez, Source | cathepsin S | 17858 | -4.107 | 0.0068 | No |
