Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_WNT_BETA_CATENIN_SIGNALING |
| Enrichment Score (ES) | -0.28049326 |
| Normalized Enrichment Score (NES) | -0.9313936 |
| Nominal p-value | 0.6034483 |
| FDR q-value | 0.6559234 |
| FWER p-Value | 0.998 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | TCF7 | NA | TCF7 Entrez, Source | transcription factor 7 (T-cell specific, HMG-box) | 189 | 4.141 | 0.0686 | No |
| 2 | JAG1 | NA | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 309 | 3.715 | 0.1330 | No |
| 3 | JAG2 | NA | JAG2 Entrez, Source | jagged 2 | 548 | 3.041 | 0.1779 | No |
| 4 | FZD1 | NA | FZD1 Entrez, Source | frizzled homolog 1 (Drosophila) | 599 | 2.912 | 0.2307 | No |
| 5 | DKK1 | NA | DKK1 Entrez, Source | dickkopf homolog 1 (Xenopus laevis) | 1345 | 1.998 | 0.2274 | No |
| 6 | ADAM17 | NA | ADAM17 Entrez, Source | ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) | 2321 | 1.405 | 0.1999 | No |
| 7 | PSEN2 | NA | PSEN2 Entrez, Source | presenilin 2 (Alzheimer disease 4) | 2516 | 1.317 | 0.2142 | No |
| 8 | GNAI1 | NA | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 2654 | 1.262 | 0.2307 | No |
| 9 | NCSTN | NA | NCSTN Entrez, Source | nicastrin | 2656 | 1.261 | 0.2548 | No |
| 10 | RBPJ | NA | 3441 | 1.018 | 0.2305 | No | ||
| 11 | WNT5B | NA | WNT5B Entrez, Source | wingless-type MMTV integration site family, member 5B | 3645 | 0.957 | 0.2375 | No |
| 12 | HEY2 | NA | HEY2 Entrez, Source | hairy/enhancer-of-split related with YRPW motif 2 | 3725 | 0.935 | 0.2510 | No |
| 13 | AXIN2 | NA | AXIN2 Entrez, Source | axin 2 (conductin, axil) | 4028 | 0.861 | 0.2506 | No |
| 14 | PPARD | NA | PPARD Entrez, Source | peroxisome proliferative activated receptor, delta | 5578 | 0.537 | 0.1745 | No |
| 15 | NOTCH1 | NA | NOTCH1 Entrez, Source | Notch homolog 1, translocation-associated (Drosophila) | 6392 | 0.398 | 0.1368 | No |
| 16 | CUL1 | NA | CUL1 Entrez, Source | cullin 1 | 6459 | 0.390 | 0.1406 | No |
| 17 | MAML1 | NA | MAML1 Entrez, Source | mastermind-like 1 (Drosophila) | 7602 | 0.243 | 0.0816 | No |
| 18 | PTCH1 | NA | PTCH1 Entrez, Source | patched homolog 1 (Drosophila) | 7938 | 0.211 | 0.0669 | No |
| 19 | DKK4 | NA | DKK4 Entrez, Source | dickkopf homolog 4 (Xenopus laevis) | 8141 | 0.184 | 0.0592 | No |
| 20 | KAT2A | NA | 9102 | 0.090 | 0.0074 | No | ||
| 21 | WNT1 | NA | WNT1 Entrez, Source | wingless-type MMTV integration site family, member 1 | 9146 | 0.085 | 0.0066 | No |
| 22 | WNT6 | NA | WNT6 Entrez, Source | wingless-type MMTV integration site family, member 6 | 11385 | -0.123 | -0.1158 | No |
| 23 | NUMB | NA | NUMB Entrez, Source | numb homolog (Drosophila) | 12489 | -0.249 | -0.1725 | No |
| 24 | CSNK1E | NA | CSNK1E Entrez, Source | casein kinase 1, epsilon | 12659 | -0.272 | -0.1768 | No |
| 25 | AXIN1 | NA | AXIN1 Entrez, Source | axin 1 | 12933 | -0.308 | -0.1861 | No |
| 26 | FZD8 | NA | FZD8 Entrez, Source | frizzled homolog 8 (Drosophila) | 14067 | -0.504 | -0.2396 | No |
| 27 | HEY1 | NA | HEY1 Entrez, Source | hairy/enhancer-of-split related with YRPW motif 1 | 14801 | -0.669 | -0.2677 | Yes |
| 28 | CTNNB1 | NA | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 14895 | -0.694 | -0.2596 | Yes |
| 29 | MYC | NA | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 15151 | -0.760 | -0.2593 | Yes |
| 30 | DVL2 | NA | DVL2 Entrez, Source | dishevelled, dsh homolog 2 (Drosophila) | 15387 | -0.831 | -0.2565 | Yes |
| 31 | HDAC2 | NA | HDAC2 Entrez, Source | histone deacetylase 2 | 15558 | -0.884 | -0.2491 | Yes |
| 32 | NKD1 | NA | NKD1 Entrez, Source | naked cuticle homolog 1 (Drosophila) | 15890 | -1.003 | -0.2484 | Yes |
| 33 | HDAC11 | NA | HDAC11 Entrez, Source | histone deacetylase 11 | 16037 | -1.059 | -0.2363 | Yes |
| 34 | LEF1 | NA | LEF1 Entrez, Source | lymphoid enhancer-binding factor 1 | 16125 | -1.101 | -0.2201 | Yes |
| 35 | NCOR2 | NA | NCOR2 Entrez, Source | nuclear receptor co-repressor 2 | 16864 | -1.565 | -0.2313 | Yes |
| 36 | CCND2 | NA | CCND2 Entrez, Source | cyclin D2 | 16961 | -1.643 | -0.2053 | Yes |
| 37 | SKP2 | NA | SKP2 Entrez, Source | S-phase kinase-associated protein 2 (p45) | 16986 | -1.674 | -0.1746 | Yes |
| 38 | FRAT1 | NA | FRAT1 Entrez, Source | frequently rearranged in advanced T-cell lymphomas | 17115 | -1.805 | -0.1473 | Yes |
| 39 | HDAC5 | NA | HDAC5 Entrez, Source | histone deacetylase 5 | 17138 | -1.831 | -0.1135 | Yes |
| 40 | TP53 | NA | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 17352 | -2.136 | -0.0845 | Yes |
| 41 | DLL1 | NA | DLL1 Entrez, Source | delta-like 1 (Drosophila) | 17404 | -2.241 | -0.0446 | Yes |
| 42 | NOTCH4 | NA | NOTCH4 Entrez, Source | Notch homolog 4 (Drosophila) | 17843 | -4.009 | 0.0076 | Yes |
