Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | HALLMARK_UV_RESPONSE_DN |
| Enrichment Score (ES) | 0.4134275 |
| Normalized Enrichment Score (NES) | 1.4345975 |
| Nominal p-value | 0.0072639226 |
| FDR q-value | 0.033953518 |
| FWER p-Value | 0.41 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | ID1 | NA | ID1 Entrez, Source | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 64 | 4.691 | 0.0241 | Yes |
| 2 | LPAR1 | NA | 161 | 4.273 | 0.0439 | Yes | ||
| 3 | GJA1 | NA | GJA1 Entrez, Source | gap junction protein, alpha 1, 43kDa (connexin 43) | 285 | 3.782 | 0.0593 | Yes |
| 4 | BDNF | NA | BDNF Entrez, Source | brain-derived neurotrophic factor | 461 | 3.232 | 0.0685 | Yes |
| 5 | VLDLR | NA | VLDLR Entrez, Source | very low density lipoprotein receptor | 477 | 3.198 | 0.0865 | Yes |
| 6 | FHL2 | NA | FHL2 Entrez, Source | four and a half LIM domains 2 | 536 | 3.067 | 0.1013 | Yes |
| 7 | F3 | NA | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 576 | 2.979 | 0.1167 | Yes |
| 8 | TGFBR3 | NA | TGFBR3 Entrez, Source | transforming growth factor, beta receptor III (betaglycan, 300kDa) | 753 | 2.642 | 0.1224 | Yes |
| 9 | CELF2 | NA | 778 | 2.614 | 0.1365 | Yes | ||
| 10 | IRS1 | NA | IRS1 Entrez, Source | insulin receptor substrate 1 | 843 | 2.527 | 0.1478 | Yes |
| 11 | MT1E | NA | MT1E Entrez, Source | metallothionein 1E (functional) | 847 | 2.519 | 0.1625 | Yes |
| 12 | SYNE1 | NA | SYNE1 Entrez, Source | spectrin repeat containing, nuclear envelope 1 | 944 | 2.410 | 0.1713 | Yes |
| 13 | PDLIM5 | NA | PDLIM5 Entrez, Source | PDZ and LIM domain 5 | 975 | 2.367 | 0.1836 | Yes |
| 14 | LTBP1 | NA | LTBP1 Entrez, Source | latent transforming growth factor beta binding protein 1 | 1022 | 2.308 | 0.1946 | Yes |
| 15 | SERPINE1 | NA | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 1051 | 2.268 | 0.2064 | Yes |
| 16 | MET | NA | MET Entrez, Source | met proto-oncogene (hepatocyte growth factor receptor) | 1052 | 2.268 | 0.2197 | Yes |
| 17 | RND3 | NA | RND3 Entrez, Source | Rho family GTPase 3 | 1167 | 2.153 | 0.2260 | Yes |
| 18 | GCNT1 | NA | GCNT1 Entrez, Source | glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase) | 1183 | 2.136 | 0.2378 | Yes |
| 19 | PEX14 | NA | PEX14 Entrez, Source | peroxisomal biogenesis factor 14 | 1214 | 2.113 | 0.2486 | Yes |
| 20 | CDON | NA | CDON Entrez, Source | Cdon homolog (mouse) | 1336 | 2.005 | 0.2536 | Yes |
| 21 | ADORA2B | NA | ADORA2B Entrez, Source | adenosine A2b receptor | 1349 | 1.992 | 0.2647 | Yes |
| 22 | DLC1 | NA | DLC1 Entrez, Source | deleted in liver cancer 1 | 1363 | 1.980 | 0.2756 | Yes |
| 23 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 1410 | 1.946 | 0.2845 | Yes |
| 24 | PRDM2 | NA | PRDM2 Entrez, Source | PR domain containing 2, with ZNF domain | 1476 | 1.893 | 0.2920 | Yes |
| 25 | NFIB | NA | NFIB Entrez, Source | nuclear factor I/B | 1481 | 1.891 | 0.3029 | Yes |
| 26 | ACVR2A | NA | ACVR2A Entrez, Source | activin A receptor, type IIA | 1493 | 1.886 | 0.3134 | Yes |
| 27 | PRKCA | NA | PRKCA Entrez, Source | protein kinase C, alpha | 1595 | 1.810 | 0.3184 | Yes |
| 28 | MAP1B | NA | MAP1B Entrez, Source | microtubule-associated protein 1B | 1640 | 1.775 | 0.3264 | Yes |
| 29 | NR3C1 | NA | NR3C1 Entrez, Source | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 1660 | 1.761 | 0.3357 | Yes |
| 30 | SDC2 | NA | SDC2 Entrez, Source | syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) | 1665 | 1.758 | 0.3459 | Yes |
| 31 | ATXN1 | NA | ATXN1 Entrez, Source | ataxin 1 | 1703 | 1.732 | 0.3540 | Yes |
| 32 | TFPI | NA | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 1721 | 1.722 | 0.3632 | Yes |
| 33 | RBPMS | NA | RBPMS Entrez, Source | RNA binding protein with multiple splicing | 1769 | 1.682 | 0.3705 | Yes |
| 34 | EFEMP1 | NA | EFEMP1 Entrez, Source | EGF-containing fibulin-like extracellular matrix protein 1 | 1831 | 1.649 | 0.3768 | Yes |
| 35 | NRP1 | NA | NRP1 Entrez, Source | neuropilin 1 | 1861 | 1.634 | 0.3848 | Yes |
| 36 | MAGI2 | NA | MAGI2 Entrez, Source | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 1919 | 1.604 | 0.3910 | Yes |
| 37 | ABCC1 | NA | ABCC1 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 2060 | 1.523 | 0.3922 | Yes |
| 38 | SMAD7 | NA | SMAD7 Entrez, Source | SMAD, mothers against DPP homolog 7 (Drosophila) | 2142 | 1.474 | 0.3963 | Yes |
| 39 | ATP2B1 | NA | ATP2B1 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 1 | 2263 | 1.425 | 0.3980 | Yes |
| 40 | PLCB4 | NA | PLCB4 Entrez, Source | phospholipase C, beta 4 | 2273 | 1.422 | 0.4059 | Yes |
| 41 | LAMC1 | NA | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 2513 | 1.318 | 0.4002 | Yes |
| 42 | CYR61 | NA | CYR61 Entrez, Source | cysteine-rich, angiogenic inducer, 61 | 2576 | 1.289 | 0.4044 | Yes |
| 43 | ATRN | NA | ATRN Entrez, Source | attractin | 2676 | 1.254 | 0.4062 | Yes |
| 44 | CDKN1B | NA | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 2680 | 1.253 | 0.4134 | Yes |
| 45 | ERBB2 | NA | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 2851 | 1.197 | 0.4110 | No |
| 46 | DUSP1 | NA | DUSP1 Entrez, Source | dual specificity phosphatase 1 | 2992 | 1.150 | 0.4099 | No |
| 47 | ATRX | NA | ATRX Entrez, Source | alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) | 3388 | 1.030 | 0.3938 | No |
| 48 | APBB2 | NA | APBB2 Entrez, Source | amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like) | 3531 | 0.990 | 0.3917 | No |
| 49 | ATP2B4 | NA | ATP2B4 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 4 | 3682 | 0.946 | 0.3889 | No |
| 50 | NOTCH2 | NA | NOTCH2 Entrez, Source | Notch homolog 2 (Drosophila) | 3723 | 0.936 | 0.3921 | No |
| 51 | CDC42BPA | NA | CDC42BPA Entrez, Source | CDC42 binding protein kinase alpha (DMPK-like) | 3792 | 0.918 | 0.3937 | No |
| 52 | PIAS3 | NA | PIAS3 Entrez, Source | protein inhibitor of activated STAT, 3 | 3944 | 0.883 | 0.3905 | No |
| 53 | RXRA | NA | RXRA Entrez, Source | retinoid X receptor, alpha | 4154 | 0.829 | 0.3836 | No |
| 54 | DLG1 | NA | DLG1 Entrez, Source | discs, large homolog 1 (Drosophila) | 4184 | 0.821 | 0.3869 | No |
| 55 | PMP22 | NA | PMP22 Entrez, Source | peripheral myelin protein 22 | 4450 | 0.760 | 0.3765 | No |
| 56 | PTPN21 | NA | PTPN21 Entrez, Source | protein tyrosine phosphatase, non-receptor type 21 | 4468 | 0.755 | 0.3800 | No |
| 57 | BMPR1A | NA | BMPR1A Entrez, Source | bone morphogenetic protein receptor, type IA | 4479 | 0.753 | 0.3839 | No |
| 58 | CITED2 | NA | CITED2 Entrez, Source | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 4501 | 0.748 | 0.3871 | No |
| 59 | ITGB3 | NA | ITGB3 Entrez, Source | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 4615 | 0.722 | 0.3850 | No |
| 60 | NR1D2 | NA | NR1D2 Entrez, Source | nuclear receptor subfamily 1, group D, member 2 | 4700 | 0.703 | 0.3845 | No |
| 61 | MAPK14 | NA | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 4701 | 0.703 | 0.3886 | No |
| 62 | COL3A1 | NA | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 4743 | 0.694 | 0.3904 | No |
| 63 | RGS4 | NA | RGS4 Entrez, Source | regulator of G-protein signalling 4 | 4864 | 0.669 | 0.3876 | No |
| 64 | YTHDC1 | NA | YTHDC1 Entrez, Source | YTH domain containing 1 | 5017 | 0.637 | 0.3829 | No |
| 65 | VAV2 | NA | VAV2 Entrez, Source | vav 2 oncogene | 5030 | 0.636 | 0.3859 | No |
| 66 | SYNJ2 | NA | SYNJ2 Entrez, Source | synaptojanin 2 | 5229 | 0.599 | 0.3784 | No |
| 67 | ARHGEF9 | NA | ARHGEF9 Entrez, Source | Cdc42 guanine nucleotide exchange factor (GEF) 9 | 5278 | 0.589 | 0.3791 | No |
| 68 | ZMIZ1 | NA | 5301 | 0.585 | 0.3814 | No | ||
| 69 | COL1A1 | NA | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 5702 | 0.515 | 0.3620 | No |
| 70 | NEK7 | NA | NEK7 Entrez, Source | NIMA (never in mitosis gene a)-related kinase 7 | 6081 | 0.454 | 0.3435 | No |
| 71 | CAP2 | NA | CAP2 Entrez, Source | CAP, adenylate cyclase-associated protein, 2 (yeast) | 6674 | 0.361 | 0.3124 | No |
| 72 | ADD3 | NA | ADD3 Entrez, Source | adducin 3 (gamma) | 7062 | 0.308 | 0.2925 | No |
| 73 | PTEN | NA | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 7094 | 0.303 | 0.2926 | No |
| 74 | WDR37 | NA | WDR37 Entrez, Source | WD repeat domain 37 | 7230 | 0.283 | 0.2867 | No |
| 75 | DYRK1A | NA | DYRK1A Entrez, Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 7487 | 0.253 | 0.2738 | No |
| 76 | PHF3 | NA | PHF3 Entrez, Source | PHD finger protein 3 | 7506 | 0.251 | 0.2743 | No |
| 77 | COL1A2 | NA | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 7660 | 0.237 | 0.2671 | No |
| 78 | DBP | NA | DBP Entrez, Source | D site of albumin promoter (albumin D-box) binding protein | 7742 | 0.230 | 0.2639 | No |
| 79 | PDGFRB | NA | PDGFRB Entrez, Source | platelet-derived growth factor receptor, beta polypeptide | 7981 | 0.204 | 0.2518 | No |
| 80 | KIT | NA | KIT Entrez, Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 8025 | 0.199 | 0.2506 | No |
| 81 | MMP16 | NA | MMP16 Entrez, Source | matrix metallopeptidase 16 (membrane-inserted) | 8258 | 0.172 | 0.2386 | No |
| 82 | IGFBP5 | NA | IGFBP5 Entrez, Source | insulin-like growth factor binding protein 5 | 8454 | 0.156 | 0.2286 | No |
| 83 | PTPRM | NA | PTPRM Entrez, Source | protein tyrosine phosphatase, receptor type, M | 8575 | 0.146 | 0.2227 | No |
| 84 | MIOS | NA | 8931 | 0.106 | 0.2034 | No | ||
| 85 | FYN | NA | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 8943 | 0.105 | 0.2034 | No |
| 86 | SPOP | NA | SPOP Entrez, Source | speckle-type POZ protein | 9004 | 0.098 | 0.2007 | No |
| 87 | AMPH | NA | AMPH Entrez, Source | amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen) | 9187 | 0.080 | 0.1909 | No |
| 88 | CDK13 | NA | 9527 | 0.049 | 0.1722 | No | ||
| 89 | PPARG | NA | PPARG Entrez, Source | peroxisome proliferative activated receptor, gamma | 9858 | 0.002 | 0.1537 | No |
| 90 | ATP5S | NA | ATP5S Entrez, Source | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B) | 10237 | -0.010 | 0.1326 | No |
| 91 | LDLR | NA | LDLR Entrez, Source | low density lipoprotein receptor (familial hypercholesterolemia) | 10241 | -0.010 | 0.1325 | No |
| 92 | ICA1 | NA | ICA1 Entrez, Source | islet cell autoantigen 1, 69kDa | 10405 | -0.024 | 0.1235 | No |
| 93 | SIPA1L1 | NA | SIPA1L1 Entrez, Source | signal-induced proliferation-associated 1 like 1 | 11307 | -0.115 | 0.0737 | No |
| 94 | MTA1 | NA | MTA1 Entrez, Source | metastasis associated 1 | 11422 | -0.126 | 0.0680 | No |
| 95 | BCKDHB | NA | BCKDHB Entrez, Source | branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) | 11857 | -0.176 | 0.0448 | No |
| 96 | SMAD3 | NA | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 12320 | -0.229 | 0.0202 | No |
| 97 | AGGF1 | NA | AGGF1 Entrez, Source | angiogenic factor with G patch and FHA domains 1 | 12346 | -0.231 | 0.0202 | No |
| 98 | TJP1 | NA | TJP1 Entrez, Source | tight junction protein 1 (zona occludens 1) | 12373 | -0.234 | 0.0201 | No |
| 99 | NIPBL | NA | NIPBL Entrez, Source | Nipped-B homolog (Drosophila) | 12581 | -0.260 | 0.0100 | No |
| 100 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 12596 | -0.262 | 0.0108 | No |
| 101 | SRI | NA | SRI Entrez, Source | sorcin | 12661 | -0.272 | 0.0088 | No |
| 102 | PAPD7 | NA | 12721 | -0.279 | 0.0072 | No | ||
| 103 | ATP2C1 | NA | ATP2C1 Entrez, Source | ATPase, Ca++ transporting, type 2C, member 1 | 13012 | -0.321 | -0.0072 | No |
| 104 | INPP4B | NA | INPP4B Entrez, Source | inositol polyphosphate-4-phosphatase, type II, 105kDa | 13362 | -0.376 | -0.0245 | No |
| 105 | FBLN5 | NA | FBLN5 Entrez, Source | fibulin 5 | 13376 | -0.378 | -0.0230 | No |
| 106 | MAP2K5 | NA | MAP2K5 Entrez, Source | mitogen-activated protein kinase kinase 5 | 13450 | -0.390 | -0.0248 | No |
| 107 | COL11A1 | NA | COL11A1 Entrez, Source | collagen, type XI, alpha 1 | 13646 | -0.426 | -0.0333 | No |
| 108 | DAB2 | NA | DAB2 Entrez, Source | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | 13780 | -0.449 | -0.0381 | No |
| 109 | CAV1 | NA | CAV1 Entrez, Source | caveolin 1, caveolae protein, 22kDa | 13813 | -0.455 | -0.0372 | No |
| 110 | SLC22A18 | NA | SLC22A18 Entrez, Source | solute carrier family 22 (organic cation transporter), member 18 | 13978 | -0.486 | -0.0435 | No |
| 111 | DDAH1 | NA | DDAH1 Entrez, Source | dimethylarginine dimethylaminohydrolase 1 | 14162 | -0.524 | -0.0507 | No |
| 112 | AKT3 | NA | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 14929 | -0.703 | -0.0895 | No |
| 113 | MYC | NA | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 15151 | -0.760 | -0.0974 | No |
| 114 | PRKCE | NA | PRKCE Entrez, Source | protein kinase C, epsilon | 15221 | -0.779 | -0.0966 | No |
| 115 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 15399 | -0.833 | -0.1016 | No |
| 116 | COL5A2 | NA | COL5A2 Entrez, Source | collagen, type V, alpha 2 | 15422 | -0.840 | -0.0979 | No |
| 117 | FZD2 | NA | FZD2 Entrez, Source | frizzled homolog 2 (Drosophila) | 15538 | -0.877 | -0.0992 | No |
| 118 | RUNX1 | NA | RUNX1 Entrez, Source | runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) | 15581 | -0.889 | -0.0963 | No |
| 119 | CACNA1A | NA | CACNA1A Entrez, Source | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 15606 | -0.897 | -0.0924 | No |
| 120 | MRPS31 | NA | MRPS31 Entrez, Source | mitochondrial ribosomal protein S31 | 15783 | -0.964 | -0.0966 | No |
| 121 | ANXA4 | NA | ANXA4 Entrez, Source | annexin A4 | 16065 | -1.071 | -0.1060 | No |
| 122 | IGF1R | NA | IGF1R Entrez, Source | insulin-like growth factor 1 receptor | 16126 | -1.101 | -0.1029 | No |
| 123 | PTGFR | NA | PTGFR Entrez, Source | prostaglandin F receptor (FP) | 16251 | -1.170 | -0.1029 | No |
| 124 | SCAF8 | NA | 16443 | -1.265 | -0.1062 | No | ||
| 125 | ANXA2 | NA | ANXA2 Entrez, Source | annexin A2 | 16655 | -1.397 | -0.1098 | No |
| 126 | SLC7A1 | NA | SLC7A1 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 16731 | -1.455 | -0.1054 | No |
| 127 | GRK5 | NA | GRK5 Entrez, Source | G protein-coupled receptor kinase 5 | 16762 | -1.478 | -0.0984 | No |
| 128 | RASA2 | NA | RASA2 Entrez, Source | RAS p21 protein activator 2 | 16895 | -1.587 | -0.0964 | No |
| 129 | TGFBR2 | NA | TGFBR2 Entrez, Source | transforming growth factor, beta receptor II (70/80kDa) | 16903 | -1.592 | -0.0874 | No |
| 130 | BHLHE40 | NA | 17041 | -1.724 | -0.0849 | No | ||
| 131 | PRKAR2B | NA | PRKAR2B Entrez, Source | protein kinase, cAMP-dependent, regulatory, type II, beta | 17207 | -1.920 | -0.0829 | No |
| 132 | KCNMA1 | NA | KCNMA1 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | 17403 | -2.240 | -0.0806 | No |
| 133 | SNAI2 | NA | SNAI2 Entrez, Source | snail homolog 2 (Drosophila) | 17547 | -2.546 | -0.0736 | No |
| 134 | MGLL | NA | MGLL Entrez, Source | monoglyceride lipase | 17566 | -2.611 | -0.0592 | No |
| 135 | INSIG1 | NA | INSIG1 Entrez, Source | insulin induced gene 1 | 17639 | -2.860 | -0.0464 | No |
| 136 | HAS2 | NA | HAS2 Entrez, Source | hyaluronan synthase 2 | 17641 | -2.871 | -0.0295 | No |
| 137 | SCN8A | NA | SCN8A Entrez, Source | sodium channel, voltage gated, type VIII, alpha | 17849 | -4.047 | -0.0173 | No |
| 138 | KALRN | NA | KALRN Entrez, Source | kalirin, RhoGEF kinase | 17867 | -4.169 | 0.0063 | No |
