Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_SPERMATOGENESIS |
| Enrichment Score (ES) | -0.3381344 |
| Normalized Enrichment Score (NES) | -1.3619343 |
| Nominal p-value | 0.015706806 |
| FDR q-value | 0.07120008 |
| FWER p-Value | 0.188 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CFTR | NA | CFTR Entrez, Source | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | 504 | 3.129 | 0.0017 | No |
| 2 | RFC4 | NA | RFC4 Entrez, Source | replication factor C (activator 1) 4, 37kDa | 853 | 2.505 | 0.0062 | No |
| 3 | MTOR | NA | 1024 | 2.302 | 0.0187 | No | ||
| 4 | VDAC3 | NA | VDAC3 Entrez, Source | voltage-dependent anion channel 3 | 1061 | 2.264 | 0.0383 | No |
| 5 | HSPA4L | NA | HSPA4L Entrez, Source | heat shock 70kDa protein 4-like | 1087 | 2.234 | 0.0583 | No |
| 6 | PCSK1N | NA | PCSK1N Entrez, Source | proprotein convertase subtilisin/kexin type 1 inhibitor | 1125 | 2.197 | 0.0772 | No |
| 7 | CAMK4 | NA | CAMK4 Entrez, Source | calcium/calmodulin-dependent protein kinase IV | 1936 | 1.594 | 0.0471 | No |
| 8 | SEPT4 | NA | SEPT4 Entrez, Source | septin 4 | 2173 | 1.461 | 0.0478 | No |
| 9 | SLC12A2 | NA | SLC12A2 Entrez, Source | solute carrier family 12 (sodium/potassium/chloride transporters), member 2 | 2193 | 1.452 | 0.0607 | No |
| 10 | GAD1 | NA | GAD1 Entrez, Source | glutamate decarboxylase 1 (brain, 67kDa) | 2280 | 1.421 | 0.0694 | No |
| 11 | CCT6B | NA | CCT6B Entrez, Source | chaperonin containing TCP1, subunit 6B (zeta 2) | 2544 | 1.302 | 0.0672 | No |
| 12 | STAM2 | NA | STAM2 Entrez, Source | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | 2632 | 1.270 | 0.0744 | No |
| 13 | ACTL7B | NA | ACTL7B Entrez, Source | actin-like 7B | 2814 | 1.208 | 0.0759 | No |
| 14 | ARL4A | NA | ARL4A Entrez, Source | ADP-ribosylation factor-like 4A | 3237 | 1.078 | 0.0625 | No |
| 15 | GSG1 | NA | GSG1 Entrez, Source | germ cell associated 1 | 3412 | 1.025 | 0.0626 | No |
| 16 | ELOVL3 | NA | ELOVL3 Entrez, Source | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 | 3437 | 1.018 | 0.0710 | No |
| 17 | AGFG1 | NA | 3458 | 1.013 | 0.0796 | No | ||
| 18 | ADCYAP1 | NA | ADCYAP1 Entrez, Source | adenylate cyclase activating polypeptide 1 (pituitary) | 3541 | 0.988 | 0.0844 | No |
| 19 | RPL39L | NA | RPL39L Entrez, Source | ribosomal protein L39-like | 3556 | 0.983 | 0.0930 | No |
| 20 | DMC1 | NA | DMC1 Entrez, Source | DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) | 3612 | 0.965 | 0.0992 | No |
| 21 | BUB1 | NA | BUB1 Entrez, Source | BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) | 3716 | 0.937 | 0.1024 | No |
| 22 | TALDO1 | NA | TALDO1 Entrez, Source | transaldolase 1 | 3852 | 0.905 | 0.1035 | No |
| 23 | EZH2 | NA | EZH2 Entrez, Source | enhancer of zeste homolog 2 (Drosophila) | 4021 | 0.863 | 0.1023 | No |
| 24 | PAPOLB | NA | PAPOLB Entrez, Source | poly(A) polymerase beta (testis specific) | 4358 | 0.780 | 0.0910 | No |
| 25 | CHFR | NA | CHFR Entrez, Source | checkpoint with forkhead and ring finger domains | 4532 | 0.741 | 0.0884 | No |
| 26 | SCG3 | NA | SCG3 Entrez, Source | secretogranin III | 4553 | 0.737 | 0.0943 | No |
| 27 | SNAP91 | NA | SNAP91 Entrez, Source | synaptosomal-associated protein, 91kDa homolog (mouse) | 4582 | 0.730 | 0.0997 | No |
| 28 | HSPA1L | NA | HSPA1L Entrez, Source | heat shock 70kDa protein 1-like | 4638 | 0.716 | 0.1035 | No |
| 29 | NOS1 | NA | NOS1 Entrez, Source | nitric oxide synthase 1 (neuronal) | 5044 | 0.633 | 0.0868 | No |
| 30 | PHF7 | NA | PHF7 Entrez, Source | PHD finger protein 7 | 6044 | 0.460 | 0.0353 | No |
| 31 | ART3 | NA | ART3 Entrez, Source | ADP-ribosyltransferase 3 | 6402 | 0.396 | 0.0191 | No |
| 32 | MAP7 | NA | MAP7 Entrez, Source | microtubule-associated protein 7 | 6454 | 0.391 | 0.0200 | No |
| 33 | OAZ3 | NA | OAZ3 Entrez, Source | ornithine decarboxylase antizyme 3 | 6585 | 0.373 | 0.0163 | No |
| 34 | NEFH | NA | NEFH Entrez, Source | neurofilament, heavy polypeptide 200kDa | 6689 | 0.358 | 0.0139 | No |
| 35 | SIRT1 | NA | SIRT1 Entrez, Source | sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) | 6905 | 0.328 | 0.0050 | No |
| 36 | TSN | NA | TSN Entrez, Source | translin | 6920 | 0.326 | 0.0073 | No |
| 37 | ADAD1 | NA | 6949 | 0.323 | 0.0089 | No | ||
| 38 | MAST2 | NA | MAST2 Entrez, Source | microtubule associated serine/threonine kinase 2 | 7156 | 0.293 | 0.0001 | No |
| 39 | ALOX15 | NA | ALOX15 Entrez, Source | arachidonate 15-lipoxygenase | 7168 | 0.291 | 0.0023 | No |
| 40 | PIAS2 | NA | PIAS2 Entrez, Source | protein inhibitor of activated STAT, 2 | 7181 | 0.290 | 0.0044 | No |
| 41 | CST8 | NA | CST8 Entrez, Source | cystatin 8 (cystatin-related epididymal specific) | 7325 | 0.271 | -0.0010 | No |
| 42 | GRM8 | NA | GRM8 Entrez, Source | glutamate receptor, metabotropic 8 | 7553 | 0.248 | -0.0114 | No |
| 43 | CHRM4 | NA | CHRM4 Entrez, Source | cholinergic receptor, muscarinic 4 | 7662 | 0.236 | -0.0151 | No |
| 44 | SHE | NA | SHE Entrez, Source | Src homology 2 domain containing E | 7686 | 0.235 | -0.0142 | No |
| 45 | HTR5A | NA | HTR5A Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 5A | 7896 | 0.215 | -0.0238 | No |
| 46 | POMC | NA | POMC Entrez, Source | proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin) | 7908 | 0.214 | -0.0224 | No |
| 47 | CCNA1 | NA | CCNA1 Entrez, Source | cyclin A1 | 8310 | 0.168 | -0.0433 | No |
| 48 | PCSK4 | NA | PCSK4 Entrez, Source | proprotein convertase subtilisin/kexin type 4 | 8665 | 0.137 | -0.0618 | No |
| 49 | CRISP2 | NA | CRISP2 Entrez, Source | cysteine-rich secretory protein 2 | 8785 | 0.123 | -0.0673 | No |
| 50 | DBF4 | NA | DBF4 Entrez, Source | DBF4 homolog (S. cerevisiae) | 8835 | 0.117 | -0.0689 | No |
| 51 | CLGN | NA | CLGN Entrez, Source | calmegin | 8934 | 0.106 | -0.0734 | No |
| 52 | CDKN3 | NA | CDKN3 Entrez, Source | cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase) | 8953 | 0.104 | -0.0734 | No |
| 53 | TSSK2 | NA | TSSK2 Entrez, Source | testis-specific serine kinase 2 | 8959 | 0.103 | -0.0727 | No |
| 54 | ZC3H14 | NA | ZC3H14 Entrez, Source | zinc finger CCCH-type containing 14 | 9217 | 0.077 | -0.0863 | No |
| 55 | THEG | NA | THEG Entrez, Source | Theg homolog (mouse) | 9342 | 0.066 | -0.0926 | No |
| 56 | CSNK2A2 | NA | CSNK2A2 Entrez, Source | casein kinase 2, alpha prime polypeptide | 9523 | 0.049 | -0.1022 | No |
| 57 | PGK2 | NA | PGK2 Entrez, Source | phosphoglycerate kinase 2 | 10128 | 0.000 | -0.1361 | No |
| 58 | IL12RB2 | NA | IL12RB2 Entrez, Source | interleukin 12 receptor, beta 2 | 10175 | -0.002 | -0.1386 | No |
| 59 | RAD17 | NA | RAD17 Entrez, Source | RAD17 homolog (S. pombe) | 10324 | -0.018 | -0.1468 | No |
| 60 | GPR182 | NA | 10463 | -0.031 | -0.1542 | No | ||
| 61 | TKTL1 | NA | TKTL1 Entrez, Source | transketolase-like 1 | 10481 | -0.031 | -0.1549 | No |
| 62 | PSMG1 | NA | 10573 | -0.038 | -0.1596 | No | ||
| 63 | SYCP1 | NA | SYCP1 Entrez, Source | synaptonemal complex protein 1 | 10717 | -0.052 | -0.1671 | No |
| 64 | HIST1H1T | NA | HIST1H1T Entrez, Source | histone cluster 1, H1t | 10738 | -0.054 | -0.1677 | No |
| 65 | DDX4 | NA | DDX4 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 | 10848 | -0.064 | -0.1732 | No |
| 66 | NPHP1 | NA | NPHP1 Entrez, Source | nephronophthisis 1 (juvenile) | 10893 | -0.068 | -0.1750 | No |
| 67 | NPY5R | NA | NPY5R Entrez, Source | neuropeptide Y receptor Y5 | 10945 | -0.076 | -0.1771 | No |
| 68 | MEP1B | NA | MEP1B Entrez, Source | meprin A, beta | 11059 | -0.087 | -0.1826 | No |
| 69 | TULP2 | NA | TULP2 Entrez, Source | tubby like protein 2 | 11065 | -0.087 | -0.1821 | No |
| 70 | SLC2A5 | NA | SLC2A5 Entrez, Source | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | 11100 | -0.092 | -0.1831 | No |
| 71 | DPEP3 | NA | DPEP3 Entrez, Source | dipeptidase 3 | 11360 | -0.121 | -0.1965 | No |
| 72 | MTNR1A | NA | MTNR1A Entrez, Source | melatonin receptor 1A | 11433 | -0.127 | -0.1993 | No |
| 73 | NAA11 | NA | 11534 | -0.137 | -0.2036 | No | ||
| 74 | ADAM2 | NA | ADAM2 Entrez, Source | ADAM metallopeptidase domain 2 (fertilin beta) | 11552 | -0.139 | -0.2032 | No |
| 75 | IP6K1 | NA | 11633 | -0.147 | -0.2063 | No | ||
| 76 | AKAP4 | NA | AKAP4 Entrez, Source | A kinase (PRKA) anchor protein 4 | 11692 | -0.154 | -0.2080 | No |
| 77 | DMRT1 | NA | DMRT1 Entrez, Source | doublesex and mab-3 related transcription factor 1 | 11763 | -0.163 | -0.2104 | No |
| 78 | IDE | NA | IDE Entrez, Source | insulin-degrading enzyme | 12179 | -0.211 | -0.2316 | No |
| 79 | NEK2 | NA | NEK2 Entrez, Source | NIMA (never in mitosis gene a)-related kinase 2 | 12202 | -0.214 | -0.2308 | No |
| 80 | YBX2 | NA | YBX2 Entrez, Source | Y box binding protein 2 | 12258 | -0.220 | -0.2318 | No |
| 81 | TUBA3C | NA | 12307 | -0.228 | -0.2323 | No | ||
| 82 | MLLT10 | NA | MLLT10 Entrez, Source | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 12372 | -0.234 | -0.2336 | No |
| 83 | CNIH2 | NA | CNIH2 Entrez, Source | cornichon homolog 2 (Drosophila) | 12473 | -0.246 | -0.2369 | No |
| 84 | DNAJB8 | NA | DNAJB8 Entrez, Source | DnaJ (Hsp40) homolog, subfamily B, member 8 | 12605 | -0.264 | -0.2417 | No |
| 85 | IFT88 | NA | IFT88 Entrez, Source | intraflagellar transport 88 homolog (Chlamydomonas) | 12744 | -0.283 | -0.2467 | No |
| 86 | KIF2C | NA | KIF2C Entrez, Source | kinesin family member 2C | 13009 | -0.320 | -0.2584 | No |
| 87 | ACRV1 | NA | ACRV1 Entrez, Source | acrosomal vesicle protein 1 | 13040 | -0.324 | -0.2570 | No |
| 88 | ACRBP | NA | ACRBP Entrez, Source | acrosin binding protein | 13091 | -0.333 | -0.2566 | No |
| 89 | LDHC | NA | LDHC Entrez, Source | lactate dehydrogenase C | 13278 | -0.362 | -0.2636 | No |
| 90 | PACRG | NA | PACRG Entrez, Source | PARK2 co-regulated | 13333 | -0.372 | -0.2631 | No |
| 91 | AURKA | NA | AURKA Entrez, Source | aurora kinase A | 13647 | -0.426 | -0.2765 | No |
| 92 | PHKG2 | NA | PHKG2 Entrez, Source | phosphorylase kinase, gamma 2 (testis) | 14156 | -0.522 | -0.3000 | No |
| 93 | PRKAR2A | NA | PRKAR2A Entrez, Source | protein kinase, cAMP-dependent, regulatory, type II, alpha | 14229 | -0.538 | -0.2989 | No |
| 94 | COIL | NA | COIL Entrez, Source | coilin | 14265 | -0.544 | -0.2956 | No |
| 95 | TEKT2 | NA | TEKT2 Entrez, Source | tektin 2 (testicular) | 14314 | -0.554 | -0.2930 | No |
| 96 | GSTM3 | NA | GSTM3 Entrez, Source | glutathione S-transferase M3 (brain) | 14435 | -0.580 | -0.2942 | No |
| 97 | HOXB1 | NA | HOXB1 Entrez, Source | homeobox B1 | 14529 | -0.599 | -0.2937 | No |
| 98 | GMCL1 | NA | GMCL1 Entrez, Source | germ cell-less homolog 1 (Drosophila) | 14630 | -0.625 | -0.2933 | No |
| 99 | BRAF | NA | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 15145 | -0.758 | -0.3148 | No |
| 100 | CLPB | NA | CLPB Entrez, Source | ClpB caseinolytic peptidase B homolog (E. coli) | 15212 | -0.777 | -0.3111 | No |
| 101 | PGS1 | NA | PGS1 Entrez, Source | phosphatidylglycerophosphate synthase 1 | 15696 | -0.928 | -0.3293 | Yes |
| 102 | HSPA2 | NA | HSPA2 Entrez, Source | heat shock 70kDa protein 2 | 15823 | -0.979 | -0.3270 | Yes |
| 103 | TCP11 | NA | TCP11 Entrez, Source | t-complex 11 (mouse) | 15991 | -1.042 | -0.3263 | Yes |
| 104 | CDK1 | NA | 16088 | -1.080 | -0.3214 | Yes | ||
| 105 | NCAPH | NA | NCAPH Entrez, Source | non-SMC condensin I complex, subunit H | 16137 | -1.109 | -0.3135 | Yes |
| 106 | STRBP | NA | STRBP Entrez, Source | spermatid perinuclear RNA binding protein | 16183 | -1.129 | -0.3052 | Yes |
| 107 | MLF1 | NA | MLF1 Entrez, Source | myeloid leukemia factor 1 | 16195 | -1.139 | -0.2949 | Yes |
| 108 | DDX25 | NA | DDX25 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 25 | 16404 | -1.252 | -0.2946 | Yes |
| 109 | SCG5 | NA | SCG5 Entrez, Source | secretogranin V (7B2 protein) | 16542 | -1.330 | -0.2895 | Yes |
| 110 | GAPDHS | NA | GAPDHS Entrez, Source | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | 16809 | -1.515 | -0.2899 | Yes |
| 111 | TOPBP1 | NA | TOPBP1 Entrez, Source | topoisomerase (DNA) II binding protein 1 | 16816 | -1.520 | -0.2757 | Yes |
| 112 | PARP2 | NA | PARP2 Entrez, Source | poly (ADP-ribose) polymerase family, member 2 | 16823 | -1.525 | -0.2615 | Yes |
| 113 | TTK | NA | TTK Entrez, Source | TTK protein kinase | 16888 | -1.582 | -0.2499 | Yes |
| 114 | CCNB2 | NA | CCNB2 Entrez, Source | cyclin B2 | 16921 | -1.610 | -0.2363 | Yes |
| 115 | NF2 | NA | NF2 Entrez, Source | neurofibromin 2 (bilateral acoustic neuroma) | 17032 | -1.716 | -0.2261 | Yes |
| 116 | PEBP1 | NA | PEBP1 Entrez, Source | phosphatidylethanolamine binding protein 1 | 17038 | -1.720 | -0.2099 | Yes |
| 117 | SPATA6 | NA | SPATA6 Entrez, Source | spermatogenesis associated 6 | 17091 | -1.779 | -0.1958 | Yes |
| 118 | GFI1 | NA | GFI1 Entrez, Source | growth factor independent 1 | 17261 | -1.991 | -0.1862 | Yes |
| 119 | CLVS1 | NA | 17359 | -2.142 | -0.1712 | Yes | ||
| 120 | TNNI3 | NA | TNNI3 Entrez, Source | troponin I type 3 (cardiac) | 17367 | -2.155 | -0.1509 | Yes |
| 121 | DCC | NA | DCC Entrez, Source | deleted in colorectal carcinoma | 17418 | -2.268 | -0.1320 | Yes |
| 122 | JAM3 | NA | JAM3 Entrez, Source | junctional adhesion molecule 3 | 17499 | -2.424 | -0.1133 | Yes |
| 123 | LPIN1 | NA | LPIN1 Entrez, Source | lipin 1 | 17517 | -2.474 | -0.0906 | Yes |
| 124 | ACE | NA | ACE Entrez, Source | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | 17524 | -2.491 | -0.0671 | Yes |
| 125 | TLE4 | NA | TLE4 Entrez, Source | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 17932 | -4.686 | -0.0451 | Yes |
| 126 | IL13RA2 | NA | IL13RA2 Entrez, Source | interleukin 13 receptor, alpha 2 | 17980 | -4.992 | 0.0000 | Yes |
