Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY |
| Enrichment Score (ES) | 0.5434252 |
| Normalized Enrichment Score (NES) | 1.6190851 |
| Nominal p-value | 0.0068965517 |
| FDR q-value | 0.010383329 |
| FWER p-Value | 0.044 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | GPX3 | NA | GPX3 Entrez, Source | glutathione peroxidase 3 (plasma) | 4 | 4.960 | 0.0780 | Yes |
| 2 | G6PD | NA | G6PD Entrez, Source | glucose-6-phosphate dehydrogenase | 230 | 3.986 | 0.1284 | Yes |
| 3 | GSR | NA | GSR Entrez, Source | glutathione reductase | 353 | 3.587 | 0.1782 | Yes |
| 4 | SRXN1 | NA | SRXN1 Entrez, Source | sulfiredoxin 1 homolog (S. cerevisiae) | 413 | 3.427 | 0.2290 | Yes |
| 5 | GLRX | NA | GLRX Entrez, Source | glutaredoxin (thioltransferase) | 443 | 3.323 | 0.2798 | Yes |
| 6 | MBP | NA | MBP Entrez, Source | myelin basic protein | 528 | 3.086 | 0.3238 | Yes |
| 7 | GCLC | NA | GCLC Entrez, Source | glutamate-cysteine ligase, catalytic subunit | 530 | 3.083 | 0.3724 | Yes |
| 8 | TXNRD1 | NA | TXNRD1 Entrez, Source | thioredoxin reductase 1 | 551 | 3.036 | 0.4192 | Yes |
| 9 | NQO1 | NA | NQO1 Entrez, Source | NAD(P)H dehydrogenase, quinone 1 | 757 | 2.636 | 0.4493 | Yes |
| 10 | FTL | NA | FTL Entrez, Source | ferritin, light polypeptide | 840 | 2.528 | 0.4847 | Yes |
| 11 | MGST1 | NA | MGST1 Entrez, Source | microsomal glutathione S-transferase 1 | 866 | 2.497 | 0.5227 | Yes |
| 12 | GCLM | NA | GCLM Entrez, Source | glutamate-cysteine ligase, modifier subunit | 1118 | 2.202 | 0.5434 | Yes |
| 13 | ABCC1 | NA | ABCC1 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 2060 | 1.523 | 0.5150 | No |
| 14 | MSRA | NA | MSRA Entrez, Source | methionine sulfoxide reductase A | 2912 | 1.177 | 0.4861 | No |
| 15 | PRNP | NA | PRNP Entrez, Source | prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) | 3123 | 1.110 | 0.4919 | No |
| 16 | TXN | NA | TXN Entrez, Source | thioredoxin | 3720 | 0.936 | 0.4735 | No |
| 17 | GLRX2 | NA | GLRX2 Entrez, Source | glutaredoxin 2 | 4016 | 0.864 | 0.4707 | No |
| 18 | PFKP | NA | PFKP Entrez, Source | phosphofructokinase, platelet | 4112 | 0.839 | 0.4786 | No |
| 19 | GPX4 | NA | GPX4 Entrez, Source | glutathione peroxidase 4 (phospholipid hydroperoxidase) | 4221 | 0.812 | 0.4854 | No |
| 20 | EGLN2 | NA | EGLN2 Entrez, Source | egl nine homolog 2 (C. elegans) | 4978 | 0.645 | 0.4534 | No |
| 21 | NDUFA6 | NA | NDUFA6 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa | 5433 | 0.561 | 0.4369 | No |
| 22 | PRDX2 | NA | PRDX2 Entrez, Source | peroxiredoxin 2 | 5554 | 0.540 | 0.4388 | No |
| 23 | HMOX2 | NA | HMOX2 Entrez, Source | heme oxygenase (decycling) 2 | 5933 | 0.480 | 0.4253 | No |
| 24 | STK25 | NA | STK25 Entrez, Source | serine/threonine kinase 25 (STE20 homolog, yeast) | 5944 | 0.477 | 0.4322 | No |
| 25 | SOD1 | NA | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 6092 | 0.452 | 0.4312 | No |
| 26 | ATOX1 | NA | ATOX1 Entrez, Source | ATX1 antioxidant protein 1 homolog (yeast) | 6164 | 0.436 | 0.4341 | No |
| 27 | IPCEF1 | NA | 6290 | 0.413 | 0.4336 | No | ||
| 28 | PRDX1 | NA | PRDX1 Entrez, Source | peroxiredoxin 1 | 6910 | 0.328 | 0.4043 | No |
| 29 | SBNO2 | NA | SBNO2 Entrez, Source | strawberry notch homolog 2 (Drosophila) | 7110 | 0.300 | 0.3979 | No |
| 30 | MPO | NA | MPO Entrez, Source | myeloperoxidase | 7536 | 0.250 | 0.3782 | No |
| 31 | CAT | NA | CAT Entrez, Source | catalase | 7933 | 0.211 | 0.3594 | No |
| 32 | CDKN2D | NA | CDKN2D Entrez, Source | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 8022 | 0.200 | 0.3577 | No |
| 33 | PDLIM1 | NA | PDLIM1 Entrez, Source | PDZ and LIM domain 1 (elfin) | 8794 | 0.122 | 0.3166 | No |
| 34 | OXSR1 | NA | OXSR1 Entrez, Source | oxidative-stress responsive 1 | 9320 | 0.068 | 0.2884 | No |
| 35 | NDUFS2 | NA | NDUFS2 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) | 10227 | -0.008 | 0.2380 | No |
| 36 | PRDX6 | NA | PRDX6 Entrez, Source | peroxiredoxin 6 | 10296 | -0.014 | 0.2344 | No |
| 37 | SCAF4 | NA | 11812 | -0.171 | 0.1527 | No | ||
| 38 | NDUFB4 | NA | NDUFB4 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa | 14127 | -0.515 | 0.0318 | No |
| 39 | PRDX4 | NA | PRDX4 Entrez, Source | peroxiredoxin 4 | 14349 | -0.562 | 0.0283 | No |
| 40 | LSP1 | NA | LSP1 Entrez, Source | lymphocyte-specific protein 1 | 14862 | -0.685 | 0.0106 | No |
| 41 | ERCC2 | NA | ERCC2 Entrez, Source | excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D) | 15971 | -1.033 | -0.0349 | No |
| 42 | JUNB | NA | JUNB Entrez, Source | jun B proto-oncogene | 16872 | -1.570 | -0.0603 | No |
| 43 | FES | NA | FES Entrez, Source | feline sarcoma oncogene | 16896 | -1.587 | -0.0365 | No |
| 44 | SOD2 | NA | SOD2 Entrez, Source | superoxide dismutase 2, mitochondrial | 17010 | -1.692 | -0.0162 | No |
| 45 | HHEX | NA | HHEX Entrez, Source | homeobox, hematopoietically expressed | 17306 | -2.059 | -0.0001 | No |
| 46 | TXNRD2 | NA | TXNRD2 Entrez, Source | thioredoxin reductase 2 | 17481 | -2.385 | 0.0278 | No |
