Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_PANCREAS_BETA_CELLS |
| Enrichment Score (ES) | -0.30166575 |
| Normalized Enrichment Score (NES) | -0.98022234 |
| Nominal p-value | 0.48550725 |
| FDR q-value | 0.5516549 |
| FWER p-Value | 0.992 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | DPP4 | NA | DPP4 Entrez, Source | dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2) | 165 | 4.220 | 0.1549 | No |
| 2 | FOXA2 | NA | FOXA2 Entrez, Source | forkhead box A2 | 758 | 2.635 | 0.2244 | No |
| 3 | IAPP | NA | IAPP Entrez, Source | islet amyloid polypeptide | 2929 | 1.171 | 0.1490 | No |
| 4 | STXBP1 | NA | STXBP1 Entrez, Source | syntaxin binding protein 1 | 3959 | 0.877 | 0.1257 | No |
| 5 | FOXO1 | NA | 6380 | 0.399 | 0.0064 | No | ||
| 6 | CHGA | NA | CHGA Entrez, Source | chromogranin A (parathyroid secretory protein 1) | 7546 | 0.249 | -0.0488 | No |
| 7 | DCX | NA | DCX Entrez, Source | doublecortex; lissencephaly, X-linked (doublecortin) | 7548 | 0.249 | -0.0392 | No |
| 8 | G6PC2 | NA | G6PC2 Entrez, Source | glucose-6-phosphatase, catalytic, 2 | 7961 | 0.208 | -0.0541 | No |
| 9 | PAK3 | NA | PAK3 Entrez, Source | p21 (CDKN1A)-activated kinase 3 | 8610 | 0.142 | -0.0847 | No |
| 10 | ABCC8 | NA | ABCC8 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 | 8848 | 0.116 | -0.0934 | No |
| 11 | PDX1 | NA | 9172 | 0.082 | -0.1082 | No | ||
| 12 | PKLR | NA | PKLR Entrez, Source | pyruvate kinase, liver and RBC | 9203 | 0.078 | -0.1068 | No |
| 13 | GCG | NA | GCG Entrez, Source | glucagon | 9439 | 0.057 | -0.1177 | No |
| 14 | PCSK2 | NA | PCSK2 Entrez, Source | proprotein convertase subtilisin/kexin type 2 | 9705 | 0.025 | -0.1315 | No |
| 15 | GCK | NA | GCK Entrez, Source | glucokinase (hexokinase 4, maturity onset diabetes of the young 2) | 9908 | 0.000 | -0.1427 | No |
| 16 | SRP14 | NA | SRP14 Entrez, Source | signal recognition particle 14kDa (homologous Alu RNA binding protein) | 10180 | -0.002 | -0.1577 | No |
| 17 | SST | NA | SST Entrez, Source | somatostatin | 10648 | -0.045 | -0.1820 | No |
| 18 | NEUROD1 | NA | NEUROD1 Entrez, Source | neurogenic differentiation 1 | 10762 | -0.054 | -0.1862 | No |
| 19 | INSM1 | NA | INSM1 Entrez, Source | insulinoma-associated 1 | 10784 | -0.057 | -0.1851 | No |
| 20 | PAX4 | NA | PAX4 Entrez, Source | paired box gene 4 | 10976 | -0.078 | -0.1928 | No |
| 21 | SCGN | NA | SCGN Entrez, Source | secretagogin, EF-hand calcium binding protein | 11536 | -0.137 | -0.2186 | No |
| 22 | NKX6-1 | NA | NKX6-1 Entrez, Source | NK6 transcription factor related, locus 1 (Drosophila) | 12010 | -0.191 | -0.2375 | No |
| 23 | MAFB | NA | MAFB Entrez, Source | v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) | 13162 | -0.343 | -0.2883 | Yes |
| 24 | ISL1 | NA | ISL1 Entrez, Source | ISL1 transcription factor, LIM/homeodomain, (islet-1) | 13222 | -0.352 | -0.2779 | Yes |
| 25 | SRP9 | NA | SRP9 Entrez, Source | signal recognition particle 9kDa | 13270 | -0.360 | -0.2666 | Yes |
| 26 | SLC2A2 | NA | SLC2A2 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 2 | 13679 | -0.431 | -0.2725 | Yes |
| 27 | VDR | NA | VDR Entrez, Source | vitamin D (1,25- dihydroxyvitamin D3) receptor | 13804 | -0.454 | -0.2618 | Yes |
| 28 | PCSK1 | NA | PCSK1 Entrez, Source | proprotein convertase subtilisin/kexin type 1 | 14400 | -0.574 | -0.2726 | Yes |
| 29 | SPCS1 | NA | SPCS1 Entrez, Source | signal peptidase complex subunit 1 homolog (S. cerevisiae) | 14849 | -0.683 | -0.2711 | Yes |
| 30 | AKT3 | NA | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 14929 | -0.703 | -0.2482 | Yes |
| 31 | ELP4 | NA | ELP4 Entrez, Source | elongation protein 4 homolog (S. cerevisiae) | 15058 | -0.735 | -0.2267 | Yes |
| 32 | SRPRB | NA | SRPRB Entrez, Source | signal recognition particle receptor, B subunit | 15528 | -0.873 | -0.2189 | Yes |
| 33 | SEC11A | NA | 15724 | -0.939 | -0.1932 | Yes | ||
| 34 | SYT13 | NA | SYT13 Entrez, Source | synaptotagmin XIII | 16022 | -1.055 | -0.1688 | Yes |
| 35 | PAX6 | NA | PAX6 Entrez, Source | paired box gene 6 (aniridia, keratitis) | 16661 | -1.401 | -0.1498 | Yes |
| 36 | HNF1A | NA | 17149 | -1.844 | -0.1053 | Yes | ||
| 37 | LMO2 | NA | LMO2 Entrez, Source | LIM domain only 2 (rhombotin-like 1) | 17822 | -3.897 | 0.0088 | Yes |
