Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_P53_PATHWAY
Enrichment Score (ES)0.43658453
Normalized Enrichment Score (NES)1.5705057
Nominal p-value0.0
FDR q-value0.014724568
FWER p-Value0.077
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_P53_PATHWAY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1INHBBNAINHBB
Entrez,  Source
inhibin, beta B (activin AB beta polypeptide)254.8720.0178Yes
2TPD52L1NATPD52L1
Entrez,  Source
tumor protein D52-like 1714.6500.0336Yes
3NUPR1NANUPR1
Entrez,  Source
-874.5620.0507Yes
4TGFANATGFA
Entrez,  Source
transforming growth factor, alpha1034.5150.0676Yes
5ITGB4NAITGB4
Entrez,  Source
integrin, beta 41104.4780.0849Yes
6SLC7A11NASLC7A11
Entrez,  Source
solute carrier family 7, (cationic amino acid transporter, y+ system) member 111634.2640.0988Yes
7S100A4NAS100A4
Entrez,  Source
S100 calcium binding protein A41674.2130.1152Yes
8HIST1H1CNAHIST1H1C
Entrez,  Source
histone cluster 1, H1c2713.8380.1246Yes
9HMOX1NAHMOX1
Entrez,  Source
heme oxygenase (decycling) 12813.8020.1391Yes
10TNFSF9NATNFSF9
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 92843.7940.1539Yes
11EPHX1NAEPHX1
Entrez,  Source
epoxide hydrolase 1, microsomal (xenobiotic)3103.7140.1671Yes
12SERPINB5NASERPINB5
Entrez,  Source
serpin peptidase inhibitor, clade B (ovalbumin), member 53473.5950.1793Yes
13FUCA1NAFUCA1
Entrez,  Source
fucosidase, alpha-L- 1, tissue3783.5130.1914Yes
14CTSDNACTSD
Entrez,  Source
cathepsin D (lysosomal aspartyl peptidase)3903.4740.2045Yes
15F2RNAF2R
Entrez,  Source
coagulation factor II (thrombin) receptor5153.1120.2098Yes
16CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)5223.1000.2216Yes
17ABHD4NAABHD4
Entrez,  Source
abhydrolase domain containing 45293.0840.2334Yes
18EPHA2NAEPHA2
Entrez,  Source
EPH receptor A25463.0430.2445Yes
19JAG2NAJAG2
Entrez,  Source
jagged 25483.0410.2565Yes
20SLC3A2NASLC3A2
Entrez,  Source
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 26142.8960.2642Yes
21FASNAFAS
Entrez,  Source
Fas (TNF receptor superfamily, member 6)7332.6790.2681Yes
22PHLDA3NAPHLDA3
Entrez,  Source
pleckstrin homology-like domain, family A, member 37502.6480.2777Yes
23KIF13BNAKIF13B
Entrez,  Source
kinesin family member 13B8262.5460.2835Yes
24DDIT4NADDIT4
Entrez,  Source
DNA-damage-inducible transcript 48692.4910.2909Yes
25DDIT3NADDIT3
Entrez,  Source
DNA-damage-inducible transcript 38732.4850.3006Yes
26IER3NAIER3
Entrez,  Source
immediate early response 38802.4820.3100Yes
27KRT17NAKRT17
Entrez,  Source
keratin 178922.4660.3191Yes
28ABCC5NAABCC5
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 59722.3690.3240Yes
29CASP1NACASP1
Entrez,  Source
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)10012.3380.3316Yes
30ZMAT3NAZMAT3
Entrez,  Source
zinc finger, matrin type 310132.3200.3401Yes
31TRAF4NATRAF4
Entrez,  Source
TNF receptor-associated factor 410322.2910.3482Yes
32KLF4NAKLF4
Entrez,  Source
Kruppel-like factor 4 (gut)10412.2840.3567Yes
33HEXIM1NAHEXIM1
Entrez,  Source
hexamethylene bis-acetamide inducible 110812.2390.3633Yes
34HSPA4LNAHSPA4L
Entrez,  Source
heat shock 70kDa protein 4-like10872.2340.3718Yes
35GM2ANAGM2A
Entrez,  Source
GM2 ganglioside activator11482.1690.3770Yes
36CCND3NACCND3
Entrez,  Source
cyclin D311722.1460.3842Yes
37MXD4NAMXD4
Entrez,  Source
MAX dimerization protein 412802.0600.3863Yes
38EPS8L2NAEPS8L2
Entrez,  Source
EPS8-like 213691.9780.3891Yes
39NINJ1NANINJ1
Entrez,  Source
ninjurin 113901.9620.3957Yes
40TOB1NATOB1
Entrez,  Source
transducer of ERBB2, 114061.9490.4026Yes
41BAK1NABAK1
Entrez,  Source
BCL2-antagonist/killer 114941.8850.4051Yes
42IRAK1NAIRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 115861.8180.4072Yes
43PLK2NAPLK2
Entrez,  Source
polo-like kinase 2 (Drosophila)16071.8000.4131Yes
44CTSFNACTSF
Entrez,  Source
cathepsin F16321.7820.4188Yes
45RNF19BNA16381.7750.4255Yes
46TSC22D1NATSC22D1
Entrez,  Source
TSC22 domain family, member 116691.7540.4307Yes
47BAIAP2NABAIAP2
Entrez,  Source
BAI1-associated protein 216881.7430.4366Yes
48POLHNAPOLH
Entrez,  Source
polymerase (DNA directed), eta18341.6470.4349No
49ST14NAST14
Entrez,  Source
suppression of tumorigenicity 14 (colon carcinoma)22361.4340.4180No
50SLC35D1NASLC35D1
Entrez,  Source
solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D123351.3990.4180No
51CSRNP2NA24081.3670.4194No
52MDM2NAMDM2
Entrez,  Source
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)25001.3240.4195No
53WWP1NAWWP1
Entrez,  Source
WW domain containing E3 ubiquitin protein ligase 126471.2650.4162No
54SLC19A2NASLC19A2
Entrez,  Source
solute carrier family 19 (thiamine transporter), member 227211.2360.4170No
55S100A10NAS100A10
Entrez,  Source
S100 calcium binding protein A1028721.1910.4133No
56IFI30NAIFI30
Entrez,  Source
interferon, gamma-inducible protein 3029771.1550.4120No
57HINT1NAHINT1
Entrez,  Source
histidine triad nucleotide binding protein 129951.1490.4156No
58LRMPNALRMP
Entrez,  Source
lymphoid-restricted membrane protein30951.1180.4144No
59SAT1NASAT1
Entrez,  Source
spermidine/spermine N1-acetyltransferase 131111.1140.4179No
60PRMT2NAPRMT2
Entrez,  Source
protein arginine methyltransferase 231841.0920.4182No
61RCHY1NARCHY1
Entrez,  Source
ring finger and CHY zinc finger domain containing 131971.0870.4218No
62NDRG1NANDRG1
Entrez,  Source
N-myc downstream regulated gene 132951.0600.4205No
63HBEGFNAHBEGF
Entrez,  Source
heparin-binding EGF-like growth factor33711.0370.4204No
64RRADNARRAD
Entrez,  Source
Ras-related associated with diabetes34811.0070.4182No
65TSPYL2NATSPYL2
Entrez,  Source
TSPY-like 237650.9240.4060No
66HDAC3NAHDAC3
Entrez,  Source
histone deacetylase 338470.9060.4050No
67RXRANARXRA
Entrez,  Source
retinoid X receptor, alpha41540.8290.3910No
68GLS2NAGLS2
Entrez,  Source
glutaminase 2 (liver, mitochondrial)42240.8110.3904No
69PMM1NAPMM1
Entrez,  Source
phosphomannomutase 142870.7960.3900No
70DGKANADGKA
Entrez,  Source
diacylglycerol kinase, alpha 80kDa44440.7620.3842No
71MAPKAPK3NAMAPKAPK3
Entrez,  Source
mitogen-activated protein kinase-activated protein kinase 347180.6990.3717No
72TNNI1NATNNI1
Entrez,  Source
troponin I type 1 (skeletal, slow)47690.6890.3716No
73IER5NAIER5
Entrez,  Source
immediate early response 548300.6760.3709No
74HRASNAHRAS
Entrez,  Source
v-Ha-ras Harvey rat sarcoma viral oncogene homolog48400.6740.3730No
75H2AFJNAH2AFJ
Entrez,  Source
H2A histone family, member J49340.6540.3704No
76TM7SF3NATM7SF3
Entrez,  Source
transmembrane 7 superfamily member 349640.6490.3713No
77BLCAPNABLCAP
Entrez,  Source
bladder cancer associated protein49850.6430.3727No
78PPP1R15ANAPPP1R15A
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 15A50310.6350.3727No
79VAMP8NAVAMP8
Entrez,  Source
vesicle-associated membrane protein 8 (endobrevin)50550.6310.3739No
80CDK5R1NACDK5R1
Entrez,  Source
cyclin-dependent kinase 5, regulatory subunit 1 (p35)50740.6290.3753No
81CGRRF1NACGRRF1
Entrez,  Source
cell growth regulator with ring finger domain 151610.6120.3729No
82RGS16NARGS16
Entrez,  Source
regulator of G-protein signalling 1652060.6030.3728No
83TXNIPNATXNIP
Entrez,  Source
thioredoxin interacting protein52420.5970.3732No
84ANKRA2NAANKRA2
Entrez,  Source
ankyrin repeat, family A (RFXANK-like), 254660.5550.3628No
85MXD1NAMXD1
Entrez,  Source
MAX dimerization protein 155000.5500.3631No
86NHLH2NANHLH2
Entrez,  Source
nescient helix loop helix 255840.5360.3606No
87SERTAD3NASERTAD3
Entrez,  Source
SERTA domain containing 356740.5220.3576No
88TRIB3NATRIB3
Entrez,  Source
tribbles homolog 3 (Drosophila)56860.5190.3591No
89MKNK2NAMKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 258760.4900.3504No
90TRAFD1NATRAFD1
Entrez,  Source
TRAF-type zinc finger domain containing 159960.4670.3455No
91PLXNB2NAPLXNB2
Entrez,  Source
plexin B261520.4380.3385No
92NOTCH1NANOTCH1
Entrez,  Source
Notch homolog 1, translocation-associated (Drosophila)63920.3980.3267No
93CCNKNACCNK
Entrez,  Source
cyclin K64250.3950.3264No
94WRAP73NA65120.3820.3231No
95STEAP3NASTEAP3
Entrez,  Source
STEAP family member 367570.3470.3108No
96TGFB1NATGFB1
Entrez,  Source
transforming growth factor, beta 1 (Camurati-Engelmann disease)68160.3410.3088No
97JUNNAJUN
Entrez,  Source
jun oncogene70420.3100.2974No
98CLCA2NACLCA2
Entrez,  Source
chloride channel, calcium activated, family member 272850.2760.2849No
99ISCUNA73020.2740.2851No
100PPM1DNAPPM1D
Entrez,  Source
protein phosphatase 1D magnesium-dependent, delta isoform77040.2330.2635No
101AK1NAAK1
Entrez,  Source
adenylate kinase 177310.2310.2629No
102TCN2NATCN2
Entrez,  Source
transcobalamin II; macrocytic anemia77820.2250.2610No
103ZBTB16NAZBTB16
Entrez,  Source
zinc finger and BTB domain containing 1678970.2150.2554No
104CDKN2ANACDKN2A
Entrez,  Source
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)80270.1990.2490No
105TAP1NATAP1
Entrez,  Source
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)80460.1970.2487No
106PROCRNAPROCR
Entrez,  Source
protein C receptor, endothelial (EPCR)82240.1750.2395No
107RAB40CNARAB40C
Entrez,  Source
RAB40C, member RAS oncogene family84760.1550.2260No
108PCNANAPCNA
Entrez,  Source
proliferating cell nuclear antigen86030.1430.2195No
109PLK3NAPLK3
Entrez,  Source
polo-like kinase 3 (Drosophila)89410.1050.2009No
110BAXNABAX
Entrez,  Source
BCL2-associated X protein89660.1020.2000No
111RAD9ANARAD9A
Entrez,  Source
RAD9 homolog A (S. pombe)91440.0850.1904No
112FBXW7NAFBXW7
Entrez,  Source
F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)93910.0630.1768No
113PERPNAPERP
Entrez,  Source
PERP, TP53 apoptosis effector94810.0550.1720No
114VWA5ANA97170.0230.1589No
115RRP8NA98360.0060.1523No
116EI24NAEI24
Entrez,  Source
etoposide induced 2.4 mRNA10247-0.0110.1293No
117ALOX15BNAALOX15B
Entrez,  Source
arachidonate 15-lipoxygenase, type B10777-0.0560.0998No
118RAP2BNARAP2B
Entrez,  Source
RAP2B, member of RAS oncogene family10796-0.0580.0990No
119APAF1NAAPAF1
Entrez,  Source
apoptotic peptidase activating factor10823-0.0600.0978No
120TCHHNATCHH
Entrez,  Source
trichohyalin11049-0.0860.0855No
121FOSNAFOS
Entrez,  Source
v-fos FBJ murine osteosarcoma viral oncogene homolog11142-0.0980.0807No
122ACVR1BNAACVR1B
Entrez,  Source
activin A receptor, type IB11143-0.0980.0811No
123CDKN2BNACDKN2B
Entrez,  Source
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)11164-0.1010.0803No
124RETSATNARETSAT
Entrez,  Source
retinol saturase (all-trans-retinol 13,14-reductase)11203-0.1050.0786No
125SFNNASFN
Entrez,  Source
stratifin11342-0.1190.0713No
126RPS27LNARPS27L
Entrez,  Source
ribosomal protein S27-like11521-0.1350.0618No
127NOL8NANOL8
Entrez,  Source
nucleolar protein 811623-0.1460.0567No
128DDB2NADDB2
Entrez,  Source
damage-specific DNA binding protein 2, 48kDa11728-0.1590.0515No
129SP1NASP1
Entrez,  Source
Sp1 transcription factor12204-0.2140.0257No
130BTG1NABTG1
Entrez,  Source
B-cell translocation gene 1, anti-proliferative12253-0.2200.0238No
131CD81NACD81
Entrez,  Source
CD81 molecule12810-0.292-0.0063No
132LDHBNALDHB
Entrez,  Source
lactate dehydrogenase B12897-0.301-0.0099No
133SOCS1NASOCS1
Entrez,  Source
suppressor of cytokine signaling 112911-0.303-0.0095No
134RPL36NARPL36
Entrez,  Source
ribosomal protein L3612980-0.315-0.0120No
135POM121NAPOM121
Entrez,  Source
POM121 membrane glycoprotein (rat)13054-0.326-0.0149No
136CDKN2AIPNA13260-0.358-0.0250No
137RAD51CNARAD51C
Entrez,  Source
RAD51 homolog C (S. cerevisiae)13295-0.366-0.0254No
138SEC61A1NASEC61A1
Entrez,  Source
Sec61 alpha 1 subunit (S. cerevisiae)13364-0.377-0.0278No
139FAM162ANA13618-0.420-0.0403No
140RPL18NARPL18
Entrez,  Source
ribosomal protein L1813689-0.432-0.0426No
141XPCNAXPC
Entrez,  Source
xeroderma pigmentosum, complementation group C13729-0.442-0.0430No
142IP6K2NA13795-0.451-0.0449No
143VDRNAVDR
Entrez,  Source
vitamin D (1,25- dihydroxyvitamin D3) receptor13804-0.454-0.0436No
144GPX2NAGPX2
Entrez,  Source
glutathione peroxidase 2 (gastrointestinal)13820-0.456-0.0426No
145CCNG1NACCNG1
Entrez,  Source
cyclin G113856-0.463-0.0428No
146GADD45ANAGADD45A
Entrez,  Source
growth arrest and DNA-damage-inducible, alpha13870-0.467-0.0416No
147SDC1NASDC1
Entrez,  Source
syndecan 113933-0.476-0.0432No
148RALGDSNARALGDS
Entrez,  Source
ral guanine nucleotide dissociation stimulator14010-0.492-0.0456No
149CCP110NA14254-0.542-0.0571No
150ZFP36L1NAZFP36L1
Entrez,  Source
zinc finger protein 36, C3H type-like 114333-0.558-0.0593No
151DNTTIP2NADNTTIP2
Entrez,  Source
deoxynucleotidyltransferase, terminal, interacting protein 214360-0.565-0.0585No
152LIFNALIF
Entrez,  Source
leukemia inhibitory factor (cholinergic differentiation factor)14845-0.682-0.0830No
153DCXRNADCXR
Entrez,  Source
dicarbonyl/L-xylulose reductase14886-0.692-0.0826No
154FDXRNAFDXR
Entrez,  Source
ferredoxin reductase15019-0.726-0.0871No
155APPNAAPP
Entrez,  Source
amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)15338-0.815-0.1018No
156SESN1NASESN1
Entrez,  Source
sestrin 115363-0.824-0.0999No
157TP63NA15405-0.836-0.0989No
158ERCC5NAERCC5
Entrez,  Source
me))15420-0.839-0.0964No
159FOXO3NA15433-0.842-0.0937No
160RHBDF2NARHBDF2
Entrez,  Source
rhomboid 5 homolog 2 (Drosophila)15936-1.022-0.1179No
161RB1NARB1
Entrez,  Source
retinoblastoma 1 (including osteosarcoma)16145-1.113-0.1252No
162PTPN14NAPTPN14
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 1416250-1.169-0.1265No
163TM4SF1NATM4SF1
Entrez,  Source
transmembrane 4 L six family member 116343-1.213-0.1269No
164CD82NACD82
Entrez,  Source
CD82 molecule16441-1.265-0.1273No
165TAX1BP3NATAX1BP3
Entrez,  Source
Tax1 (human T-cell leukemia virus type I) binding protein 316483-1.288-0.1246No
166ZNF365NAZNF365
Entrez,  Source
zinc finger protein 36516570-1.349-0.1241No
167AENNA16686-1.419-0.1250No
168TRIAP1NATRIAP1
Entrez,  Source
TP53 regulated inhibitor of apoptosis 116726-1.451-0.1214No
169PRKAB1NAPRKAB1
Entrez,  Source
protein kinase, AMP-activated, beta 1 non-catalytic subunit16770-1.484-0.1180No
170RPS12NARPS12
Entrez,  Source
ribosomal protein S1216802-1.509-0.1138No
171DEF6NADEF6
Entrez,  Source
differentially expressed in FDCP 6 homolog (mouse)16848-1.544-0.1103No
172TPRKBNATPRKB
Entrez,  Source
TP53RK binding protein16906-1.594-0.1072No
173ADANAADA
Entrez,  Source
adenosine deaminase16910-1.597-0.1011No
174DRAM1NA16942-1.625-0.0964No
175CCND2NACCND2
Entrez,  Source
cyclin D216961-1.643-0.0909No
176ABATNAABAT
Entrez,  Source
4-aminobutyrate aminotransferase17094-1.782-0.0913No
177PTPRENAPTPRE
Entrez,  Source
protein tyrosine phosphatase, receptor type, E17162-1.862-0.0878No
178NUDT15NANUDT15
Entrez,  Source
nudix (nucleoside diphosphate linked moiety X)-type motif 1517190-1.901-0.0818No
179BMP2NABMP2
Entrez,  Source
bone morphogenetic protein 217210-1.924-0.0753No
180TP53NATP53
Entrez,  Source
tumor protein p53 (Li-Fraumeni syndrome)17352-2.136-0.0748No
181PDGFANAPDGFA
Entrez,  Source
platelet-derived growth factor alpha polypeptide17396-2.217-0.0685No
182PITPNC1NAPITPNC1
Entrez,  Source
phosphatidylinositol transfer protein, cytoplasmic 117397-2.218-0.0597No
183STOMNASTOM
Entrez,  Source
stomatin17473-2.363-0.0546No
184CDH13NACDH13
Entrez,  Source
cadherin 13, H-cadherin (heart)17516-2.466-0.0473No
185SPHK1NASPHK1
Entrez,  Source
sphingosine kinase 117557-2.582-0.0394No
186CEBPANACEBPA
Entrez,  Source
CCAAT/enhancer binding protein (C/EBP), alpha17574-2.639-0.0299No
187BTG2NABTG2
Entrez,  Source
BTG family, member 217866-4.154-0.0299No
188IL1ANAIL1A
Entrez,  Source
interleukin 1, alpha17880-4.259-0.0138No
189FGF13NAFGF13
Entrez,  Source
fibroblast growth factor 1317965-4.9210.0008No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_P53_PATHWAY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_P53_PATHWAY: Random ES distribution   
Gene set null distribution of ES for HALLMARK_P53_PATHWAY