Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | HALLMARK_NOTCH_SIGNALING |
| Enrichment Score (ES) | 0.4643703 |
| Normalized Enrichment Score (NES) | 1.2958298 |
| Nominal p-value | 0.11379801 |
| FDR q-value | 0.11641229 |
| FWER p-Value | 0.917 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | JAG1 | NA | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 309 | 3.715 | 0.0858 | Yes |
| 2 | FZD7 | NA | FZD7 Entrez, Source | frizzled homolog 7 (Drosophila) | 381 | 3.504 | 0.1790 | Yes |
| 3 | FZD5 | NA | FZD5 Entrez, Source | frizzled homolog 5 (Drosophila) | 592 | 2.947 | 0.2491 | Yes |
| 4 | FZD1 | NA | FZD1 Entrez, Source | frizzled homolog 1 (Drosophila) | 599 | 2.912 | 0.3295 | Yes |
| 5 | LFNG | NA | LFNG Entrez, Source | lunatic fringe homolog (Drosophila) | 934 | 2.418 | 0.3779 | Yes |
| 6 | ST3GAL6 | NA | ST3GAL6 Entrez, Source | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 1594 | 1.811 | 0.3914 | Yes |
| 7 | PRKCA | NA | PRKCA Entrez, Source | protein kinase C, alpha | 1595 | 1.810 | 0.4416 | Yes |
| 8 | SKP1 | NA | 2440 | 1.349 | 0.4320 | Yes | ||
| 9 | PSEN2 | NA | PSEN2 Entrez, Source | presenilin 2 (Alzheimer disease 4) | 2516 | 1.317 | 0.4644 | Yes |
| 10 | FBXW11 | NA | FBXW11 Entrez, Source | F-box and WD-40 domain protein 11 | 3121 | 1.110 | 0.4615 | No |
| 11 | NOTCH2 | NA | NOTCH2 Entrez, Source | Notch homolog 2 (Drosophila) | 3723 | 0.936 | 0.4540 | No |
| 12 | SAP30 | NA | SAP30 Entrez, Source | Sin3A-associated protein, 30kDa | 5073 | 0.629 | 0.3963 | No |
| 13 | ARRB1 | NA | ARRB1 Entrez, Source | arrestin, beta 1 | 5139 | 0.616 | 0.4097 | No |
| 14 | CCND1 | NA | CCND1 Entrez, Source | cyclin D1 | 5252 | 0.595 | 0.4200 | No |
| 15 | MAML2 | NA | MAML2 Entrez, Source | mastermind-like 2 (Drosophila) | 5420 | 0.563 | 0.4263 | No |
| 16 | PSENEN | NA | PSENEN Entrez, Source | presenilin enhancer 2 homolog (C. elegans) | 5540 | 0.542 | 0.4347 | No |
| 17 | PPARD | NA | PPARD Entrez, Source | peroxisome proliferative activated receptor, delta | 5578 | 0.537 | 0.4475 | No |
| 18 | NOTCH1 | NA | NOTCH1 Entrez, Source | Notch homolog 1, translocation-associated (Drosophila) | 6392 | 0.398 | 0.4133 | No |
| 19 | CUL1 | NA | CUL1 Entrez, Source | cullin 1 | 6459 | 0.390 | 0.4204 | No |
| 20 | HES1 | NA | HES1 Entrez, Source | hairy and enhancer of split 1, (Drosophila) | 7424 | 0.259 | 0.3739 | No |
| 21 | WNT2 | NA | WNT2 Entrez, Source | wingless-type MMTV integration site family member 2 | 7550 | 0.248 | 0.3738 | No |
| 22 | DTX2 | NA | DTX2 Entrez, Source | deltex homolog 2 (Drosophila) | 7603 | 0.243 | 0.3776 | No |
| 23 | WNT5A | NA | WNT5A Entrez, Source | wingless-type MMTV integration site family, member 5A | 8916 | 0.107 | 0.3075 | No |
| 24 | KAT2A | NA | 9102 | 0.090 | 0.2997 | No | ||
| 25 | RBX1 | NA | RBX1 Entrez, Source | ring-box 1 | 10295 | -0.013 | 0.2337 | No |
| 26 | DTX1 | NA | DTX1 Entrez, Source | deltex homolog 1 (Drosophila) | 10913 | -0.071 | 0.2013 | No |
| 27 | TCF7L2 | NA | TCF7L2 Entrez, Source | transcription factor 7-like 2 (T-cell specific, HMG-box) | 13312 | -0.370 | 0.0779 | No |
| 28 | APH1A | NA | APH1A Entrez, Source | anterior pharynx defective 1 homolog A (C. elegans) | 14197 | -0.531 | 0.0434 | No |
| 29 | NOTCH3 | NA | NOTCH3 Entrez, Source | Notch homolog 3 (Drosophila) | 15021 | -0.726 | 0.0177 | No |
| 30 | HEYL | NA | HEYL Entrez, Source | hairy/enhancer-of-split related with YRPW motif-like | 16349 | -1.214 | -0.0226 | No |
| 31 | DTX4 | NA | DTX4 Entrez, Source | deltex 4 homolog (Drosophila) | 17153 | -1.847 | -0.0161 | No |
| 32 | DLL1 | NA | DLL1 Entrez, Source | delta-like 1 (Drosophila) | 17404 | -2.241 | 0.0321 | No |
