Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_MITOTIC_SPINDLE
Enrichment Score (ES)-0.2774156
Normalized Enrichment Score (NES)-1.1748728
Nominal p-value0.08148148
FDR q-value0.18541637
FWER p-Value0.68
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_MITOTIC_SPINDLE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DOCK2NADOCK2
Entrez,  Source
dedicator of cytokinesis 22034.0740.0103No
2SHROOM2NASHROOM2
Entrez,  Source
shroom family member 22623.8660.0277No
3DSTNADST
Entrez,  Source
dystonin6432.8480.0215No
4CLIP2NA6632.8180.0354No
5ECT2NAECT2
Entrez,  Source
epithelial cell transforming sequence 2 oncogene9262.4260.0336No
6PDLIM5NAPDLIM5
Entrez,  Source
PDZ and LIM domain 59752.3670.0436No
7PKD2NAPKD2
Entrez,  Source
polycystic kidney disease 2 (autosomal dominant)11492.1660.0454No
8KIF1BNAKIF1B
Entrez,  Source
kinesin family member 1B11702.1510.0557No
9MID1NAMID1
Entrez,  Source
midline 1 (Opitz/BBB syndrome)11732.1460.0671No
10SYNPONASYNPO
Entrez,  Source
synaptopodin12452.0910.0742No
11ALS2NAALS2
Entrez,  Source
amyotrophic lateral sclerosis 2 (juvenile)12732.0660.0837No
12BCL2L11NABCL2L11
Entrez,  Source
BCL2-like 11 (apoptosis facilitator)14531.9070.0838No
13ARHGAP5NAARHGAP5
Entrez,  Source
Rho GTPase activating protein 515741.8260.0868No
14PCM1NAPCM1
Entrez,  Source
pericentriolar material 118941.6170.0775No
15MYO9BNAMYO9B
Entrez,  Source
myosin IXB19271.6000.0842No
16DYNC1H1NADYNC1H1
Entrez,  Source
dynein, cytoplasmic 1, heavy chain 119431.5900.0919No
17CLASP1NACLASP1
Entrez,  Source
cytoplasmic linker associated protein 119771.5680.0984No
18GSNNAGSN
Entrez,  Source
gelsolin (amyloidosis, Finnish type)21511.4710.0965No
19OPHN1NAOPHN1
Entrez,  Source
oligophrenin 123741.3840.0914No
20BCRNABCR
Entrez,  Source
breakpoint cluster region24531.3450.0942No
21RAPGEF6NARAPGEF6
Entrez,  Source
Rap guanine nucleotide exchange factor (GEF) 624541.3430.1013No
22ARHGAP27NAARHGAP27
Entrez,  Source
Rho GTPase activating protein 2724911.3280.1064No
23CD2APNACD2AP
Entrez,  Source
CD2-associated protein25321.3090.1111No
24FGD4NAFGD4
Entrez,  Source
FYVE, RhoGEF and PH domain containing 425341.3080.1180No
25RASA1NARASA1
Entrez,  Source
RAS p21 protein activator (GTPase activating protein) 126491.2640.1184No
26PCGF5NAPCGF5
Entrez,  Source
polycomb group ring finger 526921.2470.1227No
27SSH2NASSH2
Entrez,  Source
slingshot homolog 2 (Drosophila)28261.2060.1216No
28FLNANAFLNA
Entrez,  Source
filamin A, alpha (actin binding protein 280)28321.2040.1277No
29NF1NANF1
Entrez,  Source
neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)28691.1920.1321No
30SPTAN1NASPTAN1
Entrez,  Source
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)29211.1750.1355No
31FLNBNAFLNB
Entrez,  Source
filamin B, beta (actin binding protein 278)30881.1210.1321No
32TOP2ANATOP2A
Entrez,  Source
topoisomerase (DNA) II alpha 170kDa32241.0820.1303No
33CCDC88ANA33301.0470.1300No
34WASF2NAWASF2
Entrez,  Source
WAS protein family, member 234761.0090.1272No
35TLK1NATLK1
Entrez,  Source
tousled-like kinase 136000.9700.1254No
36ARF6NAARF6
Entrez,  Source
ADP-ribosylation factor 636470.9570.1280No
37BUB1NABUB1
Entrez,  Source
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)37160.9370.1291No
38NOTCH2NANOTCH2
Entrez,  Source
Notch homolog 2 (Drosophila)37230.9360.1338No
39CDC42BPANACDC42BPA
Entrez,  Source
CDC42 binding protein kinase alpha (DMPK-like)37920.9180.1349No
40CAPZBNACAPZB
Entrez,  Source
capping protein (actin filament) muscle Z-line, beta37930.9180.1398No
41SOS1NASOS1
Entrez,  Source
son of sevenless homolog 1 (Drosophila)38240.9110.1429No
42RAB3GAP1NARAB3GAP1
Entrez,  Source
RAB3 GTPase activating protein subunit 1 (catalytic)39880.8700.1384No
43BCAR1NABCAR1
Entrez,  Source
breast cancer anti-estrogen resistance 141490.8290.1338No
44DLG1NADLG1
Entrez,  Source
discs, large homolog 1 (Drosophila)41840.8210.1363No
45BIN1NABIN1
Entrez,  Source
bridging integrator 142160.8120.1389No
46CDC42NACDC42
Entrez,  Source
cell division cycle 42 (GTP binding protein, 25kDa)43240.7880.1371No
47CDC27NACDC27
Entrez,  Source
cell division cycle 2743760.7760.1383No
48KLC1NA43890.7740.1418No
49SMC1ANASMC1A
Entrez,  Source
structural maintenance of chromosomes 1A44540.7590.1422No
50PALLDNAPALLD
Entrez,  Source
palladin, cytoskeletal associated protein47630.6900.1286No
51ATG4BNAATG4B
Entrez,  Source
ATG4 autophagy related 4 homolog B (S. cerevisiae)47850.6860.1311No
52TUBA4ANA47980.6830.1340No
53KIF3BNAKIF3B
Entrez,  Source
kinesin family member 3B49060.6590.1315No
54CEP72NACEP72
Entrez,  Source
centrosomal protein 72kDa51000.6230.1240No
55SPTBN1NASPTBN1
Entrez,  Source
spectrin, beta, non-erythrocytic 151600.6120.1240No
56CSNK1DNACSNK1D
Entrez,  Source
casein kinase 1, delta52840.5890.1202No
57KIFAP3NAKIFAP3
Entrez,  Source
kinesin-associated protein 354470.5570.1140No
58RFC1NARFC1
Entrez,  Source
replication factor C (activator 1) 1, 145kDa55640.5390.1104No
59PAFAH1B1NAPAFAH1B1
Entrez,  Source
platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa57590.5070.1022No
60EZRNA58550.4920.0995No
61EPB41NAEPB41
Entrez,  Source
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)58560.4920.1021No
62CYTH2NA58730.4900.1038No
63ABRNAABR
Entrez,  Source
active BCR-related gene59170.4840.1040No
64ARFIP2NAARFIP2
Entrez,  Source
ADP-ribosylation factor interacting protein 2 (arfaptin 2)59540.4760.1045No
65HDAC6NAHDAC6
Entrez,  Source
histone deacetylase 659850.4690.1053No
66NINNANIN
Entrez,  Source
ninein (GSK3B interacting protein)60020.4670.1069No
67TSC1NATSC1
Entrez,  Source
tuberous sclerosis 161020.4490.1037No
68WASLNAWASL
Entrez,  Source
Wiskott-Aldrich syndrome-like61050.4490.1060No
69HOOK3NAHOOK3
Entrez,  Source
hook homolog 3 (Drosophila)61320.4440.1069No
70STK38LNASTK38L
Entrez,  Source
serine/threonine kinase 38 like61560.4380.1079No
71ARL8ANAARL8A
Entrez,  Source
ADP-ribosylation factor-like 8A62220.4240.1066No
72NCK2NANCK2
Entrez,  Source
NCK adaptor protein 262770.4160.1057No
73SUN2NA65570.3770.0921No
74ARHGEF12NAARHGEF12
Entrez,  Source
Rho guanine nucleotide exchange factor (GEF) 1265820.3740.0927No
75SHROOM1NASHROOM1
Entrez,  Source
shroom family member 169570.3220.0734No
76CEP250NACEP250
Entrez,  Source
centrosomal protein 250kDa70520.3090.0697No
77PREX1NAPREX1
Entrez,  Source
-70830.3050.0697No
78NET1NANET1
Entrez,  Source
neuroepithelial cell transforming gene 170900.3040.0710No
79CTTNNACTTN
Entrez,  Source
cortactin71030.3010.0719No
80CENPENACENPE
Entrez,  Source
centromere protein E, 312kDa71820.2890.0691No
81ACTN4NAACTN4
Entrez,  Source
actinin, alpha 472820.2760.0650No
82DYNLL2NADYNLL2
Entrez,  Source
dynein, light chain, LC8-type 273170.2720.0645No
83RICTORNARICTOR
Entrez,  Source
-73280.2710.0654No
84TUBD1NATUBD1
Entrez,  Source
tubulin, delta 174130.2610.0620No
85CDK5RAP2NACDK5RAP2
Entrez,  Source
CDK5 regulatory subunit associated protein 274400.2570.0620No
86ARHGEF11NAARHGEF11
Entrez,  Source
Rho guanine nucleotide exchange factor (GEF) 1175670.2460.0562No
87MARK4NAMARK4
Entrez,  Source
MAP/microtubule affinity-regulating kinase 476840.2350.0509No
88ABI1NAABI1
Entrez,  Source
abl-interactor 178030.2230.0455No
89RANBP9NARANBP9
Entrez,  Source
RAN binding protein 979290.2120.0396No
90TUBGCP2NATUBGCP2
Entrez,  Source
tubulin, gamma complex associated protein 283700.1640.0157No
91ROCK1NAROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 184630.1560.0114No
92ARFGEF1NAARFGEF1
Entrez,  Source
ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)87960.121-0.0067No
93LMNB1NALMNB1
Entrez,  Source
lamin B189100.108-0.0124No
94TAOK2NATAOK2
Entrez,  Source
TAO kinase 289230.107-0.0125No
95APCNAAPC
Entrez,  Source
adenomatosis polyposis coli91290.086-0.0236No
96ABL1NAABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 191680.083-0.0253No
97SAC3D1NASAC3D1
Entrez,  Source
SAC3 domain containing 197020.026-0.0551No
98ARHGEF2NAARHGEF2
Entrez,  Source
rho/rac guanine nucleotide exchange factor (GEF) 210974-0.077-0.1262No
99RABGAP1NARABGAP1
Entrez,  Source
RAB GTPase activating protein 111090-0.090-0.1322No
100ARHGEF3NAARHGEF3
Entrez,  Source
Rho guanine nucleotide exchange factor (GEF) 311878-0.178-0.1755No
101RALBP1NARALBP1
Entrez,  Source
ralA binding protein 111955-0.186-0.1788No
102YWHAENAYWHAE
Entrez,  Source
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide12012-0.191-0.1809No
103PPP4R2NAPPP4R2
Entrez,  Source
protein phosphatase 4, regulatory subunit 212023-0.193-0.1804No
104CKAP5NACKAP5
Entrez,  Source
cytoskeleton associated protein 512093-0.200-0.1832No
105NEDD9NANEDD9
Entrez,  Source
neural precursor cell expressed, developmentally down-regulated 912124-0.204-0.1838No
106NEK2NANEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 212202-0.214-0.1870No
107CEP57NACEP57
Entrez,  Source
centrosomal protein 57kDa12434-0.241-0.1987No
108AKAP13NAAKAP13
Entrez,  Source
A kinase (PRKA) anchor protein 1312462-0.244-0.1990No
109MAP1SNAMAP1S
Entrez,  Source
microtubule-associated protein 1S12494-0.250-0.1994No
110NUMA1NANUMA1
Entrez,  Source
nuclear mitotic apparatus protein 112779-0.286-0.2138No
111NDC80NA12789-0.288-0.2128No
112NCK1NANCK1
Entrez,  Source
NCK adaptor protein 112903-0.302-0.2175No
113RACGAP1NARACGAP1
Entrez,  Source
Rac GTPase activating protein 112981-0.316-0.2202No
114KIF2CNAKIF2C
Entrez,  Source
kinesin family member 2C13009-0.320-0.2200No
115GEMIN4NAGEMIN4
Entrez,  Source
gem (nuclear organelle) associated protein 413030-0.323-0.2194No
116MYH9NAMYH9
Entrez,  Source
myosin, heavy chain 9, non-muscle13051-0.325-0.2188No
117ARHGDIANAARHGDIA
Entrez,  Source
Rho GDP dissociation inhibitor (GDI) alpha13056-0.326-0.2173No
118RAPGEF5NARAPGEF5
Entrez,  Source
Rap guanine nucleotide exchange factor (GEF) 513113-0.336-0.2186No
119PCNTNAPCNT
Entrez,  Source
pericentrin (kendrin)13135-0.338-0.2180No
120KATNB1NAKATNB1
Entrez,  Source
katanin p80 (WD repeat containing) subunit B 113193-0.348-0.2193No
121TUBGCP5NATUBGCP5
Entrez,  Source
tubulin, gamma complex associated protein 513262-0.358-0.2213No
122KIF5BNAKIF5B
Entrez,  Source
kinesin family member 5B13340-0.373-0.2236No
123NUSAP1NANUSAP1
Entrez,  Source
nucleolar and spindle associated protein 113373-0.378-0.2234No
124STAU1NASTAU1
Entrez,  Source
staufen, RNA binding protein, homolog 1 (Drosophila)13409-0.383-0.2233No
125SEPT9NASEPT9
Entrez,  Source
septin 913513-0.402-0.2270No
126AURKANAAURKA
Entrez,  Source
aurora kinase A13647-0.426-0.2322No
127KIF3CNAKIF3C
Entrez,  Source
kinesin family member 3C13648-0.426-0.2299No
128LRPPRCNALRPPRC
Entrez,  Source
leucine-rich PPR-motif containing13686-0.431-0.2297No
129BIRC5NABIRC5
Entrez,  Source
baculoviral IAP repeat-containing 5 (survivin)13772-0.448-0.2321No
130RHOT2NARHOT2
Entrez,  Source
ras homolog gene family, member T213872-0.468-0.2351No
131PLK1NAPLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)13882-0.468-0.2332No
132ANLNNAANLN
Entrez,  Source
anillin, actin binding protein13985-0.488-0.2363No
133LATS1NALATS1
Entrez,  Source
LATS, large tumor suppressor, homolog 1 (Drosophila)14245-0.541-0.2480No
134CDC42EP4NACDC42EP4
Entrez,  Source
CDC42 effector protein (Rho GTPase binding) 414264-0.544-0.2461No
135DLGAP5NA14381-0.568-0.2496No
136RASAL2NARASAL2
Entrez,  Source
RAS protein activator like 214570-0.611-0.2569No
137CEP192NACEP192
Entrez,  Source
centrosomal protein 192kDa14583-0.613-0.2543No
138ARHGAP4NAARHGAP4
Entrez,  Source
Rho GTPase activating protein 414703-0.643-0.2576No
139MAPRE1NAMAPRE1
Entrez,  Source
microtubule-associated protein, RP/EB family, member 114831-0.678-0.2611No
140KIF20BNA14879-0.690-0.2600No
141KIF11NAKIF11
Entrez,  Source
kinesin family member 1115189-0.771-0.2733Yes
142ESPL1NAESPL1
Entrez,  Source
extra spindle poles like 1 (S. cerevisiae)15227-0.781-0.2712Yes
143MAP3K11NAMAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1115238-0.784-0.2676Yes
144VCLNAVCL
Entrez,  Source
vinculin15241-0.785-0.2635Yes
145ARHGAP10NAARHGAP10
Entrez,  Source
Rho GTPase activating protein 1015255-0.788-0.2601Yes
146TPX2NATPX2
Entrez,  Source
TPX2, microtubule-associated, homolog (Xenopus laevis)15263-0.792-0.2562Yes
147PXNNAPXN
Entrez,  Source
paxillin15311-0.807-0.2546Yes
148INCENPNAINCENP
Entrez,  Source
inner centromere protein antigens 135/155kDa15456-0.849-0.2581Yes
149CDC42EP2NACDC42EP2
Entrez,  Source
CDC42 effector protein (Rho GTPase binding) 215460-0.850-0.2538Yes
150ITSN1NAITSN1
Entrez,  Source
intersectin 1 (SH3 domain protein)15541-0.877-0.2536Yes
151PIF1NA15649-0.908-0.2548Yes
152TBCDNATBCD
Entrez,  Source
tubulin-specific chaperone d15680-0.919-0.2516Yes
153ARHGEF7NAARHGEF7
Entrez,  Source
Rho guanine nucleotide exchange factor (GEF) 715720-0.939-0.2487Yes
154CLIP1NA15774-0.959-0.2466Yes
155PLEKHG2NAPLEKHG2
Entrez,  Source
pleckstrin homology domain containing, family G (with RhoGef domain) member 215785-0.965-0.2420Yes
156WASF1NAWASF1
Entrez,  Source
WAS protein family, member 115910-1.010-0.2436Yes
157TRIONATRIO
Entrez,  Source
triple functional domain (PTPRF interacting)15926-1.019-0.2390Yes
158ARHGAP29NAARHGAP29
Entrez,  Source
Rho GTPase activating protein 2915940-1.024-0.2343Yes
159KIF22NAKIF22
Entrez,  Source
kinesin family member 2215996-1.044-0.2318Yes
160CNTROBNACNTROB
Entrez,  Source
centrobin, centrosomal BRCA2 interacting protein16039-1.059-0.2285Yes
161LLGL1NALLGL1
Entrez,  Source
lethal giant larvae homolog 1 (Drosophila)16040-1.060-0.2229Yes
162MYO1ENAMYO1E
Entrez,  Source
myosin IE16057-1.067-0.2181Yes
163TUBGCP6NATUBGCP6
Entrez,  Source
tubulin, gamma complex associated protein 616058-1.068-0.2124Yes
164UXTNAUXT
Entrez,  Source
ubiquitously-expressed transcript16072-1.075-0.2074Yes
165CDK1NA16088-1.080-0.2025Yes
166CENPFNACENPF
Entrez,  Source
centromere protein F, 350/400ka (mitosin)16180-1.127-0.2016Yes
167SMC3NASMC3
Entrez,  Source
structural maintenance of chromosomes 316199-1.141-0.1965Yes
168TUBGCP3NATUBGCP3
Entrez,  Source
tubulin, gamma complex associated protein 316232-1.162-0.1921Yes
169CNTRLNA16298-1.192-0.1894Yes
170FBXO5NAFBXO5
Entrez,  Source
F-box protein 516350-1.215-0.1858Yes
171KIF4ANAKIF4A
Entrez,  Source
kinesin family member 4A16467-1.276-0.1855Yes
172CENPJNACENPJ
Entrez,  Source
centromere protein J16498-1.297-0.1803Yes
173KNTC1NAKNTC1
Entrez,  Source
kinetochore associated 116580-1.356-0.1776Yes
174MID1IP1NAMID1IP1
Entrez,  Source
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))16636-1.385-0.1733Yes
175CDC42EP1NACDC42EP1
Entrez,  Source
CDC42 effector protein (Rho GTPase binding) 116643-1.390-0.1663Yes
176KATNA1NAKATNA1
Entrez,  Source
katanin p60 (ATPase-containing) subunit A 116688-1.422-0.1612Yes
177PRC1NAPRC1
Entrez,  Source
protein regulator of cytokinesis 116819-1.523-0.1603Yes
178FGD6NAFGD6
Entrez,  Source
FYVE, RhoGEF and PH domain containing 616825-1.527-0.1525Yes
179TTKNATTK
Entrez,  Source
TTK protein kinase16888-1.582-0.1475Yes
180RASA2NARASA2
Entrez,  Source
RAS p21 protein activator 216895-1.587-0.1394Yes
181KIF15NAKIF15
Entrez,  Source
kinesin family member 1516911-1.598-0.1317Yes
182CCNB2NACCNB2
Entrez,  Source
cyclin B216921-1.610-0.1237Yes
183KPTNNAKPTN
Entrez,  Source
kaptin (actin binding protein)16952-1.634-0.1166Yes
184SMC4NASMC4
Entrez,  Source
structural maintenance of chromosomes 416963-1.647-0.1084Yes
185MARCKSNAMARCKS
Entrez,  Source
myristoylated alanine-rich protein kinase C substrate16995-1.682-0.1012Yes
186KIF23NAKIF23
Entrez,  Source
kinesin family member 2317004-1.687-0.0926Yes
187FSCN1NAFSCN1
Entrez,  Source
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)17293-2.032-0.0980Yes
188EPB41L2NAEPB41L2
Entrez,  Source
erythrocyte membrane protein band 4.1-like 217340-2.112-0.0893Yes
189DOCK4NADOCK4
Entrez,  Source
dedicator of cytokinesis 417348-2.133-0.0783Yes
190ARAP3NA17391-2.211-0.0689Yes
191BRCA2NABRCA2
Entrez,  Source
breast cancer 2, early onset17460-2.339-0.0603Yes
192ALMS1NAALMS1
Entrez,  Source
Alstrom syndrome 117475-2.365-0.0484Yes
193RHOFNARHOF
Entrez,  Source
ras homolog gene family, member F (in filopodia)17497-2.420-0.0367Yes
194MYH10NAMYH10
Entrez,  Source
myosin, heavy chain 10, non-muscle17538-2.526-0.0255Yes
195FARP1NAFARP1
Entrez,  Source
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)17578-2.653-0.0136Yes
196TIAM1NATIAM1
Entrez,  Source
T-cell lymphoma invasion and metastasis 117655-2.958-0.0021Yes
197SORBS2NASORBS2
Entrez,  Source
sorbin and SH3 domain containing 217809-3.8020.0096Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_MITOTIC_SPINDLE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_MITOTIC_SPINDLE: Random ES distribution   
Gene set null distribution of ES for HALLMARK_MITOTIC_SPINDLE