Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_KRAS_SIGNALING_UP
Enrichment Score (ES)0.43948135
Normalized Enrichment Score (NES)1.5654575
Nominal p-value0.0
FDR q-value0.0137917185
FWER p-Value0.087
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_KRAS_SIGNALING_UP   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1EREGNAEREG
Entrez,  Source
epiregulin534.7310.0122Yes
2ANXA10NAANXA10
Entrez,  Source
annexin A10684.6670.0265Yes
3HKDC1NAHKDC1
Entrez,  Source
hexokinase domain containing 11024.5230.0391Yes
4TSPAN1NATSPAN1
Entrez,  Source
tetraspanin 11094.4840.0532Yes
5TSPAN7NATSPAN7
Entrez,  Source
tetraspanin 71214.4340.0669Yes
6ST6GAL1NAST6GAL1
Entrez,  Source
ST6 beta-galactosamide alpha-2,6-sialyltranferase 11274.4160.0808Yes
7PRRX1NAPRRX1
Entrez,  Source
paired related homeobox 11314.4060.0948Yes
8CSF2RANACSF2RA
Entrez,  Source
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)1484.3330.1078Yes
9GALNT3NAGALNT3
Entrez,  Source
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)1594.2770.1210Yes
10DOCK2NADOCK2
Entrez,  Source
dedicator of cytokinesis 22034.0740.1317Yes
11JUPNAJUP
Entrez,  Source
junction plakoglobin2673.8510.1405Yes
12MALLNAMALL
Entrez,  Source
mal, T-cell differentiation protein-like2723.8360.1526Yes
13ID2NAID2
Entrez,  Source
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein2803.8060.1645Yes
14RELNNARELN
Entrez,  Source
reelin2943.7440.1758Yes
15F2RL1NAF2RL1
Entrez,  Source
coagulation factor II (thrombin) receptor-like 13293.6550.1856Yes
16BTCNABTC
Entrez,  Source
betacellulin3693.5370.1948Yes
17FUCA1NAFUCA1
Entrez,  Source
fucosidase, alpha-L- 1, tissue3783.5130.2056Yes
18ANGPTL4NAANGPTL4
Entrez,  Source
angiopoietin-like 43883.4800.2163Yes
19SEMA3BNASEMA3B
Entrez,  Source
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B3953.4680.2271Yes
20ITGA2NAITGA2
Entrez,  Source
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)4243.3790.2364Yes
21CA2NACA2
Entrez,  Source
carbonic anhydrase II4273.3690.2472Yes
22BIRC3NABIRC3
Entrez,  Source
baculoviral IAP repeat-containing 34373.3370.2574Yes
23GLRXNAGLRX
Entrez,  Source
glutaredoxin (thioltransferase)4433.3230.2678Yes
24IL1RL2NAIL1RL2
Entrez,  Source
interleukin 1 receptor-like 24603.2410.2773Yes
25CFHNACFH
Entrez,  Source
complement factor H4923.1600.2857Yes
26PLATNAPLAT
Entrez,  Source
plasminogen activator, tissue5203.1030.2942Yes
27PRKG2NAPRKG2
Entrez,  Source
protein kinase, cGMP-dependent, type II6182.8860.2980Yes
28NGFNA6702.8060.3042Yes
29SNAP25NASNAP25
Entrez,  Source
synaptosomal-associated protein, 25kDa6892.7790.3121Yes
30PLAUNAPLAU
Entrez,  Source
plasminogen activator, urokinase6912.7770.3210Yes
31GPRC5BNAGPRC5B
Entrez,  Source
G protein-coupled receptor, family C, group 5, member B7372.6760.3270Yes
32EPHB2NAEPHB2
Entrez,  Source
EPH receptor B28092.5690.3313Yes
33TNFRSF1BNATNFRSF1B
Entrez,  Source
tumor necrosis factor receptor superfamily, member 1B9002.4560.3341Yes
34ZNF639NAZNF639
Entrez,  Source
zinc finger protein 6399282.4220.3404Yes
35SPP1NASPP1
Entrez,  Source
secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)9522.3950.3468Yes
36TSPAN13NATSPAN13
Entrez,  Source
tetraspanin 139542.3910.3544Yes
37ETV1NAETV1
Entrez,  Source
ets variant gene 19892.3490.3601Yes
38KCNN4NAKCNN4
Entrez,  Source
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 410042.3320.3668Yes
39ETV5NAETV5
Entrez,  Source
ets variant gene 5 (ets-related molecule)10332.2910.3726Yes
40KLF4NAKLF4
Entrez,  Source
Kruppel-like factor 4 (gut)10412.2840.3795Yes
41GUCY1A3NAGUCY1A3
Entrez,  Source
guanylate cyclase 1, soluble, alpha 310782.2490.3847Yes
42PCSK1NNAPCSK1N
Entrez,  Source
proprotein convertase subtilisin/kexin type 1 inhibitor11252.1970.3892Yes
43ABCB1NAABCB1
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 111362.1850.3957Yes
44GADD45GNAGADD45G
Entrez,  Source
growth arrest and DNA-damage-inducible, gamma12192.1100.3979Yes
45CXCL10NACXCL10
Entrez,  Source
chemokine (C-X-C motif) ligand 1012242.1070.4044Yes
46CFBNACFB
Entrez,  Source
complement factor B12252.1070.4112Yes
47SCN1BNASCN1B
Entrez,  Source
sodium channel, voltage-gated, type I, beta13352.0090.4115Yes
48AMMECR1NAAMMECR1
Entrez,  Source
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region, gene 113531.9910.4170Yes
49EMP1NAEMP1
Entrez,  Source
epithelial membrane protein 113791.9710.4219Yes
50CPENACPE
Entrez,  Source
carboxypeptidase E14041.9490.4268Yes
51CXCR4NACXCR4
Entrez,  Source
chemokine (C-X-C motif) receptor 415611.8360.4239Yes
52PTGS2NAPTGS2
Entrez,  Source
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)16111.7970.4270Yes
53TLR8NATLR8
Entrez,  Source
toll-like receptor 817011.7330.4275Yes
54TFPINATFPI
Entrez,  Source
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)17211.7220.4320Yes
55LY96NALY96
Entrez,  Source
lymphocyte antigen 9617451.7050.4362Yes
56NRP1NANRP1
Entrez,  Source
neuropilin 118611.6340.4350Yes
57IGF2NAIGF2
Entrez,  Source
insulin-like growth factor 2 (somatomedin A)18751.6280.4395Yes
58BTBD3NABTBD3
Entrez,  Source
BTB (POZ) domain containing 320781.5100.4330No
59PECAM1NAPECAM1
Entrez,  Source
platelet/endothelial cell adhesion molecule (CD31 antigen)21281.4810.4350No
60PIGRNAPIGR
Entrez,  Source
polymeric immunoglobulin receptor22551.4270.4325No
61ADAM17NAADAM17
Entrez,  Source
ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)23211.4050.4334No
62TOR1AIP2NATOR1AIP2
Entrez,  Source
torsin A interacting protein 226041.2790.4216No
63ADAM8NAADAM8
Entrez,  Source
ADAM metallopeptidase domain 826101.2770.4254No
64CAB39LNACAB39L
Entrez,  Source
calcium binding protein 39-like27241.2350.4231No
65GPNMBNAGPNMB
Entrez,  Source
glycoprotein (transmembrane) nmb27841.2170.4237No
66CROTNACROT
Entrez,  Source
carnitine O-octanoyltransferase29031.1820.4208No
67CSF2NACSF2
Entrez,  Source
colony stimulating factor 2 (granulocyte-macrophage)29191.1750.4238No
68DUSP6NADUSP6
Entrez,  Source
dual specificity phosphatase 630371.1360.4208No
69EVI5NAEVI5
Entrez,  Source
ecotropic viral integration site 531151.1130.4201No
70KIF5CNAKIF5C
Entrez,  Source
kinesin family member 5C31181.1120.4236No
71SATB1NASATB1
Entrez,  Source
special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's)32961.0600.4170No
72SPRY2NASPRY2
Entrez,  Source
sprouty homolog 2 (Drosophila)33311.0470.4185No
73HBEGFNAHBEGF
Entrez,  Source
heparin-binding EGF-like growth factor33711.0370.4196No
74TRAF1NATRAF1
Entrez,  Source
TNF receptor-associated factor 134081.0260.4209No
75HOXD11NAHOXD11
Entrez,  Source
homeobox D1135490.9860.4162No
76WDR33NAWDR33
Entrez,  Source
WD repeat domain 3335940.9720.4168No
77CBLNACBL
Entrez,  Source
Cas-Br-M (murine) ecotropic retroviral transforming sequence37860.9200.4091No
78APODNAAPOD
Entrez,  Source
apolipoprotein D44730.7540.3729No
79SCG3NASCG3
Entrez,  Source
secretogranin III45530.7370.3709No
80CMKLR1NACMKLR1
Entrez,  Source
chemokine-like receptor 145580.7360.3730No
81FGF9NAFGF9
Entrez,  Source
fibroblast growth factor 9 (glia-activating factor)45770.7310.3743No
82SNAP91NASNAP91
Entrez,  Source
synaptosomal-associated protein, 91kDa homolog (mouse)45820.7300.3765No
83TRIB2NATRIB2
Entrez,  Source
tribbles homolog 2 (Drosophila)46740.7090.3736No
84ANO1NA48170.6780.3678No
85PPP1R15ANAPPP1R15A
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 15A50310.6350.3579No
86AVL9NA50380.6350.3596No
87RGS16NARGS16
Entrez,  Source
regulator of G-protein signalling 1652060.6030.3521No
88SLPINASLPI
Entrez,  Source
secretory leukocyte peptidase inhibitor57530.5080.3231No
89NINNANIN
Entrez,  Source
ninein (GSK3B interacting protein)60020.4670.3106No
90DNMBPNADNMBP
Entrez,  Source
dynamin binding protein60080.4660.3119No
91SPON1NASPON1
Entrez,  Source
spondin 1, extracellular matrix protein60270.4630.3123No
92CD37NACD37
Entrez,  Source
CD37 molecule61820.4340.3051No
93CBR4NACBR4
Entrez,  Source
carbonyl reductase 462130.4270.3048No
94IL33NA63090.4100.3007No
95PLAURNAPLAUR
Entrez,  Source
plasminogen activator, urokinase receptor63520.4020.2997No
96MAP7NAMAP7
Entrez,  Source
microtubule-associated protein 764540.3910.2953No
97AKT2NAAKT2
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 264980.3850.2941No
98TPH1NATPH1
Entrez,  Source
tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)67750.3450.2797No
99CLEC4ANACLEC4A
Entrez,  Source
C-type lectin domain family 4, member A71720.2910.2583No
100NR0B2NANR0B2
Entrez,  Source
nuclear receptor subfamily 0, group B, member 271960.2880.2580No
101ADAMDEC1NAADAMDEC1
Entrez,  Source
ADAM-like, decysin 173720.2650.2490No
102NAP1L2NANAP1L2
Entrez,  Source
nucleosome assembly protein 1-like 273770.2640.2496No
103RBP4NARBP4
Entrez,  Source
retinol binding protein 4, plasma75340.2500.2416No
104FLT4NAFLT4
Entrez,  Source
fms-related tyrosine kinase 476270.2400.2373No
105RBM4NARBM4
Entrez,  Source
RNA binding motif protein 476630.2360.2360No
106MMDNAMMD
Entrez,  Source
monocyte to macrophage differentiation-associated79700.2060.2195No
107ANKHNAANKH
Entrez,  Source
ankylosis, progressive homolog (mouse)84380.1580.1938No
108USP12NAUSP12
Entrez,  Source
ubiquitin specific peptidase 1284790.1550.1920No
109PTCD2NAPTCD2
Entrez,  Source
pentatricopeptide repeat domain 285320.1500.1896No
110GYPCNAGYPC
Entrez,  Source
glycophorin C (Gerbich blood group)86510.1380.1834No
111CCL20NACCL20
Entrez,  Source
chemokine (C-C motif) ligand 2087460.1270.1785No
112YRDCNAYRDC
Entrez,  Source
yrdC domain containing (E. coli)89800.1010.1657No
113HIST1H2BBNAHIST1H2BB
Entrez,  Source
histone cluster 1, H2bb91500.0840.1565No
114IL7RNAIL7R
Entrez,  Source
interleukin 7 receptor92580.0750.1507No
115ZNF277NAZNF277
Entrez,  Source
zinc finger protein 27793120.0690.1480No
116IL2RGNAIL2RG
Entrez,  Source
interleukin 2 receptor, gamma (severe combined immunodeficiency)95380.0470.1355No
117SPARCL1NASPARCL1
Entrez,  Source
SPARC-like 1 (mast9, hevin)95830.0430.1331No
118EPB41L3NAEPB41L3
Entrez,  Source
erythrocyte membrane protein band 4.1-like 397060.0250.1264No
119DCBLD2NADCBLD2
Entrez,  Source
discoidin, CUB and LCCL domain containing 297110.0250.1262No
120VWA5ANA97170.0230.1260No
121TMEM100NATMEM100
Entrez,  Source
transmembrane protein 10010462-0.0310.0843No
122WNT7ANAWNT7A
Entrez,  Source
wingless-type MMTV integration site family, member 7A10649-0.0450.0740No
123ATG10NAATG10
Entrez,  Source
ATG10 autophagy related 10 homolog (S. cerevisiae)10670-0.0460.0730No
124CBX8NACBX8
Entrez,  Source
chromobox homolog 8 (Pc class homolog, Drosophila)10854-0.0640.0629No
125MYCNNAMYCN
Entrez,  Source
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)10880-0.0660.0617No
126RABGAP1LNARABGAP1L
Entrez,  Source
RAB GTPase activating protein 1-like11222-0.1070.0429No
127PTBP2NAPTBP2
Entrez,  Source
polypyrimidine tract binding protein 211266-0.1110.0408No
128LAT2NALAT2
Entrez,  Source
linker for activation of T cells family, member 211285-0.1130.0402No
129NR1H4NANR1H4
Entrez,  Source
nuclear receptor subfamily 1, group H, member 411513-0.1340.0279No
130PEG3NAPEG3
Entrez,  Source
paternally expressed 311738-0.1600.0158No
131CFHR2NACFHR2
Entrez,  Source
complement factor H-related 211790-0.1680.0135No
132IKZF1NAIKZF1
Entrez,  Source
IKAROS family zinc finger 1 (Ikaros)11803-0.1690.0133No
133IL10RANAIL10RA
Entrez,  Source
interleukin 10 receptor, alpha12182-0.211-0.0072No
134ALDH1A2NAALDH1A2
Entrez,  Source
aldehyde dehydrogenase 1 family, member A212289-0.224-0.0125No
135TMEM176ANATMEM176A
Entrez,  Source
transmembrane protein 176A12344-0.231-0.0148No
136TNNT2NATNNT2
Entrez,  Source
troponin T type 2 (cardiac)12455-0.243-0.0202No
137STRNNASTRN
Entrez,  Source
striatin, calmodulin binding protein12820-0.294-0.0397No
138ARG1NAARG1
Entrez,  Source
arginase, liver12918-0.305-0.0441No
139MAFBNAMAFB
Entrez,  Source
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)13162-0.343-0.0567No
140PPBPNAPPBP
Entrez,  Source
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)13324-0.371-0.0646No
141IRF8NAIRF8
Entrez,  Source
interferon regulatory factor 813454-0.391-0.0706No
142IGFBP3NAIGFBP3
Entrez,  Source
insulin-like growth factor binding protein 313569-0.412-0.0756No
143TMEM176BNATMEM176B
Entrez,  Source
transmembrane protein 176B13720-0.441-0.0827No
144BPGMNABPGM
Entrez,  Source
2,3-bisphosphoglycerate mutase14516-0.595-0.1254No
145LIFNALIF
Entrez,  Source
leukemia inhibitory factor (cholinergic differentiation factor)14845-0.682-0.1417No
146FBXO4NAFBXO4
Entrez,  Source
F-box protein 414919-0.700-0.1435No
147CDADC1NACDADC1
Entrez,  Source
cytidine and dCMP deaminase domain containing 115012-0.724-0.1464No
148FCER1GNAFCER1G
Entrez,  Source
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide15054-0.735-0.1463No
149MAP3K1NAMAP3K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase 115137-0.755-0.1485No
150HDAC9NAHDAC9
Entrez,  Source
histone deacetylase 915340-0.816-0.1572No
151MMP10NAMMP10
Entrez,  Source
matrix metallopeptidase 10 (stromelysin 2)15579-0.888-0.1678No
152PSMB8NAPSMB8
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)15687-0.923-0.1708No
153USH1CNAUSH1C
Entrez,  Source
Usher syndrome 1C (autosomal recessive, severe)15729-0.941-0.1701No
154HSD11B1NAHSD11B1
Entrez,  Source
hydroxysteroid (11-beta) dehydrogenase 115732-0.941-0.1672No
155PLEK2NAPLEK2
Entrez,  Source
pleckstrin 216124-1.101-0.1856No
156SERPINA3NASERPINA3
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 316148-1.113-0.1833No
157C3AR1NAC3AR1
Entrez,  Source
complement component 3a receptor 116179-1.127-0.1814No
158MAP4K1NAMAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 116473-1.280-0.1937No
159SCG5NASCG5
Entrez,  Source
secretogranin V (7B2 protein)16542-1.330-0.1933No
160PDCD1LG2NAPDCD1LG2
Entrez,  Source
programmed cell death 1 ligand 216573-1.352-0.1906No
161ITGBL1NAITGBL1
Entrez,  Source
integrin, beta-like 1 (with EGF-like repeat domains)16834-1.532-0.2003No
162ETS1NAETS1
Entrez,  Source
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)16839-1.539-0.1956No
163TRIB1NATRIB1
Entrez,  Source
tribbles homolog 1 (Drosophila)16883-1.578-0.1929No
164PRDM1NAPRDM1
Entrez,  Source
PR domain containing 1, with ZNF domain16947-1.629-0.1912No
165CCND2NACCND2
Entrez,  Source
cyclin D216961-1.643-0.1867No
166ETV4NAETV4
Entrez,  Source
ets variant gene 4 (E1A enhancer binding protein, E1AF)16971-1.654-0.1819No
167G0S2NAG0S2
Entrez,  Source
G0/G1switch 216974-1.656-0.1767No
168TMEM158NATMEM158
Entrez,  Source
transmembrane protein 15817059-1.744-0.1758No
169GNG11NAGNG11
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma 1117066-1.755-0.1705No
170MMP11NAMMP11
Entrez,  Source
matrix metallopeptidase 11 (stromelysin 3)17076-1.766-0.1653No
171F13A1NAF13A1
Entrez,  Source
coagulation factor XIII, A1 polypeptide17085-1.773-0.1600No
172SOX9NASOX9
Entrez,  Source
SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)17093-1.781-0.1547No
173GFPT2NAGFPT2
Entrez,  Source
glutamine-fructose-6-phosphate transaminase 217096-1.783-0.1491No
174BMP2NABMP2
Entrez,  Source
bone morphogenetic protein 217210-1.924-0.1493No
175MTMR10NAMTMR10
Entrez,  Source
myotubularin related protein 1017298-2.036-0.1476No
176PTPRRNAPTPRR
Entrez,  Source
protein tyrosine phosphatase, receptor type, R17316-2.071-0.1419No
177TNFAIP3NATNFAIP3
Entrez,  Source
tumor necrosis factor, alpha-induced protein 317406-2.248-0.1397No
178ITGB2NAITGB2
Entrez,  Source
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)17429-2.286-0.1336No
179ALDH1A3NAALDH1A3
Entrez,  Source
aldehyde dehydrogenase 1 family, member A317463-2.345-0.1279No
180ACENAACE
Entrez,  Source
angiotensin I converting enzyme (peptidyl-dipeptidase A) 117524-2.491-0.1232No
181LAPTM5NALAPTM5
Entrez,  Source
lysosomal associated multispanning membrane protein 517716-3.205-0.1237No
182MPZL2NA17751-3.419-0.1146No
183MMP9NAMMP9
Entrez,  Source
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)17814-3.845-0.1057No
184SDCCAG8NASDCCAG8
Entrez,  Source
serologically defined colon cancer antigen 817819-3.881-0.0935No
185AKAP12NAAKAP12
Entrez,  Source
A kinase (PRKA) anchor protein (gravin) 1217828-3.943-0.0812No
186IL1BNAIL1B
Entrez,  Source
interleukin 1, beta17833-3.984-0.0687No
187CTSSNACTSS
Entrez,  Source
cathepsin S17858-4.107-0.0568No
188INHBANAINHBA
Entrez,  Source
inhibin, beta A (activin A, activin AB alpha polypeptide)17958-4.886-0.0467No
189GABRA3NAGABRA3
Entrez,  Source
gamma-aminobutyric acid (GABA) A receptor, alpha 317962-4.908-0.0310No
190ENGNAENG
Entrez,  Source
endoglin (Osler-Rendu-Weber syndrome 1)17972-4.949-0.0156No
191LCP1NALCP1
Entrez,  Source
lymphocyte cytosolic protein 1 (L-plastin)17977-4.9850.0002No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_KRAS_SIGNALING_UP   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_KRAS_SIGNALING_UP: Random ES distribution   
Gene set null distribution of ES for HALLMARK_KRAS_SIGNALING_UP