Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_KRAS_SIGNALING_DN
Enrichment Score (ES)0.40470827
Normalized Enrichment Score (NES)1.4451293
Nominal p-value0.002317497
FDR q-value0.037327453
FWER p-Value0.372
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_KRAS_SIGNALING_DN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1EFHD1NAEFHD1
Entrez,  Source
EF-hand domain family, member D164.9560.0283Yes
2GPRC5CNAGPRC5C
Entrez,  Source
G protein-coupled receptor, family C, group 5, member C164.9130.0563Yes
3AKR1B10NAAKR1B10
Entrez,  Source
aldo-keto reductase family 1, member B10 (aldose reductase)1134.4640.0767Yes
4SERPINB2NASERPINB2
Entrez,  Source
serpin peptidase inhibitor, clade B (ovalbumin), member 21444.3530.1002Yes
5CYP39A1NACYP39A1
Entrez,  Source
cytochrome P450, family 39, subfamily A, polypeptide 12753.8240.1151Yes
6RSAD2NARSAD2
Entrez,  Source
radical S-adenosyl methionine domain containing 23303.6490.1331Yes
7CAMK1DNACAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID3713.5220.1513Yes
8MFSD6NA3753.5170.1715Yes
9IFI44LNAIFI44L
Entrez,  Source
interferon-induced protein 44-like4723.2080.1846Yes
10FGFR3NAFGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)4893.1670.2021Yes
11FAM46CNAFAM46C
Entrez,  Source
family with sequence similarity 46, member C5722.9900.2148Yes
12PTPRJNAPTPRJ
Entrez,  Source
protein tyrosine phosphatase, receptor type, J5822.9650.2314Yes
13NR4A2NANR4A2
Entrez,  Source
nuclear receptor subfamily 4, group A, member 25872.9560.2483Yes
14MTHFRNAMTHFR
Entrez,  Source
5,10-methylenetetrahydrofolate reductase (NADPH)6312.8680.2625Yes
15BMPR1BNABMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB6742.8020.2764Yes
16THRBNATHRB
Entrez,  Source
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)6962.7580.2911Yes
17EGFNAEGF
Entrez,  Source
epidermal growth factor (beta-urogastrone)7342.6770.3046Yes
18SKILNASKIL
Entrez,  Source
SKI-like8302.5410.3139Yes
19LFNGNALFNG
Entrez,  Source
lunatic fringe homolog (Drosophila)9342.4180.3221Yes
20SLC29A3NASLC29A3
Entrez,  Source
solute carrier family 29 (nucleoside transporters), member 39592.3800.3346Yes
21KRT15NAKRT15
Entrez,  Source
keratin 159972.3420.3460Yes
22KCND1NAKCND1
Entrez,  Source
potassium voltage-gated channel, Shal-related subfamily, member 110962.2250.3534Yes
23SYNPONASYNPO
Entrez,  Source
synaptopodin12452.0910.3572Yes
24P2RX6NA12572.0790.3686Yes
25EPHA5NAEPHA5
Entrez,  Source
EPH receptor A513422.0000.3755Yes
26MX1NAMX1
Entrez,  Source
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)15871.8170.3723Yes
27CCDC106NACCDC106
Entrez,  Source
coiled-coil domain containing 10618291.6500.3683Yes
28GAMTNAGAMT
Entrez,  Source
guanidinoacetate N-methyltransferase18881.6210.3744Yes
29TGM1NATGM1
Entrez,  Source
transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)21701.4630.3671Yes
30RYR2NARYR2
Entrez,  Source
ryanodine receptor 2 (cardiac)22941.4170.3684Yes
31TGFB2NATGFB2
Entrez,  Source
transforming growth factor, beta 223021.4140.3762Yes
32TAS2R4NATAS2R4
Entrez,  Source
taste receptor, type 2, member 424301.3570.3769Yes
33P2RY4NAP2RY4
Entrez,  Source
pyrimidinergic receptor P2Y, G-protein coupled, 424391.3510.3843Yes
34PAX3NAPAX3
Entrez,  Source
paired box gene 3 (Waardenburg syndrome 1)24421.3490.3920Yes
35HSD11B2NAHSD11B2
Entrez,  Source
hydroxysteroid (11-beta) dehydrogenase 224591.3400.3988Yes
36PKP1NAPKP1
Entrez,  Source
plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)24921.3280.4047Yes
37SLC16A7NASLC16A7
Entrez,  Source
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)29201.1750.3875No
38ENTPD7NAENTPD7
Entrez,  Source
ectonucleoside triphosphate diphosphohydrolase 730871.1210.3847No
39TFF2NATFF2
Entrez,  Source
trefoil factor 2 (spasmolytic protein 1)33911.0300.3736No
40CPEB3NACPEB3
Entrez,  Source
cytoplasmic polyadenylation element binding protein 337840.9200.3569No
41SLC38A3NASLC38A3
Entrez,  Source
solute carrier family 38, member 340130.8650.3491No
42GP1BANAGP1BA
Entrez,  Source
glycoprotein Ib (platelet), alpha polypeptide40880.8450.3499No
43ADRA2CNAADRA2C
Entrez,  Source
adrenergic, alpha-2C-, receptor41110.8390.3535No
44IDUANAIDUA
Entrez,  Source
iduronidase, alpha-L-42510.8030.3503No
45ALOX12BNAALOX12B
Entrez,  Source
arachidonate 12-lipoxygenase, 12R type45560.7360.3375No
46NPHS1NANPHS1
Entrez,  Source
nephrosis 1, congenital, Finnish type (nephrin)46580.7120.3359No
47COPZ2NACOPZ2
Entrez,  Source
coatomer protein complex, subunit zeta 247910.6850.3325No
48NOS1NANOS1
Entrez,  Source
nitric oxide synthase 1 (neuronal)50440.6330.3220No
49KRT4NAKRT4
Entrez,  Source
keratin 453100.5830.3105No
50IL12BNAIL12B
Entrez,  Source
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)53560.5760.3113No
51BARD1NABARD1
Entrez,  Source
BRCA1 associated RING domain 153920.5680.3126No
52MYO15ANAMYO15A
Entrez,  Source
myosin XVA54700.5540.3115No
53SHOX2NASHOX2
Entrez,  Source
short stature homeobox 256450.5270.3048No
54SLC6A3NASLC6A3
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, dopamine), member 357170.5140.3038No
55GP2NAGP2
Entrez,  Source
glycoprotein 2 (zymogen granule membrane)59600.4740.2929No
56WNT16NAWNT16
Entrez,  Source
wingless-type MMTV integration site family, member 1660300.4620.2917No
57CD80NACD80
Entrez,  Source
CD80 molecule60650.4570.2924No
58CLDN16NACLDN16
Entrez,  Source
claudin 1661110.4480.2925No
59COL2A1NACOL2A1
Entrez,  Source
collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)62080.4280.2896No
60AMBNNAAMBN
Entrez,  Source
ameloblastin (enamel matrix protein)64180.3950.2801No
61SLC5A5NASLC5A5
Entrez,  Source
solute carrier family 5 (sodium iodide symporter), member 564270.3950.2820No
62CHRNGNACHRNG
Entrez,  Source
cholinergic receptor, nicotinic, gamma64440.3930.2833No
63IGFBP2NAIGFBP2
Entrez,  Source
insulin-like growth factor binding protein 2, 36kDa66270.3680.2752No
64STAG3NASTAG3
Entrez,  Source
stromal antigen 368320.3390.2658No
65H2AFY2NAH2AFY2
Entrez,  Source
H2A histone family, member Y269390.3240.2617No
66TEX15NATEX15
Entrez,  Source
testis expressed sequence 1570780.3060.2557No
67FGF16NAFGF16
Entrez,  Source
fibroblast growth factor 1670790.3050.2575No
68PLAG1NAPLAG1
Entrez,  Source
pleiomorphic adenoma gene 172520.2800.2494No
69RIBC2NARIBC2
Entrez,  Source
RIB43A domain with coiled-coils 273520.2670.2454No
70CAPN9NACAPN9
Entrez,  Source
calpain 975440.2490.2361No
71CCR8NACCR8
Entrez,  Source
chemokine (C-C motif) receptor 875550.2480.2370No
72SNCBNASNCB
Entrez,  Source
synuclein, beta76060.2420.2356No
73CD40LGNACD40LG
Entrez,  Source
CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome)76090.2420.2369No
74CLPSNACLPS
Entrez,  Source
colipase, pancreatic76480.2380.2361No
75HTR1BNAHTR1B
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 1B76650.2360.2366No
76IRS4NAIRS4
Entrez,  Source
insulin receptor substrate 476920.2350.2365No
77ZBTB16NAZBTB16
Entrez,  Source
zinc finger and BTB domain containing 1678970.2150.2263No
78INSL5NAINSL5
Entrez,  Source
insulin-like 579820.2040.2227No
79YPEL1NAYPEL1
Entrez,  Source
yippee-like 1 (Drosophila)82170.1750.2106No
80ARHGDIGNAARHGDIG
Entrez,  Source
Rho GDP dissociation inhibitor (GDI) gamma82890.1700.2076No
81CCNA1NACCNA1
Entrez,  Source
cyclin A183100.1680.2074No
82CDKAL1NACDKAL1
Entrez,  Source
CDK5 regulatory subunit associated protein 1-like 184500.1570.2005No
83CNTFRNACNTFR
Entrez,  Source
ciliary neurotrophic factor receptor84520.1560.2014No
84CALCBNACALCB
Entrez,  Source
calcitonin-related polypeptide, beta84610.1560.2018No
85CKMNACKM
Entrez,  Source
creatine kinase, muscle84680.1560.2024No
86RYR1NARYR1
Entrez,  Source
ryanodine receptor 1 (skeletal)84870.1540.2023No
87SOX10NASOX10
Entrez,  Source
SRY (sex determining region Y)-box 1085130.1510.2017No
88CLDN8NACLDN8
Entrez,  Source
claudin 886020.1430.1976No
89PDK2NAPDK2
Entrez,  Source
pyruvate dehydrogenase kinase, isozyme 286500.1390.1958No
90MAST3NAMAST3
Entrez,  Source
microtubule associated serine/threonine kinase 386730.1360.1953No
91ACTC1NAACTC1
Entrez,  Source
actin, alpha, cardiac muscle 189450.1050.1807No
92CLSTN3NACLSTN3
Entrez,  Source
calsyntenin 389710.1020.1799No
93KRT13NAKRT13
Entrez,  Source
keratin 1392270.0750.1660No
94MSH5NAMSH5
Entrez,  Source
mutS homolog 5 (E. coli)92830.0730.1634No
95PDE6BNAPDE6B
Entrez,  Source
phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant)93030.0700.1627No
96GPR3NAGPR3
Entrez,  Source
G protein-coupled receptor 393060.0700.1630No
97KCNQ2NAKCNQ2
Entrez,  Source
potassium voltage-gated channel, KQT-like subfamily, member 293530.0660.1608No
98FSHBNAFSHB
Entrez,  Source
follicle stimulating hormone, beta polypeptide94420.0570.1562No
99MEFVNAMEFV
Entrez,  Source
Mediterranean fever96200.0380.1465No
100ABCB11NAABCB11
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 1197750.0140.1379No
101NRIP2NANRIP2
Entrez,  Source
nuclear receptor interacting protein 298800.0000.1320No
102RGS11NARGS11
Entrez,  Source
regulator of G-protein signalling 1199040.0000.1308No
103CALML5NACALML5
Entrez,  Source
calmodulin-like 599120.0000.1304No
104SSTR4NASSTR4
Entrez,  Source
somatostatin receptor 499260.0000.1296No
105NGBNANGB
Entrez,  Source
neuroglobin99690.0000.1273No
106KCNMB1NAKCNMB1
Entrez,  Source
potassium large conductance calcium-activated channel, subfamily M, beta member 199990.0000.1256No
107NTF3NANTF3
Entrez,  Source
neurotrophin 3100000.0000.1256No
108KRT1NAKRT1
Entrez,  Source
keratin 1 (epidermolytic hyperkeratosis)100630.0000.1222No
109KCNN1NAKCNN1
Entrez,  Source
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 110228-0.0080.1130No
110SCGB1A1NASCGB1A1
Entrez,  Source
secretoglobin, family 1A, member 1 (uteroglobin)10369-0.0220.1053No
111SLC6A14NASLC6A14
Entrez,  Source
solute carrier family 6 (amino acid transporter), member 1410390-0.0230.1043No
112SMPXNASMPX
Entrez,  Source
small muscle protein, X-linked10408-0.0250.1035No
113CDH16NACDH16
Entrez,  Source
cadherin 16, KSP-cadherin10480-0.0310.0996No
114CACNG1NACACNG1
Entrez,  Source
calcium channel, voltage-dependent, gamma subunit 110482-0.0310.0998No
115MYH7NAMYH7
Entrez,  Source
myosin, heavy chain 7, cardiac muscle, beta10490-0.0310.0995No
116CHST2NACHST2
Entrez,  Source
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 210600-0.0420.0937No
117NUDT11NANUDT11
Entrez,  Source
nudix (nucleoside diphosphate linked moiety X)-type motif 1110694-0.0500.0887No
118KLK7NAKLK7
Entrez,  Source
kallikrein 7 (chymotryptic, stratum corneum)10723-0.0530.0875No
119CACNA1FNACACNA1F
Entrez,  Source
calcium channel, voltage-dependent, alpha 1F subunit10725-0.0530.0877No
120SCN10ANASCN10A
Entrez,  Source
sodium channel, voltage-gated, type X, alpha10769-0.0550.0856No
121ITIH3NAITIH3
Entrez,  Source
inter-alpha (globulin) inhibitor H310912-0.0710.0780No
122PAX4NAPAX4
Entrez,  Source
paired box gene 410976-0.0780.0750No
123THNSL2NA10981-0.0790.0752No
124C5NAC5
Entrez,  Source
complement component 511052-0.0860.0718No
125EDN2NAEDN2
Entrez,  Source
endothelin 211108-0.0930.0692No
126KLHDC8ANAKLHDC8A
Entrez,  Source
kelch domain containing 8A11238-0.1080.0626No
127KRT5NAKRT5
Entrez,  Source
keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)11484-0.1310.0496No
128GTF3C5NAGTF3C5
Entrez,  Source
general transcription factor IIIC, polypeptide 5, 63kDa11629-0.1470.0423No
129IFNGNAIFNG
Entrez,  Source
interferon, gamma11661-0.1500.0415No
130TGNATG
Entrez,  Source
thyroglobulin12062-0.1970.0201No
131SERPINA10NASERPINA10
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1012138-0.2050.0171No
132SLC12A3NASLC12A3
Entrez,  Source
solute carrier family 12 (sodium/chloride transporters), member 312141-0.2060.0182No
133EDARNAEDAR
Entrez,  Source
ectodysplasin A receptor12183-0.2110.0171No
134TSHBNATSHB
Entrez,  Source
thyroid stimulating hormone, beta12191-0.2120.0179No
135OXTNAOXT
Entrez,  Source
oxytocin, prepro- (neurophysin I)12232-0.2180.0170No
136YBX2NAYBX2
Entrez,  Source
Y box binding protein 212258-0.2200.0168No
137SPHK2NASPHK2
Entrez,  Source
sphingosine kinase 212261-0.2210.0180No
138CPA2NACPA2
Entrez,  Source
carboxypeptidase A2 (pancreatic)12337-0.2310.0151No
139CPB1NACPB1
Entrez,  Source
carboxypeptidase B1 (tissue)12383-0.2360.0140No
140ATP4ANAATP4A
Entrez,  Source
ATPase, H+/K+ exchanging, alpha polypeptide12413-0.2390.0137No
141PDCD1NAPDCD1
Entrez,  Source
programmed cell death 112716-0.278-0.0017No
142ARPP21NA12733-0.281-0.0009No
143DTNBNADTNB
Entrez,  Source
dystrobrevin, beta13390-0.380-0.0356No
144TFAP2BNATFAP2B
Entrez,  Source
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)13503-0.400-0.0396No
145GDNFNAGDNF
Entrez,  Source
glial cell derived neurotrophic factor13536-0.405-0.0390No
146MYOTNAMYOT
Entrez,  Source
myotilin13575-0.412-0.0388No
147FGGYNA13703-0.435-0.0434No
148NR6A1NANR6A1
Entrez,  Source
nuclear receptor subfamily 6, group A, member 113801-0.453-0.0462No
149DLK2NA13969-0.484-0.0528No
150GRID2NAGRID2
Entrez,  Source
glutamate receptor, ionotropic, delta 214449-0.583-0.0763No
151TLX1NATLX1
Entrez,  Source
T-cell leukemia homeobox 114454-0.583-0.0732No
152CELSR2NACELSR2
Entrez,  Source
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)14633-0.625-0.0795No
153PRODHNAPRODH
Entrez,  Source
proline dehydrogenase (oxidase) 114745-0.657-0.0820No
154PNMTNAPNMT
Entrez,  Source
phenylethanolamine N-methyltransferase14803-0.670-0.0813No
155KCNE2NAKCNE2
Entrez,  Source
potassium voltage-gated channel, Isk-related family, member 214924-0.700-0.0840No
156ABCG4NAABCG4
Entrez,  Source
ATP-binding cassette, sub-family G (WHITE), member 415031-0.729-0.0857No
157SLC25A23NASLC25A23
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 2315307-0.806-0.0965No
158CYP11B2NACYP11B2
Entrez,  Source
cytochrome P450, family 11, subfamily B, polypeptide 215521-0.872-0.1034No
159SIDT1NASIDT1
Entrez,  Source
SID1 transmembrane family, member 115575-0.887-0.1013No
160SPTBN2NASPTBN2
Entrez,  Source
spectrin, beta, non-erythrocytic 215953-1.028-0.1165No
161ASB7NAASB7
Entrez,  Source
ankyrin repeat and SOCS box-containing 715956-1.029-0.1107No
162UPK3BNAUPK3B
Entrez,  Source
uroplakin 3B16009-1.049-0.1075No
163PTGFRNAPTGFR
Entrez,  Source
prostaglandin F receptor (FP)16251-1.170-0.1143No
164BRDTNABRDT
Entrez,  Source
bromodomain, testis-specific16546-1.333-0.1231No
165GPR19NAGPR19
Entrez,  Source
G protein-coupled receptor 1916648-1.392-0.1207No
166SNNNASNN
Entrez,  Source
stannin16798-1.506-0.1203No
167HTR1DNAHTR1D
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 1D16908-1.596-0.1172No
168LYPD3NALYPD3
Entrez,  Source
LY6/PLAUR domain containing 316966-1.649-0.1109No
169EDN1NAEDN1
Entrez,  Source
endothelin 117057-1.741-0.1059No
170ITGB1BP2NAITGB1BP2
Entrez,  Source
integrin beta 1 binding protein (melusin) 217112-1.801-0.0985No
171HNF1ANA17149-1.844-0.0898No
172ATP6V1B1NAATP6V1B1
Entrez,  Source
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (Renal tubular acidosis with deafness)17260-1.990-0.0845No
173TFCP2L1NATFCP2L1
Entrez,  Source
transcription factor CP2-like 117280-2.013-0.0739No
174TNNI3NATNNI3
Entrez,  Source
troponin I type 3 (cardiac)17367-2.155-0.0663No
175DCCNADCC
Entrez,  Source
deleted in colorectal carcinoma17418-2.268-0.0559No
176CD207NACD207
Entrez,  Source
CD207 molecule, langerin17531-2.513-0.0477No
177SLC30A3NASLC30A3
Entrez,  Source
solute carrier family 30 (zinc transporter), member 317577-2.650-0.0349No
178TCF7L1NATCF7L1
Entrez,  Source
transcription factor 7-like 1 (T-cell specific, HMG-box)17581-2.658-0.0197No
179SGK1NA17686-3.097-0.0076No
180BTG2NABTG2
Entrez,  Source
BTG family, member 217866-4.1540.0064No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_KRAS_SIGNALING_DN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_KRAS_SIGNALING_DN: Random ES distribution   
Gene set null distribution of ES for HALLMARK_KRAS_SIGNALING_DN