Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | HALLMARK_INTERFERON_ALPHA_RESPONSE |
| Enrichment Score (ES) | 0.5651078 |
| Normalized Enrichment Score (NES) | 1.8582567 |
| Nominal p-value | 0.0 |
| FDR q-value | 4.318182E-4 |
| FWER p-Value | 0.001 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CD74 | NA | CD74 Entrez, Source | CD74 molecule, major histocompatibility complex, class II invariant chain | 3 | 4.961 | 0.0318 | Yes |
| 2 | BST2 | NA | BST2 Entrez, Source | bone marrow stromal cell antigen 2 | 29 | 4.845 | 0.0617 | Yes |
| 3 | CSF1 | NA | CSF1 Entrez, Source | colony stimulating factor 1 (macrophage) | 88 | 4.556 | 0.0878 | Yes |
| 4 | IFIT2 | NA | IFIT2 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 2 | 118 | 4.441 | 0.1149 | Yes |
| 5 | OASL | NA | OASL Entrez, Source | 2'-5'-oligoadenylate synthetase-like | 194 | 4.125 | 0.1373 | Yes |
| 6 | IFIT3 | NA | IFIT3 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 3 | 216 | 4.035 | 0.1622 | Yes |
| 7 | GMPR | NA | GMPR Entrez, Source | guanosine monophosphate reductase | 259 | 3.873 | 0.1848 | Yes |
| 8 | ISG15 | NA | ISG15 Entrez, Source | ISG15 ubiquitin-like modifier | 266 | 3.856 | 0.2093 | Yes |
| 9 | IFIH1 | NA | IFIH1 Entrez, Source | interferon induced with helicase C domain 1 | 279 | 3.809 | 0.2332 | Yes |
| 10 | RSAD2 | NA | RSAD2 Entrez, Source | radical S-adenosyl methionine domain containing 2 | 330 | 3.649 | 0.2540 | Yes |
| 11 | IFI44 | NA | IFI44 Entrez, Source | interferon-induced protein 44 | 386 | 3.489 | 0.2734 | Yes |
| 12 | SAMD9L | NA | SAMD9L Entrez, Source | sterile alpha motif domain containing 9-like | 400 | 3.462 | 0.2950 | Yes |
| 13 | GBP2 | NA | GBP2 Entrez, Source | guanylate binding protein 2, interferon-inducible | 448 | 3.285 | 0.3136 | Yes |
| 14 | IFI44L | NA | IFI44L Entrez, Source | interferon-induced protein 44-like | 472 | 3.208 | 0.3330 | Yes |
| 15 | SAMD9 | NA | SAMD9 Entrez, Source | sterile alpha motif domain containing 9 | 475 | 3.200 | 0.3535 | Yes |
| 16 | DDX60 | NA | 505 | 3.125 | 0.3721 | Yes | ||
| 17 | SELL | NA | SELL Entrez, Source | selectin L (lymphocyte adhesion molecule 1) | 519 | 3.105 | 0.3914 | Yes |
| 18 | CCRL2 | NA | CCRL2 Entrez, Source | chemokine (C-C motif) receptor-like 2 | 584 | 2.961 | 0.4069 | Yes |
| 19 | HERC6 | NA | HERC6 Entrez, Source | hect domain and RLD 6 | 607 | 2.907 | 0.4244 | Yes |
| 20 | DHX58 | NA | 609 | 2.906 | 0.4431 | Yes | ||
| 21 | USP18 | NA | USP18 Entrez, Source | ubiquitin specific peptidase 18 | 711 | 2.736 | 0.4551 | Yes |
| 22 | RTP4 | NA | RTP4 Entrez, Source | receptor transporter protein 4 | 799 | 2.585 | 0.4669 | Yes |
| 23 | CASP1 | NA | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 1001 | 2.338 | 0.4708 | Yes |
| 24 | FAM46A | NA | FAM46A Entrez, Source | family with sequence similarity 46, member A | 1037 | 2.287 | 0.4836 | Yes |
| 25 | GBP4 | NA | GBP4 Entrez, Source | guanylate binding protein 4 | 1139 | 2.181 | 0.4920 | Yes |
| 26 | CXCL10 | NA | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 1224 | 2.107 | 0.5009 | Yes |
| 27 | IRF7 | NA | IRF7 Entrez, Source | interferon regulatory factor 7 | 1322 | 2.023 | 0.5085 | Yes |
| 28 | CXCL11 | NA | CXCL11 Entrez, Source | chemokine (C-X-C motif) ligand 11 | 1398 | 1.950 | 0.5169 | Yes |
| 29 | LAMP3 | NA | LAMP3 Entrez, Source | lysosomal-associated membrane protein 3 | 1401 | 1.950 | 0.5294 | Yes |
| 30 | NCOA7 | NA | NCOA7 Entrez, Source | nuclear receptor coactivator 7 | 1507 | 1.880 | 0.5356 | Yes |
| 31 | OAS1 | NA | OAS1 Entrez, Source | 2',5'-oligoadenylate synthetase 1, 40/46kDa | 1556 | 1.840 | 0.5448 | Yes |
| 32 | MX1 | NA | MX1 Entrez, Source | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 1587 | 1.817 | 0.5549 | Yes |
| 33 | IL7 | NA | IL7 Entrez, Source | interleukin 7 | 1756 | 1.692 | 0.5564 | Yes |
| 34 | TRIM26 | NA | TRIM26 Entrez, Source | tripartite motif-containing 26 | 2107 | 1.494 | 0.5465 | Yes |
| 35 | PARP12 | NA | PARP12 Entrez, Source | poly (ADP-ribose) polymerase family, member 12 | 2462 | 1.340 | 0.5353 | Yes |
| 36 | PSME1 | NA | PSME1 Entrez, Source | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 2769 | 1.222 | 0.5261 | Yes |
| 37 | SP110 | NA | SP110 Entrez, Source | SP110 nuclear body protein | 2785 | 1.217 | 0.5331 | Yes |
| 38 | CASP8 | NA | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 2796 | 1.214 | 0.5404 | Yes |
| 39 | UBE2L6 | NA | UBE2L6 Entrez, Source | ubiquitin-conjugating enzyme E2L 6 | 2895 | 1.184 | 0.5425 | Yes |
| 40 | STAT2 | NA | STAT2 Entrez, Source | signal transducer and activator of transcription 2, 113kDa | 2947 | 1.166 | 0.5472 | Yes |
| 41 | IFI30 | NA | IFI30 Entrez, Source | interferon, gamma-inducible protein 30 | 2977 | 1.155 | 0.5530 | Yes |
| 42 | MOV10 | NA | MOV10 Entrez, Source | Mov10, Moloney leukemia virus 10, homolog (mouse) | 3128 | 1.109 | 0.5518 | Yes |
| 43 | CD47 | NA | CD47 Entrez, Source | CD47 molecule | 3144 | 1.105 | 0.5581 | Yes |
| 44 | LAP3 | NA | LAP3 Entrez, Source | leucine aminopeptidase 3 | 3147 | 1.104 | 0.5651 | Yes |
| 45 | IRF1 | NA | IRF1 Entrez, Source | interferon regulatory factor 1 | 3355 | 1.041 | 0.5603 | No |
| 46 | EIF2AK2 | NA | EIF2AK2 Entrez, Source | eukaryotic translation initiation factor 2-alpha kinase 2 | 3448 | 1.016 | 0.5617 | No |
| 47 | NUB1 | NA | NUB1 Entrez, Source | negative regulator of ubiquitin-like proteins 1 | 3582 | 0.976 | 0.5605 | No |
| 48 | RNF31 | NA | RNF31 Entrez, Source | ring finger protein 31 | 3729 | 0.934 | 0.5584 | No |
| 49 | TDRD7 | NA | TDRD7 Entrez, Source | tudor domain containing 7 | 3780 | 0.921 | 0.5615 | No |
| 50 | TRIM25 | NA | TRIM25 Entrez, Source | tripartite motif-containing 25 | 4151 | 0.829 | 0.5462 | No |
| 51 | WARS | NA | WARS Entrez, Source | tryptophanyl-tRNA synthetase | 4277 | 0.798 | 0.5444 | No |
| 52 | PSME2 | NA | PSME2 Entrez, Source | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | 4336 | 0.785 | 0.5462 | No |
| 53 | TRIM5 | NA | TRIM5 Entrez, Source | tripartite motif-containing 5 | 4544 | 0.738 | 0.5394 | No |
| 54 | HLA-C | NA | HLA-C Entrez, Source | major histocompatibility complex, class I, C | 4653 | 0.713 | 0.5379 | No |
| 55 | ISG20 | NA | ISG20 Entrez, Source | interferon stimulated exonuclease gene 20kDa | 4734 | 0.698 | 0.5380 | No |
| 56 | CNP | NA | CNP Entrez, Source | 2',3'-cyclic nucleotide 3' phosphodiesterase | 4770 | 0.689 | 0.5404 | No |
| 57 | EPSTI1 | NA | EPSTI1 Entrez, Source | epithelial stromal interaction 1 (breast) | 4792 | 0.684 | 0.5437 | No |
| 58 | CMPK2 | NA | 4943 | 0.652 | 0.5395 | No | ||
| 59 | LGALS3BP | NA | LGALS3BP Entrez, Source | lectin, galactoside-binding, soluble, 3 binding protein | 4976 | 0.645 | 0.5419 | No |
| 60 | TXNIP | NA | TXNIP Entrez, Source | thioredoxin interacting protein | 5242 | 0.597 | 0.5309 | No |
| 61 | LPAR6 | NA | 5499 | 0.550 | 0.5202 | No | ||
| 62 | NMI | NA | NMI Entrez, Source | N-myc (and STAT) interactor | 5629 | 0.529 | 0.5164 | No |
| 63 | TRIM21 | NA | TRIM21 Entrez, Source | tripartite motif-containing 21 | 5910 | 0.485 | 0.5038 | No |
| 64 | TRAFD1 | NA | TRAFD1 Entrez, Source | TRAF-type zinc finger domain containing 1 | 5996 | 0.467 | 0.5021 | No |
| 65 | PSMA3 | NA | PSMA3 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 3 | 6042 | 0.460 | 0.5025 | No |
| 66 | IRF9 | NA | 7114 | 0.299 | 0.4446 | No | ||
| 67 | TAP1 | NA | TAP1 Entrez, Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 8046 | 0.197 | 0.3938 | No |
| 68 | PROCR | NA | PROCR Entrez, Source | protein C receptor, endothelial (EPCR) | 8224 | 0.175 | 0.3851 | No |
| 69 | SLC25A28 | NA | SLC25A28 Entrez, Source | solute carrier family 25, member 28 | 8486 | 0.154 | 0.3715 | No |
| 70 | RIPK2 | NA | RIPK2 Entrez, Source | receptor-interacting serine-threonine kinase 2 | 9024 | 0.096 | 0.3421 | No |
| 71 | OGFR | NA | OGFR Entrez, Source | opioid growth factor receptor | 9460 | 0.057 | 0.3181 | No |
| 72 | ADAR | NA | ADAR Entrez, Source | adenosine deaminase, RNA-specific | 9569 | 0.045 | 0.3124 | No |
| 73 | TMEM140 | NA | TMEM140 Entrez, Source | transmembrane protein 140 | 9684 | 0.028 | 0.3062 | No |
| 74 | PARP14 | NA | PARP14 Entrez, Source | poly (ADP-ribose) polymerase family, member 14 | 10773 | -0.056 | 0.2457 | No |
| 75 | TRIM14 | NA | TRIM14 Entrez, Source | tripartite motif-containing 14 | 10792 | -0.058 | 0.2451 | No |
| 76 | IFI35 | NA | IFI35 Entrez, Source | interferon-induced protein 35 | 11838 | -0.173 | 0.1878 | No |
| 77 | B2M | NA | B2M Entrez, Source | beta-2-microglobulin | 11935 | -0.184 | 0.1836 | No |
| 78 | IL15 | NA | IL15 Entrez, Source | interleukin 15 | 12477 | -0.247 | 0.1549 | No |
| 79 | PARP9 | NA | PARP9 Entrez, Source | poly (ADP-ribose) polymerase family, member 9 | 14190 | -0.529 | 0.0626 | No |
| 80 | IRF2 | NA | IRF2 Entrez, Source | interferon regulatory factor 2 | 14428 | -0.579 | 0.0531 | No |
| 81 | ELF1 | NA | ELF1 Entrez, Source | E74-like factor 1 (ets domain transcription factor) | 14909 | -0.697 | 0.0308 | No |
| 82 | IL4R | NA | IL4R Entrez, Source | interleukin 4 receptor | 15445 | -0.844 | 0.0063 | No |
| 83 | PNPT1 | NA | PNPT1 Entrez, Source | polyribonucleotide nucleotidyltransferase 1 | 15458 | -0.850 | 0.0111 | No |
| 84 | PSMB8 | NA | PSMB8 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | 15687 | -0.923 | 0.0043 | No |
| 85 | IFITM1 | NA | IFITM1 Entrez, Source | interferon induced transmembrane protein 1 (9-27) | 16005 | -1.047 | -0.0066 | No |
| 86 | PLSCR1 | NA | PLSCR1 Entrez, Source | phospholipid scramblase 1 | 16511 | -1.310 | -0.0264 | No |
| 87 | UBA7 | NA | 16774 | -1.485 | -0.0315 | No | ||
| 88 | LY6E | NA | LY6E Entrez, Source | lymphocyte antigen 6 complex, locus E | 16836 | -1.538 | -0.0250 | No |
| 89 | IFITM3 | NA | IFITM3 Entrez, Source | interferon induced transmembrane protein 3 (1-8U) | 17099 | -1.789 | -0.0281 | No |
| 90 | PSMB9 | NA | PSMB9 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) | 17189 | -1.900 | -0.0208 | No |
| 91 | C1S | NA | C1S Entrez, Source | complement component 1, s subcomponent | 17464 | -2.349 | -0.0210 | No |
| 92 | BATF2 | NA | BATF2 Entrez, Source | basic leucine zipper transcription factor, ATF-like 2 | 17495 | -2.417 | -0.0070 | No |
| 93 | IFITM2 | NA | IFITM2 Entrez, Source | interferon induced transmembrane protein 2 (1-8D) | 17573 | -2.638 | 0.0057 | No |
| 94 | IFI27 | NA | IFI27 Entrez, Source | interferon, alpha-inducible protein 27 | 17575 | -2.640 | 0.0226 | No |
