Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_INFLAMMATORY_RESPONSE
Enrichment Score (ES)0.43403617
Normalized Enrichment Score (NES)1.5550778
Nominal p-value0.0
FDR q-value0.01397753
FWER p-Value0.101
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_INFLAMMATORY_RESPONSE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1BST2NABST2
Entrez,  Source
bone marrow stromal cell antigen 2294.8450.0165Yes
2EREGNAEREG
Entrez,  Source
epiregulin534.7310.0330Yes
3ICOSLGNAICOSLG
Entrez,  Source
inducible T-cell co-stimulator ligand814.5950.0487Yes
4TLR2NATLR2
Entrez,  Source
toll-like receptor 2844.5700.0657Yes
5CSF1NACSF1
Entrez,  Source
colony stimulating factor 1 (macrophage)884.5560.0826Yes
6PCDH7NAPCDH7
Entrez,  Source
BH-protocadherin (brain-heart)904.5520.0996Yes
7TNFSF10NATNFSF10
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 101084.4970.1155Yes
8SLC4A4NASLC4A4
Entrez,  Source
solute carrier family 4, sodium bicarbonate cotransporter, member 41364.3830.1304Yes
9IL1R1NAIL1R1
Entrez,  Source
interleukin 1 receptor, type I1414.3590.1465Yes
10LPAR1NA1614.2730.1614Yes
11P2RY2NAP2RY2
Entrez,  Source
purinergic receptor P2Y, G-protein coupled, 22134.0530.1737Yes
12TNFSF9NATNFSF9
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 92843.7940.1840Yes
13IL18NAIL18
Entrez,  Source
interleukin 18 (interferon-gamma-inducing factor)3383.6230.1946Yes
14PTGER2NAPTGER2
Entrez,  Source
prostaglandin E receptor 2 (subtype EP2), 53kDa3403.6170.2081Yes
15CD55NACD55
Entrez,  Source
CD55 molecule, decay accelerating factor for complement (Cromer blood group)3443.5990.2214Yes
16CD14NACD14
Entrez,  Source
CD14 molecule4023.4560.2312Yes
17SELLNASELL
Entrez,  Source
selectin L (lymphocyte adhesion molecule 1)5193.1050.2363Yes
18CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)5223.1000.2478Yes
19SGMS2NA5583.0270.2572Yes
20F3NAF3
Entrez,  Source
coagulation factor III (thromboplastin, tissue factor)5762.9790.2674Yes
21CCRL2NACCRL2
Entrez,  Source
chemokine (C-C motif) receptor-like 25842.9610.2781Yes
22FZD5NAFZD5
Entrez,  Source
frizzled homolog 5 (Drosophila)5922.9470.2887Yes
23NDPNANDP
Entrez,  Source
Norrie disease (pseudoglioma)6652.8140.2952Yes
24SLC7A2NASLC7A2
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 26862.7890.3045Yes
25IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)6902.7780.3148Yes
26AHRNAAHR
Entrez,  Source
aryl hydrocarbon receptor7962.5890.3186Yes
27RTP4NARTP4
Entrez,  Source
receptor transporter protein 47992.5850.3282Yes
28ICAM4NAICAM4
Entrez,  Source
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)8902.4720.3324Yes
29TNFRSF1BNATNFRSF1B
Entrez,  Source
tumor necrosis factor receptor superfamily, member 1B9002.4560.3411Yes
30VIPNAVIP
Entrez,  Source
vasoactive intestinal peptide9792.3620.3455Yes
31NAMPTNA10172.3150.3521Yes
32SERPINE1NASERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 110512.2680.3588Yes
33METNAMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)10522.2680.3673Yes
34KIF1BNAKIF1B
Entrez,  Source
kinesin family member 1B11702.1510.3687Yes
35CXCL10NACXCL10
Entrez,  Source
chemokine (C-X-C motif) ligand 1012242.1070.3737Yes
36FPR1NAFPR1
Entrez,  Source
formyl peptide receptor 112322.1000.3811Yes
37OPRK1NAOPRK1
Entrez,  Source
opioid receptor, kappa 112462.0900.3882Yes
38TPBGNATPBG
Entrez,  Source
trophoblast glycoprotein13112.0330.3923Yes
39IRF7NAIRF7
Entrez,  Source
interferon regulatory factor 713222.0230.3993Yes
40SCN1BNASCN1B
Entrez,  Source
sodium channel, voltage-gated, type I, beta13352.0090.4061Yes
41ADORA2BNAADORA2B
Entrez,  Source
adenosine A2b receptor13491.9920.4129Yes
42MMP14NAMMP14
Entrez,  Source
matrix metallopeptidase 14 (membrane-inserted)13831.9690.4184Yes
43CXCL11NACXCL11
Entrez,  Source
chemokine (C-X-C motif) ligand 1113981.9500.4249Yes
44LAMP3NALAMP3
Entrez,  Source
lysosomal-associated membrane protein 314011.9500.4321Yes
45ACVR2ANAACVR2A
Entrez,  Source
activin A receptor, type IIA14931.8860.4340Yes
46RNF144BNA16891.7430.4296No
47SLC31A2NASLC31A2
Entrez,  Source
solute carrier family 31 (copper transporters), member 219201.6040.4227No
48TAPBPNATAPBP
Entrez,  Source
TAP binding protein (tapasin)21391.4750.4159No
49TIMP1NATIMP1
Entrez,  Source
TIMP metallopeptidase inhibitor 121841.4550.4189No
50ATP2B1NAATP2B1
Entrez,  Source
ATPase, Ca++ transporting, plasma membrane 122631.4250.4199No
51SELENASELE
Entrez,  Source
selectin E (endothelial adhesion molecule 1)23831.3780.4183No
52CALCRLNACALCRL
Entrez,  Source
calcitonin receptor-like25631.2950.4131No
53PVRNAPVR
Entrez,  Source
poliovirus receptor26451.2650.4133No
54GPR132NAGPR132
Entrez,  Source
G protein-coupled receptor 13227811.2180.4103No
55CCR7NACCR7
Entrez,  Source
chemokine (C-C motif) receptor 730931.1180.3970No
56TLR1NATLR1
Entrez,  Source
toll-like receptor 132451.0760.3925No
57PSEN1NAPSEN1
Entrez,  Source
presenilin 1 (Alzheimer disease 3)32901.0620.3940No
58HIF1ANAHIF1A
Entrez,  Source
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)33371.0460.3954No
59OSMRNAOSMR
Entrez,  Source
oncostatin M receptor33451.0440.3989No
60IRF1NAIRF1
Entrez,  Source
interferon regulatory factor 133551.0410.4023No
61HBEGFNAHBEGF
Entrez,  Source
heparin-binding EGF-like growth factor33711.0370.4053No
62EIF2AK2NAEIF2AK2
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 234481.0160.4049No
63SLC31A1NASLC31A1
Entrez,  Source
solute carrier family 31 (copper transporters), member 134911.0020.4063No
64RASGRP1NARASGRP1
Entrez,  Source
RAS guanyl releasing protein 1 (calcium and DAG-regulated)35930.9730.4042No
65SEMA4DNASEMA4D
Entrez,  Source
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D36130.9640.4068No
66GABBR1NAGABBR1
Entrez,  Source
gamma-aminobutyric acid (GABA) B receptor, 139800.8720.3895No
67AXLNAAXL
Entrez,  Source
AXL receptor tyrosine kinase39930.8690.3920No
68LCKNALCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase40120.8650.3943No
69GP1BANAGP1BA
Entrez,  Source
glycoprotein Ib (platelet), alpha polypeptide40880.8450.3932No
70IFNAR1NAIFNAR1
Entrez,  Source
interferon (alpha, beta and omega) receptor 141720.8230.3916No
71PDPNNAPDPN
Entrez,  Source
podoplanin41850.8210.3940No
72CD69NACD69
Entrez,  Source
CD69 molecule42130.8120.3956No
73CMKLR1NACMKLR1
Entrez,  Source
chemokine-like receptor 145580.7360.3790No
74ITGA5NAITGA5
Entrez,  Source
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)45730.7320.3809No
75ITGB3NAITGB3
Entrez,  Source
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)46150.7220.3813No
76KCNJ2NAKCNJ2
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 246800.7070.3804No
77LCP2NALCP2
Entrez,  Source
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)46830.7070.3829No
78SLC1A2NASLC1A2
Entrez,  Source
solute carrier family 1 (glial high affinity glutamate transporter), member 246980.7040.3848No
79APLNRNA47280.6990.3858No
80EMP3NAEMP3
Entrez,  Source
epithelial membrane protein 349010.6620.3786No
81CCL5NACCL5
Entrez,  Source
chemokine (C-C motif) ligand 551080.6220.3693No
82RGS16NARGS16
Entrez,  Source
regulator of G-protein signalling 1652060.6030.3661No
83IL12BNAIL12B
Entrez,  Source
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)53560.5760.3599No
84IL15RANAIL15RA
Entrez,  Source
interleukin 15 receptor, alpha53820.5700.3606No
85TACR1NATACR1
Entrez,  Source
tachykinin receptor 153930.5680.3622No
86PTAFRNAPTAFR
Entrez,  Source
platelet-activating factor receptor54390.5590.3618No
87LTANALTA
Entrez,  Source
lymphotoxin alpha (TNF superfamily, member 1)54800.5530.3616No
88MXD1NAMXD1
Entrez,  Source
MAX dimerization protein 155000.5500.3626No
89NMINANMI
Entrez,  Source
N-myc (and STAT) interactor56290.5290.3574No
90HPNNAHPN
Entrez,  Source
hepsin (transmembrane protease, serine 1)57280.5120.3538No
91CSF3RNACSF3R
Entrez,  Source
colony stimulating factor 3 receptor (granulocyte)57950.5010.3519No
92RHOGNARHOG
Entrez,  Source
ras homolog gene family, member G (rho G)58350.4960.3516No
93PLAURNAPLAUR
Entrez,  Source
plasminogen activator, urokinase receptor63520.4020.3241No
94GNA15NAGNA15
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)66770.3600.3072No
95C5AR1NAC5AR1
Entrez,  Source
complement component 5a receptor 167160.3530.3064No
96FFAR2NAFFAR2
Entrez,  Source
free fatty acid receptor 268720.3330.2989No
97GNAI3NAGNAI3
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 369120.3270.2980No
98CCL17NACCL17
Entrez,  Source
chemokine (C-C motif) ligand 1769360.3240.2979No
99ADMNAADM
Entrez,  Source
adrenomedullin70460.3100.2929No
100SLAMF1NASLAMF1
Entrez,  Source
signaling lymphocytic activation molecule family member 171390.2960.2889No
101IFNGR2NAIFNGR2
Entrez,  Source
interferon gamma receptor 2 (interferon gamma transducer 1)71500.2940.2894No
102P2RX7NAP2RX7
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 771510.2940.2905No
103CCL7NACCL7
Entrez,  Source
chemokine (C-C motif) ligand 772260.2840.2874No
104CD70NA73190.2720.2832No
105ADRM1NAADRM1
Entrez,  Source
adhesion regulating molecule 176210.2410.2672No
106ABI1NAABI1
Entrez,  Source
abl-interactor 178030.2230.2579No
107CXCL9NACXCL9
Entrez,  Source
chemokine (C-X-C motif) ligand 981560.1810.2388No
108SLC11A2NASLC11A2
Entrez,  Source
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 282800.1710.2325No
109NMUR1NANMUR1
Entrez,  Source
neuromedin U receptor 182980.1700.2322No
110STAB1NASTAB1
Entrez,  Source
stabilin 183770.1640.2284No
111ATP2A2NAATP2A2
Entrez,  Source
ATPase, Ca++ transporting, cardiac muscle, slow twitch 285210.1500.2209No
112KCNMB2NAKCNMB2
Entrez,  Source
potassium large conductance calcium-activated channel, subfamily M, beta member 285240.1500.2214No
113BDKRB1NABDKRB1
Entrez,  Source
bradykinin receptor B186670.1370.2139No
114CCL20NACCL20
Entrez,  Source
chemokine (C-C motif) ligand 2087460.1270.2100No
115KLF6NAKLF6
Entrez,  Source
Kruppel-like factor 687640.1240.2095No
116ROS1NAROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)89540.1030.1993No
117RIPK2NARIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 290240.0960.1957No
118CXCR6NACXCR6
Entrez,  Source
chemokine (C-X-C motif) receptor 691560.0840.1887No
119KCNA3NAKCNA3
Entrez,  Source
potassium voltage-gated channel, shaker-related subfamily, member 392000.0780.1866No
120IL7RNAIL7R
Entrez,  Source
interleukin 7 receptor92580.0750.1836No
121IL18RAPNAIL18RAP
Entrez,  Source
interleukin 18 receptor accessory protein92660.0740.1835No
122CCL24NACCL24
Entrez,  Source
chemokine (C-C motif) ligand 2493570.0660.1787No
123GPC3NAGPC3
Entrez,  Source
glypican 393850.0640.1774No
124OLR1NAOLR1
Entrez,  Source
oxidised low density lipoprotein (lectin-like) receptor 194170.0590.1759No
125OSMNAOSM
Entrez,  Source
oncostatin M94500.0570.1743No
126LYNNALYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog94980.0530.1719No
127MEFVNAMEFV
Entrez,  Source
Mediterranean fever96200.0380.1652No
128NPFFR2NANPFFR2
Entrez,  Source
neuropeptide FF receptor 297070.0250.1605No
129DCBLD2NADCBLD2
Entrez,  Source
discoidin, CUB and LCCL domain containing 297110.0250.1604No
130ICAM1NAICAM1
Entrez,  Source
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor97160.0230.1603No
131NFKBIANANFKBIA
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha97930.0120.1560No
132IL10NAIL10
Entrez,  Source
interleukin 1098030.0100.1556No
133PIK3R5NAPIK3R5
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 5, p10198450.0040.1533No
134TACR3NATACR3
Entrez,  Source
tachykinin receptor 3100420.0000.1423No
135LDLRNALDLR
Entrez,  Source
low density lipoprotein receptor (familial hypercholesterolemia)10241-0.0100.1312No
136CCL22NACCL22
Entrez,  Source
chemokine (C-C motif) ligand 2210385-0.0220.1232No
137AQP9NAAQP9
Entrez,  Source
aquaporin 910466-0.0310.1188No
138CX3CL1NACX3CL1
Entrez,  Source
chemokine (C-X3-C motif) ligand 110558-0.0360.1138No
139CHST2NACHST2
Entrez,  Source
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 210600-0.0420.1117No
140TNFAIP6NATNFAIP6
Entrez,  Source
tumor necrosis factor, alpha-induced protein 610656-0.0460.1088No
141GPR183NA10671-0.0470.1082No
142PTGER4NAPTGER4
Entrez,  Source
prostaglandin E receptor 4 (subtype EP4)10716-0.0520.1059No
143CLEC5ANACLEC5A
Entrez,  Source
C-type lectin domain family 5, member A10719-0.0520.1060No
144RELANARELA
Entrez,  Source
v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)10834-0.0620.0998No
145PDE4BNAPDE4B
Entrez,  Source
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)10926-0.0740.0949No
146ACVR1BNAACVR1B
Entrez,  Source
activin A receptor, type IB11143-0.0980.0832No
147TLR3NATLR3
Entrez,  Source
toll-like receptor 311270-0.1110.0765No
148CXCL6NACXCL6
Entrez,  Source
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)11409-0.1250.0692No
149IL18R1NAIL18R1
Entrez,  Source
interleukin 18 receptor 111507-0.1340.0642No
150RGS1NARGS1
Entrez,  Source
regulator of G-protein signalling 111586-0.1430.0604No
151BEST1NA11858-0.1760.0458No
152IRAK2NAIRAK2
Entrez,  Source
interleukin-1 receptor-associated kinase 212088-0.1990.0337No
153IL10RANAIL10RA
Entrez,  Source
interleukin 10 receptor, alpha12182-0.2110.0293No
154GCH1NAGCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)12220-0.2160.0280No
155MARCONAMARCO
Entrez,  Source
macrophage receptor with collagenous structure12385-0.2360.0196No
156IL15NAIL15
Entrez,  Source
interleukin 1512477-0.2470.0154No
157HRH1NAHRH1
Entrez,  Source
histamine receptor H112617-0.2660.0086No
158SRINASRI
Entrez,  Source
sorcin12661-0.2720.0072No
159MEP1ANAMEP1A
Entrez,  Source
meprin A, alpha (PABA peptide hydrolase)12942-0.309-0.0074No
160ATP2C1NAATP2C1
Entrez,  Source
ATPase, Ca++ transporting, type 2C, member 113012-0.321-0.0100No
161NOD2NA13329-0.371-0.0264No
162ITGB8NAITGB8
Entrez,  Source
integrin, beta 813357-0.375-0.0265No
163SLC28A2NASLC28A2
Entrez,  Source
solute carrier family 28 (sodium-coupled nucleoside transporter), member 213759-0.446-0.0474No
164RAF1NARAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 113760-0.446-0.0457No
165TNFRSF9NATNFRSF9
Entrez,  Source
tumor necrosis factor receptor superfamily, member 914406-0.575-0.0798No
166PROK2NAPROK2
Entrez,  Source
prokineticin 214473-0.588-0.0814No
167CCL2NACCL2
Entrez,  Source
chemokine (C-C motif) ligand 214501-0.592-0.0807No
168LIFNALIF
Entrez,  Source
leukemia inhibitory factor (cholinergic differentiation factor)14845-0.682-0.0974No
169CD48NACD48
Entrez,  Source
CD48 molecule14917-0.699-0.0988No
170MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)15151-0.760-0.1090No
171NFKB1NANFKB1
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)15399-0.833-0.1198No
172IL4RNAIL4R
Entrez,  Source
interleukin 4 receptor15445-0.844-0.1191No
173IFITM1NAIFITM1
Entrez,  Source
interferon induced transmembrane protein 1 (9-27)16005-1.047-0.1467No
174C3AR1NAC3AR1
Entrez,  Source
complement component 3a receptor 116179-1.127-0.1522No
175CD82NACD82
Entrez,  Source
CD82 molecule16441-1.265-0.1621No
176SLC7A1NASLC7A1
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 116731-1.455-0.1729No
177LY6ENALY6E
Entrez,  Source
lymphocyte antigen 6 complex, locus E16836-1.538-0.1730No
178EDN1NAEDN1
Entrez,  Source
endothelin 117057-1.741-0.1788No
179PTPRENAPTPRE
Entrez,  Source
protein tyrosine phosphatase, receptor type, E17162-1.862-0.1777No
180PTGIRNAPTGIR
Entrez,  Source
prostaglandin I2 (prostacyclin) receptor (IP)17279-2.012-0.1767No
181NLRP3NA17415-2.265-0.1758No
182P2RX4NAP2RX4
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 417444-2.314-0.1687No
183CYBBNACYBB
Entrez,  Source
cytochrome b-245, beta polypeptide (chronic granulomatous disease)17454-2.328-0.1605No
184ABCA1NAABCA1
Entrez,  Source
ATP-binding cassette, sub-family A (ABC1), member 117541-2.529-0.1558No
185SPHK1NASPHK1
Entrez,  Source
sphingosine kinase 117557-2.582-0.1470No
186IL2RBNAIL2RB
Entrez,  Source
interleukin 2 receptor, beta17603-2.732-0.1393No
187HAS2NAHAS2
Entrez,  Source
hyaluronan synthase 217641-2.871-0.1306No
188MSR1NAMSR1
Entrez,  Source
macrophage scavenger receptor 117671-3.042-0.1209No
189CD40NACD40
Entrez,  Source
CD40 molecule, TNF receptor superfamily member 517681-3.081-0.1098No
190SCARF1NASCARF1
Entrez,  Source
scavenger receptor class F, member 117684-3.092-0.0983No
191IL1BNAIL1B
Entrez,  Source
interleukin 1, beta17833-3.984-0.0917No
192EBI3NAEBI3
Entrez,  Source
Epstein-Barr virus induced gene 317838-3.997-0.0770No
193BTG2NABTG2
Entrez,  Source
BTG family, member 217866-4.154-0.0629No
194IL1ANAIL1A
Entrez,  Source
interleukin 1, alpha17880-4.259-0.0477No
195TNFSF15NATNFSF15
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 1517905-4.488-0.0322No
196CSF3NACSF3
Entrez,  Source
colony stimulating factor 3 (granulocyte)17948-4.815-0.0166No
197INHBANAINHBA
Entrez,  Source
inhibin, beta A (activin A, activin AB alpha polypeptide)17958-4.8860.0012No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_INFLAMMATORY_RESPONSE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_INFLAMMATORY_RESPONSE: Random ES distribution   
Gene set null distribution of ES for HALLMARK_INFLAMMATORY_RESPONSE