Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | HALLMARK_IL6_JAK_STAT3_SIGNALING |
| Enrichment Score (ES) | 0.46624398 |
| Normalized Enrichment Score (NES) | 1.5218295 |
| Nominal p-value | 0.0012515645 |
| FDR q-value | 0.018456317 |
| FWER p-Value | 0.161 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | TLR2 | NA | TLR2 Entrez, Source | toll-like receptor 2 | 84 | 4.570 | 0.0402 | Yes |
| 2 | CSF1 | NA | CSF1 Entrez, Source | colony stimulating factor 1 (macrophage) | 88 | 4.556 | 0.0847 | Yes |
| 3 | IL1R1 | NA | IL1R1 Entrez, Source | interleukin 1 receptor, type I | 141 | 4.359 | 0.1246 | Yes |
| 4 | CSF2RA | NA | CSF2RA Entrez, Source | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 148 | 4.333 | 0.1668 | Yes |
| 5 | HMOX1 | NA | HMOX1 Entrez, Source | heme oxygenase (decycling) 1 | 281 | 3.802 | 0.1967 | Yes |
| 6 | CRLF2 | NA | CRLF2 Entrez, Source | cytokine receptor-like factor 2 | 328 | 3.664 | 0.2301 | Yes |
| 7 | CD14 | NA | CD14 Entrez, Source | CD14 molecule | 402 | 3.456 | 0.2599 | Yes |
| 8 | TNFRSF21 | NA | TNFRSF21 Entrez, Source | tumor necrosis factor receptor superfamily, member 21 | 446 | 3.302 | 0.2899 | Yes |
| 9 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 690 | 2.778 | 0.3036 | Yes |
| 10 | FAS | NA | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 733 | 2.679 | 0.3275 | Yes |
| 11 | TNFRSF1B | NA | TNFRSF1B Entrez, Source | tumor necrosis factor receptor superfamily, member 1B | 900 | 2.456 | 0.3424 | Yes |
| 12 | CXCL10 | NA | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 1224 | 2.107 | 0.3450 | Yes |
| 13 | CXCL11 | NA | CXCL11 Entrez, Source | chemokine (C-X-C motif) ligand 11 | 1398 | 1.950 | 0.3545 | Yes |
| 14 | BAK1 | NA | BAK1 Entrez, Source | BCL2-antagonist/killer 1 | 1494 | 1.885 | 0.3677 | Yes |
| 15 | LEPR | NA | LEPR Entrez, Source | leptin receptor | 1604 | 1.804 | 0.3793 | Yes |
| 16 | IL7 | NA | IL7 Entrez, Source | interleukin 7 | 1756 | 1.692 | 0.3874 | Yes |
| 17 | STAT1 | NA | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 2025 | 1.543 | 0.3876 | Yes |
| 18 | CD9 | NA | CD9 Entrez, Source | CD9 molecule | 2046 | 1.529 | 0.4015 | Yes |
| 19 | TNFRSF1A | NA | TNFRSF1A Entrez, Source | tumor necrosis factor receptor superfamily, member 1A | 2326 | 1.403 | 0.3997 | Yes |
| 20 | PIM1 | NA | PIM1 Entrez, Source | pim-1 oncogene | 2508 | 1.320 | 0.4025 | Yes |
| 21 | IL6ST | NA | IL6ST Entrez, Source | interleukin 6 signal transducer (gp130, oncostatin M receptor) | 2573 | 1.292 | 0.4116 | Yes |
| 22 | STAM2 | NA | STAM2 Entrez, Source | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | 2632 | 1.270 | 0.4208 | Yes |
| 23 | IL1R2 | NA | IL1R2 Entrez, Source | interleukin 1 receptor, type II | 2880 | 1.188 | 0.4187 | Yes |
| 24 | CSF2 | NA | CSF2 Entrez, Source | colony stimulating factor 2 (granulocyte-macrophage) | 2919 | 1.175 | 0.4281 | Yes |
| 25 | STAT2 | NA | STAT2 Entrez, Source | signal transducer and activator of transcription 2, 113kDa | 2947 | 1.166 | 0.4380 | Yes |
| 26 | MAP3K8 | NA | MAP3K8 Entrez, Source | mitogen-activated protein kinase kinase kinase 8 | 2993 | 1.150 | 0.4468 | Yes |
| 27 | OSMR | NA | OSMR Entrez, Source | oncostatin M receptor | 3345 | 1.044 | 0.4374 | Yes |
| 28 | IRF1 | NA | IRF1 Entrez, Source | interferon regulatory factor 1 | 3355 | 1.041 | 0.4471 | Yes |
| 29 | TNFRSF12A | NA | TNFRSF12A Entrez, Source | tumor necrosis factor receptor superfamily, member 12A | 3527 | 0.990 | 0.4473 | Yes |
| 30 | CD38 | NA | CD38 Entrez, Source | CD38 molecule | 3611 | 0.965 | 0.4521 | Yes |
| 31 | CBL | NA | CBL Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 3786 | 0.920 | 0.4514 | Yes |
| 32 | CSF2RB | NA | CSF2RB Entrez, Source | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 4105 | 0.841 | 0.4419 | Yes |
| 33 | IFNAR1 | NA | IFNAR1 Entrez, Source | interferon (alpha, beta and omega) receptor 1 | 4172 | 0.823 | 0.4463 | Yes |
| 34 | LTBR | NA | LTBR Entrez, Source | lymphotoxin beta receptor (TNFR superfamily, member 3) | 4199 | 0.816 | 0.4529 | Yes |
| 35 | IL10RB | NA | IL10RB Entrez, Source | interleukin 10 receptor, beta | 4234 | 0.808 | 0.4589 | Yes |
| 36 | ITGA4 | NA | ITGA4 Entrez, Source | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | 4245 | 0.805 | 0.4662 | Yes |
| 37 | ITGB3 | NA | ITGB3 Entrez, Source | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 4615 | 0.722 | 0.4527 | No |
| 38 | PF4 | NA | PF4 Entrez, Source | platelet factor 4 (chemokine (C-X-C motif) ligand 4) | 5200 | 0.605 | 0.4260 | No |
| 39 | IL15RA | NA | IL15RA Entrez, Source | interleukin 15 receptor, alpha | 5382 | 0.570 | 0.4215 | No |
| 40 | HAX1 | NA | HAX1 Entrez, Source | HCLS1 associated protein X-1 | 5680 | 0.521 | 0.4100 | No |
| 41 | CSF3R | NA | CSF3R Entrez, Source | colony stimulating factor 3 receptor (granulocyte) | 5795 | 0.501 | 0.4085 | No |
| 42 | SOCS3 | NA | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 5999 | 0.467 | 0.4018 | No |
| 43 | TGFB1 | NA | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 6816 | 0.341 | 0.3595 | No |
| 44 | PTPN2 | NA | PTPN2 Entrez, Source | protein tyrosine phosphatase, non-receptor type 2 | 6865 | 0.334 | 0.3601 | No |
| 45 | JUN | NA | JUN Entrez, Source | jun oncogene | 7042 | 0.310 | 0.3533 | No |
| 46 | IRF9 | NA | 7114 | 0.299 | 0.3523 | No | ||
| 47 | IFNGR2 | NA | IFNGR2 Entrez, Source | interferon gamma receptor 2 (interferon gamma transducer 1) | 7150 | 0.294 | 0.3532 | No |
| 48 | CCL7 | NA | CCL7 Entrez, Source | chemokine (C-C motif) ligand 7 | 7226 | 0.284 | 0.3518 | No |
| 49 | CXCL9 | NA | CXCL9 Entrez, Source | chemokine (C-X-C motif) ligand 9 | 8156 | 0.181 | 0.3017 | No |
| 50 | IL2RA | NA | IL2RA Entrez, Source | interleukin 2 receptor, alpha | 8334 | 0.167 | 0.2934 | No |
| 51 | PTPN1 | NA | PTPN1 Entrez, Source | protein tyrosine phosphatase, non-receptor type 1 | 8424 | 0.159 | 0.2900 | No |
| 52 | CNTFR | NA | CNTFR Entrez, Source | ciliary neurotrophic factor receptor | 8452 | 0.156 | 0.2900 | No |
| 53 | CD36 | NA | CD36 Entrez, Source | CD36 molecule (thrombospondin receptor) | 9075 | 0.092 | 0.2562 | No |
| 54 | IL2RG | NA | IL2RG Entrez, Source | interleukin 2 receptor, gamma (severe combined immunodeficiency) | 9538 | 0.047 | 0.2308 | No |
| 55 | PIK3R5 | NA | PIK3R5 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 5, p101 | 9845 | 0.004 | 0.2138 | No |
| 56 | IL12RB1 | NA | IL12RB1 Entrez, Source | interleukin 12 receptor, beta 1 | 9980 | 0.000 | 0.2063 | No |
| 57 | CD44 | NA | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 10693 | -0.050 | 0.1670 | No |
| 58 | IL3RA | NA | IL3RA Entrez, Source | interleukin 3 receptor, alpha (low affinity) | 10696 | -0.050 | 0.1674 | No |
| 59 | ACVR1B | NA | ACVR1B Entrez, Source | activin A receptor, type IB | 11143 | -0.098 | 0.1434 | No |
| 60 | ACVRL1 | NA | ACVRL1 Entrez, Source | activin A receptor type II-like 1 | 11425 | -0.127 | 0.1289 | No |
| 61 | STAT3 | NA | STAT3 Entrez, Source | signal transducer and activator of transcription 3 (acute-phase response factor) | 11455 | -0.129 | 0.1286 | No |
| 62 | IL18R1 | NA | IL18R1 Entrez, Source | interleukin 18 receptor 1 | 11507 | -0.134 | 0.1270 | No |
| 63 | REG1A | NA | REG1A Entrez, Source | regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein) | 11745 | -0.161 | 0.1154 | No |
| 64 | PLA2G2A | NA | PLA2G2A Entrez, Source | phospholipase A2, group IIA (platelets, synovial fluid) | 11827 | -0.172 | 0.1125 | No |
| 65 | A2M | NA | A2M Entrez, Source | alpha-2-macroglobulin | 11895 | -0.180 | 0.1106 | No |
| 66 | IL17RB | NA | IL17RB Entrez, Source | interleukin 17 receptor B | 12002 | -0.190 | 0.1065 | No |
| 67 | GRB2 | NA | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 12056 | -0.196 | 0.1055 | No |
| 68 | IFNGR1 | NA | IFNGR1 Entrez, Source | interferon gamma receptor 1 | 12333 | -0.231 | 0.0923 | No |
| 69 | DNTT | NA | DNTT Entrez, Source | deoxynucleotidyltransferase, terminal | 12492 | -0.250 | 0.0859 | No |
| 70 | TNF | NA | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 12645 | -0.269 | 0.0801 | No |
| 71 | SOCS1 | NA | SOCS1 Entrez, Source | suppressor of cytokine signaling 1 | 12911 | -0.303 | 0.0682 | No |
| 72 | CXCL13 | NA | CXCL13 Entrez, Source | chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) | 12929 | -0.307 | 0.0703 | No |
| 73 | TYK2 | NA | TYK2 Entrez, Source | tyrosine kinase 2 | 13230 | -0.353 | 0.0570 | No |
| 74 | MYD88 | NA | MYD88 Entrez, Source | myeloid differentiation primary response gene (88) | 13247 | -0.356 | 0.0596 | No |
| 75 | PTPN11 | NA | PTPN11 Entrez, Source | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 14694 | -0.640 | -0.0149 | No |
| 76 | IL17RA | NA | IL17RA Entrez, Source | interleukin 17 receptor A | 15208 | -0.777 | -0.0360 | No |
| 77 | PDGFC | NA | PDGFC Entrez, Source | platelet derived growth factor C | 15242 | -0.785 | -0.0301 | No |
| 78 | IL4R | NA | IL4R Entrez, Source | interleukin 4 receptor | 15445 | -0.844 | -0.0331 | No |
| 79 | CCR1 | NA | CCR1 Entrez, Source | chemokine (C-C motif) receptor 1 | 15496 | -0.861 | -0.0275 | No |
| 80 | CXCL3 | NA | CXCL3 Entrez, Source | chemokine (C-X-C motif) ligand 3 | 15611 | -0.898 | -0.0250 | No |
| 81 | IL13RA1 | NA | IL13RA1 Entrez, Source | interleukin 13 receptor, alpha 1 | 15985 | -1.040 | -0.0357 | No |
| 82 | INHBE | NA | INHBE Entrez, Source | inhibin, beta E | 16082 | -1.076 | -0.0305 | No |
| 83 | IL9R | NA | IL9R Entrez, Source | interleukin 9 receptor | 16500 | -1.298 | -0.0410 | No |
| 84 | LTB | NA | LTB Entrez, Source | lymphotoxin beta (TNF superfamily, member 3) | 16882 | -1.578 | -0.0468 | No |
| 85 | CXCL1 | NA | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 17669 | -3.027 | -0.0611 | No |
| 86 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 17833 | -3.984 | -0.0311 | No |
| 87 | EBI3 | NA | EBI3 Entrez, Source | Epstein-Barr virus induced gene 3 | 17838 | -3.997 | 0.0079 | No |
