Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_HYPOXIA
Enrichment Score (ES)0.40562174
Normalized Enrichment Score (NES)1.4423729
Nominal p-value0.0058411215
FDR q-value0.03516633
FWER p-Value0.376
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_HYPOXIA   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1S100A4NAS100A4
Entrez,  Source
S100 calcium binding protein A41674.2130.0076Yes
2SELENBP1NASELENBP1
Entrez,  Source
selenium binding protein 12283.9920.0203Yes
3HMOX1NAHMOX1
Entrez,  Source
heme oxygenase (decycling) 12813.8020.0327Yes
4HS3ST1NAHS3ST1
Entrez,  Source
heparan sulfate (glucosamine) 3-O-sulfotransferase 13833.4980.0412Yes
5ANGPTL4NAANGPTL4
Entrez,  Source
angiopoietin-like 43883.4800.0550Yes
6GLRXNAGLRX
Entrez,  Source
glutaredoxin (thioltransferase)4433.3230.0653Yes
7GPC1NAGPC1
Entrez,  Source
glypican 14543.2570.0779Yes
8ATP7ANAATP7A
Entrez,  Source
ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome)4563.2510.0909Yes
9LOXNALOX
Entrez,  Source
lysyl oxidase4573.2480.1040Yes
10KLHL24NAKLHL24
Entrez,  Source
kelch-like 24 (Drosophila)4703.2130.1163Yes
11DTNANADTNA
Entrez,  Source
dystrobrevin, alpha4733.2010.1291Yes
12VLDLRNAVLDLR
Entrez,  Source
very low density lipoprotein receptor4773.1980.1418Yes
13CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)5223.1000.1519Yes
14F3NAF3
Entrez,  Source
coagulation factor III (thromboplastin, tissue factor)5762.9790.1609Yes
15ERRFI1NAERRFI1
Entrez,  Source
ERBB receptor feedback inhibitor 16272.8750.1697Yes
16PPARGC1ANAPPARGC1A
Entrez,  Source
peroxisome proliferative activated receptor, gamma, coactivator 1, alpha6402.8510.1805Yes
17MT2ANAMT2A
Entrez,  Source
metallothionein 2A6512.8340.1914Yes
18IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)6902.7780.2004Yes
19FOSL2NAFOSL2
Entrez,  Source
FOS-like antigen 27932.5920.2051Yes
20STBD1NA7972.5890.2154Yes
21PLIN2NA8132.5650.2249Yes
22MT1ENAMT1E
Entrez,  Source
metallothionein 1E (functional)8472.5190.2332Yes
23DDIT4NADDIT4
Entrez,  Source
DNA-damage-inducible transcript 48692.4910.2421Yes
24DDIT3NADDIT3
Entrez,  Source
DNA-damage-inducible transcript 38732.4850.2519Yes
25IER3NAIER3
Entrez,  Source
immediate early response 38802.4820.2616Yes
26PLAC8NAPLAC8
Entrez,  Source
placenta-specific 88882.4740.2712Yes
27BNIP3LNABNIP3L
Entrez,  Source
BCL2/adenovirus E1B 19kDa interacting protein 3-like8952.4610.2807Yes
28SERPINE1NASERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 110512.2680.2812Yes
29STC2NASTC2
Entrez,  Source
stanniocalcin 210652.2600.2896Yes
30CHST3NACHST3
Entrez,  Source
carbohydrate (chondroitin 6) sulfotransferase 311502.1650.2936Yes
31P4HA2NAP4HA2
Entrez,  Source
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II12092.1160.2988Yes
32TPBGNATPBG
Entrez,  Source
trophoblast glycoprotein13112.0330.3014Yes
33ADORA2BNAADORA2B
Entrez,  Source
adenosine A2b receptor13491.9920.3073Yes
34VEGFANA13541.9910.3151Yes
35ENO1NAENO1
Entrez,  Source
enolase 1, (alpha)13761.9720.3219Yes
36GCNT2NAGCNT2
Entrez,  Source
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)14211.9380.3272Yes
37CASP6NACASP6
Entrez,  Source
caspase 6, apoptosis-related cysteine peptidase14901.8880.3310Yes
38IDSNAIDS
Entrez,  Source
iduronate 2-sulfatase (Hunter syndrome)15061.8800.3377Yes
39TMEM45ANATMEM45A
Entrez,  Source
transmembrane protein 45A15421.8490.3432Yes
40CXCR4NACXCR4
Entrez,  Source
chemokine (C-X-C motif) receptor 415611.8360.3496Yes
41PRKCANAPRKCA
Entrez,  Source
protein kinase C, alpha15951.8100.3551Yes
42SLC6A6NASLC6A6
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, taurine), member 616131.7930.3613Yes
43COL5A1NACOL5A1
Entrez,  Source
collagen, type V, alpha 116311.7830.3676Yes
44NR3C1NANR3C1
Entrez,  Source
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)16601.7610.3731Yes
45SDC2NASDC2
Entrez,  Source
syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan)16651.7580.3800Yes
46CCNG2NACCNG2
Entrez,  Source
cyclin G217391.7110.3827Yes
47PHKG1NAPHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)18181.6540.3850Yes
48PGFNAPGF
Entrez,  Source
placental growth factor, vascular endothelial growth factor-related protein18731.6290.3886Yes
49PAMNAPAM
Entrez,  Source
peptidylglycine alpha-amidating monooxygenase18791.6260.3948Yes
50CSRP2NACSRP2
Entrez,  Source
cysteine and glycine-rich protein 219931.5580.3948Yes
51IGFBP1NAIGFBP1
Entrez,  Source
insulin-like growth factor binding protein 120591.5230.3973Yes
52TGFB3NATGFB3
Entrez,  Source
transforming growth factor, beta 322741.4220.3910Yes
53TESNATES
Entrez,  Source
testis derived transcript (3 LIM domains)23081.4120.3948Yes
54PKP1NAPKP1
Entrez,  Source
plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)24921.3280.3899Yes
55WISP2NAWISP2
Entrez,  Source
WNT1 inducible signaling pathway protein 225041.3230.3946Yes
56PIM1NAPIM1
Entrez,  Source
pim-1 oncogene25081.3200.3997Yes
57CYR61NACYR61
Entrez,  Source
cysteine-rich, angiogenic inducer, 6125761.2890.4012Yes
58NDST1NANDST1
Entrez,  Source
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 126191.2750.4039Yes
59CDKN1BNACDKN1B
Entrez,  Source
cyclin-dependent kinase inhibitor 1B (p27, Kip1)26801.2530.4056Yes
60ZFP36NAZFP36
Entrez,  Source
zinc finger protein 36, C3H type, homolog (mouse)28521.1970.4008No
61DUSP1NADUSP1
Entrez,  Source
dual specificity phosphatase 129921.1500.3977No
62SLC2A1NASLC2A1
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 130601.1280.3984No
63CPNACP
Entrez,  Source
ceruloplasmin (ferroxidase)30811.1220.4018No
64NDRG1NANDRG1
Entrez,  Source
N-myc downstream regulated gene 132951.0600.3941No
65TPST2NATPST2
Entrez,  Source
tyrosylprotein sulfotransferase 233621.0400.3946No
66EGFRNAEGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)34281.0200.3951No
67RBPJNA34411.0180.3985No
68NFIL3NANFIL3
Entrez,  Source
nuclear factor, interleukin 3 regulated34990.9990.3993No
69PGK1NAPGK1
Entrez,  Source
phosphoglycerate kinase 136910.9440.3924No
70HDLBPNAHDLBP
Entrez,  Source
high density lipoprotein binding protein (vigilin)37880.9200.3907No
71SLC2A3NASLC2A3
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 338710.9000.3897No
72HSPA5NAHSPA5
Entrez,  Source
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)39340.8840.3898No
73B3GALT6NAB3GALT6
Entrez,  Source
UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 639360.8830.3933No
74BCL2NABCL2
Entrez,  Source
B-cell CLL/lymphoma 240640.8510.3896No
75PFKPNAPFKP
Entrez,  Source
phosphofructokinase, platelet41120.8390.3903No
76TPD52NATPD52
Entrez,  Source
tumor protein D5244660.7560.3736No
77CITED2NACITED2
Entrez,  Source
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 245010.7480.3747No
78GAPDHNAGAPDH
Entrez,  Source
glyceraldehyde-3-phosphate dehydrogenase47070.7020.3660No
79ISG20NAISG20
Entrez,  Source
interferon stimulated exonuclease gene 20kDa47340.6980.3673No
80TIPARPNATIPARP
Entrez,  Source
TCDD-inducible poly(ADP-ribose) polymerase48460.6720.3638No
81B4GALNT2NAB4GALNT2
Entrez,  Source
beta-1,4-N-acetyl-galactosaminyl transferase 250110.6380.3571No
82PPP1R15ANAPPP1R15A
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 15A50310.6350.3586No
83SAP30NASAP30
Entrez,  Source
Sin3A-associated protein, 30kDa50730.6290.3589No
84GBE1NAGBE1
Entrez,  Source
glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage disease type IV)51730.6100.3558No
85MXI1NAMXI1
Entrez,  Source
MAX interactor 155760.5380.3353No
86PGM1NAPGM1
Entrez,  Source
phosphoglucomutase 156460.5260.3336No
87GPINAGPI
Entrez,  Source
glucose phosphate isomerase57760.5040.3283No
88ENO2NAENO2
Entrez,  Source
enolase 2 (gamma, neuronal)58710.4900.3250No
89HK1NAHK1
Entrez,  Source
hexokinase 160360.4610.3177No
90NDST2NANDST2
Entrez,  Source
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 263470.4040.3019No
91PLAURNAPLAUR
Entrez,  Source
plasminogen activator, urokinase receptor63520.4020.3033No
92PPP1R3CNAPPP1R3C
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 3C63720.4010.3038No
93PDK1NAPDK1
Entrez,  Source
pyruvate dehydrogenase kinase, isozyme 164840.3880.2992No
94DCNNADCN
Entrez,  Source
decorin65230.3820.2986No
95GPC4NAGPC4
Entrez,  Source
glypican 465270.3820.2999No
96STC1NASTC1
Entrez,  Source
stanniocalcin 165660.3760.2993No
97PCK1NAPCK1
Entrez,  Source
phosphoenolpyruvate carboxykinase 1 (soluble)66500.3640.2961No
98ALDOBNAALDOB
Entrez,  Source
aldolase B, fructose-bisphosphate67140.3540.2940No
99ALDOANAALDOA
Entrez,  Source
aldolase A, fructose-bisphosphate68570.3350.2874No
100NCANNA69180.3270.2853No
101PFKFB3NAPFKFB3
Entrez,  Source
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 369770.3190.2833No
102JUNNAJUN
Entrez,  Source
jun oncogene70420.3100.2810No
103ADMNAADM
Entrez,  Source
adrenomedullin70460.3100.2821No
104IRS2NAIRS2
Entrez,  Source
insulin receptor substrate 277370.2310.2442No
105DPYSL4NADPYSL4
Entrez,  Source
dihydropyrimidinase-like 477550.2280.2442No
106EFNA1NAEFNA1
Entrez,  Source
ephrin-A182760.1710.2156No
107KLF6NAKLF6
Entrez,  Source
Kruppel-like factor 687640.1240.1888No
108LDHANALDHA
Entrez,  Source
lactate dehydrogenase A89170.1070.1806No
109HAS1NAHAS1
Entrez,  Source
hyaluronan synthase 190580.0930.1732No
110PKLRNAPKLR
Entrez,  Source
pyruvate kinase, liver and RBC92030.0780.1654No
111GPC3NAGPC3
Entrez,  Source
glypican 393850.0640.1555No
112PRDX5NAPRDX5
Entrez,  Source
peroxiredoxin 594220.0580.1537No
113BGNNABGN
Entrez,  Source
biglycan96030.0390.1437No
114SULT2B1NASULT2B1
Entrez,  Source
sulfotransferase family, cytosolic, 2B, member 196160.0380.1432No
115SDC3NASDC3
Entrez,  Source
syndecan 3 (N-syndecan)98680.0020.1291No
116GCKNAGCK
Entrez,  Source
glucokinase (hexokinase 4, maturity onset diabetes of the young 2)99080.0000.1269No
117TKTL1NATKTL1
Entrez,  Source
transketolase-like 110481-0.0310.0949No
118TPI1NATPI1
Entrez,  Source
triosephosphate isomerase 110496-0.0310.0942No
119WSB1NAWSB1
Entrez,  Source
WD repeat and SOCS box-containing 110589-0.0400.0892No
120CHST2NACHST2
Entrez,  Source
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 210600-0.0420.0888No
121P4HA1NAP4HA1
Entrez,  Source
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I10896-0.0690.0725No
122SLC2A5NASLC2A5
Entrez,  Source
solute carrier family 2 (facilitated glucose/fructose transporter), member 511100-0.0920.0615No
123EDN2NAEDN2
Entrez,  Source
endothelin 211108-0.0930.0614No
124INHANAINHA
Entrez,  Source
inhibin, alpha11109-0.0930.0618No
125FOSNAFOS
Entrez,  Source
v-fos FBJ murine osteosarcoma viral oncogene homolog11142-0.0980.0604No
126GRHPRNAGRHPR
Entrez,  Source
glyoxylate reductase/hydroxypyruvate reductase11161-0.1000.0598No
127PGM2NAPGM2
Entrez,  Source
phosphoglucomutase 211441-0.1280.0446No
128JMJD6NA11916-0.1820.0187No
129PGAM2NAPGAM2
Entrez,  Source
phosphoglycerate mutase 2 (muscle)12188-0.2120.0043No
130BTG1NABTG1
Entrez,  Source
B-cell translocation gene 1, anti-proliferative12253-0.2200.0016No
131NAGKNANAGK
Entrez,  Source
N-acetylglucosamine kinase12273-0.2230.0015No
132CA12NACA12
Entrez,  Source
carbonic anhydrase XII12382-0.236-0.0037No
133ILVBLNAILVBL
Entrez,  Source
ilvB (bacterial acetolactate synthase)-like12429-0.240-0.0053No
134PNRC1NAPNRC1
Entrez,  Source
proline-rich nuclear receptor coactivator 112449-0.242-0.0054No
135SCARB1NASCARB1
Entrez,  Source
scavenger receptor class B, member 112515-0.254-0.0080No
136ANKZF1NAANKZF1
Entrez,  Source
ankyrin repeat and zinc finger domain containing 112726-0.280-0.0187No
137PFKLNAPFKL
Entrez,  Source
phosphofructokinase, liver12905-0.303-0.0275No
138MYH9NAMYH9
Entrez,  Source
myosin, heavy chain 9, non-muscle13051-0.325-0.0343No
139LDHCNALDHC
Entrez,  Source
lactate dehydrogenase C13278-0.362-0.0456No
140MAFFNAMAFF
Entrez,  Source
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)13323-0.371-0.0465No
141LALBANALALBA
Entrez,  Source
lactalbumin, alpha-13412-0.383-0.0499No
142FBP1NAFBP1
Entrez,  Source
fructose-1,6-bisphosphatase 113489-0.398-0.0526No
143KDELR3NAKDELR3
Entrez,  Source
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 313543-0.405-0.0539No
144IGFBP3NAIGFBP3
Entrez,  Source
insulin-like growth factor binding protein 313569-0.412-0.0537No
145FAM162ANA13618-0.420-0.0547No
146CAV1NACAV1
Entrez,  Source
caveolin 1, caveolae protein, 22kDa13813-0.455-0.0638No
147CTGFNACTGF
Entrez,  Source
connective tissue growth factor14025-0.495-0.0736No
148SDC4NASDC4
Entrez,  Source
syndecan 4 (amphiglycan, ryudocan)14353-0.563-0.0897No
149MIFNAMIF
Entrez,  Source
macrophage migration inhibitory factor (glycosylation-inhibiting factor)14383-0.569-0.0891No
150SIAH2NASIAH2
Entrez,  Source
seven in absentia homolog 2 (Drosophila)14605-0.620-0.0990No
151VHLNAVHL
Entrez,  Source
von Hippel-Lindau tumor suppressor14659-0.632-0.0994No
152GYS1NAGYS1
Entrez,  Source
glycogen synthase 1 (muscle)14691-0.639-0.0986No
153EXT1NAEXT1
Entrez,  Source
exostoses (multiple) 114735-0.656-0.0984No
154LXNNALXN
Entrez,  Source
latexin14777-0.664-0.0980No
155XPNPEP1NAXPNPEP1
Entrez,  Source
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble14857-0.685-0.0997No
156MAP3K1NAMAP3K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase 115137-0.755-0.1123No
157FOXO3NA15433-0.842-0.1255No
158CDKN1CNACDKN1C
Entrez,  Source
cyclin-dependent kinase inhibitor 1C (p57, Kip2)15437-0.843-0.1223No
159KIF5ANAKIF5A
Entrez,  Source
kinesin family member 5A15636-0.905-0.1298No
160AK4NA15673-0.916-0.1281No
161NEDD4LNANEDD4L
Entrez,  Source
neural precursor cell expressed, developmentally down-regulated 4-like15764-0.955-0.1293No
162GALK1NAGALK1
Entrez,  Source
galactokinase 115787-0.965-0.1266No
163RRAGDNARRAGD
Entrez,  Source
Ras-related GTP binding D15806-0.972-0.1237No
164HOXB9NAHOXB9
Entrez,  Source
homeobox B915988-1.041-0.1297No
165KDM3ANA16025-1.055-0.1275No
166SLC37A4NASLC37A4
Entrez,  Source
solute carrier family 37 (glycerol-6-phosphate transporter), member 416312-1.197-0.1387No
167PYGMNAPYGM
Entrez,  Source
phosphorylase, glycogen; muscle (McArdle syndrome, glycogen storage disease type V)16614-1.376-0.1501No
168SLC25A1NASLC25A1
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 116615-1.376-0.1446No
169ANXA2NAANXA2
Entrez,  Source
annexin A216655-1.397-0.1411No
170GAANAGAA
Entrez,  Source
glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II)16678-1.412-0.1367No
171GAPDHSNAGAPDHS
Entrez,  Source
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic16809-1.515-0.1379No
172ETS1NAETS1
Entrez,  Source
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)16839-1.539-0.1333No
173UGP2NAUGP2
Entrez,  Source
UDP-glucose pyrophosphorylase 216844-1.541-0.1273No
174ENO3NAENO3
Entrez,  Source
enolase 3 (beta, muscle)16943-1.626-0.1262No
175ZNF292NAZNF292
Entrez,  Source
zinc finger protein 29217015-1.698-0.1234No
176BHLHE40NA17041-1.724-0.1179No
177EFNA3NAEFNA3
Entrez,  Source
ephrin-A317103-1.792-0.1141No
178HK2NAHK2
Entrez,  Source
hexokinase 217109-1.798-0.1071No
179KLF7NAKLF7
Entrez,  Source
Kruppel-like factor 7 (ubiquitous)17175-1.886-0.1031No
180AMPD3NAAMPD3
Entrez,  Source
adenosine monophosphate deaminase (isoform E)17219-1.934-0.0978No
181SRPXNASRPX
Entrez,  Source
sushi-repeat-containing protein, X-linked17358-2.142-0.0969No
182HEXANAHEXA
Entrez,  Source
hexosaminidase A (alpha polypeptide)17383-2.194-0.0894No
183TNFAIP3NATNFAIP3
Entrez,  Source
tumor necrosis factor, alpha-induced protein 317406-2.248-0.0816No
184PDGFBNAPDGFB
Entrez,  Source
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)17514-2.462-0.0776No
185TGM2NATGM2
Entrez,  Source
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)17660-2.987-0.0738No
186PDK3NAPDK3
Entrez,  Source
pyruvate dehydrogenase kinase, isozyme 317674-3.051-0.0622No
187BCANNABCAN
Entrez,  Source
brevican17788-3.650-0.0538No
188ALDOCNAALDOC
Entrez,  Source
aldolase C, fructose-bisphosphate17800-3.718-0.0394No
189TGFBINATGFBI
Entrez,  Source
transforming growth factor, beta-induced, 68kDa17821-3.886-0.0249No
190AKAP12NAAKAP12
Entrez,  Source
A kinase (PRKA) anchor protein (gravin) 1217828-3.943-0.0093No
191RORANARORA
Entrez,  Source
RAR-related orphan receptor A17895-4.4230.0048No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_HYPOXIA   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_HYPOXIA: Random ES distribution   
Gene set null distribution of ES for HALLMARK_HYPOXIA