Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_G2M_CHECKPOINT
Enrichment Score (ES)-0.37568924
Normalized Enrichment Score (NES)-1.5810418
Nominal p-value0.0
FDR q-value0.010803551
FWER p-Value0.025
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_G2M_CHECKPOINT   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1HIST1H2BKNAHIST1H2BK
Entrez,  Source
histone cluster 1, H2bk6152.890-0.0149No
2MT2ANAMT2A
Entrez,  Source
metallothionein 2A6512.8340.0025No
3EGFNAEGF
Entrez,  Source
epidermal growth factor (beta-urogastrone)7342.6770.0161No
4EFNA5NAEFNA5
Entrez,  Source
ephrin-A512862.053-0.0009No
5SLC7A5NASLC7A5
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 514401.9230.0036No
6ODC1NAODC1
Entrez,  Source
ornithine decarboxylase 117701.681-0.0034No
7CDC25BNACDC25B
Entrez,  Source
cell division cycle 25B21241.483-0.0131No
8SLC12A2NASLC12A2
Entrez,  Source
solute carrier family 12 (sodium/potassium/chloride transporters), member 221931.452-0.0071No
9WRNNAWRN
Entrez,  Source
Werner syndrome26081.278-0.0216No
10HMGA1NAHMGA1
Entrez,  Source
high mobility group AT-hook 126441.265-0.0150No
11CDKN1BNACDKN1B
Entrez,  Source
cyclin-dependent kinase inhibitor 1B (p27, Kip1)26801.253-0.0084No
12TOP2ANATOP2A
Entrez,  Source
topoisomerase (DNA) II alpha 170kDa32241.082-0.0315No
13HIF1ANAHIF1A
Entrez,  Source
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)33371.046-0.0307No
14ATRXNAATRX
Entrez,  Source
alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)33881.030-0.0265No
15PURANAPURA
Entrez,  Source
purine-rich element binding protein A35740.978-0.0302No
16PTTG1NAPTTG1
Entrez,  Source
pituitary tumor-transforming 136190.964-0.0261No
17BUB1NABUB1
Entrez,  Source
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)37160.937-0.0251No
18NOTCH2NANOTCH2
Entrez,  Source
Notch homolog 2 (Drosophila)37230.936-0.0191No
19CDC6NACDC6
Entrez,  Source
CDC6 cell division cycle 6 homolog (S. cerevisiae)38290.910-0.0188No
20EZH2NAEZH2
Entrez,  Source
enhancer of zeste homolog 2 (Drosophila)40210.863-0.0236No
21TRA2BNA41830.821-0.0271No
22CDC27NACDC27
Entrez,  Source
cell division cycle 2743760.776-0.0326No
23SMC1ANASMC1A
Entrez,  Source
structural maintenance of chromosomes 1A44540.759-0.0317No
24CUL3NACUL3
Entrez,  Source
cullin 346190.722-0.0360No
25MAPK14NAMAPK14
Entrez,  Source
mitogen-activated protein kinase 1447010.703-0.0358No
26E2F3NAE2F3
Entrez,  Source
E2F transcription factor 347870.686-0.0359No
27RBM14NARBM14
Entrez,  Source
RNA binding motif protein 1449370.653-0.0398No
28YTHDC1NAYTHDC1
Entrez,  Source
YTH domain containing 150170.637-0.0399No
29DTYMKNADTYMK
Entrez,  Source
deoxythymidylate kinase (thymidylate kinase)50460.633-0.0372No
30SAP30NASAP30
Entrez,  Source
Sin3A-associated protein, 30kDa50730.629-0.0344No
31CCNT1NACCNT1
Entrez,  Source
cyclin T150880.625-0.0309No
32PRIM2NA51110.621-0.0279No
33HSPA8NAHSPA8
Entrez,  Source
heat shock 70kDa protein 852160.601-0.0296No
34CCND1NACCND1
Entrez,  Source
cyclin D152520.595-0.0275No
35BARD1NABARD1
Entrez,  Source
BRCA1 associated RING domain 153920.568-0.0315No
36UBE2SNAUBE2S
Entrez,  Source
ubiquitin-conjugating enzyme E2S54080.565-0.0285No
37PRMT5NAPRMT5
Entrez,  Source
protein arginine methyltransferase 557570.507-0.0446No
38PAFAH1B1NAPAFAH1B1
Entrez,  Source
platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa57590.507-0.0412No
39LIG3NALIG3
Entrez,  Source
ligase III, DNA, ATP-dependent59620.474-0.0493No
40H2AFZNAH2AFZ
Entrez,  Source
H2A histone family, member Z61240.445-0.0553No
41DR1NADR1
Entrez,  Source
down-regulator of transcription 1, TBP-binding (negative cofactor 2)64410.394-0.0704No
42CUL1NACUL1
Entrez,  Source
cullin 164590.390-0.0687No
43HMGN2NAHMGN2
Entrez,  Source
high-mobility group nucleosomal binding domain 267350.350-0.0818No
44TGFB1NATGFB1
Entrez,  Source
transforming growth factor, beta 1 (Camurati-Engelmann disease)68160.341-0.0839No
45PBKNAPBK
Entrez,  Source
PDZ binding kinase69650.321-0.0901No
46TACC3NATACC3
Entrez,  Source
transforming, acidic coiled-coil containing protein 370100.315-0.0904No
47ARID4ANAARID4A
Entrez,  Source
AT rich interactive domain 4A (RBP1-like)71020.301-0.0935No
48CENPENACENPE
Entrez,  Source
centromere protein E, 312kDa71820.289-0.0959No
49SFPQNASFPQ
Entrez,  Source
splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)71880.289-0.0942No
50SRSF1NA74270.259-0.1059No
51CUL5NACUL5
Entrez,  Source
cullin 574360.258-0.1046No
52RPA2NARPA2
Entrez,  Source
replication protein A2, 32kDa75840.245-0.1112No
53RAD54LNARAD54L
Entrez,  Source
RAD54-like (S. cerevisiae)75980.243-0.1102No
54NCLNANCL
Entrez,  Source
nucleolin80960.189-0.1369No
55H2AFVNAH2AFV
Entrez,  Source
H2A histone family, member V87430.128-0.1723No
56DBF4NADBF4
Entrez,  Source
DBF4 homolog (S. cerevisiae)88350.117-0.1766No
57G3BP1NA88420.117-0.1762No
58KPNB1NAKPNB1
Entrez,  Source
karyopherin (importin) beta 189010.110-0.1787No
59ATF5NAATF5
Entrez,  Source
activating transcription factor 589030.109-0.1780No
60LMNB1NALMNB1
Entrez,  Source
lamin B189100.108-0.1776No
61CDKN3NACDKN3
Entrez,  Source
cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)89530.104-0.1793No
62ABL1NAABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 191680.083-0.1907No
63MCM3NAMCM3
Entrez,  Source
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)91900.079-0.1914No
64DDX39ANA93730.065-0.2011No
65SRSF10NA97040.025-0.2195No
66TROAPNATROAP
Entrez,  Source
trophinin associated protein (tastin)97650.016-0.2228No
67HUS1NAHUS1
Entrez,  Source
HUS1 checkpoint homolog (S. pombe)10198-0.005-0.2470No
68HNRNPDNA10211-0.007-0.2477No
69POLENAPOLE
Entrez,  Source
polymerase (DNA directed), epsilon10242-0.010-0.2493No
70SLC38A1NASLC38A1
Entrez,  Source
solute carrier family 38, member 110313-0.016-0.2531No
71FOXN3NA10382-0.022-0.2568No
72SS18NASS18
Entrez,  Source
synovial sarcoma translocation, chromosome 1810441-0.029-0.2599No
73CBX1NACBX1
Entrez,  Source
chromobox homolog 1 (HP1 beta homolog Drosophila )10732-0.053-0.2758No
74H2AFXNAH2AFX
Entrez,  Source
H2A histone family, member X10835-0.062-0.2811No
75MCM6NAMCM6
Entrez,  Source
MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)10954-0.076-0.2872No
76MNAT1NAMNAT1
Entrez,  Source
menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)11204-0.105-0.3005No
77UPF1NAUPF1
Entrez,  Source
UPF1 regulator of nonsense transcripts homolog (yeast)11219-0.106-0.3006No
78STMN1NASTMN1
Entrez,  Source
stathmin 1/oncoprotein 1811315-0.116-0.3051No
79CKS2NACKS2
Entrez,  Source
CDC28 protein kinase regulatory subunit 211549-0.139-0.3173No
80CDC20NACDC20
Entrez,  Source
CDC20 cell division cycle 20 homolog (S. cerevisiae)11913-0.182-0.3364No
81E2F2NAE2F2
Entrez,  Source
E2F transcription factor 211934-0.184-0.3363No
82TNPO2NATNPO2
Entrez,  Source
transportin 2 (importin 3, karyopherin beta 2b)12018-0.192-0.3397No
83ORC5NA12155-0.207-0.3459No
84CCNFNACCNF
Entrez,  Source
cyclin F12190-0.212-0.3464No
85NEK2NANEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 212202-0.214-0.3455No
86KPNA2NAKPNA2
Entrez,  Source
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)12208-0.215-0.3443No
87CDC7NACDC7
Entrez,  Source
CDC7 cell division cycle 7 (S. cerevisiae)12259-0.220-0.3457No
88UCK2NAUCK2
Entrez,  Source
uridine-cytidine kinase 212301-0.227-0.3464No
89SMAD3NASMAD3
Entrez,  Source
SMAD, mothers against DPP homolog 3 (Drosophila)12320-0.229-0.3459No
90SUV39H1NASUV39H1
Entrez,  Source
suppressor of variegation 3-9 homolog 1 (Drosophila)12521-0.254-0.3554No
91RAD23BNARAD23B
Entrez,  Source
RAD23 homolog B (S. cerevisiae)12585-0.261-0.3571No
92NUP50NANUP50
Entrez,  Source
nucleoporin 50kDa12662-0.273-0.3595No
93PAPD7NA12721-0.279-0.3609No
94TOP1NATOP1
Entrez,  Source
topoisomerase (DNA) I12749-0.283-0.3605No
95NUMA1NANUMA1
Entrez,  Source
nuclear mitotic apparatus protein 112779-0.286-0.3602No
96GSPT1NAGSPT1
Entrez,  Source
G1 to S phase transition 112787-0.288-0.3586No
97NDC80NA12789-0.288-0.3567No
98PMLNAPML
Entrez,  Source
promyelocytic leukemia12858-0.297-0.3585No
99RACGAP1NARACGAP1
Entrez,  Source
Rac GTPase activating protein 112981-0.316-0.3632No
100KIF2CNAKIF2C
Entrez,  Source
kinesin family member 2C13009-0.320-0.3625No
101SMC2NASMC2
Entrez,  Source
structural maintenance of chromosomes 213032-0.323-0.3616No
102CTCFNACTCF
Entrez,  Source
CCCTC-binding factor (zinc finger protein)13127-0.337-0.3645No
103CHEK1NACHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)13319-0.370-0.3728No
104KIF5BNAKIF5B
Entrez,  Source
kinesin family member 5B13340-0.373-0.3713No
105NUSAP1NANUSAP1
Entrez,  Source
nucleolar and spindle associated protein 113373-0.378-0.3706No
106CDC45NA13429-0.386-0.3710No
107FANCCNAFANCC
Entrez,  Source
Fanconi anemia, complementation group C13479-0.396-0.3711No
108NASPNANASP
Entrez,  Source
nuclear autoantigenic sperm protein (histone-binding)13562-0.410-0.3729Yes
109EWSR1NAEWSR1
Entrez,  Source
Ewing sarcoma breakpoint region 113597-0.415-0.3720Yes
110AURKANAAURKA
Entrez,  Source
aurora kinase A13647-0.426-0.3718Yes
111HNRNPUNA13685-0.431-0.3710Yes
112BCL3NABCL3
Entrez,  Source
B-cell CLL/lymphoma 313694-0.432-0.3685Yes
113SRSF2NA13723-0.441-0.3670Yes
114LBRNALBR
Entrez,  Source
lamin B receptor13764-0.446-0.3662Yes
115BIRC5NABIRC5
Entrez,  Source
baculoviral IAP repeat-containing 5 (survivin)13772-0.448-0.3636Yes
116HMGB3NAHMGB3
Entrez,  Source
high-mobility group box 313802-0.453-0.3621Yes
117PLK1NAPLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)13882-0.468-0.3634Yes
118ILF3NAILF3
Entrez,  Source
interleukin enhancer binding factor 3, 90kDa13888-0.469-0.3605Yes
119PRPF4BNAPRPF4B
Entrez,  Source
PRP4 pre-mRNA processing factor 4 homolog B (yeast)13913-0.473-0.3586Yes
120MTF2NAMTF2
Entrez,  Source
metal response element binding transcription factor 213926-0.475-0.3560Yes
121CHAF1ANACHAF1A
Entrez,  Source
chromatin assembly factor 1, subunit A (p150)13929-0.475-0.3529Yes
122E2F1NAE2F1
Entrez,  Source
E2F transcription factor 113943-0.479-0.3504Yes
123CUL4ANACUL4A
Entrez,  Source
cullin 4A13971-0.485-0.3486Yes
124POLA2NAPOLA2
Entrez,  Source
polymerase (DNA directed), alpha 2 (70kD subunit)14091-0.507-0.3518Yes
125RBL1NARBL1
Entrez,  Source
retinoblastoma-like 1 (p107)14122-0.513-0.3500Yes
126DKC1NADKC1
Entrez,  Source
dyskeratosis congenita 1, dyskerin14327-0.557-0.3577Yes
127NUP98NANUP98
Entrez,  Source
nucleoporin 98kDa14329-0.557-0.3539Yes
128POLQNAPOLQ
Entrez,  Source
polymerase (DNA directed), theta14464-0.586-0.3575Yes
129EXO1NAEXO1
Entrez,  Source
exonuclease 114480-0.589-0.3543Yes
130STILNASTIL
Entrez,  Source
SCL/TAL1 interrupting locus14484-0.589-0.3505Yes
131RASAL2NARASAL2
Entrez,  Source
RAS protein activator like 214570-0.611-0.3511Yes
132SNRPD1NASNRPD1
Entrez,  Source
small nuclear ribonucleoprotein D1 polypeptide 16kDa14580-0.613-0.3474Yes
133CDKN2CNACDKN2C
Entrez,  Source
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)14645-0.628-0.3467Yes
134MEIS2NAMEIS2
Entrez,  Source
Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse)14712-0.646-0.3460Yes
135RAD21NARAD21
Entrez,  Source
RAD21 homolog (S. pombe)14716-0.647-0.3418Yes
136CCNA2NACCNA2
Entrez,  Source
cyclin A214721-0.650-0.3376Yes
137TRAIPNATRAIP
Entrez,  Source
TRAF interacting protein14743-0.657-0.3343Yes
138CENPANACENPA
Entrez,  Source
centromere protein A14761-0.661-0.3307Yes
139CKS1BNACKS1B
Entrez,  Source
CDC28 protein kinase regulatory subunit 1B14797-0.669-0.3281Yes
140BUB3NABUB3
Entrez,  Source
BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)14864-0.686-0.3272Yes
141KIF20BNA14879-0.690-0.3233Yes
142HIRANAHIRA
Entrez,  Source
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)14965-0.712-0.3232Yes
143CDK4NACDK4
Entrez,  Source
cyclin-dependent kinase 414970-0.714-0.3185Yes
144MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)15151-0.760-0.3235Yes
145AMD1NAAMD1
Entrez,  Source
adenosylmethionine decarboxylase 115153-0.761-0.3183Yes
146ORC6NA15182-0.769-0.3147Yes
147KIF11NAKIF11
Entrez,  Source
kinesin family member 1115189-0.771-0.3098Yes
148MAD2L1NAMAD2L1
Entrez,  Source
MAD2 mitotic arrest deficient-like 1 (yeast)15220-0.779-0.3061Yes
149ESPL1NAESPL1
Entrez,  Source
extra spindle poles like 1 (S. cerevisiae)15227-0.781-0.3012Yes
150TPX2NATPX2
Entrez,  Source
TPX2, microtubule-associated, homolog (Xenopus laevis)15263-0.792-0.2977Yes
151E2F4NAE2F4
Entrez,  Source
E2F transcription factor 4, p107/p130-binding15392-0.832-0.2992Yes
152PLK4NAPLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)15455-0.849-0.2969Yes
153INCENPNAINCENP
Entrez,  Source
inner centromere protein antigens 135/155kDa15456-0.849-0.2912Yes
154CDC25ANACDC25A
Entrez,  Source
cell division cycle 25A15476-0.855-0.2864Yes
155TLE3NATLE3
Entrez,  Source
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)15647-0.908-0.2898Yes
156KIF22NAKIF22
Entrez,  Source
kinesin family member 2215996-1.044-0.3022Yes
157CDK1NA16088-1.080-0.3000Yes
158MCM5NAMCM5
Entrez,  Source
MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)16100-1.089-0.2931Yes
159CENPFNACENPF
Entrez,  Source
centromere protein F, 350/400ka (mitosin)16180-1.127-0.2899Yes
160NOLC1NANOLC1
Entrez,  Source
nucleolar and coiled-body phosphoprotein 116254-1.172-0.2860Yes
161TMPONATMPO
Entrez,  Source
thymopoietin16338-1.211-0.2824Yes
162FBXO5NAFBXO5
Entrez,  Source
F-box protein 516350-1.215-0.2748Yes
163MYBL2NAMYBL2
Entrez,  Source
v-myb myeloblastosis viral oncogene homolog (avian)-like 216463-1.276-0.2724Yes
164KIF4ANAKIF4A
Entrez,  Source
kinesin family member 4A16467-1.276-0.2638Yes
165CHMP1ANA16496-1.297-0.2566Yes
166ODF2NAODF2
Entrez,  Source
outer dense fiber of sperm tails 216499-1.297-0.2478Yes
167SMARCC1NASMARCC1
Entrez,  Source
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 116550-1.336-0.2415Yes
168TFDP1NATFDP1
Entrez,  Source
transcription factor Dp-116594-1.367-0.2346Yes
169HMMRNAHMMR
Entrez,  Source
hyaluronan-mediated motility receptor (RHAMM)16608-1.373-0.2260Yes
170KATNA1NAKATNA1
Entrez,  Source
katanin p60 (ATPase-containing) subunit A 116688-1.422-0.2207Yes
171SLC7A1NASLC7A1
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 116731-1.455-0.2132Yes
172STAG1NASTAG1
Entrez,  Source
stromal antigen 116777-1.486-0.2056Yes
173XPO1NAXPO1
Entrez,  Source
exportin 1 (CRM1 homolog, yeast)16804-1.509-0.1968Yes
174PRC1NAPRC1
Entrez,  Source
protein regulator of cytokinesis 116819-1.523-0.1872Yes
175SYNCRIPNASYNCRIP
Entrez,  Source
synaptotagmin binding, cytoplasmic RNA interacting protein16841-1.540-0.1778Yes
176TTKNATTK
Entrez,  Source
TTK protein kinase16888-1.582-0.1696Yes
177KIF15NAKIF15
Entrez,  Source
kinesin family member 1516911-1.598-0.1600Yes
178CCNB2NACCNB2
Entrez,  Source
cyclin B216921-1.610-0.1495Yes
179RPS6KA5NARPS6KA5
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 516937-1.624-0.1393Yes
180SMC4NASMC4
Entrez,  Source
structural maintenance of chromosomes 416963-1.647-0.1295Yes
181MARCKSNAMARCKS
Entrez,  Source
myristoylated alanine-rich protein kinase C substrate16995-1.682-0.1197Yes
182KIF23NAKIF23
Entrez,  Source
kinesin family member 2317004-1.687-0.1087Yes
183PDS5BNA17005-1.689-0.0972Yes
184SQLENASQLE
Entrez,  Source
squalene epoxidase17023-1.704-0.0865Yes
185MKI67NAMKI67
Entrez,  Source
antigen identified by monoclonal antibody Ki-6717067-1.756-0.0770Yes
186MCM2NAMCM2
Entrez,  Source
MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)17118-1.808-0.0674Yes
187AURKBNAAURKB
Entrez,  Source
aurora kinase B17127-1.818-0.0555Yes
188GINS2NAGINS2
Entrez,  Source
GINS complex subunit 2 (Psf2 homolog)17226-1.949-0.0477Yes
189MEIS1NAMEIS1
Entrez,  Source
Meis1, myeloid ecotropic viral integration site 1 homolog (mouse)17311-2.063-0.0384Yes
190CASP8AP2NACASP8AP2
Entrez,  Source
CASP8 associated protein 217365-2.154-0.0267Yes
191HOXC10NAHOXC10
Entrez,  Source
homeobox C1017375-2.179-0.0123Yes
192BRCA2NABRCA2
Entrez,  Source
breast cancer 2, early onset17460-2.339-0.0011Yes
193DMDNADMD
Entrez,  Source
dystrophin (muscular dystrophy, Duchenne and Becker types)17900-4.4420.0045Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_G2M_CHECKPOINT   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_G2M_CHECKPOINT: Random ES distribution   
Gene set null distribution of ES for HALLMARK_G2M_CHECKPOINT