Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_ESTROGEN_RESPONSE_EARLY
Enrichment Score (ES)0.430714
Normalized Enrichment Score (NES)1.5291681
Nominal p-value0.0011402508
FDR q-value0.01848298
FWER p-Value0.147
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_ESTROGEN_RESPONSE_EARLY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1KRT19NAKRT19
Entrez,  Source
keratin 1904.9950.0187Yes
2INHBBNAINHBB
Entrez,  Source
inhibin, beta B (activin AB beta polypeptide)254.8720.0356Yes
3CLIC3NACLIC3
Entrez,  Source
chloride intracellular channel 3384.7810.0529Yes
4SYBUNA444.7620.0704Yes
5TPD52L1NATPD52L1
Entrez,  Source
tumor protein D52-like 1714.6500.0864Yes
6SLC1A4NASLC1A4
Entrez,  Source
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4984.5350.1019Yes
7AREGNAAREG
Entrez,  Source
amphiregulin (schwannoma-derived growth factor)1004.5280.1188Yes
8CALCRNACALCR
Entrez,  Source
calcitonin receptor1204.4350.1344Yes
9SYT12NASYT12
Entrez,  Source
synaptotagmin XII1404.3760.1497Yes
10ESRP2NA1844.1660.1629Yes
11P2RY2NAP2RY2
Entrez,  Source
purinergic receptor P2Y, G-protein coupled, 22134.0530.1765Yes
12IGFBP4NAIGFBP4
Entrez,  Source
insulin-like growth factor binding protein 42323.9800.1904Yes
13GJA1NAGJA1
Entrez,  Source
gap junction protein, alpha 1, 43kDa (connexin 43)2853.7820.2017Yes
14SLC27A2NASLC27A2
Entrez,  Source
solute carrier family 27 (fatty acid transporter), member 23233.6730.2133Yes
15RHOBTB3NARHOBTB3
Entrez,  Source
Rho-related BTB domain containing 33373.6300.2262Yes
16SEMA3BNASEMA3B
Entrez,  Source
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B3953.4680.2360Yes
17FAM102ANAFAM102A
Entrez,  Source
family with sequence similarity 102, member A3963.4680.2490Yes
18MLPHNAMLPH
Entrez,  Source
melanophilin5093.1220.2544Yes
19AQP3NAAQP3
Entrez,  Source
aquaporin 3 (Gill blood group)5143.1160.2658Yes
20FHL2NAFHL2
Entrez,  Source
four and a half LIM domains 25363.0670.2762Yes
21SLC26A2NASLC26A2
Entrez,  Source
solute carrier family 26 (sulfate transporter), member 25593.0250.2863Yes
22GLANAGLA
Entrez,  Source
galactosidase, alpha6532.8290.2916Yes
23SLC7A2NASLC7A2
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 26862.7890.3003Yes
24SLC1A1NASLC1A1
Entrez,  Source
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 17082.7450.3094Yes
25TSKUNA9462.4050.3051Yes
26TMEM164NATMEM164
Entrez,  Source
transmembrane protein 1649662.3730.3129Yes
27KRT15NAKRT15
Entrez,  Source
keratin 159972.3420.3200Yes
28RHODNARHOD
Entrez,  Source
ras homolog gene family, member D10022.3370.3285Yes
29KLF4NAKLF4
Entrez,  Source
Kruppel-like factor 4 (gut)10412.2840.3349Yes
30STC2NASTC2
Entrez,  Source
stanniocalcin 210652.2600.3421Yes
31TPBGNATPBG
Entrez,  Source
trophoblast glycoprotein13112.0330.3360Yes
32DLC1NADLC1
Entrez,  Source
deleted in liver cancer 113631.9800.3405Yes
33TOB1NATOB1
Entrez,  Source
transducer of ERBB2, 114061.9490.3454Yes
34SLC7A5NASLC7A5
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 514401.9230.3508Yes
35SCNN1ANASCNN1A
Entrez,  Source
sodium channel, nonvoltage-gated 1 alpha14841.8890.3555Yes
36PMAIP1NAPMAIP1
Entrez,  Source
phorbol-12-myristate-13-acetate-induced protein 115081.8800.3612Yes
37ALDH3B1NAALDH3B1
Entrez,  Source
aldehyde dehydrogenase 3 family, member B115221.8620.3675Yes
38MICBNAMICB
Entrez,  Source
MHC class I polypeptide-related sequence B16051.8030.3696Yes
39KRT8NAKRT8
Entrez,  Source
keratin 816241.7880.3753Yes
40OPN3NAOPN3
Entrez,  Source
opsin 3 (encephalopsin, panopsin)17411.7090.3752Yes
41AFF1NAAFF1
Entrez,  Source
AF4/FMR2 family, member 118841.6220.3733Yes
42WFS1NAWFS1
Entrez,  Source
Wolfram syndrome 1 (wolframin)19391.5920.3762Yes
43ELF3NAELF3
Entrez,  Source
E74-like factor 3 (ets domain transcription factor, epithelial-specific )20111.5480.3780Yes
44BLVRBNABLVRB
Entrez,  Source
biliverdin reductase B (flavin reductase (NADPH))20221.5440.3832Yes
45PTGESNAPTGES
Entrez,  Source
prostaglandin E synthase20231.5440.3890Yes
46SNX24NASNX24
Entrez,  Source
sorting nexing 2420281.5420.3946Yes
47ANXA9NAANXA9
Entrez,  Source
annexin A920391.5340.3997Yes
48RAB17NARAB17
Entrez,  Source
RAB17, member RAS oncogene family21531.4710.3989Yes
49B4GALT1NAB4GALT1
Entrez,  Source
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 121781.4590.4030Yes
50DEPTORNA22151.4440.4064Yes
51MYBL1NAMYBL1
Entrez,  Source
v-myb myeloblastosis viral oncogene homolog (avian)-like 122791.4210.4082Yes
52PODXLNAPODXL
Entrez,  Source
podocalyxin-like23961.3720.4068Yes
53PGRNAPGR
Entrez,  Source
progesterone receptor24471.3480.4090Yes
54WISP2NAWISP2
Entrez,  Source
WNT1 inducible signaling pathway protein 225041.3230.4109Yes
55IL6STNAIL6ST
Entrez,  Source
interleukin 6 signal transducer (gp130, oncostatin M receptor)25731.2920.4119Yes
56DHRS3NADHRS3
Entrez,  Source
dehydrogenase/reductase (SDR family) member 325851.2850.4161Yes
57MYBNAMYB
Entrez,  Source
v-myb myeloblastosis viral oncogene homolog (avian)26201.2740.4189Yes
58SLC22A5NASLC22A5
Entrez,  Source
solute carrier family 22 (organic cation transporter), member 526241.2720.4235Yes
59SLC19A2NASLC19A2
Entrez,  Source
solute carrier family 19 (thiamine transporter), member 227211.2360.4228Yes
60CELSR1NACELSR1
Entrez,  Source
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)27611.2250.4252Yes
61SLC16A1NASLC16A1
Entrez,  Source
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)28021.2120.4275Yes
62ENDOD1NAENDOD1
Entrez,  Source
endonuclease domain containing 128541.1960.4291Yes
63BCL11BNABCL11B
Entrez,  Source
B-cell CLL/lymphoma 11B (zinc finger protein)29711.1570.4269Yes
64SLC2A1NASLC2A1
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 130601.1280.4262Yes
65FLNBNAFLNB
Entrez,  Source
filamin B, beta (actin binding protein 278)30881.1210.4288Yes
66ABLIM1NAABLIM1
Entrez,  Source
actin binding LIM protein 131331.1080.4305Yes
67HRNAHR
Entrez,  Source
hairless homolog (mouse)33251.0490.4237Yes
68HSPB8NAHSPB8
Entrez,  Source
heat shock 22kDa protein 833441.0450.4266Yes
69TFF3NATFF3
Entrez,  Source
trefoil factor 3 (intestinal)33981.0280.4275Yes
70KLF10NAKLF10
Entrez,  Source
Kruppel-like factor 1034731.0090.4271Yes
71PLA2G16NA34771.0080.4307Yes
72RASGRP1NARASGRP1
Entrez,  Source
RAS guanyl releasing protein 1 (calcium and DAG-regulated)35930.9730.4279No
73PDZK1NAPDZK1
Entrez,  Source
PDZ domain containing 136180.9640.4302No
74RARANARARA
Entrez,  Source
retinoic acid receptor, alpha38060.9140.4231No
75MYOFNA38880.8940.4219No
76WWC1NAWWC1
Entrez,  Source
WW, C2 and coiled-coil domain containing 139510.8790.4217No
77RAPGEFL1NARAPGEFL1
Entrez,  Source
Rap guanine nucleotide exchange factor (GEF)-like 139620.8750.4244No
78JAK2NAJAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)40580.8520.4222No
79BCL2NABCL2
Entrez,  Source
B-cell CLL/lymphoma 240640.8510.4252No
80NXT1NANXT1
Entrez,  Source
NTF2-like export factor 142000.8160.4206No
81KAZNNA42930.7940.4184No
82RAB31NARAB31
Entrez,  Source
RAB31, member RAS oncogene family45760.7310.4053No
83ADCY9NAADCY9
Entrez,  Source
adenylate cyclase 946060.7240.4064No
84KDM4BNA46360.7160.4074No
85GAB2NAGAB2
Entrez,  Source
GRB2-associated binding protein 247510.6930.4036No
86NADSYN1NANADSYN1
Entrez,  Source
NAD synthetase 147520.6930.4062No
87REEP1NAREEP1
Entrez,  Source
receptor accessory protein 147610.6910.4084No
88PRSS23NAPRSS23
Entrez,  Source
protease, serine, 2348200.6780.4076No
89TIPARPNATIPARP
Entrez,  Source
TCDD-inducible poly(ADP-ribose) polymerase48460.6720.4088No
90EGR3NAEGR3
Entrez,  Source
early growth response 349030.6610.4081No
91PEX11ANAPEX11A
Entrez,  Source
peroxisomal biogenesis factor 11A51160.6210.3985No
92FKBP4NAFKBP4
Entrez,  Source
FK506 binding protein 4, 59kDa51890.6060.3967No
93CCND1NACCND1
Entrez,  Source
cyclin D152520.5950.3955No
94ARNAAR
Entrez,  Source
androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)53340.5790.3931No
95ASB13NAASB13
Entrez,  Source
ankyrin repeat and SOCS box-containing 1357410.5100.3722No
96SEC14L2NASEC14L2
Entrez,  Source
SEC14-like 2 (S. cerevisiae)60580.4580.3561No
97KCNK5NAKCNK5
Entrez,  Source
potassium channel, subfamily K, member 562110.4280.3492No
98SLC39A6NASLC39A6
Entrez,  Source
solute carrier family 39 (zinc transporter), member 665510.3770.3315No
99KCNK15NAKCNK15
Entrez,  Source
potassium channel, subfamily K, member 1566010.3710.3302No
100XBP1NAXBP1
Entrez,  Source
X-box binding protein 167870.3440.3210No
101TMPRSS3NATMPRSS3
Entrez,  Source
transmembrane protease, serine 369340.3240.3140No
102CLDN7NACLDN7
Entrez,  Source
claudin 770060.3150.3112No
103NPY1RNANPY1R
Entrez,  Source
neuropeptide Y receptor Y170390.3110.3106No
104ADD3NAADD3
Entrez,  Source
adducin 3 (gamma)70620.3080.3105No
105MED24NA71910.2890.3044No
106ARL3NAARL3
Entrez,  Source
ADP-ribosylation factor-like 374060.2610.2933No
107HES1NAHES1
Entrez,  Source
hairy and enhancer of split 1, (Drosophila)74240.2590.2934No
108OVOL2NAOVOL2
Entrez,  Source
ovo-like 2 (Drosophila)77400.2300.2765No
109ITPK1NAITPK1
Entrez,  Source
inositol 1,3,4-triphosphate 5/6 kinase78430.2200.2716No
110AMFRNAAMFR
Entrez,  Source
autocrine motility factor receptor79120.2130.2686No
111MPPED2NAMPPED2
Entrez,  Source
metallophosphoesterase domain containing 279840.2040.2654No
112ADCY1NAADCY1
Entrez,  Source
adenylate cyclase 1 (brain)81590.1810.2562No
113KRT18NAKRT18
Entrez,  Source
keratin 1883620.1640.2455No
114CANT1NACANT1
Entrez,  Source
calcium activated nucleotidase 184910.1530.2389No
115RBBP8NARBBP8
Entrez,  Source
retinoblastoma binding protein 885070.1520.2386No
116SLC24A3NASLC24A3
Entrez,  Source
solute carrier family 24 (sodium/potassium/calcium exchanger), member 385460.1490.2370No
117TTC39ANA87210.1300.2277No
118SOX3NASOX3
Entrez,  Source
SRY (sex determining region Y)-box 390000.0990.2125No
119ELOVL2NAELOVL2
Entrez,  Source
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 290870.0910.2080No
120KRT13NAKRT13
Entrez,  Source
keratin 1392270.0750.2004No
121SH3BP5NASH3BP5
Entrez,  Source
SH3-domain binding protein 5 (BTK-associated)94120.0590.1903No
122CXCL12NACXCL12
Entrez,  Source
chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)94240.0580.1899No
123SULT2B1NASULT2B1
Entrez,  Source
sulfotransferase family, cytosolic, 2B, member 196160.0380.1793No
124MSMBNAMSMB
Entrez,  Source
microseminoprotein, beta-10273-0.0120.1425No
125INPP5FNAINPP5F
Entrez,  Source
inositol polyphosphate-5-phosphatase F10304-0.0150.1409No
126CD44NACD44
Entrez,  Source
CD44 molecule (Indian blood group)10693-0.0500.1192No
127UGCGNAUGCG
Entrez,  Source
UDP-glucose ceramide glucosyltransferase10783-0.0570.1144No
128UNC119NAUNC119
Entrez,  Source
unc-119 homolog (C. elegans)10928-0.0740.1066No
129RETNARET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)10972-0.0770.1045No
130MAST4NAMAST4
Entrez,  Source
microtubule associated serine/threonine kinase family member 411022-0.0840.1021No
131KLK10NAKLK10
Entrez,  Source
kallikrein 1011047-0.0860.1010No
132FOSNAFOS
Entrez,  Source
v-fos FBJ murine osteosarcoma viral oncogene homolog11142-0.0980.0961No
133RRP12NA11150-0.0990.0961No
134OLFM1NAOLFM1
Entrez,  Source
olfactomedin 111193-0.1030.0941No
135SFNNASFN
Entrez,  Source
stratifin11342-0.1190.0862No
136MREGNA11515-0.1350.0771No
137ELOVL5NAELOVL5
Entrez,  Source
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)11888-0.1790.0568No
138DYNLT3NADYNLT3
Entrez,  Source
dynein, light chain, Tctex-type 311972-0.1870.0529No
139IL17RBNAIL17RB
Entrez,  Source
interleukin 17 receptor B12002-0.1900.0519No
140FKBP5NAFKBP5
Entrez,  Source
FK506 binding protein 512380-0.2350.0316No
141CA12NACA12
Entrez,  Source
carbonic anhydrase XII12382-0.2360.0325No
142CBFA2T3NACBFA2T3
Entrez,  Source
core-binding factor, runt domain, alpha subunit 2; translocated to, 312425-0.2400.0310No
143SCARB1NASCARB1
Entrez,  Source
scavenger receptor class B, member 112515-0.2540.0269No
144MYBBP1ANAMYBBP1A
Entrez,  Source
MYB binding protein (P160) 1a12607-0.2640.0228No
145AKAP1NAAKAP1
Entrez,  Source
A kinase (PRKA) anchor protein 112750-0.2830.0159No
146LAD1NALAD1
Entrez,  Source
ladinin 113047-0.3250.0005No
147CHPT1NACHPT1
Entrez,  Source
choline phosphotransferase 113394-0.381-0.0176No
148ZNF185NAZNF185
Entrez,  Source
zinc finger protein 185 (LIM domain)13702-0.435-0.0332No
149MED13LNA13880-0.468-0.0414No
150TFF1NATFF1
Entrez,  Source
trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in)13987-0.489-0.0455No
151NBL1NANBL1
Entrez,  Source
neuroblastoma, suppression of tumorigenicity 114241-0.540-0.0577No
152PPIFNAPPIF
Entrez,  Source
peptidylprolyl isomerase F (cyclophilin F)14568-0.610-0.0738No
153ABHD2NAABHD2
Entrez,  Source
abhydrolase domain containing 214576-0.612-0.0719No
154SIAH2NASIAH2
Entrez,  Source
seven in absentia homolog 2 (Drosophila)14605-0.620-0.0711No
155CELSR2NACELSR2
Entrez,  Source
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)14633-0.625-0.0703No
156FRKNAFRK
Entrez,  Source
fyn-related kinase14679-0.637-0.0704No
157SYNGR1NASYNGR1
Entrez,  Source
synaptogyrin 114687-0.638-0.0684No
158BAG1NABAG1
Entrez,  Source
BCL2-associated athanogene14725-0.652-0.0681No
159ELF1NAELF1
Entrez,  Source
E74-like factor 1 (ets domain transcription factor)14909-0.697-0.0758No
160NAV2NANAV2
Entrez,  Source
neuron navigator 214956-0.708-0.0757No
161SVILNASVIL
Entrez,  Source
supervillin15147-0.758-0.0835No
162MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)15151-0.760-0.0809No
163PAPSS2NAPAPSS2
Entrez,  Source
3'-phosphoadenosine 5'-phosphosulfate synthase 215156-0.761-0.0782No
164SLC37A1NASLC37A1
Entrez,  Source
solute carrier family 37 (glycerol-3-phosphate transporter), member 115309-0.807-0.0838No
165SLC9A3R1NASLC9A3R1
Entrez,  Source
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 115779-0.962-0.1065No
166FDFT1NAFDFT1
Entrez,  Source
farnesyl-diphosphate farnesyltransferase 115889-1.003-0.1089No
167TUBB2BNATUBB2B
Entrez,  Source
tubulin, beta 2B15946-1.026-0.1082No
168FOXC1NAFOXC1
Entrez,  Source
forkhead box C116048-1.063-0.1099No
169IGF1RNAIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor16126-1.101-0.1101No
170TBC1D30NA16418-1.258-0.1217No
171ABCA3NAABCA3
Entrez,  Source
ATP-binding cassette, sub-family A (ABC1), member 316475-1.282-0.1201No
172GFRA1NAGFRA1
Entrez,  Source
GDNF family receptor alpha 116505-1.300-0.1168No
173PDLIM3NAPDLIM3
Entrez,  Source
PDZ and LIM domain 316563-1.345-0.1150No
174DHCR7NADHCR7
Entrez,  Source
7-dehydrocholesterol reductase16843-1.541-0.1249No
175NCOR2NANCOR2
Entrez,  Source
nuclear receptor co-repressor 216864-1.565-0.1202No
176DHRS2NADHRS2
Entrez,  Source
dehydrogenase/reductase (SDR family) member 216924-1.612-0.1175No
177BHLHE40NA17041-1.724-0.1175No
178ABATNAABAT
Entrez,  Source
4-aminobutyrate aminotransferase17094-1.782-0.1138No
179TGIF2NATGIF2
Entrez,  Source
TGFB-induced factor 2 (TALE family homeobox)17105-1.793-0.1076No
180GREB1NAGREB1
Entrez,  Source
-17130-1.822-0.1021No
181OLFML3NAOLFML3
Entrez,  Source
olfactomedin-like 317174-1.884-0.0975No
182CALB2NACALB2
Entrez,  Source
calbindin 2, 29kDa (calretinin)17373-2.167-0.1005No
183FASNNAFASN
Entrez,  Source
fatty acid synthase17408-2.255-0.0940No
184TFAP2CNATFAP2C
Entrez,  Source
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)17452-2.326-0.0877No
185THSD4NATHSD4
Entrez,  Source
thrombospondin, type I, domain containing 417459-2.338-0.0793No
186RPS6KA2NARPS6KA2
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 217479-2.377-0.0714No
187CISHNACISH
Entrez,  Source
cytokine inducible SH2-containing protein17506-2.432-0.0638No
188MUC1NAMUC1
Entrez,  Source
mucin 1, cell surface associated17540-2.528-0.0561No
189FARP1NAFARP1
Entrez,  Source
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)17578-2.653-0.0483No
190MAPTNAMAPT
Entrez,  Source
microtubule-associated protein tau17632-2.826-0.0407No
191TIAM1NATIAM1
Entrez,  Source
T-cell lymphoma invasion and metastasis 117655-2.958-0.0308No
192TGM2NATGM2
Entrez,  Source
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)17660-2.987-0.0199No
193CYP26B1NACYP26B1
Entrez,  Source
cytochrome P450, family 26, subfamily B, polypeptide 117703-3.155-0.0104No
194NRIP1NANRIP1
Entrez,  Source
nuclear receptor interacting protein 117723-3.2560.0007No
195LRIG1NALRIG1
Entrez,  Source
leucine-rich repeats and immunoglobulin-like domains 117784-3.6460.0110No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_ESTROGEN_RESPONSE_EARLY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_ESTROGEN_RESPONSE_EARLY: Random ES distribution   
Gene set null distribution of ES for HALLMARK_ESTROGEN_RESPONSE_EARLY