Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_E2F_TARGETS
Enrichment Score (ES)-0.483341
Normalized Enrichment Score (NES)-2.1076937
Nominal p-value0.0
FDR q-value0.0
FWER p-Value0.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_E2F_TARGETS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)5223.100-0.0063No
2GINS4NAGINS4
Entrez,  Source
GINS complex subunit 4 (Sld5 homolog)19111.607-0.0723No
3CDC25BNACDC25B
Entrez,  Source
cell division cycle 25B21241.483-0.0732No
4HMGA1NAHMGA1
Entrez,  Source
high mobility group AT-hook 126441.265-0.0930No
5CDKN1BNACDKN1B
Entrez,  Source
cyclin-dependent kinase inhibitor 1B (p27, Kip1)26801.253-0.0856No
6PRPS1NAPRPS1
Entrez,  Source
phosphoribosyl pyrophosphate synthetase 130761.124-0.0994No
7ORC2NA31571.099-0.0958No
8TOP2ANATOP2A
Entrez,  Source
topoisomerase (DNA) II alpha 170kDa32241.082-0.0914No
9PTTG1NAPTTG1
Entrez,  Source
pituitary tumor-transforming 136190.964-0.1064No
10EZH2NAEZH2
Entrez,  Source
enhancer of zeste homolog 2 (Drosophila)40210.863-0.1225No
11TRA2BNA41830.821-0.1254No
12SPAG5NASPAG5
Entrez,  Source
sperm associated antigen 543660.778-0.1299No
13SMC1ANASMC1A
Entrez,  Source
structural maintenance of chromosomes 1A44540.759-0.1291No
14TUBBNATUBB
Entrez,  Source
tubulin, beta49020.662-0.1493No
15CCNE1NACCNE1
Entrez,  Source
cyclin E150080.639-0.1505No
16MXD3NAMXD3
Entrez,  Source
MAX dimerization protein 350270.636-0.1467No
17PRIM2NA51110.621-0.1468No
18PSMC3IPNAPSMC3IP
Entrez,  Source
PSMC3 interacting protein52270.599-0.1488No
19RBBP7NARBBP7
Entrez,  Source
retinoblastoma binding protein 752550.594-0.1459No
20RRM2NARRM2
Entrez,  Source
ribonucleotide reductase M2 polypeptide53610.574-0.1475No
21BARD1NABARD1
Entrez,  Source
BRCA1 associated RING domain 153920.568-0.1450No
22UBE2SNAUBE2S
Entrez,  Source
ubiquitin-conjugating enzyme E2S54080.565-0.1416No
23RAD50NARAD50
Entrez,  Source
RAD50 homolog (S. cerevisiae)55230.546-0.1439No
24RFC1NARFC1
Entrez,  Source
replication factor C (activator 1) 1, 145kDa55640.539-0.1422No
25NOP56NA56790.521-0.1447No
26LYARNALYAR
Entrez,  Source
-57730.505-0.1462No
27H2AFZNAH2AFZ
Entrez,  Source
H2A histone family, member Z61240.445-0.1625No
28PPP1R8NAPPP1R8
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 864490.392-0.1778No
29DCKNADCK
Entrez,  Source
deoxycytidine kinase65300.381-0.1795No
30BRMS1LNABRMS1L
Entrez,  Source
breast cancer metastasis-suppressor 1-like67730.345-0.1905No
31SNRPBNASNRPB
Entrez,  Source
small nuclear ribonucleoprotein polypeptides B and B168550.335-0.1926No
32TACC3NATACC3
Entrez,  Source
transforming, acidic coiled-coil containing protein 370100.315-0.1989No
33PAICSNAPAICS
Entrez,  Source
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase71130.299-0.2024No
34CENPENACENPE
Entrez,  Source
centromere protein E, 312kDa71820.289-0.2041No
35ASF1ANAASF1A
Entrez,  Source
ASF1 anti-silencing function 1 homolog A (S. cerevisiae)72280.283-0.2045No
36SRSF1NA74270.259-0.2137No
37TFRCNATFRC
Entrez,  Source
transferrin receptor (p90, CD71)75370.249-0.2180No
38RPA2NARPA2
Entrez,  Source
replication protein A2, 32kDa75840.245-0.2187No
39PPM1DNAPPM1D
Entrez,  Source
protein phosphatase 1D magnesium-dependent, delta isoform77040.233-0.2237No
40CDKN2ANACDKN2A
Entrez,  Source
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)80270.199-0.2403No
41DEPDC1NADEPDC1
Entrez,  Source
DEP domain containing 183410.166-0.2567No
42PCNANAPCNA
Entrez,  Source
proliferating cell nuclear antigen86030.143-0.2703No
43PNNNAPNN
Entrez,  Source
pinin, desmosome associated protein86400.140-0.2713No
44TUBG1NATUBG1
Entrez,  Source
tubulin, gamma 187310.129-0.2754No
45CDCA3NACDCA3
Entrez,  Source
cell division cycle associated 388250.119-0.2797No
46LMNB1NALMNB1
Entrez,  Source
lamin B189100.108-0.2836No
47CDKN3NACDKN3
Entrez,  Source
cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)89530.104-0.2852No
48MSH2NAMSH2
Entrez,  Source
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)90250.096-0.2885No
49MCM3NAMCM3
Entrez,  Source
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)91900.079-0.2971No
50DDX39ANA93730.065-0.3069No
51TIMELESSNATIMELESS
Entrez,  Source
timeless homolog (Drosophila)96770.029-0.3237No
52SLBPNASLBP
Entrez,  Source
stem-loop (histone) binding protein97150.023-0.3256No
53NUP153NANUP153
Entrez,  Source
nucleoporin 153kDa10187-0.003-0.3520No
54HUS1NAHUS1
Entrez,  Source
HUS1 checkpoint homolog (S. pombe)10198-0.005-0.3526No
55HNRNPDNA10211-0.007-0.3532No
56POLENAPOLE
Entrez,  Source
polymerase (DNA directed), epsilon10242-0.010-0.3548No
57RNASEH2ANARNASEH2A
Entrez,  Source
ribonuclease H2, subunit A10243-0.010-0.3547No
58H2AFXNAH2AFX
Entrez,  Source
H2A histone family, member X10835-0.062-0.3875No
59MCM6NAMCM6
Entrez,  Source
MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)10954-0.076-0.3936No
60RPA1NARPA1
Entrez,  Source
replication protein A1, 70kDa10991-0.080-0.3950No
61RANNARAN
Entrez,  Source
RAN, member RAS oncogene family11223-0.107-0.4072No
62DONSONNADONSON
Entrez,  Source
downstream neighbor of SON11282-0.112-0.4096No
63EIF2S1NAEIF2S1
Entrez,  Source
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa11291-0.113-0.4092No
64STMN1NASTMN1
Entrez,  Source
stathmin 1/oncoprotein 1811315-0.116-0.4096No
65SPC24NA11382-0.123-0.4124No
66CKS2NACKS2
Entrez,  Source
CDC28 protein kinase regulatory subunit 211549-0.139-0.4207No
67CBX5NACBX5
Entrez,  Source
chromobox homolog 5 (HP1 alpha homolog, Drosophila)11565-0.140-0.4205No
68RPA3NARPA3
Entrez,  Source
replication protein A3, 14kDa11617-0.146-0.4223No
69SPC25NA11622-0.146-0.4215No
70DEKNADEK
Entrez,  Source
DEK oncogene (DNA binding)11747-0.161-0.4272No
71CDC20NACDC20
Entrez,  Source
CDC20 cell division cycle 20 homolog (S. cerevisiae)11913-0.182-0.4352No
72PRKDCNAPRKDC
Entrez,  Source
protein kinase, DNA-activated, catalytic polypeptide11998-0.190-0.4385No
73KPNA2NAKPNA2
Entrez,  Source
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)12208-0.215-0.4486No
74POP7NAPOP7
Entrez,  Source
processing of precursor 7, ribonuclease P subunit (S. cerevisiae)12281-0.223-0.4510No
75SUV39H1NASUV39H1
Entrez,  Source
suppressor of variegation 3-9 homolog 1 (Drosophila)12521-0.254-0.4625No
76ING3NAING3
Entrez,  Source
inhibitor of growth family, member 312524-0.255-0.4608No
77PA2G4NAPA2G4
Entrez,  Source
proliferation-associated 2G4, 38kDa12564-0.258-0.4610No
78RFC2NARFC2
Entrez,  Source
replication factor C (activator 1) 2, 40kDa12780-0.287-0.4710No
79GSPT1NAGSPT1
Entrez,  Source
G1 to S phase transition 112787-0.288-0.4692No
80PMS2NAPMS2
Entrez,  Source
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)12868-0.298-0.4715No
81MELKNAMELK
Entrez,  Source
maternal embryonic leucine zipper kinase12979-0.315-0.4753No
82RACGAP1NARACGAP1
Entrez,  Source
Rac GTPase activating protein 112981-0.316-0.4730No
83KIF2CNAKIF2C
Entrez,  Source
kinesin family member 2C13009-0.320-0.4721No
84CTCFNACTCF
Entrez,  Source
CCCTC-binding factor (zinc finger protein)13127-0.337-0.4762No
85TK1NATK1
Entrez,  Source
thymidine kinase 1, soluble13255-0.357-0.4807Yes
86RAD51CNARAD51C
Entrez,  Source
RAD51 homolog C (S. cerevisiae)13295-0.366-0.4802Yes
87MMS22LNA13304-0.368-0.4779Yes
88CHEK1NACHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)13319-0.370-0.4759Yes
89POLD1NAPOLD1
Entrez,  Source
polymerase (DNA directed), delta 1, catalytic subunit 125kDa13347-0.374-0.4746Yes
90ANP32ENAANP32E
Entrez,  Source
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E13404-0.382-0.4749Yes
91NME1NANME1
Entrez,  Source
non-metastatic cells 1, protein (NM23A) expressed in13473-0.394-0.4758Yes
92AK2NAAK2
Entrez,  Source
adenylate kinase 213481-0.397-0.4733Yes
93NASPNANASP
Entrez,  Source
nuclear autoantigenic sperm protein (histone-binding)13562-0.410-0.4747Yes
94TBRG4NATBRG4
Entrez,  Source
transforming growth factor beta regulator 413587-0.413-0.4730Yes
95UBE2TNAUBE2T
Entrez,  Source
ubiquitin-conjugating enzyme E2T (putative)13599-0.416-0.4705Yes
96AURKANAAURKA
Entrez,  Source
aurora kinase A13647-0.426-0.4700Yes
97SRSF2NA13723-0.441-0.4709Yes
98LBRNALBR
Entrez,  Source
lamin B receptor13764-0.446-0.4698Yes
99BIRC5NABIRC5
Entrez,  Source
baculoviral IAP repeat-containing 5 (survivin)13772-0.448-0.4669Yes
100DSCC1NA13778-0.448-0.4638Yes
101HMGB3NAHMGB3
Entrez,  Source
high-mobility group box 313802-0.453-0.4617Yes
102PLK1NAPLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)13882-0.468-0.4627Yes
103ILF3NAILF3
Entrez,  Source
interleukin enhancer binding factor 3, 90kDa13888-0.469-0.4595Yes
104ASF1BNAASF1B
Entrez,  Source
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)13997-0.490-0.4619Yes
105SSRP1NASSRP1
Entrez,  Source
structure specific recognition protein 114035-0.496-0.4603Yes
106UBR7NA14076-0.505-0.4588Yes
107LUC7L3NA14084-0.506-0.4554Yes
108POLA2NAPOLA2
Entrez,  Source
polymerase (DNA directed), alpha 2 (70kD subunit)14091-0.507-0.4520Yes
109RAD51AP1NARAD51AP1
Entrez,  Source
RAD51 associated protein 114092-0.507-0.4482Yes
110POLD3NAPOLD3
Entrez,  Source
polymerase (DNA-directed), delta 3, accessory subunit14094-0.508-0.4445Yes
111RAD1NARAD1
Entrez,  Source
RAD1 homolog (S. pombe)14181-0.527-0.4454Yes
112UNGNAUNG
Entrez,  Source
uracil-DNA glycosylase14205-0.533-0.4427Yes
113USP1NAUSP1
Entrez,  Source
ubiquitin specific peptidase 114206-0.534-0.4387Yes
114TCF19NATCF19
Entrez,  Source
transcription factor 19 (SC1)14247-0.541-0.4370Yes
115CCP110NA14254-0.542-0.4333Yes
116PHF5ANAPHF5A
Entrez,  Source
PHD finger protein 5A14336-0.559-0.4336Yes
117PRDX4NAPRDX4
Entrez,  Source
peroxiredoxin 414349-0.562-0.4301Yes
118DLGAP5NA14381-0.568-0.4276Yes
119RANBP1NARANBP1
Entrez,  Source
RAN binding protein 114451-0.583-0.4272Yes
120NBNNANBN
Entrez,  Source
nibrin14559-0.607-0.4287Yes
121DNMT1NADNMT1
Entrez,  Source
DNA (cytosine-5-)-methyltransferase 114601-0.618-0.4264Yes
122CDCA8NACDCA8
Entrez,  Source
cell division cycle associated 814611-0.622-0.4222Yes
123IPO7NAIPO7
Entrez,  Source
importin 714623-0.624-0.4182Yes
124DCLRE1BNADCLRE1B
Entrez,  Source
DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)14625-0.624-0.4136Yes
125CDKN2CNACDKN2C
Entrez,  Source
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)14645-0.628-0.4100Yes
126RAD21NARAD21
Entrez,  Source
RAD21 homolog (S. pombe)14716-0.647-0.4091Yes
127CKS1BNACKS1B
Entrez,  Source
CDC28 protein kinase regulatory subunit 1B14797-0.669-0.4087Yes
128HELLSNAHELLS
Entrez,  Source
helicase, lymphoid-specific14833-0.678-0.4056Yes
129CHEK2NACHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)14944-0.705-0.4065Yes
130NUP205NANUP205
Entrez,  Source
nucleoporin 205kDa14945-0.705-0.4013Yes
131ATAD2NAATAD2
Entrez,  Source
ATPase family, AAA domain containing 214964-0.712-0.3970Yes
132CDK4NACDK4
Entrez,  Source
cyclin-dependent kinase 414970-0.714-0.3919Yes
133TIPINNATIPIN
Entrez,  Source
TIMELESS interacting protein15024-0.727-0.3895Yes
134XRCC6NAXRCC6
Entrez,  Source
X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa)15113-0.750-0.3889Yes
135MCM7NAMCM7
Entrez,  Source
MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)15124-0.752-0.3838Yes
136MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)15151-0.760-0.3796Yes
137PAN2NA15179-0.768-0.3754Yes
138ORC6NA15182-0.769-0.3698Yes
139CSE1LNACSE1L
Entrez,  Source
CSE1 chromosome segregation 1-like (yeast)15183-0.769-0.3641Yes
140MLH1NAMLH1
Entrez,  Source
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)15190-0.771-0.3587Yes
141NAP1L1NANAP1L1
Entrez,  Source
nucleosome assembly protein 1-like 115209-0.777-0.3539Yes
142MAD2L1NAMAD2L1
Entrez,  Source
MAD2 mitotic arrest deficient-like 1 (yeast)15220-0.779-0.3487Yes
143ESPL1NAESPL1
Entrez,  Source
extra spindle poles like 1 (S. cerevisiae)15227-0.781-0.3432Yes
144TRIP13NATRIP13
Entrez,  Source
thyroid hormone receptor interactor 1315229-0.781-0.3374Yes
145MCM4NAMCM4
Entrez,  Source
MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)15270-0.795-0.3338Yes
146ZW10NAZW10
Entrez,  Source
ZW10, kinetochore associated, homolog (Drosophila)15294-0.801-0.3291Yes
147NUP107NANUP107
Entrez,  Source
nucleoporin 107kDa15349-0.818-0.3261Yes
148LIG1NALIG1
Entrez,  Source
ligase I, DNA, ATP-dependent15395-0.833-0.3224Yes
149PLK4NAPLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)15455-0.849-0.3194Yes
150CDC25ANACDC25A
Entrez,  Source
cell division cycle 25A15476-0.855-0.3141Yes
151BUB1BNABUB1B
Entrez,  Source
BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)15492-0.860-0.3086Yes
152NCAPD2NANCAPD2
Entrez,  Source
non-SMC condensin I complex, subunit D215534-0.875-0.3044Yes
153DUTNADUT
Entrez,  Source
dUTP pyrophosphatase15698-0.930-0.3066Yes
154CENPMNACENPM
Entrez,  Source
centromere protein M15702-0.932-0.2998Yes
155SMC6NASMC6
Entrez,  Source
structural maintenance of chromosomes 615735-0.942-0.2946Yes
156GINS3NAGINS3
Entrez,  Source
GINS complex subunit 3 (Psf3 homolog)15838-0.983-0.2930Yes
157POLD2NAPOLD2
Entrez,  Source
polymerase (DNA directed), delta 2, regulatory subunit 50kDa15846-0.985-0.2861Yes
158GINS1NAGINS1
Entrez,  Source
GINS complex subunit 1 (Psf1 homolog)15848-0.986-0.2788Yes
159BRCA1NABRCA1
Entrez,  Source
breast cancer 1, early onset15925-1.019-0.2755Yes
160KIF22NAKIF22
Entrez,  Source
kinesin family member 2215996-1.044-0.2716Yes
161WEE1NAWEE1
Entrez,  Source
WEE1 homolog (S. pombe)16033-1.057-0.2658Yes
162PSIP1NAPSIP1
Entrez,  Source
PC4 and SFRS1 interacting protein 116042-1.061-0.2583Yes
163CDK1NA16088-1.080-0.2528Yes
164MCM5NAMCM5
Entrez,  Source
MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)16100-1.089-0.2453Yes
165DCTPP1NA16105-1.093-0.2374Yes
166SMC3NASMC3
Entrez,  Source
structural maintenance of chromosomes 316199-1.141-0.2342Yes
167NOLC1NANOLC1
Entrez,  Source
nucleolar and coiled-body phosphoprotein 116254-1.172-0.2285Yes
168TMPONATMPO
Entrez,  Source
thymopoietin16338-1.211-0.2241Yes
169E2F8NAE2F8
Entrez,  Source
E2F transcription factor 816433-1.263-0.2200Yes
170MYBL2NAMYBL2
Entrez,  Source
v-myb myeloblastosis viral oncogene homolog (avian)-like 216463-1.276-0.2121Yes
171KIF4ANAKIF4A
Entrez,  Source
kinesin family member 4A16467-1.276-0.2028Yes
172NAA38NA16474-1.281-0.1936Yes
173SHMT1NASHMT1
Entrez,  Source
serine hydroxymethyltransferase 1 (soluble)16560-1.342-0.1884Yes
174HMMRNAHMMR
Entrez,  Source
hyaluronan-mediated motility receptor (RHAMM)16608-1.373-0.1808Yes
175EXOSC8NAEXOSC8
Entrez,  Source
exosome component 816652-1.395-0.1728Yes
176RFC3NARFC3
Entrez,  Source
replication factor C (activator 1) 3, 38kDa16669-1.404-0.1633Yes
177NUDT21NANUDT21
Entrez,  Source
nudix (nucleoside diphosphate linked moiety X)-type motif 2116695-1.425-0.1541Yes
178STAG1NASTAG1
Entrez,  Source
stromal antigen 116777-1.486-0.1475Yes
179XPO1NAXPO1
Entrez,  Source
exportin 1 (CRM1 homolog, yeast)16804-1.509-0.1378Yes
180HMGB2NAHMGB2
Entrez,  Source
high-mobility group box 216811-1.517-0.1268Yes
181WDR90NAWDR90
Entrez,  Source
WD repeat domain 9016822-1.525-0.1160Yes
182SYNCRIPNASYNCRIP
Entrez,  Source
synaptotagmin binding, cytoplasmic RNA interacting protein16841-1.540-0.1056Yes
183CCNB2NACCNB2
Entrez,  Source
cyclin B216921-1.610-0.0980Yes
184SMC4NASMC4
Entrez,  Source
structural maintenance of chromosomes 416963-1.647-0.0881Yes
185PDS5BNA17005-1.689-0.0778Yes
186CITNACIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)17061-1.749-0.0679Yes
187MKI67NAMKI67
Entrez,  Source
antigen identified by monoclonal antibody Ki-6717067-1.756-0.0551Yes
188MCM2NAMCM2
Entrez,  Source
MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)17118-1.808-0.0444Yes
189AURKBNAAURKB
Entrez,  Source
aurora kinase B17127-1.818-0.0313Yes
190MTHFD2NAMTHFD2
Entrez,  Source
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase17201-1.913-0.0212Yes
191DIAPH3NADIAPH3
Entrez,  Source
diaphanous homolog 3 (Drosophila)17328-2.087-0.0127Yes
192POLE4NAPOLE4
Entrez,  Source
polymerase (DNA-directed), epsilon 4 (p12 subunit)17350-2.1350.0020Yes
193TP53NATP53
Entrez,  Source
tumor protein p53 (Li-Fraumeni syndrome)17352-2.1360.0178Yes
194BRCA2NABRCA2
Entrez,  Source
breast cancer 2, early onset17460-2.3390.0292Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_E2F_TARGETS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_E2F_TARGETS: Random ES distribution   
Gene set null distribution of ES for HALLMARK_E2F_TARGETS