Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_DNA_REPAIR
Enrichment Score (ES)-0.29859352
Normalized Enrichment Score (NES)-1.2166022
Nominal p-value0.06666667
FDR q-value0.15272532
FWER p-Value0.558
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_DNA_REPAIR   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1NPR2NANPR2
Entrez,  Source
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)5373.0650.0004No
2POLBNAPOLB
Entrez,  Source
polymerase (DNA directed), beta6172.8870.0246No
3RFC4NARFC4
Entrez,  Source
replication factor C (activator 1) 4, 37kDa8532.5050.0364No
4POLR2HNAPOLR2H
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide H10112.3220.0507No
5BRF2NABRF2
Entrez,  Source
BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like15791.8230.0370No
6NUDT9NANUDT9
Entrez,  Source
nudix (nucleoside diphosphate linked moiety X)-type motif 917471.7040.0446No
7SURF1NASURF1
Entrez,  Source
surfeit 118201.6530.0570No
8POLHNAPOLH
Entrez,  Source
polymerase (DNA directed), eta18341.6470.0726No
9POLR2DNAPOLR2D
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide D20851.5060.0736No
10SNAPC5NASNAPC5
Entrez,  Source
small nuclear RNA activating complex, polypeptide 5, 19kDa25471.3000.0607No
11CDANACDA
Entrez,  Source
cytidine deaminase27511.2270.0615No
12STX3NASTX3
Entrez,  Source
syntaxin 329611.1610.0613No
13NME3NANME3
Entrez,  Source
non-metastatic cells 3, protein expressed in32361.0780.0567No
14TAF13NATAF13
Entrez,  Source
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa34191.0240.0566No
15ERCC3NAERCC3
Entrez,  Source
excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)37140.9380.0495No
16GMPR2NAGMPR2
Entrez,  Source
guanosine monophosphate reductase 237830.9200.0548No
17RRM2BNARRM2B
Entrez,  Source
ribonucleotide reductase M2 B (TP53 inducible)38790.8970.0584No
18GPX4NAGPX4
Entrez,  Source
glutathione peroxidase 4 (phospholipid hydroperoxidase)42210.8120.0474No
19AK3NAAK3
Entrez,  Source
adenylate kinase 348070.6800.0214No
20DCTN4NADCTN4
Entrez,  Source
dynactin 4 (p62)48660.6690.0248No
21CMPK2NA49430.6520.0270No
22DAD1NADAD1
Entrez,  Source
defender against cell death 151380.6160.0222No
23POLR1CNAPOLR1C
Entrez,  Source
polymerase (RNA) I polypeptide C, 30kDa51500.6140.0277No
24SMAD5NASMAD5
Entrez,  Source
SMAD, mothers against DPP homolog 5 (Drosophila)51920.6060.0314No
25TAF12NATAF12
Entrez,  Source
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa52910.5880.0318No
26ITPANAITPA
Entrez,  Source
inosine triphosphatase (nucleoside triphosphate pyrophosphatase)53510.5760.0342No
27POLLNAPOLL
Entrez,  Source
polymerase (DNA directed), lambda55870.5360.0264No
28ZNF707NAZNF707
Entrez,  Source
zinc finger protein 70755940.5350.0313No
29CCNONA56850.5190.0315No
30POLR2ANAPOLR2A
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa59240.4820.0229No
31SUPT5HNASUPT5H
Entrez,  Source
suppressor of Ty 5 homolog (S. cerevisiae)60370.4610.0212No
32VPS37DNAVPS37D
Entrez,  Source
vacuolar protein sorting 37 homolog D (S. cerevisiae)62260.4240.0149No
33GTF2H1NAGTF2H1
Entrez,  Source
general transcription factor IIH, polypeptide 1, 62kDa65700.375-0.0006No
34DGCR8NADGCR8
Entrez,  Source
DiGeorge syndrome critical region gene 867970.343-0.0098No
35TAF9NATAF9
Entrez,  Source
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa68240.340-0.0079No
36VPS37BNAVPS37B
Entrez,  Source
vacuolar protein sorting 37 homolog B (S. cerevisiae)72790.277-0.0306No
37TK2NATK2
Entrez,  Source
thymidine kinase 2, mitochondrial74230.259-0.0361No
38ZNRD1NAZNRD1
Entrez,  Source
zinc ribbon domain containing 175200.250-0.0390No
39TAF10NATAF10
Entrez,  Source
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa75220.250-0.0365No
40RPA2NARPA2
Entrez,  Source
replication protein A2, 32kDa75840.245-0.0375No
41ADRM1NAADRM1
Entrez,  Source
adhesion regulating molecule 176210.241-0.0371No
42AK1NAAK1
Entrez,  Source
adenylate kinase 177310.231-0.0409No
43ADCY6NAADCY6
Entrez,  Source
adenylate cyclase 679680.207-0.0521No
44CANT1NACANT1
Entrez,  Source
calcium activated nucleotidase 184910.153-0.0799No
45PCNANAPCNA
Entrez,  Source
proliferating cell nuclear antigen86030.143-0.0847No
46TSG101NATSG101
Entrez,  Source
tumor susceptibility gene 10187060.131-0.0891No
47VPS28NAVPS28
Entrez,  Source
vacuolar protein sorting 28 homolog (S. cerevisiae)87360.128-0.0894No
48EDF1NAEDF1
Entrez,  Source
endothelial differentiation-related factor 189120.108-0.0982No
49EIF1BNAEIF1B
Entrez,  Source
eukaryotic translation initiation factor 1B89480.104-0.0991No
50ARL6IP1NAARL6IP1
Entrez,  Source
ADP-ribosylation factor-like 6 interacting protein 191170.087-0.1076No
51NFX1NANFX1
Entrez,  Source
nuclear transcription factor, X-box binding 191850.080-0.1106No
52MRPL40NAMRPL40
Entrez,  Source
mitochondrial ribosomal protein L4091980.079-0.1105No
53POLR2GNAPOLR2G
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide G93880.063-0.1204No
54POLR3GLNAPOLR3GL
Entrez,  Source
polymerase (RNA) III (DNA directed) polypeptide G (32kD) like93960.062-0.1202No
55GTF2BNAGTF2B
Entrez,  Source
general transcription factor IIB95400.047-0.1278No
56SAC3D1NASAC3D1
Entrez,  Source
SAC3 domain containing 197020.026-0.1365No
57POLR3CNAPOLR3C
Entrez,  Source
polymerase (RNA) III (DNA directed) polypeptide C (62kD)98400.005-0.1442No
58ERCC4NAERCC4
Entrez,  Source
excision repair cross-complementing rodent repair deficiency, complementation group 410209-0.007-0.1647No
59POLR2CNAPOLR2C
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide C, 33kDa10245-0.011-0.1666No
60SDCBPNASDCBP
Entrez,  Source
syndecan binding protein (syntenin)10258-0.012-0.1671No
61RBX1NARBX1
Entrez,  Source
ring-box 110295-0.013-0.1690No
62GTF2F1NAGTF2F1
Entrez,  Source
general transcription factor IIF, polypeptide 1, 74kDa10347-0.020-0.1717No
63TAF6NATAF6
Entrez,  Source
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa10416-0.026-0.1752No
64DDB1NADDB1
Entrez,  Source
damage-specific DNA binding protein 1, 127kDa10604-0.043-0.1853No
65POLR2ENAPOLR2E
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa10795-0.058-0.1954No
66NCBP2NANCBP2
Entrez,  Source
nuclear cap binding protein subunit 2, 20kDa10803-0.059-0.1952No
67TARBP2NATARBP2
Entrez,  Source
Tar (HIV-1) RNA binding protein 210851-0.064-0.1972No
68PDE4BNAPDE4B
Entrez,  Source
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)10926-0.074-0.2006No
69ZWINTNAZWINT
Entrez,  Source
ZW10 interactor11329-0.117-0.2219No
70RPA3NARPA3
Entrez,  Source
replication protein A3, 14kDa11617-0.146-0.2366No
71GTF3C5NAGTF3C5
Entrez,  Source
general transcription factor IIIC, polypeptide 5, 63kDa11629-0.147-0.2357No
72SUPT4H1NASUPT4H1
Entrez,  Source
suppressor of Ty 4 homolog 1 (S. cerevisiae)11704-0.156-0.2383No
73DDB2NADDB2
Entrez,  Source
damage-specific DNA binding protein 2, 48kDa11728-0.159-0.2380No
74SNAPC4NASNAPC4
Entrez,  Source
small nuclear RNA activating complex, polypeptide 4, 190kDa11779-0.166-0.2392No
75POLD4NAPOLD4
Entrez,  Source
polymerase (DNA-directed), delta 412128-0.204-0.2567No
76CLP1NA12134-0.205-0.2549No
77PDE6GNAPDE6G
Entrez,  Source
phosphodiesterase 6G, cGMP-specific, rod, gamma12157-0.208-0.2541No
78RNMTNARNMT
Entrez,  Source
RNA (guanine-7-) methyltransferase12265-0.222-0.2579No
79ERCC8NAERCC8
Entrez,  Source
excision repair cross-complementing rodent repair deficiency, complementation group 812324-0.230-0.2588No
80CSTF3NACSTF3
Entrez,  Source
cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa12500-0.251-0.2662No
81RFC2NARFC2
Entrez,  Source
replication factor C (activator 1) 2, 40kDa12780-0.287-0.2789No
82RAD52NARAD52
Entrez,  Source
RAD52 homolog (S. cerevisiae)13031-0.323-0.2897No
83POM121NAPOM121
Entrez,  Source
POM121 membrane glycoprotein (rat)13054-0.326-0.2877No
84SRSF6NA13182-0.346-0.2914No
85PRIM1NAPRIM1
Entrez,  Source
primase, polypeptide 1, 49kDa13189-0.347-0.2883No
86POLD1NAPOLD1
Entrez,  Source
polymerase (DNA directed), delta 1, catalytic subunit 125kDa13347-0.374-0.2934Yes
87SEC61A1NASEC61A1
Entrez,  Source
Sec61 alpha 1 subunit (S. cerevisiae)13364-0.377-0.2905Yes
88CETN2NACETN2
Entrez,  Source
centrin, EF-hand protein, 213457-0.392-0.2918Yes
89NME1NANME1
Entrez,  Source
non-metastatic cells 1, protein (NM23A) expressed in13473-0.394-0.2887Yes
90POLR2KNAPOLR2K
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa13545-0.406-0.2887Yes
91UPF3BNAUPF3B
Entrez,  Source
UPF3 regulator of nonsense transcripts homolog B (yeast)13552-0.407-0.2850Yes
92RAD51NARAD51
Entrez,  Source
RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)13663-0.429-0.2869Yes
93RAE1NARAE1
Entrez,  Source
RAE1 RNA export 1 homolog (S. pombe)13721-0.441-0.2857Yes
94XPCNAXPC
Entrez,  Source
xeroderma pigmentosum, complementation group C13729-0.442-0.2817Yes
95POLR2INAPOLR2I
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa13914-0.473-0.2873Yes
96SSRP1NASSRP1
Entrez,  Source
structure specific recognition protein 114035-0.496-0.2891Yes
97TMED2NATMED2
Entrez,  Source
transmembrane emp24 domain trafficking protein 214041-0.497-0.2844Yes
98GUK1NAGUK1
Entrez,  Source
guanylate kinase 114064-0.503-0.2807Yes
99POLA2NAPOLA2
Entrez,  Source
polymerase (DNA directed), alpha 2 (70kD subunit)14091-0.507-0.2771Yes
100POLD3NAPOLD3
Entrez,  Source
polymerase (DNA-directed), delta 3, accessory subunit14094-0.508-0.2721Yes
101MPGNAMPG
Entrez,  Source
N-methylpurine-DNA glycosylase14407-0.575-0.2839Yes
102POLR2FNAPOLR2F
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide F14438-0.581-0.2798Yes
103USP11NAUSP11
Entrez,  Source
ubiquitin specific peptidase 1114774-0.664-0.2920Yes
104GTF2A2NAGTF2A2
Entrez,  Source
general transcription factor IIA, 2, 12kDa14808-0.671-0.2872Yes
105ELLNAELL
Entrez,  Source
elongation factor RNA polymerase II14856-0.684-0.2830Yes
106GTF2H3NAGTF2H3
Entrez,  Source
general transcription factor IIH, polypeptide 3, 34kDa14878-0.690-0.2773Yes
107POLR2JNAPOLR2J
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa15000-0.721-0.2769Yes
108TYMSNATYMS
Entrez,  Source
thymidylate synthetase15272-0.795-0.2842Yes
109BCAP31NABCAP31
Entrez,  Source
B-cell receptor-associated protein 3115298-0.802-0.2776Yes
110IMPDH2NAIMPDH2
Entrez,  Source
IMP (inosine monophosphate) dehydrogenase 215390-0.831-0.2745Yes
111LIG1NALIG1
Entrez,  Source
ligase I, DNA, ATP-dependent15395-0.833-0.2664Yes
112ERCC5NAERCC5
Entrez,  Source
me))15420-0.839-0.2594Yes
113FEN1NAFEN1
Entrez,  Source
flap structure-specific endonuclease 115451-0.848-0.2527Yes
114RALANARALA
Entrez,  Source
v-ral simian leukemia viral oncogene homolog A (ras related)15526-0.872-0.2482Yes
115RFC5NARFC5
Entrez,  Source
replication factor C (activator 1) 5, 36.5kDa15582-0.889-0.2424Yes
116GTF2H5NAGTF2H5
Entrez,  Source
general transcription factor IIH, polypeptide 515677-0.917-0.2386Yes
117DUTNADUT
Entrez,  Source
dUTP pyrophosphatase15698-0.930-0.2304Yes
118APRTNAAPRT
Entrez,  Source
adenine phosphoribosyltransferase15817-0.976-0.2273Yes
119TAF1CNATAF1C
Entrez,  Source
TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa15885-1.002-0.2211Yes
120AAASNAAAAS
Entrez,  Source
achalasia, adrenocortical insufficiency, alacrimia (Allgrove, triple-A)15917-1.013-0.2128Yes
121ERCC2NAERCC2
Entrez,  Source
excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)15971-1.033-0.2055Yes
122POLA1NAPOLA1
Entrez,  Source
polymerase (DNA directed), alpha 116027-1.056-0.1981Yes
123NT5CNANT5C
Entrez,  Source
5', 3'-nucleotidase, cytosolic16283-1.186-0.2006Yes
124ERCC1NAERCC1
Entrez,  Source
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)16301-1.193-0.1897Yes
125REV3LNAREV3L
Entrez,  Source
REV3-like, catalytic subunit of DNA polymerase zeta (yeast)16316-1.199-0.1785Yes
126COX17NACOX17
Entrez,  Source
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)16318-1.200-0.1667Yes
127SF3A3NASF3A3
Entrez,  Source
splicing factor 3a, subunit 3, 60kDa16509-1.308-0.1643Yes
128HPRT1NAHPRT1
Entrez,  Source
hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome)16531-1.324-0.1523Yes
129UMPSNAUMPS
Entrez,  Source
uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)16559-1.342-0.1405Yes
130RFC3NARFC3
Entrez,  Source
replication factor C (activator 1) 3, 38kDa16669-1.404-0.1326Yes
131NUDT21NANUDT21
Entrez,  Source
nudix (nucleoside diphosphate linked moiety X)-type motif 2116695-1.425-0.1199Yes
132POLR1DNAPOLR1D
Entrez,  Source
polymerase (RNA) I polypeptide D, 16kDa16713-1.443-0.1065Yes
133PNPNA16769-1.484-0.0948Yes
134BCAMNABCAM
Entrez,  Source
basal cell adhesion molecule (Lutheran blood group)16828-1.528-0.0829Yes
135ADANAADA
Entrez,  Source
adenosine deaminase16910-1.597-0.0715Yes
136NME4NANME4
Entrez,  Source
non-metastatic cells 4, protein expressed in16975-1.660-0.0586Yes
137POLE4NAPOLE4
Entrez,  Source
polymerase (DNA-directed), epsilon 4 (p12 subunit)17350-2.135-0.0584Yes
138TP53NATP53
Entrez,  Source
tumor protein p53 (Li-Fraumeni syndrome)17352-2.136-0.0372Yes
139DGUOKNADGUOK
Entrez,  Source
deoxyguanosine kinase17428-2.282-0.0187Yes
140HCLS1NAHCLS1
Entrez,  Source
hematopoietic cell-specific Lyn substrate 117978-4.9870.0001Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_DNA_REPAIR   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_DNA_REPAIR: Random ES distribution   
Gene set null distribution of ES for HALLMARK_DNA_REPAIR