Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | HALLMARK_COAGULATION |
| Enrichment Score (ES) | 0.41479564 |
| Normalized Enrichment Score (NES) | 1.43651 |
| Nominal p-value | 0.011124846 |
| FDR q-value | 0.03556948 |
| FWER p-Value | 0.402 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CRIP2 | NA | CRIP2 Entrez, Source | cysteine-rich protein 2 | 134 | 4.396 | 0.0180 | Yes |
| 2 | SERPINB2 | NA | SERPINB2 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 144 | 4.353 | 0.0428 | Yes |
| 3 | F2RL2 | NA | F2RL2 Entrez, Source | coagulation factor II (thrombin) receptor-like 2 | 157 | 4.289 | 0.0671 | Yes |
| 4 | DPP4 | NA | DPP4 Entrez, Source | dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2) | 165 | 4.220 | 0.0912 | Yes |
| 5 | MASP2 | NA | MASP2 Entrez, Source | mannan-binding lectin serine peptidase 2 | 212 | 4.055 | 0.1122 | Yes |
| 6 | TIMP3 | NA | TIMP3 Entrez, Source | TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 220 | 4.024 | 0.1351 | Yes |
| 7 | THBD | NA | THBD Entrez, Source | thrombomodulin | 406 | 3.436 | 0.1447 | Yes |
| 8 | ITGA2 | NA | ITGA2 Entrez, Source | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 424 | 3.379 | 0.1634 | Yes |
| 9 | HTRA1 | NA | HTRA1 Entrez, Source | HtrA serine peptidase 1 | 429 | 3.364 | 0.1827 | Yes |
| 10 | CFH | NA | CFH Entrez, Source | complement factor H | 492 | 3.160 | 0.1976 | Yes |
| 11 | PLAT | NA | PLAT Entrez, Source | plasminogen activator, tissue | 520 | 3.103 | 0.2141 | Yes |
| 12 | F3 | NA | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 576 | 2.979 | 0.2284 | Yes |
| 13 | PLAU | NA | PLAU Entrez, Source | plasminogen activator, urokinase | 691 | 2.777 | 0.2381 | Yes |
| 14 | CTSB | NA | CTSB Entrez, Source | cathepsin B | 721 | 2.715 | 0.2523 | Yes |
| 15 | ADAM9 | NA | ADAM9 Entrez, Source | ADAM metallopeptidase domain 9 (meltrin gamma) | 736 | 2.676 | 0.2670 | Yes |
| 16 | BMP1 | NA | BMP1 Entrez, Source | bone morphogenetic protein 1 | 802 | 2.579 | 0.2784 | Yes |
| 17 | CASP9 | NA | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 841 | 2.527 | 0.2909 | Yes |
| 18 | SERPINE1 | NA | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 1051 | 2.268 | 0.2924 | Yes |
| 19 | HNF4A | NA | HNF4A Entrez, Source | hepatocyte nuclear factor 4, alpha | 1137 | 2.184 | 0.3003 | Yes |
| 20 | CFB | NA | CFB Entrez, Source | complement factor B | 1225 | 2.107 | 0.3077 | Yes |
| 21 | LRP1 | NA | LRP1 Entrez, Source | low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | 1285 | 2.054 | 0.3163 | Yes |
| 22 | PLG | NA | PLG Entrez, Source | plasminogen | 1315 | 2.029 | 0.3265 | Yes |
| 23 | FBN1 | NA | FBN1 Entrez, Source | fibrillin 1 | 1350 | 1.992 | 0.3361 | Yes |
| 24 | MMP14 | NA | MMP14 Entrez, Source | matrix metallopeptidase 14 (membrane-inserted) | 1383 | 1.969 | 0.3458 | Yes |
| 25 | CFD | NA | CFD Entrez, Source | complement factor D (adipsin) | 1445 | 1.919 | 0.3535 | Yes |
| 26 | THBS1 | NA | THBS1 Entrez, Source | thrombospondin 1 | 1449 | 1.914 | 0.3644 | Yes |
| 27 | C2 | NA | C2 Entrez, Source | complement component 2 | 1559 | 1.836 | 0.3690 | Yes |
| 28 | WDR1 | NA | WDR1 Entrez, Source | WD repeat domain 1 | 1661 | 1.760 | 0.3736 | Yes |
| 29 | KLKB1 | NA | KLKB1 Entrez, Source | kallikrein B, plasma (Fletcher factor) 1 | 1761 | 1.687 | 0.3778 | Yes |
| 30 | DUSP14 | NA | DUSP14 Entrez, Source | dual specificity phosphatase 14 | 1940 | 1.591 | 0.3771 | Yes |
| 31 | CD9 | NA | CD9 Entrez, Source | CD9 molecule | 2046 | 1.529 | 0.3801 | Yes |
| 32 | MMP15 | NA | MMP15 Entrez, Source | matrix metallopeptidase 15 (membrane-inserted) | 2090 | 1.504 | 0.3864 | Yes |
| 33 | PECAM1 | NA | PECAM1 Entrez, Source | platelet/endothelial cell adhesion molecule (CD31 antigen) | 2128 | 1.481 | 0.3929 | Yes |
| 34 | GSN | NA | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 2151 | 1.471 | 0.4003 | Yes |
| 35 | TIMP1 | NA | TIMP1 Entrez, Source | TIMP metallopeptidase inhibitor 1 | 2184 | 1.455 | 0.4069 | Yes |
| 36 | RABIF | NA | RABIF Entrez, Source | RAB interacting factor | 2233 | 1.435 | 0.4126 | Yes |
| 37 | SIRT2 | NA | SIRT2 Entrez, Source | sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) | 2339 | 1.397 | 0.4148 | Yes |
| 38 | TMPRSS6 | NA | TMPRSS6 Entrez, Source | transmembrane protease, serine 6 | 2699 | 1.246 | 0.4019 | No |
| 39 | DUSP6 | NA | DUSP6 Entrez, Source | dual specificity phosphatase 6 | 3037 | 1.136 | 0.3896 | No |
| 40 | ANXA1 | NA | ANXA1 Entrez, Source | annexin A1 | 3074 | 1.124 | 0.3942 | No |
| 41 | TF | NA | TF Entrez, Source | transferrin | 3096 | 1.118 | 0.3995 | No |
| 42 | CTSO | NA | CTSO Entrez, Source | cathepsin O | 3308 | 1.054 | 0.3938 | No |
| 43 | LGMN | NA | LGMN Entrez, Source | legumain | 3465 | 1.012 | 0.3909 | No |
| 44 | F10 | NA | F10 Entrez, Source | coagulation factor X | 3502 | 0.999 | 0.3947 | No |
| 45 | HMGCS2 | NA | HMGCS2 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | 3548 | 0.986 | 0.3979 | No |
| 46 | MMP3 | NA | MMP3 Entrez, Source | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 3672 | 0.949 | 0.3965 | No |
| 47 | C1R | NA | C1R Entrez, Source | complement component 1, r subcomponent | 3774 | 0.922 | 0.3962 | No |
| 48 | TFPI2 | NA | TFPI2 Entrez, Source | tissue factor pathway inhibitor 2 | 3974 | 0.873 | 0.3901 | No |
| 49 | APOA1 | NA | APOA1 Entrez, Source | apolipoprotein A-I | 3989 | 0.870 | 0.3944 | No |
| 50 | GP1BA | NA | GP1BA Entrez, Source | glycoprotein Ib (platelet), alpha polypeptide | 4088 | 0.845 | 0.3938 | No |
| 51 | CTSK | NA | CTSK Entrez, Source | cathepsin K (pycnodysostosis) | 4477 | 0.753 | 0.3765 | No |
| 52 | PROZ | NA | PROZ Entrez, Source | protein Z, vitamin K-dependent plasma glycoprotein | 4543 | 0.738 | 0.3771 | No |
| 53 | ITGB3 | NA | ITGB3 Entrez, Source | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 4615 | 0.722 | 0.3773 | No |
| 54 | PRSS23 | NA | PRSS23 Entrez, Source | protease, serine, 23 | 4820 | 0.678 | 0.3698 | No |
| 55 | PF4 | NA | PF4 Entrez, Source | platelet factor 4 (chemokine (C-X-C motif) ligand 4) | 5200 | 0.605 | 0.3521 | No |
| 56 | SH2B2 | NA | SH2B2 Entrez, Source | SH2B adaptor protein 2 | 5303 | 0.584 | 0.3498 | No |
| 57 | CFI | NA | CFI Entrez, Source | complement factor I | 5379 | 0.571 | 0.3489 | No |
| 58 | MSRB2 | NA | MSRB2 Entrez, Source | methionine sulfoxide reductase B2 | 5609 | 0.533 | 0.3392 | No |
| 59 | HPN | NA | HPN Entrez, Source | hepsin (transmembrane protease, serine 1) | 5728 | 0.512 | 0.3355 | No |
| 60 | PROC | NA | PROC Entrez, Source | protein C (inactivator of coagulation factors Va and VIIIa) | 5748 | 0.508 | 0.3374 | No |
| 61 | PROS1 | NA | PROS1 Entrez, Source | protein S (alpha) | 6635 | 0.367 | 0.2899 | No |
| 62 | PEF1 | NA | PEF1 Entrez, Source | penta-EF-hand domain containing 1 | 6695 | 0.357 | 0.2887 | No |
| 63 | GP9 | NA | GP9 Entrez, Source | glycoprotein IX (platelet) | 7138 | 0.296 | 0.2656 | No |
| 64 | MMP2 | NA | MMP2 Entrez, Source | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 7178 | 0.290 | 0.2651 | No |
| 65 | ISCU | NA | 7302 | 0.274 | 0.2598 | No | ||
| 66 | LTA4H | NA | LTA4H Entrez, Source | leukotriene A4 hydrolase | 7586 | 0.244 | 0.2454 | No |
| 67 | F13B | NA | F13B Entrez, Source | coagulation factor XIII, B polypeptide | 7678 | 0.235 | 0.2417 | No |
| 68 | CAPN2 | NA | CAPN2 Entrez, Source | calpain 2, (m/II) large subunit | 7696 | 0.234 | 0.2421 | No |
| 69 | LEFTY2 | NA | LEFTY2 Entrez, Source | left-right determination factor 2 | 7816 | 0.222 | 0.2367 | No |
| 70 | C8A | NA | C8A Entrez, Source | complement component 8, alpha polypeptide | 7878 | 0.216 | 0.2345 | No |
| 71 | C8B | NA | C8B Entrez, Source | complement component 8, beta polypeptide | 8400 | 0.162 | 0.2063 | No |
| 72 | C9 | NA | C9 Entrez, Source | complement component 9 | 8604 | 0.143 | 0.1957 | No |
| 73 | FGG | NA | FGG Entrez, Source | fibrinogen gamma chain | 8607 | 0.142 | 0.1965 | No |
| 74 | F8 | NA | F8 Entrez, Source | coagulation factor VIII, procoagulant component (hemophilia A) | 8850 | 0.116 | 0.1836 | No |
| 75 | FYN | NA | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 8943 | 0.105 | 0.1790 | No |
| 76 | SERPING1 | NA | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 8994 | 0.099 | 0.1768 | No |
| 77 | MMP7 | NA | MMP7 Entrez, Source | matrix metallopeptidase 7 (matrilysin, uterine) | 9086 | 0.091 | 0.1722 | No |
| 78 | OLR1 | NA | OLR1 Entrez, Source | oxidised low density lipoprotein (lectin-like) receptor 1 | 9417 | 0.059 | 0.1541 | No |
| 79 | CSRP1 | NA | CSRP1 Entrez, Source | cysteine and glycine-rich protein 1 | 9418 | 0.059 | 0.1544 | No |
| 80 | ARF4 | NA | ARF4 Entrez, Source | ADP-ribosylation factor 4 | 9502 | 0.052 | 0.1501 | No |
| 81 | FGA | NA | FGA Entrez, Source | fibrinogen alpha chain | 9903 | 0.000 | 0.1277 | No |
| 82 | ANG | NA | ANG Entrez, Source | angiogenin, ribonuclease, RNase A family, 5 | 10429 | -0.027 | 0.0984 | No |
| 83 | C8G | NA | C8G Entrez, Source | complement component 8, gamma polypeptide | 10761 | -0.054 | 0.0802 | No |
| 84 | MMP8 | NA | MMP8 Entrez, Source | matrix metallopeptidase 8 (neutrophil collagenase) | 11136 | -0.097 | 0.0598 | No |
| 85 | HRG | NA | HRG Entrez, Source | histidine-rich glycoprotein | 11240 | -0.108 | 0.0547 | No |
| 86 | CPN1 | NA | CPN1 Entrez, Source | carboxypeptidase N, polypeptide 1, 50kD | 11283 | -0.112 | 0.0530 | No |
| 87 | F9 | NA | F9 Entrez, Source | coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B) | 11505 | -0.134 | 0.0414 | No |
| 88 | RGN | NA | RGN Entrez, Source | regucalcin (senescence marker protein-30) | 11736 | -0.160 | 0.0294 | No |
| 89 | A2M | NA | A2M Entrez, Source | alpha-2-macroglobulin | 11895 | -0.180 | 0.0216 | No |
| 90 | APOC2 | NA | APOC2 Entrez, Source | apolipoprotein C-II | 12279 | -0.223 | 0.0014 | No |
| 91 | F11 | NA | F11 Entrez, Source | coagulation factor XI (plasma thromboplastin antecedent) | 12536 | -0.256 | -0.0114 | No |
| 92 | LAMP2 | NA | LAMP2 Entrez, Source | lysosomal-associated membrane protein 2 | 12603 | -0.264 | -0.0136 | No |
| 93 | MEP1A | NA | MEP1A Entrez, Source | meprin A, alpha (PABA peptide hydrolase) | 12942 | -0.309 | -0.0307 | No |
| 94 | S100A13 | NA | S100A13 Entrez, Source | S100 calcium binding protein A13 | 12953 | -0.311 | -0.0295 | No |
| 95 | CPB2 | NA | CPB2 Entrez, Source | carboxypeptidase B2 (plasma, carboxypeptidase U) | 12985 | -0.317 | -0.0294 | No |
| 96 | COMP | NA | COMP Entrez, Source | cartilage oligomeric matrix protein | 12990 | -0.317 | -0.0278 | No |
| 97 | CAPN5 | NA | CAPN5 Entrez, Source | calpain 5 | 13073 | -0.330 | -0.0304 | No |
| 98 | F2 | NA | F2 Entrez, Source | coagulation factor II (thrombin) | 13096 | -0.334 | -0.0297 | No |
| 99 | RAC1 | NA | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 13101 | -0.334 | -0.0280 | No |
| 100 | MST1 | NA | MST1 Entrez, Source | macrophage stimulating 1 (hepatocyte growth factor-like) | 13300 | -0.367 | -0.0370 | No |
| 101 | MAFF | NA | MAFF Entrez, Source | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) | 13323 | -0.371 | -0.0361 | No |
| 102 | MBL2 | NA | MBL2 Entrez, Source | mannose-binding lectin (protein C) 2, soluble (opsonic defect) | 13389 | -0.380 | -0.0375 | No |
| 103 | GDA | NA | GDA Entrez, Source | guanine deaminase | 13654 | -0.427 | -0.0498 | No |
| 104 | GNB2 | NA | GNB2 Entrez, Source | guanine nucleotide binding protein (G protein), beta polypeptide 2 | 13939 | -0.478 | -0.0629 | No |
| 105 | SPARC | NA | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 14252 | -0.542 | -0.0773 | No |
| 106 | ITIH1 | NA | ITIH1 Entrez, Source | inter-alpha (globulin) inhibitor H1 | 14727 | -0.653 | -0.1000 | No |
| 107 | VWF | NA | VWF Entrez, Source | von Willebrand factor | 14741 | -0.657 | -0.0969 | No |
| 108 | USP11 | NA | USP11 Entrez, Source | ubiquitin specific peptidase 11 | 14774 | -0.664 | -0.0949 | No |
| 109 | PLEK | NA | PLEK Entrez, Source | pleckstrin | 14912 | -0.698 | -0.0985 | No |
| 110 | ACOX2 | NA | ACOX2 Entrez, Source | acyl-Coenzyme A oxidase 2, branched chain | 15200 | -0.773 | -0.1101 | No |
| 111 | GNG12 | NA | GNG12 Entrez, Source | guanine nucleotide binding protein (G protein), gamma 12 | 15316 | -0.810 | -0.1118 | No |
| 112 | MMP10 | NA | MMP10 Entrez, Source | matrix metallopeptidase 10 (stromelysin 2) | 15579 | -0.888 | -0.1214 | No |
| 113 | DCT | NA | DCT Entrez, Source | dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) | 15908 | -1.009 | -0.1339 | No |
| 114 | FN1 | NA | FN1 Entrez, Source | fibronectin 1 | 16023 | -1.055 | -0.1341 | No |
| 115 | APOC1 | NA | APOC1 Entrez, Source | apolipoprotein C-I | 16075 | -1.075 | -0.1307 | No |
| 116 | PREP | NA | PREP Entrez, Source | prolyl endopeptidase | 16240 | -1.166 | -0.1331 | No |
| 117 | P2RY1 | NA | P2RY1 Entrez, Source | purinergic receptor P2Y, G-protein coupled, 1 | 16416 | -1.256 | -0.1357 | No |
| 118 | F12 | NA | F12 Entrez, Source | coagulation factor XII (Hageman factor) | 16749 | -1.471 | -0.1457 | No |
| 119 | SERPINC1 | NA | SERPINC1 Entrez, Source | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 16829 | -1.529 | -0.1413 | No |
| 120 | CTSH | NA | CTSH Entrez, Source | cathepsin H | 16852 | -1.551 | -0.1335 | No |
| 121 | S100A1 | NA | S100A1 Entrez, Source | S100 calcium binding protein A1 | 16962 | -1.645 | -0.1300 | No |
| 122 | FURIN | NA | FURIN Entrez, Source | furin (paired basic amino acid cleaving enzyme) | 17051 | -1.734 | -0.1249 | No |
| 123 | MMP11 | NA | MMP11 Entrez, Source | matrix metallopeptidase 11 (stromelysin 3) | 17076 | -1.766 | -0.1160 | No |
| 124 | KLF7 | NA | KLF7 Entrez, Source | Kruppel-like factor 7 (ubiquitous) | 17175 | -1.886 | -0.1105 | No |
| 125 | RAPGEF3 | NA | RAPGEF3 Entrez, Source | Rap guanine nucleotide exchange factor (GEF) 3 | 17305 | -2.055 | -0.1058 | No |
| 126 | C1S | NA | C1S Entrez, Source | complement component 1, s subcomponent | 17464 | -2.349 | -0.1010 | No |
| 127 | PDGFB | NA | PDGFB Entrez, Source | platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) | 17514 | -2.462 | -0.0894 | No |
| 128 | MMP1 | NA | MMP1 Entrez, Source | matrix metallopeptidase 1 (interstitial collagenase) | 17706 | -3.173 | -0.0817 | No |
| 129 | CTSE | NA | CTSE Entrez, Source | cathepsin E | 17795 | -3.692 | -0.0652 | No |
| 130 | MMP9 | NA | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 17814 | -3.845 | -0.0439 | No |
| 131 | C3 | NA | C3 Entrez, Source | complement component 3 | 17907 | -4.505 | -0.0228 | No |
| 132 | SERPINA1 | NA | SERPINA1 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 17926 | -4.627 | 0.0030 | No |
