Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_CHOLESTEROL_HOMEOSTASIS |
| Enrichment Score (ES) | -0.33736983 |
| Normalized Enrichment Score (NES) | -1.226933 |
| Nominal p-value | 0.13135593 |
| FDR q-value | 0.16291153 |
| FWER p-Value | 0.521 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | MAL2 | NA | MAL2 Entrez, Source | mal, T-cell differentiation protein 2 | 21 | 4.884 | 0.0505 | No |
| 2 | CPEB2 | NA | CPEB2 Entrez, Source | cytoplasmic polyadenylation element binding protein 2 | 247 | 3.932 | 0.0795 | No |
| 3 | JAG1 | NA | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 309 | 3.715 | 0.1154 | No |
| 4 | SEMA3B | NA | SEMA3B Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 395 | 3.468 | 0.1473 | No |
| 5 | ERRFI1 | NA | ERRFI1 Entrez, Source | ERBB receptor feedback inhibitor 1 | 627 | 2.875 | 0.1648 | No |
| 6 | TP53INP1 | NA | TP53INP1 Entrez, Source | tumor protein p53 inducible nuclear protein 1 | 699 | 2.754 | 0.1900 | No |
| 7 | CXCL16 | NA | CXCL16 Entrez, Source | chemokine (C-X-C motif) ligand 16 | 870 | 2.489 | 0.2068 | No |
| 8 | TM7SF2 | NA | TM7SF2 Entrez, Source | transmembrane 7 superfamily member 2 | 1048 | 2.272 | 0.2210 | No |
| 9 | GSTM2 | NA | GSTM2 Entrez, Source | glutathione S-transferase M2 (muscle) | 1567 | 1.832 | 0.2114 | No |
| 10 | CD9 | NA | CD9 Entrez, Source | CD9 molecule | 2046 | 1.529 | 0.2009 | No |
| 11 | GNAI1 | NA | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 2654 | 1.262 | 0.1804 | No |
| 12 | ALCAM | NA | ALCAM Entrez, Source | activated leukocyte cell adhesion molecule | 2855 | 1.196 | 0.1819 | No |
| 13 | ANTXR2 | NA | ANTXR2 Entrez, Source | anthrax toxin receptor 2 | 2982 | 1.154 | 0.1870 | No |
| 14 | FBXO6 | NA | FBXO6 Entrez, Source | F-box protein 6 | 3006 | 1.147 | 0.1979 | No |
| 15 | PMVK | NA | PMVK Entrez, Source | phosphomevalonate kinase | 3153 | 1.100 | 0.2014 | No |
| 16 | FAM129A | NA | 3168 | 1.097 | 0.2122 | No | ||
| 17 | LGALS3 | NA | LGALS3 Entrez, Source | lectin, galactoside-binding, soluble, 3 (galectin 3) | 3363 | 1.039 | 0.2123 | No |
| 18 | LGMN | NA | LGMN Entrez, Source | legumain | 3465 | 1.012 | 0.2174 | No |
| 19 | NFIL3 | NA | NFIL3 Entrez, Source | nuclear factor, interleukin 3 regulated | 3499 | 0.999 | 0.2261 | No |
| 20 | TNFRSF12A | NA | TNFRSF12A Entrez, Source | tumor necrosis factor receptor superfamily, member 12A | 3527 | 0.990 | 0.2351 | No |
| 21 | ANXA5 | NA | ANXA5 Entrez, Source | annexin A5 | 3740 | 0.929 | 0.2331 | No |
| 22 | ACTG1 | NA | ACTG1 Entrez, Source | actin, gamma 1 | 4144 | 0.830 | 0.2194 | No |
| 23 | AVPR1A | NA | AVPR1A Entrez, Source | arginine vasopressin receptor 1A | 4401 | 0.773 | 0.2132 | No |
| 24 | PCYT2 | NA | PCYT2 Entrez, Source | phosphate cytidylyltransferase 2, ethanolamine | 5462 | 0.555 | 0.1599 | No |
| 25 | TRIB3 | NA | TRIB3 Entrez, Source | tribbles homolog 3 (Drosophila) | 5686 | 0.519 | 0.1530 | No |
| 26 | ATXN2 | NA | ATXN2 Entrez, Source | ataxin 2 | 5936 | 0.479 | 0.1441 | No |
| 27 | GPX8 | NA | 6116 | 0.447 | 0.1389 | No | ||
| 28 | ACSS2 | NA | ACSS2 Entrez, Source | acyl-CoA synthetase short-chain family member 2 | 6123 | 0.446 | 0.1432 | No |
| 29 | S100A11 | NA | S100A11 Entrez, Source | S100 calcium binding protein A11 | 6204 | 0.428 | 0.1433 | No |
| 30 | PLAUR | NA | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 6352 | 0.402 | 0.1394 | No |
| 31 | ECH1 | NA | ECH1 Entrez, Source | enoyl Coenzyme A hydratase 1, peroxisomal | 6542 | 0.379 | 0.1328 | No |
| 32 | CHKA | NA | CHKA Entrez, Source | choline kinase alpha | 7687 | 0.235 | 0.0714 | No |
| 33 | ANXA13 | NA | ANXA13 Entrez, Source | annexin A13 | 8866 | 0.114 | 0.0069 | No |
| 34 | ATF5 | NA | ATF5 Entrez, Source | activating transcription factor 5 | 8903 | 0.109 | 0.0060 | No |
| 35 | LPL | NA | LPL Entrez, Source | lipoprotein lipase | 8999 | 0.099 | 0.0017 | No |
| 36 | PPARG | NA | PPARG Entrez, Source | peroxisome proliferative activated receptor, gamma | 9858 | 0.002 | -0.0461 | No |
| 37 | LDLR | NA | LDLR Entrez, Source | low density lipoprotein receptor (familial hypercholesterolemia) | 10241 | -0.010 | -0.0674 | No |
| 38 | CBS | NA | CBS Entrez, Source | cystathionine-beta-synthase | 10540 | -0.036 | -0.0836 | No |
| 39 | ADH4 | NA | ADH4 Entrez, Source | alcohol dehydrogenase 4 (class II), pi polypeptide | 10599 | -0.042 | -0.0864 | No |
| 40 | TMEM97 | NA | TMEM97 Entrez, Source | transmembrane protein 97 | 11080 | -0.088 | -0.1123 | No |
| 41 | GLDC | NA | GLDC Entrez, Source | glycine dehydrogenase (decarboxylating) | 11842 | -0.174 | -0.1529 | No |
| 42 | PNRC1 | NA | PNRC1 Entrez, Source | proline-rich nuclear receptor coactivator 1 | 12449 | -0.242 | -0.1842 | No |
| 43 | STX5 | NA | STX5 Entrez, Source | syntaxin 5 | 12527 | -0.255 | -0.1858 | No |
| 44 | NSDHL | NA | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 13603 | -0.416 | -0.2414 | No |
| 45 | ETHE1 | NA | ETHE1 Entrez, Source | ethylmalonic encephalopathy 1 | 13665 | -0.429 | -0.2403 | No |
| 46 | ABCA2 | NA | ABCA2 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 2 | 14180 | -0.527 | -0.2634 | No |
| 47 | EBP | NA | EBP Entrez, Source | emopamil binding protein (sterol isomerase) | 14287 | -0.549 | -0.2635 | No |
| 48 | CTNNB1 | NA | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 14895 | -0.694 | -0.2901 | No |
| 49 | CYP51A1 | NA | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 15055 | -0.735 | -0.2912 | No |
| 50 | LSS | NA | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 15280 | -0.797 | -0.2953 | No |
| 51 | STARD4 | NA | STARD4 Entrez, Source | START domain containing 4, sterol regulated | 15384 | -0.830 | -0.2923 | No |
| 52 | FDFT1 | NA | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 15889 | -1.003 | -0.3098 | No |
| 53 | IDI1 | NA | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 16384 | -1.239 | -0.3243 | Yes |
| 54 | HSD17B7 | NA | HSD17B7 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 7 | 16440 | -1.265 | -0.3140 | Yes |
| 55 | PLSCR1 | NA | PLSCR1 Entrez, Source | phospholipid scramblase 1 | 16511 | -1.310 | -0.3040 | Yes |
| 56 | GUSB | NA | GUSB Entrez, Source | glucuronidase, beta | 16663 | -1.403 | -0.2976 | Yes |
| 57 | ACAT2 | NA | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 16675 | -1.410 | -0.2833 | Yes |
| 58 | FDPS | NA | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 16721 | -1.448 | -0.2705 | Yes |
| 59 | DHCR7 | NA | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 16843 | -1.541 | -0.2610 | Yes |
| 60 | SQLE | NA | SQLE Entrez, Source | squalene epoxidase | 17023 | -1.704 | -0.2529 | Yes |
| 61 | MVK | NA | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 17142 | -1.834 | -0.2401 | Yes |
| 62 | FABP5 | NA | FABP5 Entrez, Source | fatty acid binding protein 5 (psoriasis-associated) | 17262 | -1.992 | -0.2257 | Yes |
| 63 | HMGCR | NA | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 17292 | -2.029 | -0.2059 | Yes |
| 64 | SREBF2 | NA | SREBF2 Entrez, Source | sterol regulatory element binding transcription factor 2 | 17381 | -2.188 | -0.1876 | Yes |
| 65 | FASN | NA | FASN Entrez, Source | fatty acid synthase | 17408 | -2.255 | -0.1652 | Yes |
| 66 | MVD | NA | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 17431 | -2.287 | -0.1423 | Yes |
| 67 | HMGCS1 | NA | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 17448 | -2.317 | -0.1187 | Yes |
| 68 | FADS2 | NA | FADS2 Entrez, Source | fatty acid desaturase 2 | 17604 | -2.732 | -0.0984 | Yes |
| 69 | PDK3 | NA | PDK3 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 3 | 17674 | -3.051 | -0.0700 | Yes |
| 70 | ALDOC | NA | ALDOC Entrez, Source | aldolase C, fructose-bisphosphate | 17800 | -3.718 | -0.0377 | Yes |
| 71 | SCD | NA | SCD Entrez, Source | stearoyl-CoA desaturase (delta-9-desaturase) | 17908 | -4.505 | 0.0040 | Yes |
