Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_BILE_ACID_METABOLISM |
| Enrichment Score (ES) | -0.2973398 |
| Normalized Enrichment Score (NES) | -1.1690255 |
| Nominal p-value | 0.10837439 |
| FDR q-value | 0.17132182 |
| FWER p-Value | 0.695 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CH25H | NA | CH25H Entrez, Source | cholesterol 25-hydroxylase | 138 | 4.378 | 0.0308 | No |
| 2 | HSD3B7 | NA | HSD3B7 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 260 | 3.872 | 0.0581 | No |
| 3 | CYP39A1 | NA | CYP39A1 Entrez, Source | cytochrome P450, family 39, subfamily A, polypeptide 1 | 275 | 3.824 | 0.0910 | No |
| 4 | SLC27A2 | NA | SLC27A2 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 2 | 323 | 3.673 | 0.1207 | No |
| 5 | NR3C2 | NA | NR3C2 Entrez, Source | nuclear receptor subfamily 3, group C, member 2 | 769 | 2.624 | 0.1189 | No |
| 6 | SLC35B2 | NA | SLC35B2 Entrez, Source | solute carrier family 35, member B2 | 1072 | 2.256 | 0.1218 | No |
| 7 | GCLM | NA | GCLM Entrez, Source | glutamate-cysteine ligase, modifier subunit | 1118 | 2.202 | 0.1387 | No |
| 8 | NPC1 | NA | NPC1 Entrez, Source | Niemann-Pick disease, type C1 | 1166 | 2.154 | 0.1550 | No |
| 9 | ABCA5 | NA | ABCA5 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 5 | 1498 | 1.883 | 0.1531 | No |
| 10 | ATXN1 | NA | ATXN1 Entrez, Source | ataxin 1 | 1703 | 1.732 | 0.1569 | No |
| 11 | ABCD2 | NA | ABCD2 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 2 | 1899 | 1.615 | 0.1602 | No |
| 12 | HSD17B11 | NA | 2082 | 1.508 | 0.1633 | No | ||
| 13 | IDH1 | NA | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 2150 | 1.471 | 0.1725 | No |
| 14 | SLC29A1 | NA | SLC29A1 Entrez, Source | solute carrier family 29 (nucleoside transporters), member 1 | 2296 | 1.416 | 0.1768 | No |
| 15 | PEX12 | NA | PEX12 Entrez, Source | peroxisomal biogenesis factor 12 | 2515 | 1.317 | 0.1762 | No |
| 16 | NUDT12 | NA | NUDT12 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 12 | 2663 | 1.258 | 0.1791 | No |
| 17 | ISOC1 | NA | ISOC1 Entrez, Source | isochorismatase domain containing 1 | 2723 | 1.236 | 0.1866 | No |
| 18 | HSD17B4 | NA | HSD17B4 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 4 | 2732 | 1.233 | 0.1971 | No |
| 19 | CROT | NA | CROT Entrez, Source | carnitine O-octanoyltransferase | 2903 | 1.182 | 0.1979 | No |
| 20 | SLC23A2 | NA | SLC23A2 Entrez, Source | solute carrier family 23 (nucleobase transporters), member 2 | 3409 | 1.026 | 0.1787 | No |
| 21 | PHYH | NA | PHYH Entrez, Source | phytanoyl-CoA 2-hydroxylase | 3583 | 0.976 | 0.1776 | No |
| 22 | SLC23A1 | NA | SLC23A1 Entrez, Source | solute carrier family 23 (nucleobase transporters), member 1 | 3680 | 0.947 | 0.1806 | No |
| 23 | EFHC1 | NA | EFHC1 Entrez, Source | EF-hand domain (C-terminal) containing 1 | 3766 | 0.923 | 0.1840 | No |
| 24 | APOA1 | NA | APOA1 Entrez, Source | apolipoprotein A-I | 3989 | 0.870 | 0.1792 | No |
| 25 | AMACR | NA | AMACR Entrez, Source | alpha-methylacyl-CoA racemase | 3995 | 0.868 | 0.1866 | No |
| 26 | LCK | NA | LCK Entrez, Source | lymphocyte-specific protein tyrosine kinase | 4012 | 0.865 | 0.1933 | No |
| 27 | PEX6 | NA | PEX6 Entrez, Source | peroxisomal biogenesis factor 6 | 4038 | 0.860 | 0.1994 | No |
| 28 | PECR | NA | PECR Entrez, Source | peroxisomal trans-2-enoyl-CoA reductase | 4122 | 0.836 | 0.2021 | No |
| 29 | RXRA | NA | RXRA Entrez, Source | retinoid X receptor, alpha | 4154 | 0.829 | 0.2077 | No |
| 30 | BMP6 | NA | BMP6 Entrez, Source | bone morphogenetic protein 6 | 4962 | 0.649 | 0.1683 | No |
| 31 | SCP2 | NA | SCP2 Entrez, Source | sterol carrier protein 2 | 5068 | 0.629 | 0.1679 | No |
| 32 | PEX11A | NA | PEX11A Entrez, Source | peroxisomal biogenesis factor 11A | 5116 | 0.621 | 0.1707 | No |
| 33 | AR | NA | AR Entrez, Source | androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) | 5334 | 0.579 | 0.1637 | No |
| 34 | ABCA9 | NA | ABCA9 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 9 | 5374 | 0.572 | 0.1666 | No |
| 35 | PEX1 | NA | PEX1 Entrez, Source | peroxisome biogenesis factor 1 | 5398 | 0.567 | 0.1703 | No |
| 36 | MLYCD | NA | MLYCD Entrez, Source | malonyl-CoA decarboxylase | 5443 | 0.558 | 0.1727 | No |
| 37 | SOD1 | NA | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 6092 | 0.452 | 0.1404 | No |
| 38 | SOAT2 | NA | SOAT2 Entrez, Source | sterol O-acyltransferase 2 | 6221 | 0.425 | 0.1370 | No |
| 39 | PFKM | NA | PFKM Entrez, Source | phosphofructokinase, muscle | 6734 | 0.351 | 0.1114 | No |
| 40 | ABCD3 | NA | ABCD3 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 3 | 6740 | 0.350 | 0.1142 | No |
| 41 | NR0B2 | NA | NR0B2 Entrez, Source | nuclear receptor subfamily 0, group B, member 2 | 7196 | 0.288 | 0.0913 | No |
| 42 | EPHX2 | NA | EPHX2 Entrez, Source | epoxide hydrolase 2, cytoplasmic | 7232 | 0.283 | 0.0918 | No |
| 43 | OPTN | NA | OPTN Entrez, Source | optineurin | 7276 | 0.277 | 0.0919 | No |
| 44 | ABCD1 | NA | ABCD1 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 1 | 7762 | 0.228 | 0.0667 | No |
| 45 | PNPLA8 | NA | PNPLA8 Entrez, Source | patatin-like phospholipase domain containing 8 | 7811 | 0.222 | 0.0660 | No |
| 46 | CAT | NA | CAT Entrez, Source | catalase | 7933 | 0.211 | 0.0611 | No |
| 47 | DIO1 | NA | DIO1 Entrez, Source | deiodinase, iodothyronine, type I | 7969 | 0.206 | 0.0609 | No |
| 48 | TTR | NA | TTR Entrez, Source | transthyretin (prealbumin, amyloidosis type I) | 8207 | 0.176 | 0.0492 | No |
| 49 | ALDH8A1 | NA | ALDH8A1 Entrez, Source | aldehyde dehydrogenase 8 family, member A1 | 8398 | 0.162 | 0.0400 | No |
| 50 | LONP2 | NA | 8553 | 0.148 | 0.0327 | No | ||
| 51 | GSTK1 | NA | GSTK1 Entrez, Source | glutathione S-transferase kappa 1 | 8680 | 0.135 | 0.0268 | No |
| 52 | ABCG8 | NA | ABCG8 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2) | 8703 | 0.131 | 0.0268 | No |
| 53 | RXRG | NA | RXRG Entrez, Source | retinoid X receptor, gamma | 9140 | 0.085 | 0.0031 | No |
| 54 | AGXT | NA | AGXT Entrez, Source | alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase) | 9348 | 0.066 | -0.0079 | No |
| 55 | PRDX5 | NA | PRDX5 Entrez, Source | peroxiredoxin 5 | 9422 | 0.058 | -0.0115 | No |
| 56 | CYP46A1 | NA | CYP46A1 Entrez, Source | cytochrome P450, family 46, subfamily A, polypeptide 1 | 9478 | 0.055 | -0.0140 | No |
| 57 | SULT2B1 | NA | SULT2B1 Entrez, Source | sulfotransferase family, cytosolic, 2B, member 1 | 9616 | 0.038 | -0.0214 | No |
| 58 | RBP1 | NA | RBP1 Entrez, Source | retinol binding protein 1, cellular | 9853 | 0.003 | -0.0346 | No |
| 59 | AQP9 | NA | AQP9 Entrez, Source | aquaporin 9 | 10466 | -0.031 | -0.0685 | No |
| 60 | PEX16 | NA | PEX16 Entrez, Source | peroxisomal biogenesis factor 16 | 10565 | -0.037 | -0.0737 | No |
| 61 | ALDH1A1 | NA | ALDH1A1 Entrez, Source | aldehyde dehydrogenase 1 family, member A1 | 10593 | -0.041 | -0.0748 | No |
| 62 | CYP7A1 | NA | CYP7A1 Entrez, Source | cytochrome P450, family 7, subfamily A, polypeptide 1 | 10825 | -0.061 | -0.0872 | No |
| 63 | AKR1D1 | NA | AKR1D1 Entrez, Source | aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | 10876 | -0.066 | -0.0895 | No |
| 64 | GNPAT | NA | GNPAT Entrez, Source | glyceronephosphate O-acyltransferase | 11056 | -0.087 | -0.0987 | No |
| 65 | RETSAT | NA | RETSAT Entrez, Source | retinol saturase (all-trans-retinol 13,14-reductase) | 11203 | -0.105 | -0.1060 | No |
| 66 | BBOX1 | NA | BBOX1 Entrez, Source | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 11218 | -0.106 | -0.1058 | No |
| 67 | SLC27A5 | NA | SLC27A5 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 5 | 11293 | -0.113 | -0.1090 | No |
| 68 | NR1H4 | NA | NR1H4 Entrez, Source | nuclear receptor subfamily 1, group H, member 4 | 11513 | -0.134 | -0.1200 | No |
| 69 | CYP8B1 | NA | CYP8B1 Entrez, Source | cytochrome P450, family 8, subfamily B, polypeptide 1 | 11756 | -0.162 | -0.1321 | No |
| 70 | SLCO1A2 | NA | SLCO1A2 Entrez, Source | solute carrier organic anion transporter family, member 1A2 | 11772 | -0.165 | -0.1315 | No |
| 71 | CYP7B1 | NA | CYP7B1 Entrez, Source | cytochrome P450, family 7, subfamily B, polypeptide 1 | 11985 | -0.189 | -0.1417 | No |
| 72 | ABCA4 | NA | ABCA4 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 4 | 11991 | -0.190 | -0.1403 | No |
| 73 | ABCA6 | NA | ABCA6 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 6 | 12105 | -0.202 | -0.1449 | No |
| 74 | SERPINA6 | NA | SERPINA6 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 | 12303 | -0.227 | -0.1539 | No |
| 75 | PEX19 | NA | PEX19 Entrez, Source | peroxisomal biogenesis factor 19 | 12411 | -0.239 | -0.1578 | No |
| 76 | LIPE | NA | LIPE Entrez, Source | lipase, hormone-sensitive | 12430 | -0.241 | -0.1567 | No |
| 77 | BCAR3 | NA | BCAR3 Entrez, Source | breast cancer anti-estrogen resistance 3 | 12635 | -0.268 | -0.1657 | No |
| 78 | PIPOX | NA | PIPOX Entrez, Source | pipecolic acid oxidase | 12870 | -0.298 | -0.1762 | No |
| 79 | ABCA8 | NA | ABCA8 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 8 | 13064 | -0.328 | -0.1841 | No |
| 80 | ACSL1 | NA | ACSL1 Entrez, Source | acyl-CoA synthetase long-chain family member 1 | 13248 | -0.356 | -0.1912 | No |
| 81 | KLF1 | NA | KLF1 Entrez, Source | Kruppel-like factor 1 (erythroid) | 13297 | -0.366 | -0.1907 | No |
| 82 | PEX13 | NA | PEX13 Entrez, Source | peroxisome biogenesis factor 13 | 13471 | -0.394 | -0.1969 | No |
| 83 | PEX26 | NA | PEX26 Entrez, Source | peroxisome biogenesis factor 26 | 13528 | -0.404 | -0.1965 | No |
| 84 | ALDH9A1 | NA | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 13537 | -0.405 | -0.1934 | No |
| 85 | SLC22A18 | NA | SLC22A18 Entrez, Source | solute carrier family 22 (organic cation transporter), member 18 | 13978 | -0.486 | -0.2137 | No |
| 86 | PXMP2 | NA | PXMP2 Entrez, Source | peroxisomal membrane protein 2, 22kDa | 14070 | -0.505 | -0.2144 | No |
| 87 | ABCA2 | NA | ABCA2 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 2 | 14180 | -0.527 | -0.2158 | No |
| 88 | FDXR | NA | FDXR Entrez, Source | ferredoxin reductase | 15019 | -0.726 | -0.2563 | No |
| 89 | ABCG4 | NA | ABCG4 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 4 | 15031 | -0.729 | -0.2505 | No |
| 90 | GNMT | NA | GNMT Entrez, Source | glycine N-methyltransferase | 15474 | -0.854 | -0.2678 | No |
| 91 | PAOX | NA | PAOX Entrez, Source | polyamine oxidase (exo-N4-amino) | 15595 | -0.894 | -0.2666 | No |
| 92 | ACSL5 | NA | ACSL5 Entrez, Source | acyl-CoA synthetase long-chain family member 5 | 15957 | -1.029 | -0.2778 | No |
| 93 | NEDD4 | NA | NEDD4 Entrez, Source | neural precursor cell expressed, developmentally down-regulated 4 | 16308 | -1.194 | -0.2868 | Yes |
| 94 | IDI1 | NA | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 16384 | -1.239 | -0.2801 | Yes |
| 95 | HACL1 | NA | HACL1 Entrez, Source | 2-hydroxyacyl-CoA lyase 1 | 16465 | -1.276 | -0.2734 | Yes |
| 96 | ABCA3 | NA | ABCA3 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 3 | 16475 | -1.282 | -0.2626 | Yes |
| 97 | NR1I2 | NA | NR1I2 Entrez, Source | nuclear receptor subfamily 1, group I, member 2 | 16518 | -1.313 | -0.2534 | Yes |
| 98 | PEX11G | NA | PEX11G Entrez, Source | peroxisomal biogenesis factor 11 gamma | 16659 | -1.400 | -0.2489 | Yes |
| 99 | HSD3B1 | NA | HSD3B1 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | 16756 | -1.475 | -0.2413 | Yes |
| 100 | PEX7 | NA | PEX7 Entrez, Source | peroxisomal biogenesis factor 7 | 16831 | -1.530 | -0.2320 | Yes |
| 101 | CYP27A1 | NA | CYP27A1 Entrez, Source | cytochrome P450, family 27, subfamily A, polypeptide 1 | 17146 | -1.837 | -0.2334 | Yes |
| 102 | FADS1 | NA | FADS1 Entrez, Source | fatty acid desaturase 1 | 17269 | -1.998 | -0.2226 | Yes |
| 103 | TFCP2L1 | NA | TFCP2L1 Entrez, Source | transcription factor CP2-like 1 | 17280 | -2.013 | -0.2054 | Yes |
| 104 | HSD17B6 | NA | HSD17B6 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 6 | 17409 | -2.256 | -0.1927 | Yes |
| 105 | ABCA1 | NA | ABCA1 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 1 | 17541 | -2.529 | -0.1778 | Yes |
| 106 | FADS2 | NA | FADS2 Entrez, Source | fatty acid desaturase 2 | 17604 | -2.732 | -0.1572 | Yes |
| 107 | DHCR24 | NA | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 17715 | -3.203 | -0.1352 | Yes |
| 108 | IDH2 | NA | IDH2 Entrez, Source | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 17775 | -3.598 | -0.1068 | Yes |
| 109 | DIO2 | NA | DIO2 Entrez, Source | deiodinase, iodothyronine, type II | 17815 | -3.853 | -0.0751 | Yes |
| 110 | HAO1 | NA | HAO1 Entrez, Source | hydroxyacid oxidase (glycolate oxidase) 1 | 17929 | -4.665 | -0.0404 | Yes |
| 111 | SULT1B1 | NA | SULT1B1 Entrez, Source | sulfotransferase family, cytosolic, 1B, member 1 | 17961 | -4.906 | 0.0011 | Yes |
