Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_APOPTOSIS
Enrichment Score (ES)0.4242943
Normalized Enrichment Score (NES)1.4919572
Nominal p-value0.008158508
FDR q-value0.022715064
FWER p-Value0.228
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_APOPTOSIS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1GPX3NAGPX3
Entrez,  Source
glutathione peroxidase 3 (plasma)44.9600.0235Yes
2EREGNAEREG
Entrez,  Source
epiregulin534.7310.0435Yes
3TNFSF10NATNFSF10
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 101084.4970.0619Yes
4ERBB3NAERBB3
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)1434.3550.0809Yes
5SLC20A1NASLC20A1
Entrez,  Source
solute carrier family 20 (phosphate transporter), member 12194.0270.0959Yes
6TIMP3NATIMP3
Entrez,  Source
TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)2204.0240.1152Yes
7HMOX1NAHMOX1
Entrez,  Source
heme oxygenase (decycling) 12813.8020.1300Yes
8IL18NAIL18
Entrez,  Source
interleukin 18 (interferon-gamma-inducing factor)3383.6230.1442Yes
9GSRNAGSR
Entrez,  Source
glutathione reductase3533.5870.1606Yes
10CD14NACD14
Entrez,  Source
CD14 molecule4023.4560.1745Yes
11BIRC3NABIRC3
Entrez,  Source
baculoviral IAP repeat-containing 34373.3370.1885Yes
12SQSTM1NASQSTM1
Entrez,  Source
sequestosome 14393.3350.2044Yes
13F2RNAF2R
Entrez,  Source
coagulation factor II (thrombin) receptor5153.1120.2151Yes
14PLATNAPLAT
Entrez,  Source
plasminogen activator, tissue5203.1030.2297Yes
15CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)5223.1000.2445Yes
16LUMNALUM
Entrez,  Source
lumican5613.0210.2568Yes
17IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)6902.7780.2629Yes
18IGFBP6NAIGFBP6
Entrez,  Source
insulin-like growth factor binding protein 67152.7250.2746Yes
19FASNAFAS
Entrez,  Source
Fas (TNF receptor superfamily, member 6)7332.6790.2865Yes
20TGFBR3NATGFBR3
Entrez,  Source
transforming growth factor, beta receptor III (betaglycan, 300kDa)7532.6420.2981Yes
21CTHNACTH
Entrez,  Source
cystathionase (cystathionine gamma-lyase)7642.6300.3101Yes
22CASP9NACASP9
Entrez,  Source
caspase 9, apoptosis-related cysteine peptidase8412.5270.3179Yes
23DDIT3NADDIT3
Entrez,  Source
DNA-damage-inducible transcript 38732.4850.3281Yes
24IER3NAIER3
Entrez,  Source
immediate early response 38802.4820.3396Yes
25BNIP3LNABNIP3L
Entrez,  Source
BCL2/adenovirus E1B 19kDa interacting protein 3-like8952.4610.3506Yes
26CASP1NACASP1
Entrez,  Source
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)10012.3380.3559Yes
27EMP1NAEMP1
Entrez,  Source
epithelial membrane protein 113791.9710.3442Yes
28BCL2L11NABCL2L11
Entrez,  Source
BCL2-like 11 (apoptosis facilitator)14531.9070.3492Yes
29CASP6NACASP6
Entrez,  Source
caspase 6, apoptosis-related cysteine peptidase14901.8880.3562Yes
30BCL2L1NABCL2L1
Entrez,  Source
BCL2-like 114991.8830.3648Yes
31PMAIP1NAPMAIP1
Entrez,  Source
phorbol-12-myristate-13-acetate-induced protein 115081.8800.3733Yes
32DFFANADFFA
Entrez,  Source
DNA fragmentation factor, 45kDa, alpha polypeptide16751.7510.3724Yes
33TIMP2NATIMP2
Entrez,  Source
TIMP metallopeptidase inhibitor 216821.7470.3804Yes
34PPP2R5BNAPPP2R5B
Entrez,  Source
protein phosphatase 2, regulatory subunit B (B56), beta isoform19031.6120.3758Yes
35CDC25BNACDC25B
Entrez,  Source
cell division cycle 25B21241.4830.3706Yes
36SMAD7NASMAD7
Entrez,  Source
SMAD, mothers against DPP homolog 7 (Drosophila)21421.4740.3767Yes
37GSNNAGSN
Entrez,  Source
gelsolin (amyloidosis, Finnish type)21511.4710.3832Yes
38CYLDNACYLD
Entrez,  Source
cylindromatosis (turban tumor syndrome)21661.4640.3895Yes
39TIMP1NATIMP1
Entrez,  Source
TIMP metallopeptidase inhibitor 121841.4550.3955Yes
40TGFB2NATGFB2
Entrez,  Source
transforming growth factor, beta 223021.4140.3957Yes
41PSEN2NAPSEN2
Entrez,  Source
presenilin 2 (Alzheimer disease 4)25161.3170.3900Yes
42LMNANALMNA
Entrez,  Source
lamin A/C26551.2620.3883Yes
43CDKN1BNACDKN1B
Entrez,  Source
cyclin-dependent kinase inhibitor 1B (p27, Kip1)26801.2530.3930Yes
44CASP8NACASP8
Entrez,  Source
caspase 8, apoptosis-related cysteine peptidase27961.2140.3923Yes
45ERBB2NAERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)28511.1970.3950Yes
46SPTAN1NASPTAN1
Entrez,  Source
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)29211.1750.3968Yes
47BCL2L2NABCL2L2
Entrez,  Source
BCL2-like 230001.1480.3979Yes
48ANXA1NAANXA1
Entrez,  Source
annexin A130741.1240.3992Yes
49SAT1NASAT1
Entrez,  Source
spermidine/spermine N1-acetyltransferase 131111.1140.4025Yes
50TOP2ANATOP2A
Entrez,  Source
topoisomerase (DNA) II alpha 170kDa32241.0820.4014Yes
51ADD1NAADD1
Entrez,  Source
adducin 1 (alpha)32441.0760.4055Yes
52PRF1NAPRF1
Entrez,  Source
perforin 1 (pore forming protein)32671.0690.4093Yes
53PSEN1NAPSEN1
Entrez,  Source
presenilin 1 (Alzheimer disease 3)32901.0620.4132Yes
54SATB1NASATB1
Entrez,  Source
special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's)32961.0600.4180Yes
55IRF1NAIRF1
Entrez,  Source
interferon regulatory factor 133551.0410.4197Yes
56LGALS3NALGALS3
Entrez,  Source
lectin, galactoside-binding, soluble, 3 (galectin 3)33631.0390.4243Yes
57TNFRSF12ANATNFRSF12A
Entrez,  Source
tumor necrosis factor receptor superfamily, member 12A35270.9900.4199No
58CD38NACD38
Entrez,  Source
CD38 molecule36110.9650.4198No
59RARANARARA
Entrez,  Source
retinoic acid receptor, alpha38060.9140.4133No
60CD69NACD69
Entrez,  Source
CD69 molecule42130.8120.3945No
61GPX4NAGPX4
Entrez,  Source
glutathione peroxidase 4 (phospholipid hydroperoxidase)42210.8120.3979No
62BMFNABMF
Entrez,  Source
Bcl2 modifying factor43310.7860.3956No
63AVPR1ANAAVPR1A
Entrez,  Source
arginine vasopressin receptor 1A44010.7730.3954No
64CFLARNACFLAR
Entrez,  Source
CASP8 and FADD-like apoptosis regulator44180.7690.3982No
65FASLGNAFASLG
Entrez,  Source
Fas ligand (TNF superfamily, member 6)46080.7230.3911No
66ETF1NAETF1
Entrez,  Source
eukaryotic translation termination factor 146880.7060.3900No
67RHOBNARHOB
Entrez,  Source
ras homolog gene family, member B47300.6980.3910No
68ISG20NAISG20
Entrez,  Source
interferon stimulated exonuclease gene 20kDa47340.6980.3942No
69CASP7NACASP7
Entrez,  Source
caspase 7, apoptosis-related cysteine peptidase47710.6890.3955No
70EGR3NAEGR3
Entrez,  Source
early growth response 349030.6610.3913No
71TXNIPNATXNIP
Entrez,  Source
thioredoxin interacting protein52420.5970.3752No
72CCND1NACCND1
Entrez,  Source
cyclin D152520.5950.3775No
73MADDNAMADD
Entrez,  Source
MAP-kinase activating death domain52820.5890.3787No
74ENO2NAENO2
Entrez,  Source
enolase 2 (gamma, neuronal)58710.4900.3481No
75SOD1NASOD1
Entrez,  Source
superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))60920.4520.3379No
76DCNNADCN
Entrez,  Source
decorin65230.3820.3156No
77IFNB1NAIFNB1
Entrez,  Source
interferon, beta 1, fibroblast65910.3720.3136No
78XIAPNA66050.3700.3147No
79GNA15NAGNA15
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)66770.3600.3124No
80NEFHNANEFH
Entrez,  Source
neurofilament, heavy polypeptide 200kDa66890.3580.3135No
81JUNNAJUN
Entrez,  Source
jun oncogene70420.3100.2953No
82VDAC2NAVDAC2
Entrez,  Source
voltage-dependent anion channel 271070.3000.2931No
83MMP2NAMMP2
Entrez,  Source
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)71780.2900.2906No
84DNAJA1NADNAJA1
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily A, member 173030.2740.2849No
85PDGFRBNAPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide79810.2040.2479No
86TAP1NATAP1
Entrez,  Source
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)80460.1970.2453No
87IGF2RNAIGF2R
Entrez,  Source
insulin-like growth factor 2 receptor81780.1790.2388No
88CCNA1NACCNA1
Entrez,  Source
cyclin A183100.1680.2322No
89KRT18NAKRT18
Entrez,  Source
keratin 1883620.1640.2301No
90ANKHNAANKH
Entrez,  Source
ankylosis, progressive homolog (mouse)84380.1580.2267No
91ROCK1NAROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 184630.1560.2261No
92PTK2NAPTK2
Entrez,  Source
PTK2 protein tyrosine kinase 287770.1230.2091No
93BCL10NABCL10
Entrez,  Source
B-cell CLL/lymphoma 1088520.1160.2055No
94BAXNABAX
Entrez,  Source
BCL2-associated X protein89660.1020.1997No
95DNM1LNADNM1L
Entrez,  Source
dynamin 1-like90630.0930.1947No
96GSTM1NAGSTM1
Entrez,  Source
glutathione S-transferase M194900.0540.1711No
97BGNNABGN
Entrez,  Source
biglycan96030.0390.1650No
98GPX1NAGPX1
Entrez,  Source
glutathione peroxidase 197420.0200.1574No
99CD2NACD2
Entrez,  Source
CD2 molecule98900.0000.1491No
100CREBBPNACREBBP
Entrez,  Source
CREB binding protein (Rubinstein-Taybi syndrome)10327-0.0180.1247No
101GUCY2DNAGUCY2D
Entrez,  Source
guanylate cyclase 2D, membrane (retina-specific)10495-0.0310.1155No
102CD44NACD44
Entrez,  Source
CD44 molecule (Indian blood group)10693-0.0500.1047No
103RELANARELA
Entrez,  Source
v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)10834-0.0620.0971No
104RETSATNARETSAT
Entrez,  Source
retinol saturase (all-trans-retinol 13,14-reductase)11203-0.1050.0770No
105FEZ1NAFEZ1
Entrez,  Source
fasciculation and elongation protein zeta 1 (zygin I)11431-0.1270.0649No
106BCL2L10NABCL2L10
Entrez,  Source
BCL2-like 10 (apoptosis facilitator)11964-0.1870.0359No
107NEDD9NANEDD9
Entrez,  Source
neural precursor cell expressed, developmentally down-regulated 912124-0.2040.0280No
108GCH1NAGCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)12220-0.2160.0237No
109IFNGR1NAIFNGR1
Entrez,  Source
interferon gamma receptor 112333-0.2310.0185No
110GADD45BNAGADD45B
Entrez,  Source
growth arrest and DNA-damage-inducible, beta12568-0.2590.0066No
111TNFNATNF
Entrez,  Source
tumor necrosis factor (TNF superfamily, member 2)12645-0.2690.0036No
112F2NAF2
Entrez,  Source
coagulation factor II (thrombin)13096-0.334-0.0200No
113DAP3NADAP3
Entrez,  Source
death associated protein 313206-0.350-0.0245No
114BIDNABID
Entrez,  Source
BH3 interacting domain death agonist13231-0.353-0.0241No
115PEA15NAPEA15
Entrez,  Source
phosphoprotein enriched in astrocytes 1513670-0.430-0.0466No
116CAV1NACAV1
Entrez,  Source
caveolin 1, caveolae protein, 22kDa13813-0.455-0.0524No
117GADD45ANAGADD45A
Entrez,  Source
growth arrest and DNA-damage-inducible, alpha13870-0.467-0.0533No
118RHOT2NARHOT2
Entrez,  Source
ras homolog gene family, member T213872-0.468-0.0511No
119HGFNAHGF
Entrez,  Source
hepatocyte growth factor (hepapoietin A; scatter factor)13877-0.468-0.0491No
120DNAJC3NADNAJC3
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily C, member 313927-0.475-0.0496No
121EBPNAEBP
Entrez,  Source
emopamil binding protein (sterol isomerase)14287-0.549-0.0671No
122CASP4NACASP4
Entrez,  Source
caspase 4, apoptosis-related cysteine peptidase14446-0.582-0.0732No
123CTNNB1NACTNNB1
Entrez,  Source
catenin (cadherin-associated protein), beta 1, 88kDa14895-0.694-0.0950No
124FDXRNAFDXR
Entrez,  Source
ferredoxin reductase15019-0.726-0.0984No
125PAK1NAPAK1
Entrez,  Source
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)15023-0.727-0.0951No
126HSPB1NAHSPB1
Entrez,  Source
heat shock 27kDa protein 115080-0.741-0.0947No
127BCAP31NABCAP31
Entrez,  Source
B-cell receptor-associated protein 3115298-0.802-0.1031No
128TSPONATSPO
Entrez,  Source
translocator protein (18kDa)15306-0.805-0.0996No
129APPNAAPP
Entrez,  Source
amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)15338-0.815-0.0974No
130PPT1NAPPT1
Entrez,  Source
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)15446-0.845-0.0994No
131CDK2NACDK2
Entrez,  Source
cyclin-dependent kinase 215469-0.852-0.0966No
132MCL1NAMCL1
Entrez,  Source
myeloid cell leukemia sequence 1 (BCL2-related)15498-0.862-0.0940No
133CASP2NACASP2
Entrez,  Source
caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2)15835-0.982-0.1081No
134BRCA1NABRCA1
Entrez,  Source
breast cancer 1, early onset15925-1.019-0.1083No
135WEE1NAWEE1
Entrez,  Source
WEE1 homolog (S. pombe)16033-1.057-0.1092No
136RNASELNARNASEL
Entrez,  Source
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)16046-1.062-0.1048No
137LEF1NALEF1
Entrez,  Source
lymphoid enhancer-binding factor 116125-1.101-0.1039No
138PPP3R1NAPPP3R1
Entrez,  Source
protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)16468-1.277-0.1170No
139DIABLONADIABLO
Entrez,  Source
diablo homolog (Drosophila)16520-1.314-0.1136No
140BTG3NABTG3
Entrez,  Source
BTG family, member 316612-1.375-0.1121No
141HMGB2NAHMGB2
Entrez,  Source
high-mobility group box 216811-1.517-0.1159No
142H1F0NAH1F0
Entrez,  Source
H1 histone family, member 016847-1.544-0.1105No
143CCND2NACCND2
Entrez,  Source
cyclin D216961-1.643-0.1090No
144SOD2NASOD2
Entrez,  Source
superoxide dismutase 2, mitochondrial17010-1.692-0.1036No
145DPYDNADPYD
Entrez,  Source
dihydropyrimidine dehydrogenase17018-1.701-0.0958No
146IFITM3NAIFITM3
Entrez,  Source
interferon induced transmembrane protein 3 (1-8U)17099-1.789-0.0918No
147BMP2NABMP2
Entrez,  Source
bone morphogenetic protein 217210-1.924-0.0887No
148BIKNABIK
Entrez,  Source
BCL2-interacting killer (apoptosis-inducing)17283-2.016-0.0831No
149PDCD4NAPDCD4
Entrez,  Source
programmed cell death 4 (neoplastic transformation inhibitor)17295-2.032-0.0740No
150CASP3NACASP3
Entrez,  Source
caspase 3, apoptosis-related cysteine peptidase17337-2.106-0.0662No
151DAPNADAP
Entrez,  Source
death-associated protein17625-2.801-0.0689No
152PLCB2NAPLCB2
Entrez,  Source
phospholipase C, beta 217672-3.047-0.0569No
153AIFM3NA17678-3.065-0.0425No
154IL1BNAIL1B
Entrez,  Source
interleukin 1, beta17833-3.984-0.0321No
155BTG2NABTG2
Entrez,  Source
BTG family, member 217866-4.154-0.0140No
156IL1ANAIL1A
Entrez,  Source
interleukin 1, alpha17880-4.2590.0056No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_APOPTOSIS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_APOPTOSIS: Random ES distribution   
Gene set null distribution of ES for HALLMARK_APOPTOSIS