Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_APICAL_JUNCTION
Enrichment Score (ES)-0.26483548
Normalized Enrichment Score (NES)-1.1503221
Nominal p-value0.092307694
FDR q-value0.17858948
FWER p-Value0.75
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_APICAL_JUNCTION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ITGB4NAITGB4
Entrez,  Source
integrin, beta 41104.4780.0139No
2PCDH1NAPCDH1
Entrez,  Source
protocadherin 1 (cadherin-like 1)1394.3760.0320No
3CLDN4NACLDN4
Entrez,  Source
claudin 41524.3070.0507No
4SHROOM2NASHROOM2
Entrez,  Source
shroom family member 22623.8660.0619No
5JUPNAJUP
Entrez,  Source
junction plakoglobin2673.8510.0790No
6ADAM23NAADAM23
Entrez,  Source
ADAM metallopeptidase domain 232873.7810.0949No
7LAMA3NALAMA3
Entrez,  Source
laminin, alpha 32933.7460.1115No
8ITGA2NAITGA2
Entrez,  Source
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)4243.3790.1194No
9NRTNNANRTN
Entrez,  Source
neurturin5413.0510.1265No
10CDH11NACDH11
Entrez,  Source
cadherin 11, type 2, OB-cadherin (osteoblast)6682.8070.1321No
11ADAM9NAADAM9
Entrez,  Source
ADAM metallopeptidase domain 9 (meltrin gamma)7362.6760.1403No
12GRB7NAGRB7
Entrez,  Source
growth factor receptor-bound protein 77902.5960.1490No
13BMP1NABMP1
Entrez,  Source
bone morphogenetic protein 18022.5790.1600No
14IKBKGNAIKBKG
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma8182.5620.1706No
15IRS1NAIRS1
Entrez,  Source
insulin receptor substrate 18432.5270.1807No
16ICAM4NAICAM4
Entrez,  Source
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)8902.4720.1892No
17AMIGO2NAAMIGO2
Entrez,  Source
adhesion molecule with Ig-like domain 29852.3520.1945No
18SLIT2NASLIT2
Entrez,  Source
slit homolog 2 (Drosophila)10062.3290.2038No
19ITGA3NAITGA3
Entrez,  Source
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)10382.2850.2123No
20PPP2R2CNAPPP2R2C
Entrez,  Source
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform12652.0720.2089No
21FBN1NAFBN1
Entrez,  Source
fibrillin 113501.9920.2131No
22PIK3R3NAPIK3R3
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)14101.9460.2186No
23CNTN1NACNTN1
Entrez,  Source
contactin 114721.8970.2237No
24BAIAP2NABAIAP2
Entrez,  Source
BAI1-associated protein 216881.7430.2194No
25LDLRAP1NALDLRAP1
Entrez,  Source
low density lipoprotein receptor adaptor protein 117621.6860.2229No
26CTNNA1NACTNNA1
Entrez,  Source
catenin (cadherin-associated protein), alpha 1, 102kDa17981.6680.2284No
27GAMTNAGAMT
Entrez,  Source
guanidinoacetate N-methyltransferase18881.6210.2307No
28TNFRSF11BNATNFRSF11B
Entrez,  Source
tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)19471.5870.2346No
29CRB3NACRB3
Entrez,  Source
crumbs homolog 3 (Drosophila)20711.5140.2344No
30PECAM1NAPECAM1
Entrez,  Source
platelet/endothelial cell adhesion molecule (CD31 antigen)21281.4810.2379No
31B4GALT1NAB4GALT1
Entrez,  Source
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 121781.4590.2417No
32STX4NASTX4
Entrez,  Source
syntaxin 422441.4310.2445No
33SPEGNASPEG
Entrez,  Source
SPEG complex locus22641.4240.2499No
34CD99NACD99
Entrez,  Source
CD99 molecule23641.3890.2505No
35ADRA1BNAADRA1B
Entrez,  Source
adrenergic, alpha-1B-, receptor24231.3620.2534No
36RASA1NARASA1
Entrez,  Source
RAS p21 protein activator (GTPase activating protein) 126491.2640.2464No
37GNAI1NAGNAI1
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 126541.2620.2519No
38NF1NANF1
Entrez,  Source
neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)28691.1920.2452No
39CLDN14NACLDN14
Entrez,  Source
claudin 1428891.1850.2494No
40PBX2NAPBX2
Entrez,  Source
pre-B-cell leukemia transcription factor 229041.1820.2540No
41LAYNNALAYN
Entrez,  Source
layilin31051.1170.2477No
42FLNCNAFLNC
Entrez,  Source
filamin C, gamma (actin binding protein 280)32641.0710.2437No
43DHX16NADHX16
Entrez,  Source
DEAH (Asp-Glu-Ala-His) box polypeptide 1633811.0330.2418No
44TRAF1NATRAF1
Entrez,  Source
TNF receptor-associated factor 134081.0260.2449No
45EGFRNAEGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)34281.0200.2485No
46MDKNAMDK
Entrez,  Source
midkine (neurite growth-promoting factor 2)35290.9900.2473No
47LIMA1NALIMA1
Entrez,  Source
LIM domain and actin binding 135840.9750.2486No
48MPZL1NAMPZL1
Entrez,  Source
myelin protein zero-like 136360.9580.2501No
49CLDN9NACLDN9
Entrez,  Source
claudin 936500.9560.2536No
50VCAM1NAVCAM1
Entrez,  Source
vascular cell adhesion molecule 137220.9360.2538No
51CADM2NA40180.8640.2411No
52ACTG1NAACTG1
Entrez,  Source
actin, gamma 141440.8300.2378No
53DLG1NADLG1
Entrez,  Source
discs, large homolog 1 (Drosophila)41840.8210.2393No
54ATP1A3NAATP1A3
Entrez,  Source
ATPase, Na+/K+ transporting, alpha 3 polypeptide43370.7850.2343No
55MYL12BNA43450.7820.2374No
56MAPK14NAMAPK14
Entrez,  Source
mitogen-activated protein kinase 1447010.7030.2206No
57TRONATRO
Entrez,  Source
trophinin47270.6990.2224No
58ICAM5NAICAM5
Entrez,  Source
intercellular adhesion molecule 5, telencephalin48210.6780.2202No
59SRCNASRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)48270.6760.2229No
60ITGA10NAITGA10
Entrez,  Source
integrin, alpha 1048370.6750.2255No
61HRASNAHRAS
Entrez,  Source
v-Ha-ras Harvey rat sarcoma viral oncogene homolog48400.6740.2284No
62LAMC2NALAMC2
Entrez,  Source
laminin, gamma 249100.6590.2275No
63CDH1NACDH1
Entrez,  Source
cadherin 1, type 1, E-cadherin (epithelial)49400.6530.2288No
64VAV2NAVAV2
Entrez,  Source
vav 2 oncogene50300.6360.2266No
65RRASNARRAS
Entrez,  Source
related RAS viral (r-ras) oncogene homolog50470.6330.2286No
66CD209NACD209
Entrez,  Source
CD209 molecule51200.6190.2273No
67AMIGO1NAAMIGO1
Entrez,  Source
adhesion molecule with Ig-like domain 151420.6150.2289No
68INPPL1NAINPPL1
Entrez,  Source
inositol polyphosphate phosphatase-like 157120.5150.1992No
69CLDN6NACLDN6
Entrez,  Source
claudin 659010.4870.1908No
70CD34NACD34
Entrez,  Source
CD34 molecule59900.4680.1880No
71CRATNACRAT
Entrez,  Source
carnitine acetyltransferase60170.4640.1886No
72TSC1NATSC1
Entrez,  Source
tuberous sclerosis 161020.4490.1859No
73WASLNAWASL
Entrez,  Source
Wiskott-Aldrich syndrome-like61050.4490.1878No
74NEXNNANEXN
Entrez,  Source
nexilin (F actin binding protein)63560.4020.1755No
75SKAP2NASKAP2
Entrez,  Source
src kinase associated phosphoprotein 264280.3950.1733No
76ITGB1NAITGB1
Entrez,  Source
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)64950.3860.1713No
77AKT2NAAKT2
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 264980.3850.1730No
78CNN2NACNN2
Entrez,  Source
calponin 265890.3730.1696No
79DMP1NADMP1
Entrez,  Source
dentin matrix acidic phosphoprotein68590.3350.1560No
80CLDN7NACLDN7
Entrez,  Source
claudin 770060.3150.1492No
81PTENNAPTEN
Entrez,  Source
phosphatase and tensin homolog (mutated in multiple advanced cancers 1)70940.3030.1456No
82EXOC4NAEXOC4
Entrez,  Source
exocyst complex component 471010.3020.1467No
83NEGR1NANEGR1
Entrez,  Source
neuronal growth regulator 171470.2950.1454No
84MMP2NAMMP2
Entrez,  Source
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)71780.2900.1451No
85CDH15NACDH15
Entrez,  Source
cadherin 15, M-cadherin (myotubule)72330.2830.1433No
86ACTN4NAACTN4
Entrez,  Source
actinin, alpha 472820.2760.1418No
87ADAMTS5NAADAMTS5
Entrez,  Source
ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2)74930.2530.1312No
88PIK3CBNAPIK3CB
Entrez,  Source
phosphoinositide-3-kinase, catalytic, beta polypeptide76350.2400.1243No
89CTNND1NACTNND1
Entrez,  Source
catenin (cadherin-associated protein), delta 177480.2290.1191No
90SYMPKNASYMPK
Entrez,  Source
symplekin78690.2170.1133No
91TSPAN4NATSPAN4
Entrez,  Source
tetraspanin 479220.2120.1113No
92CADM3NA80210.2000.1067No
93SORBS3NASORBS3
Entrez,  Source
sorbin and SH3 domain containing 385920.1430.0753No
94CLDN8NACLDN8
Entrez,  Source
claudin 886020.1430.0754No
95MSNNAMSN
Entrez,  Source
moesin86680.1370.0724No
96TUBG1NATUBG1
Entrez,  Source
tubulin, gamma 187310.1290.0695No
97TIAL1NATIAL1
Entrez,  Source
TIA1 cytotoxic granule-associated RNA binding protein-like 187580.1250.0686No
98PTK2NAPTK2
Entrez,  Source
PTK2 protein tyrosine kinase 287770.1230.0681No
99CDH6NACDH6
Entrez,  Source
cadherin 6, type 2, K-cadherin (fetal kidney)88050.1210.0672No
100RSU1NARSU1
Entrez,  Source
Ras suppressor protein 188100.1200.0675No
101ARHGEF6NAARHGEF6
Entrez,  Source
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 688220.1190.0674No
102NRAPNANRAP
Entrez,  Source
nebulin-related anchoring protein89060.1090.0632No
103TAOK2NATAOK2
Entrez,  Source
TAO kinase 289230.1070.0628No
104ACTC1NAACTC1
Entrez,  Source
actin, alpha, cardiac muscle 189450.1050.0621No
105NLGN2NANLGN2
Entrez,  Source
neuroligin 290010.0990.0594No
106PDZD3NAPDZD3
Entrez,  Source
PDZ domain containing 393150.0690.0421No
107CDSNNACDSN
Entrez,  Source
corneodesmosin96580.0320.0231No
108ICAM1NAICAM1
Entrez,  Source
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor97160.0230.0200No
109NRXN2NANRXN2
Entrez,  Source
neurexin 297400.0200.0188No
110CLDN18NACLDN18
Entrez,  Source
claudin 1897680.0150.0173No
111SDC3NASDC3
Entrez,  Source
syndecan 3 (N-syndecan)98680.0020.0118No
112COL9A1NACOL9A1
Entrez,  Source
collagen, type IX, alpha 199620.0000.0065No
113KRT31NAKRT31
Entrez,  Source
keratin 31101210.000-0.0024No
114SYKNASYK
Entrez,  Source
spleen tyrosine kinase10297-0.014-0.0121No
115THY1NATHY1
Entrez,  Source
Thy-1 cell surface antigen10307-0.015-0.0126No
116GTF2F1NAGTF2F1
Entrez,  Source
general transcription factor IIF, polypeptide 1, 74kDa10347-0.020-0.0147No
117CX3CL1NACX3CL1
Entrez,  Source
chemokine (C-X3-C motif) ligand 110558-0.036-0.0263No
118KCNH2NAKCNH2
Entrez,  Source
potassium voltage-gated channel, subfamily H (eag-related), member 210650-0.045-0.0312No
119CD274NACD274
Entrez,  Source
CD274 molecule10770-0.056-0.0377No
120ALOX15BNAALOX15B
Entrez,  Source
arachidonate 15-lipoxygenase, type B10777-0.056-0.0378No
121CDH8NACDH8
Entrez,  Source
cadherin 8, type 210901-0.069-0.0444No
122PTPRCNAPTPRC
Entrez,  Source
protein tyrosine phosphatase, receptor type, C10903-0.069-0.0441No
123MADCAM1NAMADCAM1
Entrez,  Source
mucosal vascular addressin cell adhesion molecule 111063-0.087-0.0527No
124CD86NACD86
Entrez,  Source
CD86 molecule11217-0.106-0.0608No
125CERCAMNA11463-0.129-0.0740No
126MYL9NAMYL9
Entrez,  Source
myosin, light chain 9, regulatory11585-0.142-0.0801No
127PARVANAPARVA
Entrez,  Source
parvin, alpha11837-0.173-0.0935No
128MPP5NAMPP5
Entrez,  Source
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)11932-0.183-0.0979No
129CLDN19NACLDN19
Entrez,  Source
claudin 1912025-0.193-0.1022No
130ARPC2NAARPC2
Entrez,  Source
actin related protein 2/3 complex, subunit 2, 34kDa12069-0.197-0.1038No
131YWHAHNAYWHAH
Entrez,  Source
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide12222-0.217-0.1113No
132RAC2NARAC2
Entrez,  Source
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)12326-0.230-0.1161No
133TJP1NATJP1
Entrez,  Source
tight junction protein 1 (zona occludens 1)12373-0.234-0.1176No
134DSC3NADSC3
Entrez,  Source
desmocollin 312506-0.252-0.1239No
135ZYXNAZYX
Entrez,  Source
zyxin12759-0.285-0.1368No
136ACTA1NAACTA1
Entrez,  Source
actin, alpha 1, skeletal muscle12765-0.286-0.1358No
137MAPK13NAMAPK13
Entrez,  Source
mitogen-activated protein kinase 1312817-0.293-0.1374No
138SGCENASGCE
Entrez,  Source
sarcoglycan, epsilon12881-0.299-0.1395No
139HADHNAHADH
Entrez,  Source
hydroxyacyl-Coenzyme A dehydrogenase12939-0.309-0.1414No
140MYH9NAMYH9
Entrez,  Source
myosin, heavy chain 9, non-muscle13051-0.325-0.1461No
141ADAM15NAADAM15
Entrez,  Source
ADAM metallopeptidase domain 15 (metargidin)13274-0.361-0.1570No
142CAP1NACAP1
Entrez,  Source
CAP, adenylate cyclase-associated protein 1 (yeast)13387-0.380-0.1616No
143PKD1NAPKD1
Entrez,  Source
polycystic kidney disease 1 (autosomal dominant)13544-0.405-0.1685No
144ACTBNAACTB
Entrez,  Source
actin, beta13884-0.468-0.1855No
145PLCG1NAPLCG1
Entrez,  Source
phospholipase C, gamma 113897-0.470-0.1841No
146CD276NACD276
Entrez,  Source
CD276 molecule13932-0.476-0.1838No
147MAP4K2NAMAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 213986-0.488-0.1846No
148AMHNAAMH
Entrez,  Source
anti-Mullerian hormone14138-0.517-0.1908No
149COL17A1NACOL17A1
Entrez,  Source
collagen, type XVII, alpha 114296-0.551-0.1971No
150LAMB3NALAMB3
Entrez,  Source
laminin, beta 314450-0.583-0.2031No
151PFN1NAPFN1
Entrez,  Source
profilin 114671-0.636-0.2126No
152VWFNAVWF
Entrez,  Source
von Willebrand factor14741-0.657-0.2136No
153AKT3NAAKT3
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)14929-0.703-0.2209No
154CDK8NACDK8
Entrez,  Source
cyclin-dependent kinase 815008-0.723-0.2221No
155ACTN3NAACTN3
Entrez,  Source
actinin, alpha 315102-0.747-0.2239No
156CLDN5NACLDN5
Entrez,  Source
claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)15135-0.754-0.2223No
157VCLNAVCL
Entrez,  Source
vinculin15241-0.785-0.2247No
158ICAM2NAICAM2
Entrez,  Source
intercellular adhesion molecule 215276-0.795-0.2231No
159DSC1NADSC1
Entrez,  Source
desmocollin 115525-0.872-0.2331No
160GNAI2NAGNAI2
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 215665-0.914-0.2368No
161NFASCNANFASC
Entrez,  Source
neurofascin homolog (chicken)15671-0.915-0.2330No
162CLDN15NACLDN15
Entrez,  Source
claudin 1515759-0.954-0.2336No
163PARD6GNAPARD6G
Entrez,  Source
par-6 partitioning defective 6 homolog gamma (C. elegans)15796-0.969-0.2312No
164VASPNAVASP
Entrez,  Source
vasodilator-stimulated phosphoprotein16003-1.047-0.2381No
165CDH3NACDH3
Entrez,  Source
cadherin 3, type 1, P-cadherin (placental)16305-1.194-0.2497No
166TMEM8BNA16399-1.247-0.2493No
167COL16A1NACOL16A1
Entrez,  Source
collagen, type XVI, alpha 116611-1.375-0.2550No
168ACTN1NAACTN1
Entrez,  Source
actinin, alpha 116729-1.453-0.2550No
169THBS3NATHBS3
Entrez,  Source
thrombospondin 316890-1.585-0.2569No
170NF2NANF2
Entrez,  Source
neurofibromin 2 (bilateral acoustic neuroma)17032-1.716-0.2571Yes
171SHC1NASHC1
Entrez,  Source
SHC (Src homology 2 domain containing) transforming protein 117055-1.738-0.2506Yes
172NLGN3NANLGN3
Entrez,  Source
neuroligin 317104-1.792-0.2452Yes
173ITGA9NAITGA9
Entrez,  Source
integrin, alpha 917192-1.903-0.2415Yes
174FSCN1NAFSCN1
Entrez,  Source
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)17293-2.032-0.2380Yes
175EPB41L2NAEPB41L2
Entrez,  Source
erythrocyte membrane protein band 4.1-like 217340-2.112-0.2311Yes
176CALB2NACALB2
Entrez,  Source
calbindin 2, 29kDa (calretinin)17373-2.167-0.2232Yes
177MAPK11NAMAPK11
Entrez,  Source
mitogen-activated protein kinase 1117421-2.271-0.2156Yes
178MVDNAMVD
Entrez,  Source
mevalonate (diphospho) decarboxylase17431-2.287-0.2059Yes
179CDH4NACDH4
Entrez,  Source
cadherin 4, type 1, R-cadherin (retinal)17438-2.303-0.1959Yes
180ACTN2NAACTN2
Entrez,  Source
actinin, alpha 217447-2.317-0.1859Yes
181RHOFNARHOF
Entrez,  Source
ras homolog gene family, member F (in filopodia)17497-2.420-0.1778Yes
182JAM3NAJAM3
Entrez,  Source
junctional adhesion molecule 317499-2.424-0.1669Yes
183MYH10NAMYH10
Entrez,  Source
myosin, heavy chain 10, non-muscle17538-2.526-0.1577Yes
184CLDN11NACLDN11
Entrez,  Source
claudin 11 (oligodendrocyte transmembrane protein)17568-2.617-0.1476Yes
185SLC30A3NASLC30A3
Entrez,  Source
solute carrier family 30 (zinc transporter), member 317577-2.650-0.1361Yes
186INSIG1NAINSIG1
Entrez,  Source
insulin induced gene 117639-2.860-0.1267Yes
187MPZL2NA17751-3.419-0.1176Yes
188WNK4NAWNK4
Entrez,  Source
WNK lysine deficient protein kinase 417761-3.500-0.1024Yes
189MMP9NAMMP9
Entrez,  Source
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)17814-3.845-0.0880Yes
190TGFBINATGFBI
Entrez,  Source
transforming growth factor, beta-induced, 68kDa17821-3.886-0.0709Yes
191SIRPANASIRPA
Entrez,  Source
signal-regulatory protein alpha17853-4.054-0.0544Yes
192EVLNAEVL
Entrez,  Source
Enah/Vasp-like17874-4.221-0.0366Yes
193VCANNA17912-4.524-0.0184Yes
194ACTG2NAACTG2
Entrez,  Source
actin, gamma 2, smooth muscle, enteric17966-4.9230.0008Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_APICAL_JUNCTION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_APICAL_JUNCTION: Random ES distribution   
Gene set null distribution of ES for HALLMARK_APICAL_JUNCTION