Motif ID: ZKSCAN3

Z-value: 0.265


Transcription factors associated with ZKSCAN3:

Gene SymbolEntrez IDGene Name
ZKSCAN3 ENSG00000189298.9 ZKSCAN3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZKSCAN3hg19_v2_chr6_+_28317685_283177610.166.9e-01Click!


Activity profile for motif ZKSCAN3.

activity profile for motif ZKSCAN3


Sorted Z-values histogram for motif ZKSCAN3

Sorted Z-values for motif ZKSCAN3



Network of associatons between targets according to the STRING database.



First level regulatory network of ZKSCAN3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_169239921 0.614 ENST00000514995.1
ENST00000393743.3
 DDX60

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60

chr22_+_50312379 0.347 ENST00000407217.3
ENST00000403427.3
 CRELD2

cysteine-rich with EGF-like domains 2

chr22_+_50312316 0.332 ENST00000328268.4
 CRELD2
cysteine-rich with EGF-like domains 2
chr22_+_50312274 0.305 ENST00000404488.3
 CRELD2
cysteine-rich with EGF-like domains 2
chr17_+_18625336 0.225 ENST00000395671.4
ENST00000571542.1
ENST00000395672.2
ENST00000414850.2
ENST00000424146.2
 TRIM16L




tripartite motif containing 16-like




chr2_+_191745535 0.209 ENST00000320717.3
 GLS
glutaminase
chr19_+_39786962 0.195 ENST00000333625.2
 IFNL1
interferon, lambda 1
chr1_+_66258846 0.172 ENST00000341517.4
 PDE4B
phosphodiesterase 4B, cAMP-specific
chr2_+_191745560 0.145 ENST00000338435.4
 GLS
glutaminase
chr19_-_49258606 0.133 ENST00000310160.3
 FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr22_-_28392227 0.125 ENST00000431039.1
 TTC28
tetratricopeptide repeat domain 28
chr19_+_54372639 0.120 ENST00000391769.2
 MYADM
myeloid-associated differentiation marker
chr5_-_180235755 0.115 ENST00000502678.1
 MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr11_-_64013663 0.105 ENST00000392210.2
 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr19_-_4182530 0.101 ENST00000601571.1
ENST00000601488.1
ENST00000305232.6
ENST00000381935.3
ENST00000337491.2
 SIRT6




sirtuin 6




chr11_+_66610883 0.093 ENST00000309657.3
ENST00000524506.1
 RCE1

Ras converting CAAX endopeptidase 1

chr1_+_114473350 0.078 ENST00000503968.1
 HIPK1
homeodomain interacting protein kinase 1
chr11_-_64013288 0.071 ENST00000542235.1
 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr1_+_114472992 0.071 ENST00000514621.1
 HIPK1
homeodomain interacting protein kinase 1
chr2_-_61244308 0.069 ENST00000407787.1
ENST00000398658.2
 PUS10

pseudouridylate synthase 10

chr16_-_1429010 0.059 ENST00000513783.1
 UNKL
unkempt family zinc finger-like
chrX_+_153775869 0.055 ENST00000424839.1
 IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr5_-_114598548 0.053 ENST00000379615.3
ENST00000419445.1
 PGGT1B

protein geranylgeranyltransferase type I, beta subunit

chr18_-_74728998 0.050 ENST00000359645.3
ENST00000397875.3
ENST00000397869.3
ENST00000578193.1
ENST00000578873.1
ENST00000397866.4
ENST00000528160.1
ENST00000527041.1
ENST00000526111.1
ENST00000397865.5
ENST00000382582.3
 MBP










myelin basic protein










chrX_+_153775821 0.050 ENST00000263518.6
ENST00000470142.1
ENST00000393549.2
ENST00000455588.2
ENST00000369602.3
 IKBKG




inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma




chr6_+_32936353 0.048 ENST00000374825.4
 BRD2
bromodomain containing 2
chr5_+_140079919 0.042 ENST00000274712.3
 ZMAT2
zinc finger, matrin-type 2
chr1_-_935361 0.038 ENST00000484667.2
 HES4
hes family bHLH transcription factor 4
chr14_-_106926724 0.033 ENST00000434710.1
 IGHV3-43
immunoglobulin heavy variable 3-43
chr19_-_4182497 0.033 ENST00000597896.1
 SIRT6
sirtuin 6
chr1_-_115259337 0.032 ENST00000369535.4
 NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr16_+_2479390 0.030 ENST00000397066.4
 CCNF
cyclin F
chr6_+_116850174 0.026 ENST00000416171.2
ENST00000368597.2
ENST00000452373.1
ENST00000405399.1
 FAM26D



family with sequence similarity 26, member D



chr21_+_39668478 0.025 ENST00000398927.1
 KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_-_19811962 0.024 ENST00000375142.1
ENST00000264202.6
 CAPZB

capping protein (actin filament) muscle Z-line, beta

chr16_-_28506840 0.023 ENST00000569430.1
 CLN3
ceroid-lipofuscinosis, neuronal 3
chr21_+_39668831 0.023 ENST00000419868.1
 KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr12_+_113796347 0.022 ENST00000545182.2
ENST00000280800.3
 PLBD2

phospholipase B domain containing 2

chr7_+_1084206 0.019 ENST00000444847.1
 GPR146
G protein-coupled receptor 146
chrX_+_23352133 0.019 ENST00000379361.4
 PTCHD1
patched domain containing 1
chr1_-_28415075 0.017 ENST00000373863.3
ENST00000436342.2
ENST00000540618.1
ENST00000545175.1
 EYA3



eyes absent homolog 3 (Drosophila)



chr2_-_167232484 0.016 ENST00000375387.4
ENST00000303354.6
ENST00000409672.1
 SCN9A


sodium channel, voltage-gated, type IX, alpha subunit


chr3_+_50316458 0.016 ENST00000316436.3
 LSMEM2
leucine-rich single-pass membrane protein 2
chr16_-_4039001 0.014 ENST00000576936.1
 ADCY9
adenylate cyclase 9
chr1_-_19811996 0.013 ENST00000264203.3
ENST00000401084.2
 CAPZB

capping protein (actin filament) muscle Z-line, beta

chr16_-_745946 0.012 ENST00000562563.1
 FBXL16
F-box and leucine-rich repeat protein 16
chr19_+_52693259 0.010 ENST00000322088.6
ENST00000454220.2
ENST00000444322.2
ENST00000477989.1
 PPP2R1A



protein phosphatase 2, regulatory subunit A, alpha



chr10_+_21823243 0.009 ENST00000307729.7
ENST00000377091.2
 MLLT10

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10

chr12_+_100867694 0.007 ENST00000392986.3
ENST00000549996.1
 NR1H4

nuclear receptor subfamily 1, group H, member 4

chr12_+_100867486 0.005 ENST00000548884.1
 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr10_+_21823079 0.005 ENST00000377100.3
ENST00000377072.3
ENST00000446906.2
 MLLT10


myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10


chr19_+_49258775 0.005 ENST00000593756.1
 FGF21
fibroblast growth factor 21
chr1_-_19811132 0.005 ENST00000433834.1
 CAPZB
capping protein (actin filament) muscle Z-line, beta
chr12_+_100867733 0.004 ENST00000546380.1
 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr8_+_123793633 0.001 ENST00000314393.4
 ZHX2
zinc fingers and homeoboxes 2
chr13_-_111567353 0.000 ENST00000310847.4
ENST00000267339.2
ENST00000375758.5
 ANKRD10


ankyrin repeat domain 10



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1 0.2 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
0.1 0.4 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.1 GO:0080120 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.0 0.1 GO:1990619 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) histone H3-K9 deacetylation(GO:1990619)
0.0 0.1 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.1 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.2 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:0060235 embryonic retina morphogenesis in camera-type eye(GO:0060059) lens induction in camera-type eye(GO:0060235)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.0 0.1 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.1 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0046969 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.0 0.4 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.1 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.0 0.1 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle