Motif ID: ZFHX3

Z-value: 0.338


Transcription factors associated with ZFHX3:

Gene SymbolEntrez IDGene Name
ZFHX3 ENSG00000140836.10 ZFHX3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZFHX3hg19_v2_chr16_-_73093597_73093597-0.274.7e-01Click!


Activity profile for motif ZFHX3.

activity profile for motif ZFHX3


Sorted Z-values histogram for motif ZFHX3

Sorted Z-values for motif ZFHX3



Network of associatons between targets according to the STRING database.



First level regulatory network of ZFHX3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_15619076 0.512 ENST00000252519.3
 ACE2
angiotensin I converting enzyme 2
chr12_-_10321754 0.321 ENST00000539518.1
 OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chr7_-_100026280 0.219 ENST00000360951.4
ENST00000398027.2
ENST00000324725.6
ENST00000472716.1
 ZCWPW1



zinc finger, CW type with PWWP domain 1



chrX_-_18690210 0.166 ENST00000379984.3
 RS1
retinoschisin 1
chr9_-_95298314 0.159 ENST00000344604.5
ENST00000375540.1
 ECM2

extracellular matrix protein 2, female organ and adipocyte specific

chr16_-_28192360 0.154 ENST00000570033.1
 XPO6
exportin 6
chr22_+_39101728 0.145 ENST00000216044.5
ENST00000484657.1
 GTPBP1

GTP binding protein 1

chr12_+_131438443 0.144 ENST00000261654.5
 GPR133
G protein-coupled receptor 133
chr2_+_133174147 0.135 ENST00000329321.3
 GPR39
G protein-coupled receptor 39
chr9_-_95298254 0.127 ENST00000444490.2
 ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr6_-_31681839 0.126 ENST00000461287.1
ENST00000409239.1
 XXbac-BPG32J3.20
LY6G6E
Uncharacterized protein
lymphocyte antigen 6 complex, locus G6E (pseudogene)
chr1_-_153585539 0.124 ENST00000368706.4
 S100A16
S100 calcium binding protein A16
chr5_+_140625147 0.115 ENST00000231173.3
 PCDHB15
protocadherin beta 15
chr15_+_76352178 0.108 ENST00000388942.3
 C15orf27
chromosome 15 open reading frame 27
chr16_-_75284758 0.105 ENST00000561970.1
 BCAR1
breast cancer anti-estrogen resistance 1
chr9_-_123812542 0.103 ENST00000223642.1
 C5
complement component 5
chr8_-_9762871 0.088 ENST00000521242.1
 LINC00599
long intergenic non-protein coding RNA 599
chr8_-_145754428 0.083 ENST00000527462.1
ENST00000313465.5
ENST00000524821.1
 C8orf82


chromosome 8 open reading frame 82


chr6_+_34204642 0.083 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
 HMGA1




high mobility group AT-hook 1




chrM_+_10464 0.080 ENST00000361335.1
 MT-ND4L
mitochondrially encoded NADH dehydrogenase 4L
chr8_+_92114060 0.078 ENST00000518304.1
 LRRC69
leucine rich repeat containing 69
chr11_-_61687739 0.076 ENST00000531922.1
ENST00000301773.5
 RAB3IL1

RAB3A interacting protein (rabin3)-like 1

chr15_-_76352069 0.076 ENST00000305435.10
ENST00000563910.1
 NRG4

neuregulin 4

chrX_-_110655306 0.073 ENST00000371993.2
 DCX
doublecortin
chr17_-_26733179 0.066 ENST00000440501.1
ENST00000321666.5
 SLC46A1

solute carrier family 46 (folate transporter), member 1

chr22_-_30722912 0.064 ENST00000215790.7
 TBC1D10A
TBC1 domain family, member 10A
chr22_-_30642728 0.064 ENST00000403987.3
 LIF
leukemia inhibitory factor
chr7_+_150725510 0.059 ENST00000461373.1
ENST00000358849.4
ENST00000297504.6
ENST00000542328.1
ENST00000498578.1
ENST00000356058.4
ENST00000477719.1
ENST00000477092.1
 ABCB8







ATP-binding cassette, sub-family B (MDR/TAP), member 8







chr18_+_20494078 0.057 ENST00000579124.1
ENST00000577588.1
ENST00000582354.1
ENST00000581819.1
 RBBP8



retinoblastoma binding protein 8



chrM_+_8527 0.054 ENST00000361899.2
 MT-ATP6
mitochondrially encoded ATP synthase 6
chr11_+_74459876 0.053 ENST00000299563.4
 RNF169
ring finger protein 169
chr1_-_150944411 0.050 ENST00000368949.4
 CERS2
ceramide synthase 2
chr17_+_17685422 0.049 ENST00000395774.1
 RAI1
retinoic acid induced 1
chrX_+_16668278 0.049 ENST00000380200.3
 S100G
S100 calcium binding protein G
chr14_+_38033252 0.046 ENST00000554829.1
 RP11-356O9.1
RP11-356O9.1
chr17_+_4692230 0.046 ENST00000331264.7
 GLTPD2
glycolipid transfer protein domain containing 2
chr2_+_190541153 0.044 ENST00000313581.4
ENST00000438402.2
ENST00000431575.2
ENST00000281412.6
 ANKAR



ankyrin and armadillo repeat containing



chr6_+_161123270 0.043 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
 PLG


plasminogen


chr1_-_197036364 0.039 ENST00000367412.1
 F13B
coagulation factor XIII, B polypeptide
chr2_+_88047606 0.036 ENST00000359481.4
 PLGLB2
plasminogen-like B2
chr4_-_152149033 0.035 ENST00000514152.1
 SH3D19
SH3 domain containing 19
chr16_-_69385681 0.034 ENST00000288025.3
 TMED6
transmembrane emp24 protein transport domain containing 6
chr6_+_126070726 0.033 ENST00000368364.3
 HEY2
hes-related family bHLH transcription factor with YRPW motif 2
chr11_+_71934962 0.032 ENST00000543234.1
 INPPL1
inositol polyphosphate phosphatase-like 1
chr17_-_64225508 0.026 ENST00000205948.6
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr11_-_58378759 0.026 ENST00000601906.1
 AP001350.1
Uncharacterized protein
chr3_+_69915363 0.026 ENST00000451708.1
 MITF
microphthalmia-associated transcription factor
chr11_-_559377 0.026 ENST00000486629.1
 C11orf35
chromosome 11 open reading frame 35
chr3_+_77088989 0.025 ENST00000461745.1
 ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr8_+_104831472 0.025 ENST00000262231.10
ENST00000507740.1
 RIMS2

regulating synaptic membrane exocytosis 2

chr5_+_118690466 0.025 ENST00000503646.1
 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr2_+_234621551 0.024 ENST00000373414.3
ENST00000608381.1
 UGT1A5
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A5
UDP glucuronosyltransferase 1 family, polypeptide A8
chr19_+_926000 0.023 ENST00000263620.3
 ARID3A
AT rich interactive domain 3A (BRIGHT-like)
chr11_+_57559005 0.023 ENST00000534647.1
 CTNND1
catenin (cadherin-associated protein), delta 1
chr7_+_100026406 0.022 ENST00000414441.1
 MEPCE
methylphosphate capping enzyme
chr8_+_98900132 0.022 ENST00000520016.1
 MATN2
matrilin 2
chr14_+_39703084 0.022 ENST00000553728.1
 RP11-407N17.3
cTAGE family member 5 isoform 4
chr3_+_69812701 0.021 ENST00000472437.1
 MITF
microphthalmia-associated transcription factor
chr7_-_7575477 0.019 ENST00000399429.3
 COL28A1
collagen, type XXVIII, alpha 1
chr7_+_143806607 0.019 ENST00000408979.2
 OR2A2
olfactory receptor, family 2, subfamily A, member 2
chr16_-_15474904 0.019 ENST00000534094.1
 NPIPA5
nuclear pore complex interacting protein family, member A5
chr20_-_33735070 0.018 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
 EDEM2


ER degradation enhancer, mannosidase alpha-like 2


chr8_-_87242589 0.018 ENST00000419776.2
ENST00000297524.3
 SLC7A13

solute carrier family 7 (anionic amino acid transporter), member 13

chr12_-_91546926 0.017 ENST00000550758.1
 DCN
decorin
chr4_-_149365827 0.016 ENST00000344721.4
 NR3C2
nuclear receptor subfamily 3, group C, member 2
chr6_+_25754927 0.016 ENST00000377905.4
ENST00000439485.2
 SLC17A4

solute carrier family 17, member 4

chr4_-_155511887 0.015 ENST00000302053.3
ENST00000403106.3
 FGA

fibrinogen alpha chain

chr12_+_53835539 0.015 ENST00000547368.1
ENST00000379786.4
ENST00000551945.1
 PRR13


proline rich 13


chr8_+_104831440 0.015 ENST00000515551.1
 RIMS2
regulating synaptic membrane exocytosis 2
chr3_+_69915385 0.014 ENST00000314589.5
 MITF
microphthalmia-associated transcription factor
chr8_-_70745575 0.014 ENST00000524945.1
 SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr12_+_53835425 0.014 ENST00000549924.1
 PRR13
proline rich 13
chr6_+_28317685 0.013 ENST00000252211.2
ENST00000341464.5
ENST00000377255.3
 ZKSCAN3


zinc finger with KRAB and SCAN domains 3


chr12_+_53835383 0.012 ENST00000429243.2
 PRR13
proline rich 13
chr17_+_41052808 0.012 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
 G6PC


glucose-6-phosphatase, catalytic subunit


chr14_+_23709555 0.011 ENST00000430154.2
 C14orf164
chromosome 14 open reading frame 164
chr1_-_227505289 0.011 ENST00000366765.3
 CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr11_+_22696314 0.010 ENST00000532398.1
ENST00000433790.1
 GAS2

growth arrest-specific 2

chr7_-_142181009 0.009 ENST00000390368.2
 TRBV6-5
T cell receptor beta variable 6-5
chr19_-_46234119 0.009 ENST00000317683.3
 FBXO46
F-box protein 46
chr11_-_107729887 0.008 ENST00000525815.1
 SLC35F2
solute carrier family 35, member F2
chr7_-_91794590 0.008 ENST00000430130.2
ENST00000454089.2
 LRRD1

leucine-rich repeats and death domain containing 1

chr17_-_60142609 0.008 ENST00000397786.2
 MED13
mediator complex subunit 13
chr12_-_131200810 0.008 ENST00000536002.1
ENST00000544034.1
 RIMBP2
RP11-662M24.2
RIMS binding protein 2
RP11-662M24.2
chr1_-_247921982 0.008 ENST00000408896.2
 OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr2_+_234637754 0.008 ENST00000609767.1
ENST00000482026.1
 UGT1A1
UGT1A3
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A3
chr7_-_86595190 0.007 ENST00000398276.2
ENST00000416314.1
ENST00000425689.1
 KIAA1324L


KIAA1324-like


chr13_+_113301358 0.007 ENST00000356049.1
 C13orf35
chromosome 13 open reading frame 35
chr2_-_60780607 0.006 ENST00000537768.1
ENST00000335712.6
ENST00000356842.4
 BCL11A


B-cell CLL/lymphoma 11A (zinc finger protein)


chrX_+_1710484 0.006 ENST00000313871.3
ENST00000381261.3
 AKAP17A

A kinase (PRKA) anchor protein 17A

chrM_+_14741 0.006 ENST00000361789.2
 MT-CYB
mitochondrially encoded cytochrome b
chr22_-_22337204 0.006 ENST00000430142.1
ENST00000357179.5
 TOP3B

topoisomerase (DNA) III beta

chr1_-_168464875 0.005 ENST00000422253.1
 RP5-968D22.3
RP5-968D22.3
chr11_-_102576537 0.005 ENST00000260229.4
 MMP27
matrix metallopeptidase 27
chr11_-_107729287 0.005 ENST00000375682.4
 SLC35F2
solute carrier family 35, member F2
chr16_+_87636474 0.005 ENST00000284262.2
 JPH3
junctophilin 3
chr12_+_80750134 0.004 ENST00000546620.1
 OTOGL
otogelin-like
chr6_-_128239685 0.004 ENST00000368250.1
 THEMIS
thymocyte selection associated
chrX_+_84258832 0.003 ENST00000373173.2
 APOOL
apolipoprotein O-like
chr11_-_107729504 0.002 ENST00000265836.7
 SLC35F2
solute carrier family 35, member F2
chr12_+_53835508 0.002 ENST00000541275.1
ENST00000551003.1
ENST00000549068.1
ENST00000549740.1
ENST00000546581.1
ENST00000549581.1
 PCBP2
PRR13




poly(rC) binding protein 2
proline rich 13




chr4_-_69111401 0.001 ENST00000332644.5
 TMPRSS11B
transmembrane protease, serine 11B
chr7_+_48211048 0.000 ENST00000435803.1
 ABCA13
ATP-binding cassette, sub-family A (ABC1), member 13
chrY_-_20935572 0.000 ENST00000382852.1
ENST00000344884.4
ENST00000304790.3
 HSFY2


heat shock transcription factor, Y linked 2


chr9_-_215744 0.000 ENST00000382387.2
 C9orf66
chromosome 9 open reading frame 66

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.0 0.2 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.0 0.1 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.0 0.1 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.0 0.1 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 0.1 GO:0035188 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.0 GO:1905045 Schwann cell proliferation involved in axon regeneration(GO:0014011) negative regulation of Schwann cell migration(GO:1900148) regulation of Schwann cell proliferation involved in axon regeneration(GO:1905044) negative regulation of Schwann cell proliferation involved in axon regeneration(GO:1905045)
0.0 0.0 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621)
0.0 0.1 GO:0051958 methotrexate transport(GO:0051958)
0.0 0.0 GO:0052047 positive regulation of fibrinolysis(GO:0051919) interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 0.3 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.0 0.0 GO:1904854 proteasome core complex binding(GO:1904854)
0.0 0.1 GO:0015350 methotrexate transporter activity(GO:0015350)
0.0 0.2 GO:0070492 oligosaccharide binding(GO:0070492)