Motif ID: UUGUUCG

Z-value: 0.267


Mature miRNA associated with seed UUGUUCG:

NamemiRBase Accession
hsa-miR-375 MIMAT0000728



Activity profile for motif UUGUUCG.

activity profile for motif UUGUUCG


Sorted Z-values histogram for motif UUGUUCG

Sorted Z-values for motif UUGUUCG



Network of associatons between targets according to the STRING database.



First level regulatory network of UUGUUCG

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_43453734 0.179 ENST00000282388.3
 ZFP36L2
ZFP36 ring finger protein-like 2
chr12_-_76425368 0.158 ENST00000602540.1
 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr17_+_38599693 0.156 ENST00000542955.1
ENST00000269593.4
 IGFBP4

insulin-like growth factor binding protein 4

chr9_+_4985228 0.154 ENST00000381652.3
 JAK2
Janus kinase 2
chr9_-_110251836 0.125 ENST00000374672.4
 KLF4
Kruppel-like factor 4 (gut)
chr17_-_49198216 0.118 ENST00000262013.7
ENST00000357122.4
 SPAG9

sperm associated antigen 9

chr4_-_139163491 0.105 ENST00000280612.5
 SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr10_-_71930222 0.104 ENST00000458634.2
ENST00000373239.2
ENST00000373242.2
ENST00000373241.4
 SAR1A



SAR1 homolog A (S. cerevisiae)



chr1_-_213189108 0.082 ENST00000535388.1
 ANGEL2
angel homolog 2 (Drosophila)
chr2_+_133174147 0.081 ENST00000329321.3
 GPR39
G protein-coupled receptor 39
chr13_-_31736027 0.075 ENST00000380406.5
ENST00000320027.5
ENST00000380405.4
 HSPH1


heat shock 105kDa/110kDa protein 1


chr9_-_16870704 0.071 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
 BNC2



basonuclin 2



chr8_+_120220561 0.068 ENST00000276681.6
 MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr18_+_19749386 0.067 ENST00000269216.3
 GATA6
GATA binding protein 6
chr7_+_17338239 0.067 ENST00000242057.4
 AHR
aryl hydrocarbon receptor
chr1_-_57045228 0.067 ENST00000371250.3
 PPAP2B
phosphatidic acid phosphatase type 2B
chr18_+_18943554 0.064 ENST00000580732.2
 GREB1L
growth regulation by estrogen in breast cancer-like
chr9_-_38069208 0.059 ENST00000377707.3
ENST00000377700.4
 SHB

Src homology 2 domain containing adaptor protein B

chr19_-_7293942 0.058 ENST00000341500.5
ENST00000302850.5
 INSR

insulin receptor

chr5_+_56111361 0.055 ENST00000399503.3
 MAP3K1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chr1_-_182573514 0.055 ENST00000367558.5
 RGS16
regulator of G-protein signaling 16
chr2_+_179345173 0.054 ENST00000234453.5
 PLEKHA3
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3
chr1_-_149982624 0.053 ENST00000417191.1
ENST00000369135.4
 OTUD7B

OTU domain containing 7B

chr18_+_32558208 0.049 ENST00000436190.2
 MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr17_+_28804380 0.046 ENST00000225724.5
ENST00000451249.2
ENST00000467337.2
ENST00000581721.1
ENST00000414833.2
 GOSR1




golgi SNAP receptor complex member 1




chr1_+_62902308 0.044 ENST00000339950.4
 USP1
ubiquitin specific peptidase 1
chr21_-_38362497 0.042 ENST00000427746.1
ENST00000336648.4
 HLCS

holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)

chr5_-_56247935 0.041 ENST00000381199.3
ENST00000381226.3
ENST00000381213.3
 MIER3


mesoderm induction early response 1, family member 3


chr7_-_105517021 0.041 ENST00000318724.4
ENST00000419735.3
 ATXN7L1

ataxin 7-like 1

chr22_+_51112800 0.037 ENST00000414786.2
 SHANK3
SH3 and multiple ankyrin repeat domains 3
chr3_+_152017181 0.037 ENST00000498502.1
ENST00000324196.5
ENST00000545754.1
ENST00000357472.3
 MBNL1



muscleblind-like splicing regulator 1



chr9_+_15553055 0.037 ENST00000380701.3
 CCDC171
coiled-coil domain containing 171
chr11_-_86666427 0.036 ENST00000531380.1
 FZD4
frizzled family receptor 4
chr11_+_101981169 0.036 ENST00000526343.1
ENST00000282441.5
ENST00000537274.1
ENST00000345877.2
 YAP1



Yes-associated protein 1



chr12_-_51477333 0.034 ENST00000228515.1
ENST00000548206.1
ENST00000546935.1
ENST00000548981.1
 CSRNP2



cysteine-serine-rich nuclear protein 2



chr5_+_145583156 0.034 ENST00000265271.5
 RBM27
RNA binding motif protein 27
chr1_+_199996702 0.033 ENST00000367362.3
 NR5A2
nuclear receptor subfamily 5, group A, member 2
chr15_-_101792137 0.032 ENST00000254190.3
 CHSY1
chondroitin sulfate synthase 1
chr1_-_120612240 0.030 ENST00000256646.2
 NOTCH2
notch 2
chr7_+_92158083 0.029 ENST00000265732.5
ENST00000481551.1
ENST00000496410.1
 RBM48


RNA binding motif protein 48


chr8_+_61591337 0.027 ENST00000423902.2
 CHD7
chromodomain helicase DNA binding protein 7
chr9_+_115983808 0.027 ENST00000374210.6
ENST00000374212.4
 SLC31A1

solute carrier family 31 (copper transporter), member 1

chr7_-_27183263 0.027 ENST00000222726.3
 HOXA5
homeobox A5
chr10_+_126490354 0.025 ENST00000298492.5
 FAM175B
family with sequence similarity 175, member B
chr3_+_88199099 0.024 ENST00000486971.1
 C3orf38
chromosome 3 open reading frame 38
chr1_-_225840747 0.024 ENST00000366843.2
ENST00000366844.3
 ENAH

enabled homolog (Drosophila)

chr15_+_41709302 0.024 ENST00000389629.4
 RTF1
Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr8_-_101965146 0.023 ENST00000395957.2
ENST00000395948.2
ENST00000457309.1
 YWHAZ


tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta


chr15_+_36887069 0.023 ENST00000566807.1
ENST00000567389.1
ENST00000562877.1
 C15orf41


chromosome 15 open reading frame 41


chr7_-_128695147 0.022 ENST00000482320.1
ENST00000393245.1
ENST00000471234.1
 TNPO3


transportin 3


chr3_+_197687071 0.022 ENST00000482695.1
ENST00000330198.4
ENST00000419117.1
ENST00000420910.2
ENST00000332636.5
 LMLN




leishmanolysin-like (metallopeptidase M8 family)




chr5_+_95997918 0.021 ENST00000395812.2
ENST00000395813.1
ENST00000359176.4
ENST00000325674.7
 CAST



calpastatin



chr3_-_128369643 0.021 ENST00000296255.3
 RPN1
ribophorin I
chr14_-_68283291 0.021 ENST00000555452.1
ENST00000347230.4
 ZFYVE26

zinc finger, FYVE domain containing 26

chr2_+_223725652 0.020 ENST00000357430.3
ENST00000392066.3
 ACSL3

acyl-CoA synthetase long-chain family member 3

chr1_+_233463507 0.019 ENST00000366623.3
ENST00000366624.3
 MLK4

Mitogen-activated protein kinase kinase kinase MLK4

chr7_-_558876 0.018 ENST00000354513.5
ENST00000402802.3
 PDGFA

platelet-derived growth factor alpha polypeptide

chr15_-_72410109 0.018 ENST00000564571.1
 MYO9A
myosin IXA
chr1_+_66999799 0.018 ENST00000371035.3
ENST00000371036.3
ENST00000371037.4
 SGIP1


SH3-domain GRB2-like (endophilin) interacting protein 1


chr16_-_12897642 0.017 ENST00000433677.2
ENST00000261660.4
ENST00000381774.4
 CPPED1


calcineurin-like phosphoesterase domain containing 1


chr1_-_205601064 0.017 ENST00000357992.4
ENST00000289703.4
 ELK4

ELK4, ETS-domain protein (SRF accessory protein 1)

chr12_+_50690489 0.017 ENST00000598429.1
 AC140061.12
Uncharacterized protein
chr2_-_74405929 0.017 ENST00000396049.4
 MOB1A
MOB kinase activator 1A
chr9_-_135819987 0.017 ENST00000298552.3
ENST00000403810.1
 TSC1

tuberous sclerosis 1

chr16_+_69458428 0.016 ENST00000512062.1
ENST00000307892.8
 CYB5B

cytochrome b5 type B (outer mitochondrial membrane)

chr9_-_135230336 0.016 ENST00000224140.5
ENST00000372169.2
ENST00000393220.1
 SETX


senataxin


chr9_-_127533519 0.016 ENST00000487099.2
ENST00000344523.4
ENST00000373584.3
 NR6A1


nuclear receptor subfamily 6, group A, member 1


chr10_-_126849068 0.016 ENST00000494626.2
ENST00000337195.5
 CTBP2

C-terminal binding protein 2

chr10_-_735553 0.015 ENST00000280886.6
ENST00000423550.1
 DIP2C

DIP2 disco-interacting protein 2 homolog C (Drosophila)

chrX_-_49056635 0.015 ENST00000472598.1
ENST00000538567.1
ENST00000479808.1
ENST00000263233.4
 SYP



synaptophysin



chr17_-_3749515 0.014 ENST00000158149.3
ENST00000389005.4
 C17orf85

chromosome 17 open reading frame 85

chr1_+_50574585 0.014 ENST00000371824.1
ENST00000371823.4
 ELAVL4

ELAV like neuron-specific RNA binding protein 4

chr11_-_118047376 0.014 ENST00000278947.5
 SCN2B
sodium channel, voltage-gated, type II, beta subunit
chr17_+_39845134 0.014 ENST00000591776.1
ENST00000469257.1
 EIF1

eukaryotic translation initiation factor 1

chr4_+_184020398 0.014 ENST00000403733.3
ENST00000378925.3
 WWC2

WW and C2 domain containing 2

chr1_-_10856694 0.013 ENST00000377022.3
ENST00000344008.5
 CASZ1

castor zinc finger 1

chr17_-_1465924 0.012 ENST00000573231.1
ENST00000576722.1
ENST00000576761.1
ENST00000576010.2
ENST00000313486.7
ENST00000539476.1
 PITPNA





phosphatidylinositol transfer protein, alpha





chr5_-_76935513 0.012 ENST00000306422.3
 OTP
orthopedia homeobox
chr1_+_15853308 0.012 ENST00000375838.1
ENST00000375847.3
ENST00000375849.1
 DNAJC16


DnaJ (Hsp40) homolog, subfamily C, member 16


chr12_+_20522179 0.011 ENST00000359062.3
 PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr2_+_242641442 0.011 ENST00000313552.6
ENST00000406941.1
 ING5

inhibitor of growth family, member 5

chr20_+_43514315 0.011 ENST00000353703.4
 YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
chr22_+_29168652 0.011 ENST00000249064.4
ENST00000444523.1
ENST00000448492.2
ENST00000421503.2
 CCDC117



coiled-coil domain containing 117



chr17_-_617949 0.011 ENST00000401468.3
ENST00000574029.1
ENST00000291074.5
ENST00000571805.1
ENST00000437048.2
ENST00000446250.2
 VPS53





vacuolar protein sorting 53 homolog (S. cerevisiae)





chr17_-_42143963 0.011 ENST00000585388.1
ENST00000293406.3
 LSM12

LSM12 homolog (S. cerevisiae)

chr19_+_19496624 0.011 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
 GATAD2A


GATA zinc finger domain containing 2A


chr6_+_163835669 0.010 ENST00000453779.2
ENST00000275262.7
ENST00000392127.2
ENST00000361752.3
 QKI



QKI, KH domain containing, RNA binding



chr2_+_46926048 0.010 ENST00000306503.5
 SOCS5
suppressor of cytokine signaling 5
chr6_-_71666732 0.009 ENST00000230053.6
 B3GAT2
beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
chr9_+_26956371 0.009 ENST00000380062.5
ENST00000518614.1
 IFT74

intraflagellar transport 74 homolog (Chlamydomonas)

chr15_-_25684110 0.009 ENST00000232165.3
 UBE3A
ubiquitin protein ligase E3A
chr17_-_27621125 0.009 ENST00000579665.1
ENST00000225388.4
 NUFIP2

nuclear fragile X mental retardation protein interacting protein 2

chr14_+_67707826 0.009 ENST00000261681.4
 MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr12_-_120806960 0.008 ENST00000257552.2
 MSI1
musashi RNA-binding protein 1
chr9_+_4679555 0.008 ENST00000381858.1
ENST00000381854.3
 CDC37L1

cell division cycle 37-like 1

chr10_+_126630692 0.008 ENST00000359653.4
 ZRANB1
zinc finger, RAN-binding domain containing 1
chr14_+_101359265 0.008 ENST00000599197.1
 AL117190.3
Esophagus cancer-related gene-2 interaction susceptibility protein; Uncharacterized protein
chr19_+_16607122 0.008 ENST00000221671.3
ENST00000594035.1
ENST00000599550.1
ENST00000594813.1
 C19orf44



chromosome 19 open reading frame 44



chr17_+_30813576 0.008 ENST00000313401.3
 CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr6_+_34433844 0.008 ENST00000244458.2
ENST00000374043.2
 PACSIN1

protein kinase C and casein kinase substrate in neurons 1

chr10_-_89623194 0.007 ENST00000445946.3
 KLLN
killin, p53-regulated DNA replication inhibitor
chr12_+_19592602 0.007 ENST00000398864.3
ENST00000266508.9
 AEBP2

AE binding protein 2

chr17_-_60142609 0.007 ENST00000397786.2
 MED13
mediator complex subunit 13
chr11_+_33563821 0.007 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
 KIAA1549L


KIAA1549-like


chr11_+_34127142 0.006 ENST00000257829.3
ENST00000531159.2
 NAT10

N-acetyltransferase 10 (GCN5-related)

chr2_+_178257372 0.006 ENST00000264167.4
ENST00000409888.1
 AGPS

alkylglycerone phosphate synthase

chr20_-_524455 0.006 ENST00000349736.5
ENST00000217244.3
 CSNK2A1

casein kinase 2, alpha 1 polypeptide

chr17_+_55162453 0.006 ENST00000575322.1
ENST00000337714.3
ENST00000314126.3
 AKAP1


A kinase (PRKA) anchor protein 1


chr4_-_83295103 0.006 ENST00000313899.7
ENST00000352301.4
ENST00000509107.1
ENST00000353341.4
ENST00000541060.1
 HNRNPD




heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)




chr4_-_157892498 0.006 ENST00000502773.1
 PDGFC
platelet derived growth factor C
chr1_+_39456895 0.006 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
 AKIRIN1


akirin 1


chr16_+_2587998 0.005 ENST00000441549.3
ENST00000268673.7
 PDPK1

3-phosphoinositide dependent protein kinase-1

chrX_+_73641286 0.005 ENST00000587091.1
 SLC16A2
solute carrier family 16, member 2 (thyroid hormone transporter)
chr9_+_140513438 0.005 ENST00000462484.1
ENST00000334856.6
ENST00000460843.1
 EHMT1


euchromatic histone-lysine N-methyltransferase 1


chrX_+_56259316 0.005 ENST00000468660.1
 KLF8
Kruppel-like factor 8
chr15_+_81071684 0.005 ENST00000220244.3
ENST00000394685.3
ENST00000356249.5
 KIAA1199


KIAA1199


chr4_+_113152881 0.005 ENST00000274000.5
 AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr8_-_122653630 0.005 ENST00000303924.4
 HAS2
hyaluronan synthase 2
chr13_+_51483814 0.004 ENST00000336617.3
ENST00000422660.1
 RNASEH2B

ribonuclease H2, subunit B

chr14_+_57735614 0.004 ENST00000261558.3
 AP5M1
adaptor-related protein complex 5, mu 1 subunit
chr4_+_155665123 0.004 ENST00000336356.3
 LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr7_-_132261253 0.004 ENST00000321063.4
 PLXNA4
plexin A4
chr5_+_138629417 0.004 ENST00000510056.1
ENST00000511249.1
ENST00000503811.1
ENST00000511378.1
 MATR3



matrin 3



chr18_+_42260861 0.003 ENST00000282030.5
 SETBP1
SET binding protein 1
chr1_+_224544552 0.003 ENST00000465271.1
ENST00000366858.3
 CNIH4

cornichon family AMPA receptor auxiliary protein 4

chr11_+_44117741 0.003 ENST00000395673.3
ENST00000343631.3
 EXT2

exostosin glycosyltransferase 2

chr1_-_67896095 0.002 ENST00000370994.4
 SERBP1
SERPINE1 mRNA binding protein 1
chr13_+_73632897 0.002 ENST00000377687.4
 KLF5
Kruppel-like factor 5 (intestinal)
chr10_+_114206956 0.002 ENST00000432306.1
ENST00000393077.2
 VTI1A

vesicle transport through interaction with t-SNAREs 1A

chr1_-_152332480 0.001 ENST00000388718.5
 FLG2
filaggrin family member 2
chr14_-_55878538 0.001 ENST00000247178.5
 ATG14
autophagy related 14
chr19_-_11591848 0.001 ENST00000359227.3
 ELAVL3
ELAV like neuron-specific RNA binding protein 3
chr2_+_176964458 0.001 ENST00000406506.2
ENST00000404162.2
 HOXD12

homeobox D12

chr1_-_100231349 0.001 ENST00000287474.5
ENST00000414213.1
 FRRS1

ferric-chelate reductase 1

chr11_-_88796803 0.001 ENST00000418177.2
ENST00000455756.2
 GRM5

glutamate receptor, metabotropic 5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0045210 FasL biosynthetic process(GO:0045210)
0.0 0.1 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.0 0.2 GO:1902728 mineralocorticoid receptor signaling pathway(GO:0031959) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.0 0.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 0.1 GO:1990535 neuron projection maintenance(GO:1990535)
0.0 0.0 GO:0070781 response to biotin(GO:0070781)
0.0 0.2 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.2 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.0 0.0 GO:0097114 NMDA glutamate receptor clustering(GO:0097114)
0.0 0.0 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.1 GO:0051891 negative regulation of transforming growth factor beta1 production(GO:0032911) negative regulation of transforming growth factor beta2 production(GO:0032912) positive regulation of cardioblast differentiation(GO:0051891)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0034753 nuclear aryl hydrocarbon receptor complex(GO:0034753)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.1 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.1 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway