Motif ID: TLX1_NFIC

Z-value: 1.014

Transcription factors associated with TLX1_NFIC:

Gene SymbolEntrez IDGene Name
NFIC ENSG00000141905.13 NFIC
TLX1 ENSG00000107807.8 TLX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFIChg19_v2_chr19_+_3366547_33666190.674.7e-02Click!
TLX1hg19_v2_chr10_+_102891048_1028910780.422.6e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1_NFIC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_22766766 2.527 ENST00000426291.1
ENST00000401651.1
ENST00000258743.5
ENST00000420258.2
ENST00000407492.1
ENST00000401630.3
ENST00000406575.1
IL6






interleukin 6 (interferon, beta 2)






chr1_+_79086088 1.622 ENST00000370751.5
ENST00000342282.3
IFI44L

interferon-induced protein 44-like

chr15_+_89182156 1.585 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_89182178 1.570 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_89181974 1.392 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr7_-_16844611 1.116 ENST00000401412.1
ENST00000419304.2
AGR2

anterior gradient 2

chr5_-_176923846 1.106 ENST00000506537.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chr7_+_143078652 1.076 ENST00000354434.4
ENST00000449423.2
ZYX

zyxin

chr5_-_176923803 1.034 ENST00000506161.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chr7_+_143079000 1.018 ENST00000392910.2
ZYX
zyxin
chr21_+_33784670 0.970 ENST00000300255.2
EVA1C
eva-1 homolog C (C. elegans)
chr21_+_33784957 0.931 ENST00000401402.3
ENST00000382699.3
EVA1C

eva-1 homolog C (C. elegans)

chr12_+_53491220 0.855 ENST00000548547.1
ENST00000301464.3
IGFBP6

insulin-like growth factor binding protein 6

chr2_+_7017796 0.851 ENST00000382040.3
RSAD2
radical S-adenosyl methionine domain containing 2
chr1_+_79115503 0.759 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44


interferon-induced protein 44


chr17_+_74372662 0.727 ENST00000591651.1
ENST00000545180.1
SPHK1

sphingosine kinase 1

chr22_+_41763274 0.660 ENST00000406644.3
TEF
thyrotrophic embryonic factor
chr2_+_233385173 0.638 ENST00000449534.2
PRSS56
protease, serine, 56
chr20_-_60942361 0.624 ENST00000252999.3
LAMA5
laminin, alpha 5
chr1_+_156095951 0.611 ENST00000448611.2
ENST00000368297.1
LMNA

lamin A/C

chr11_-_118789613 0.587 ENST00000532899.1
BCL9L
B-cell CLL/lymphoma 9-like
chr11_-_57089671 0.576 ENST00000532437.1
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr14_+_105939276 0.569 ENST00000483017.3
CRIP2
cysteine-rich protein 2
chr5_-_138861926 0.548 ENST00000510817.1
TMEM173
transmembrane protein 173
chr12_-_54813229 0.544 ENST00000293379.4
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr10_+_102758105 0.537 ENST00000429732.1
LZTS2
leucine zipper, putative tumor suppressor 2
chr1_-_153363452 0.537 ENST00000368732.1
ENST00000368733.3
S100A8

S100 calcium binding protein A8

chr20_-_60942326 0.527 ENST00000370677.3
ENST00000370692.3
LAMA5

laminin, alpha 5

chr20_-_39317868 0.494 ENST00000373313.2
MAFB
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
chr17_+_37894179 0.487 ENST00000577695.1
ENST00000309156.4
ENST00000309185.3
GRB7


growth factor receptor-bound protein 7


chr11_+_120110863 0.479 ENST00000543440.2
POU2F3
POU class 2 homeobox 3
chr15_+_45926919 0.467 ENST00000561735.1
ENST00000260324.7
SQRDL

sulfide quinone reductase-like (yeast)

chr11_-_66313699 0.461 ENST00000526986.1
ENST00000310442.3
ZDHHC24

zinc finger, DHHC-type containing 24

chr11_+_34663913 0.435 ENST00000532302.1
EHF
ets homologous factor
chr17_+_77030267 0.434 ENST00000581774.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr6_+_36922209 0.428 ENST00000373674.3
PI16
peptidase inhibitor 16
chr7_-_100076873 0.418 ENST00000300181.2
TSC22D4
TSC22 domain family, member 4
chr17_+_38599693 0.415 ENST00000542955.1
ENST00000269593.4
IGFBP4

insulin-like growth factor binding protein 4

chr7_-_16840820 0.407 ENST00000450569.1
AGR2
anterior gradient 2
chr1_+_156096336 0.403 ENST00000504687.1
ENST00000473598.2
LMNA

lamin A/C

chr5_+_92919043 0.398 ENST00000327111.3
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr16_+_30751953 0.398 ENST00000483578.1
RP11-2C24.4
RP11-2C24.4
chr7_-_5463175 0.396 ENST00000399537.4
ENST00000430969.1
TNRC18

trinucleotide repeat containing 18

chr12_-_15114603 0.369 ENST00000228945.4
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr12_-_109025849 0.368 ENST00000228463.6
SELPLG
selectin P ligand
chr1_+_113217309 0.363 ENST00000544796.1
ENST00000369644.1
MOV10

Mov10, Moloney leukemia virus 10, homolog (mouse)

chr19_+_42788172 0.359 ENST00000160740.3
CIC
capicua transcriptional repressor
chr19_+_677885 0.354 ENST00000591552.2
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr6_+_150920999 0.340 ENST00000367328.1
ENST00000367326.1
PLEKHG1

pleckstrin homology domain containing, family G (with RhoGef domain) member 1

chr6_+_86195088 0.338 ENST00000437581.1
NT5E
5'-nucleotidase, ecto (CD73)
chr1_+_33231221 0.335 ENST00000294521.3
KIAA1522
KIAA1522
chr17_+_37894570 0.333 ENST00000394211.3
GRB7
growth factor receptor-bound protein 7
chr17_-_73874654 0.327 ENST00000254816.2
TRIM47
tripartite motif containing 47
chr20_+_48884002 0.325 ENST00000425497.1
ENST00000445003.1
RP11-290F20.3

RP11-290F20.3

chr1_+_33231268 0.323 ENST00000373480.1
KIAA1522
KIAA1522
chr5_-_111092873 0.323 ENST00000509025.1
ENST00000515855.1
NREP

neuronal regeneration related protein

chr20_-_50722183 0.319 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr19_+_3708338 0.314 ENST00000590545.1
TJP3
tight junction protein 3
chr9_-_112970436 0.310 ENST00000400613.4
C9orf152
chromosome 9 open reading frame 152
chr19_+_4007644 0.304 ENST00000262971.2
PIAS4
protein inhibitor of activated STAT, 4
chr16_+_30662085 0.298 ENST00000569864.1
PRR14
proline rich 14
chr19_-_49258606 0.296 ENST00000310160.3
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr1_+_19967014 0.295 ENST00000428975.1
NBL1
neuroblastoma 1, DAN family BMP antagonist
chr17_+_7461781 0.292 ENST00000349228.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr17_-_48474828 0.292 ENST00000576448.1
ENST00000225972.7
LRRC59

leucine rich repeat containing 59

chr1_+_113217043 0.287 ENST00000413052.2
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr2_+_219187871 0.287 ENST00000258362.3
PNKD
paroxysmal nonkinesigenic dyskinesia
chr4_+_123653807 0.286 ENST00000314218.3
ENST00000542236.1
BBS12

Bardet-Biedl syndrome 12

chr4_+_86749045 0.285 ENST00000514229.1
ARHGAP24
Rho GTPase activating protein 24
chr22_-_39640756 0.285 ENST00000331163.6
PDGFB
platelet-derived growth factor beta polypeptide
chr1_+_9648921 0.277 ENST00000377376.4
ENST00000340305.5
ENST00000340381.6
TMEM201


transmembrane protein 201


chr5_-_111093406 0.274 ENST00000379671.3
NREP
neuronal regeneration related protein
chr5_-_114880533 0.273 ENST00000274457.3
FEM1C
fem-1 homolog c (C. elegans)
chr12_-_15114191 0.271 ENST00000541380.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr1_+_113217073 0.269 ENST00000369645.1
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr11_+_45825616 0.268 ENST00000442528.2
ENST00000456334.1
ENST00000526817.1
SLC35C1


solute carrier family 35 (GDP-fucose transporter), member C1


chr7_+_75931861 0.255 ENST00000248553.6
HSPB1
heat shock 27kDa protein 1
chr4_+_123653882 0.253 ENST00000433287.1
BBS12
Bardet-Biedl syndrome 12
chr1_+_27153173 0.250 ENST00000374142.4
ZDHHC18
zinc finger, DHHC-type containing 18
chr5_-_111093167 0.242 ENST00000446294.2
ENST00000419114.2
NREP

neuronal regeneration related protein

chr12_-_15114492 0.241 ENST00000541546.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr22_+_46449674 0.241 ENST00000381051.2
FLJ27365
hsa-mir-4763
chr1_-_44497024 0.240 ENST00000372306.3
ENST00000372310.3
ENST00000475075.2
SLC6A9


solute carrier family 6 (neurotransmitter transporter, glycine), member 9


chr1_+_113217345 0.239 ENST00000357443.2
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr19_-_8675559 0.234 ENST00000597188.1
ADAMTS10
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chr18_-_74728998 0.233 ENST00000359645.3
ENST00000397875.3
ENST00000397869.3
ENST00000578193.1
ENST00000578873.1
ENST00000397866.4
ENST00000528160.1
ENST00000527041.1
ENST00000526111.1
ENST00000397865.5
ENST00000382582.3
MBP










myelin basic protein










chr14_+_75746781 0.231 ENST00000555347.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr11_-_65149422 0.231 ENST00000526432.1
ENST00000527174.1
SLC25A45

solute carrier family 25, member 45

chr15_+_63682335 0.231 ENST00000559379.1
ENST00000559821.1
RP11-321G12.1

RP11-321G12.1

chr1_-_44497118 0.228 ENST00000537678.1
ENST00000466926.1
SLC6A9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr17_+_1633755 0.227 ENST00000545662.1
WDR81
WD repeat domain 81
chr5_-_111092930 0.225 ENST00000257435.7
NREP
neuronal regeneration related protein
chr2_-_219151984 0.224 ENST00000444000.1
ENST00000418569.1
TMBIM1

transmembrane BAX inhibitor motif containing 1

chr17_+_7462103 0.221 ENST00000396545.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr5_+_52083730 0.219 ENST00000274311.2
ENST00000282588.6
PELO
ITGA1
pelota homolog (Drosophila)
integrin, alpha 1
chr6_-_39197226 0.218 ENST00000359534.3
KCNK5
potassium channel, subfamily K, member 5
chr8_-_57233103 0.214 ENST00000303749.3
ENST00000522671.1
SDR16C5

short chain dehydrogenase/reductase family 16C, member 5

chr22_+_17082732 0.214 ENST00000558085.2
ENST00000592918.1
ENST00000400593.2
ENST00000592107.1
ENST00000426585.1
ENST00000591299.1
TPTEP1





transmembrane phosphatase with tensin homology pseudogene 1





chr20_+_61299155 0.213 ENST00000451793.1
SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr17_+_7461613 0.209 ENST00000438470.1
ENST00000436057.1
TNFSF13

tumor necrosis factor (ligand) superfamily, member 13

chr15_+_75487984 0.208 ENST00000563905.1
C15orf39
chromosome 15 open reading frame 39
chr7_-_100076765 0.206 ENST00000393991.1
TSC22D4
TSC22 domain family, member 4
chr11_-_65325664 0.206 ENST00000301873.5
LTBP3
latent transforming growth factor beta binding protein 3
chr12_-_52585765 0.206 ENST00000313234.5
ENST00000394815.2
KRT80

keratin 80

chr19_+_40871734 0.204 ENST00000359274.5
PLD3
phospholipase D family, member 3
chr11_-_62313090 0.204 ENST00000528508.1
ENST00000533365.1
AHNAK

AHNAK nucleoprotein

chr15_+_48051920 0.201 ENST00000559196.1
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr17_+_7461849 0.200 ENST00000338784.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr8_+_120428546 0.200 ENST00000259526.3
NOV
nephroblastoma overexpressed
chr19_-_40772221 0.199 ENST00000441941.2
ENST00000580747.1
AKT2

v-akt murine thymoma viral oncogene homolog 2

chr5_-_1112141 0.198 ENST00000264930.5
SLC12A7
solute carrier family 12 (potassium/chloride transporter), member 7
chr11_+_17281900 0.197 ENST00000530527.1
NUCB2
nucleobindin 2
chrX_-_53310791 0.196 ENST00000375365.2
IQSEC2
IQ motif and Sec7 domain 2
chr1_+_100818009 0.195 ENST00000370125.2
ENST00000361544.6
ENST00000370124.3
CDC14A


cell division cycle 14A


chr4_+_86748898 0.191 ENST00000509300.1
ARHGAP24
Rho GTPase activating protein 24
chr9_-_98268883 0.190 ENST00000551630.1
ENST00000548420.1
PTCH1

patched 1

chr15_-_40633101 0.190 ENST00000559313.1
C15orf52
chromosome 15 open reading frame 52
chr16_+_30662050 0.190 ENST00000568754.1
PRR14
proline rich 14
chr3_-_98620500 0.187 ENST00000326840.6
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr8_-_145331153 0.185 ENST00000377412.4
KM-PA-2
KM-PA-2 protein; Uncharacterized protein
chr5_-_73937244 0.185 ENST00000302351.4
ENST00000510316.1
ENST00000508331.1
ENC1


ectodermal-neural cortex 1 (with BTB domain)


chr11_-_71752100 0.182 ENST00000542977.1
NUMA1
nuclear mitotic apparatus protein 1
chr9_-_130487143 0.182 ENST00000419060.1
PTRH1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr7_-_27187393 0.182 ENST00000222728.3
HOXA6
homeobox A6
chr16_-_2097787 0.180 ENST00000566380.1
ENST00000219066.1
NTHL1

nth endonuclease III-like 1 (E. coli)

chr19_-_1155118 0.180 ENST00000590998.1
SBNO2
strawberry notch homolog 2 (Drosophila)
chr7_+_73242490 0.173 ENST00000431918.1
CLDN4
claudin 4
chr9_+_139871948 0.169 ENST00000224167.2
ENST00000457950.1
ENST00000371625.3
ENST00000371623.3
PTGDS



prostaglandin D2 synthase 21kDa (brain)



chr1_-_200992827 0.168 ENST00000332129.2
ENST00000422435.2
KIF21B

kinesin family member 21B

chr17_-_45899126 0.167 ENST00000007414.3
ENST00000392507.3
OSBPL7

oxysterol binding protein-like 7

chr20_+_44034676 0.165 ENST00000372723.3
ENST00000372722.3
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr1_+_32674675 0.165 ENST00000409358.1
DCDC2B
doublecortin domain containing 2B
chr5_+_176784837 0.164 ENST00000408923.3
RGS14
regulator of G-protein signaling 14
chr17_+_7344057 0.164 ENST00000575398.1
ENST00000575082.1
FGF11

fibroblast growth factor 11

chr17_+_72428218 0.163 ENST00000392628.2
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr5_-_111093340 0.163 ENST00000508870.1
NREP
neuronal regeneration related protein
chr1_+_100818156 0.160 ENST00000336454.3
CDC14A
cell division cycle 14A
chr11_+_71938925 0.159 ENST00000538751.1
INPPL1
inositol polyphosphate phosphatase-like 1
chr7_+_73242069 0.157 ENST00000435050.1
CLDN4
claudin 4
chr17_+_38501493 0.155 ENST00000475125.1
RARA
retinoic acid receptor, alpha
chr11_-_72414256 0.154 ENST00000427971.2
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr22_+_24551765 0.154 ENST00000337989.7
CABIN1
calcineurin binding protein 1
chr11_+_64126671 0.154 ENST00000530504.1
RPS6KA4
ribosomal protein S6 kinase, 90kDa, polypeptide 4
chr1_+_160370344 0.154 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chrX_-_153744507 0.153 ENST00000442929.1
ENST00000426266.1
ENST00000359889.5
ENST00000369641.3
ENST00000447601.2
ENST00000434658.2
FAM3A





family with sequence similarity 3, member A





chr11_+_22646739 0.152 ENST00000428556.2
AC103801.2
AC103801.2
chr5_-_111093081 0.151 ENST00000453526.2
ENST00000509427.1
NREP

neuronal regeneration related protein

chr11_+_64126614 0.151 ENST00000528057.1
ENST00000334205.4
ENST00000294261.4
RPS6KA4


ribosomal protein S6 kinase, 90kDa, polypeptide 4


chr15_-_72523924 0.150 ENST00000566809.1
ENST00000567087.1
ENST00000569050.1
ENST00000568883.1
PKM



pyruvate kinase, muscle



chr17_+_73089382 0.150 ENST00000538213.2
ENST00000584118.1
SLC16A5

solute carrier family 16 (monocarboxylate transporter), member 5

chr1_+_36621174 0.149 ENST00000429533.2
MAP7D1
MAP7 domain containing 1
chr21_+_17792672 0.145 ENST00000602620.1
LINC00478
long intergenic non-protein coding RNA 478
chr11_-_67771513 0.142 ENST00000227471.2
UNC93B1
unc-93 homolog B1 (C. elegans)
chr2_+_179317994 0.139 ENST00000375129.4
DFNB59
deafness, autosomal recessive 59
chr16_+_30662184 0.139 ENST00000300835.4
PRR14
proline rich 14
chr11_+_45825896 0.136 ENST00000314134.3
SLC35C1
solute carrier family 35 (GDP-fucose transporter), member C1
chr7_-_5569588 0.136 ENST00000417101.1
ACTB
actin, beta
chr3_+_9791621 0.136 ENST00000302003.7
ENST00000344629.7
ENST00000302036.7
ENST00000349503.5
ENST00000339511.5
OGG1




8-oxoguanine DNA glycosylase




chr3_-_112356944 0.134 ENST00000461431.1
CCDC80
coiled-coil domain containing 80
chr9_+_34992846 0.133 ENST00000443266.1
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr19_-_6737576 0.133 ENST00000601716.1
ENST00000264080.7
GPR108

G protein-coupled receptor 108

chr10_+_88718314 0.132 ENST00000348795.4
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr9_-_139915246 0.131 ENST00000470535.1
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr10_-_61469837 0.129 ENST00000395348.3
SLC16A9
solute carrier family 16, member 9
chr11_-_61124711 0.128 ENST00000536915.1
CYB561A3
cytochrome b561 family, member A3
chr8_+_38243967 0.127 ENST00000524874.1
ENST00000379957.4
ENST00000523983.2
LETM2


leucine zipper-EF-hand containing transmembrane protein 2


chr19_+_17326521 0.127 ENST00000593597.1
USE1
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr11_-_65325430 0.126 ENST00000322147.4
LTBP3
latent transforming growth factor beta binding protein 3
chrX_-_154376044 0.126 ENST00000362018.2
MTCP1
mature T-cell proliferation 1
chr17_+_78193443 0.125 ENST00000577155.1
SLC26A11
solute carrier family 26 (anion exchanger), member 11
chr16_-_8962544 0.125 ENST00000570125.1
CARHSP1
calcium regulated heat stable protein 1, 24kDa
chr2_-_219146839 0.124 ENST00000425694.1
TMBIM1
transmembrane BAX inhibitor motif containing 1
chr16_-_2264779 0.124 ENST00000333503.7
PGP
phosphoglycolate phosphatase
chr14_-_50999373 0.122 ENST00000554273.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr20_+_44034804 0.121 ENST00000357275.2
ENST00000372720.3
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr14_+_24605361 0.119 ENST00000206451.6
ENST00000559123.1
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr3_+_52350335 0.117 ENST00000420323.2
DNAH1
dynein, axonemal, heavy chain 1
chr22_+_45072925 0.117 ENST00000006251.7
PRR5
proline rich 5 (renal)
chr1_-_16539094 0.113 ENST00000270747.3
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr11_+_125462690 0.113 ENST00000392708.4
ENST00000529196.1
ENST00000531491.1
STT3A


STT3A, subunit of the oligosaccharyltransferase complex (catalytic)


chr16_-_67514982 0.112 ENST00000565835.1
ENST00000540149.1
ENST00000290949.3
ATP6V0D1


ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1


chr6_+_34204642 0.112 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1




high mobility group AT-hook 1




chr15_-_93199069 0.110 ENST00000327355.5
FAM174B
family with sequence similarity 174, member B
chr7_-_100065686 0.110 ENST00000423266.1
ENST00000456330.1
TSC22D4

TSC22 domain family, member 4

chr1_+_12538594 0.110 ENST00000543710.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr20_-_25207370 0.109 ENST00000593352.1
AL035252.1
HCG2018895; Uncharacterized protein
chr5_+_72251857 0.109 ENST00000507345.2
ENST00000512348.1
ENST00000287761.6
FCHO2


FCH domain only 2


chr15_+_90728145 0.109 ENST00000561085.1
ENST00000379122.3
ENST00000332496.6
SEMA4B


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B


chr1_+_33219592 0.106 ENST00000373481.3
KIAA1522
KIAA1522
chr17_+_7462031 0.105 ENST00000380535.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr10_+_17271266 0.105 ENST00000224237.5
VIM
vimentin
chrX_-_54522558 0.104 ENST00000375135.3
FGD1
FYVE, RhoGEF and PH domain containing 1
chr11_+_34664014 0.104 ENST00000527935.1
EHF
ets homologous factor
chr17_-_4890919 0.104 ENST00000572543.1
ENST00000381311.5
ENST00000348066.3
ENST00000358183.4
CAMTA2



calmodulin binding transcription activator 2



chr19_+_39926791 0.103 ENST00000594990.1
SUPT5H
suppressor of Ty 5 homolog (S. cerevisiae)
chr1_-_153538292 0.103 ENST00000497140.1
ENST00000368708.3
S100A2

S100 calcium binding protein A2

chrX_-_153744434 0.103 ENST00000369643.1
ENST00000393572.1
FAM3A

family with sequence similarity 3, member A

chr19_+_3708376 0.102 ENST00000539908.2
TJP3
tight junction protein 3
chr4_+_144303093 0.102 ENST00000505913.1
GAB1
GRB2-associated binding protein 1
chr2_+_220325977 0.102 ENST00000396686.1
ENST00000396689.2
SPEG

SPEG complex locus


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.5 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.8 2.5 GO:2000364 regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.2 0.7 GO:0046521 sphingoid catabolic process(GO:0046521)
0.2 1.5 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.2 1.0 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.2 0.5 GO:0035283 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.2 0.5 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 1.0 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.1 0.9 GO:0071461 cellular response to redox state(GO:0071461)
0.1 1.2 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 0.3 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 1.1 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.1 0.4 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.1 0.3 GO:0061760 antifungal innate immune response(GO:0061760)
0.1 0.7 GO:0070235 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.4 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.1 0.3 GO:0072255 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.1 0.5 GO:0090027 negative regulation of monocyte chemotaxis(GO:0090027)
0.1 0.4 GO:1902045 negative regulation of Fas signaling pathway(GO:1902045)
0.1 0.3 GO:0046086 adenosine biosynthetic process(GO:0046086)
0.1 0.3 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.1 0.3 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 0.2 GO:1901291 negative regulation of double-strand break repair via single-strand annealing(GO:1901291)
0.1 0.3 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.1 0.4 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1 0.2 GO:0060490 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 0.3 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.0 0.2 GO:0010157 response to chlorate(GO:0010157)
0.0 0.1 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.0 0.2 GO:0071348 cellular response to interleukin-11(GO:0071348)
0.0 0.3 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 1.2 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.4 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.2 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.0 0.5 GO:0032119 sequestering of zinc ion(GO:0032119)
0.0 0.2 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.0 0.5 GO:0033160 positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0 0.5 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.8 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.2 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.0 0.1 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.0 0.2 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.2 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.2 GO:0097473 cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.0 0.1 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0 0.5 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 0.1 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.0 0.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 1.2 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.0 0.2 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.0 0.2 GO:0014887 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.0 0.1 GO:0021938 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938) notochord regression(GO:0060032)
0.0 0.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.4 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.4 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.0 0.0 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.0 0.3 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.2 GO:0035826 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.0 0.2 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.0 0.1 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.2 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.0 0.2 GO:0097475 motor neuron migration(GO:0097475)
0.0 1.8 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.2 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.6 GO:0042755 eating behavior(GO:0042755)
0.0 0.2 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.6 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.1 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.3 GO:0007097 nuclear migration(GO:0007097)
0.0 0.2 GO:0045008 depyrimidination(GO:0045008)
0.0 0.3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.0 GO:0060364 uterine wall breakdown(GO:0042704) frontal suture morphogenesis(GO:0060364)
0.0 0.1 GO:0046415 urate metabolic process(GO:0046415)
0.0 2.1 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.6 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.0 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.2 1.2 GO:0043260 laminin-11 complex(GO:0043260)
0.1 0.5 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.1 1.0 GO:0005638 lamin filament(GO:0005638)
0.1 0.8 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.1 0.2 GO:0034665 integrin alpha1-beta1 complex(GO:0034665)
0.0 3.7 GO:0015030 Cajal body(GO:0015030)
0.0 0.2 GO:0060187 cell pole(GO:0060187)
0.0 0.1 GO:1902912 pyruvate kinase complex(GO:1902912)
0.0 0.4 GO:0060091 kinocilium(GO:0060091)
0.0 0.4 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.2 GO:0035976 AP1 complex(GO:0035976)
0.0 4.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.1 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.3 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.5 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.2 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 0.1 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.2 GO:0005593 FACIT collagen trimer(GO:0005593)
0.0 0.4 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.2 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.0 0.1 GO:0032044 DSIF complex(GO:0032044)
0.0 0.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.1 GO:1990769 proximal neuron projection(GO:1990769)
0.0 0.1 GO:0032009 early phagosome(GO:0032009)
0.0 0.2 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0008859 exoribonuclease II activity(GO:0008859)
0.2 2.3 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 0.5 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 1.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 0.7 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 0.3 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 0.4 GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534)
0.1 0.9 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.4 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.1 0.5 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 0.3 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 0.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 0.3 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.1 0.6 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 1.5 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0035501 MH1 domain binding(GO:0035501)
0.0 0.5 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.2 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.0 0.3 GO:0016015 morphogen activity(GO:0016015)
0.0 0.3 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.2 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.2 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.2 GO:0005119 smoothened binding(GO:0005119) hedgehog family protein binding(GO:0097108)
0.0 0.2 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.2 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 0.2 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.1 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 1.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.5 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.3 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.3 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176) platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.0 0.2 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.2 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.0 0.8 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.4 GO:0005123 death receptor binding(GO:0005123)
0.0 0.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.7 GO:0003700 transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.1 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 ST_STAT3_PATHWAY STAT3 Pathway
0.0 2.3 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 1.0 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.0 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 0.8 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 2.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.1 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.2 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 1.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 4.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.2 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.3 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.5 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.8 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.5 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.1 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 1.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.8 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.0 0.2 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.1 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR