Motif ID: THRB

Z-value: 0.361


Transcription factors associated with THRB:

Gene SymbolEntrez IDGene Name
THRB ENSG00000151090.13 THRB

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
THRBhg19_v2_chr3_-_24536253_245363280.817.4e-03Click!


Activity profile for motif THRB.

activity profile for motif THRB


Sorted Z-values histogram for motif THRB

Sorted Z-values for motif THRB



Network of associatons between targets according to the STRING database.



First level regulatory network of THRB

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_151042224 0.336 ENST00000358517.2
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr13_+_27844464 0.332 ENST00000241463.4
RASL11A
RAS-like, family 11, member A
chr19_-_9003586 0.313 ENST00000380951.5
MUC16
mucin 16, cell surface associated
chr17_+_1646130 0.244 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
SERPINF2




serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2




chr8_-_100905363 0.235 ENST00000524245.1
COX6C
cytochrome c oxidase subunit VIc
chr8_-_100905850 0.218 ENST00000520271.1
ENST00000522940.1
ENST00000523016.1
ENST00000517682.2
ENST00000297564.2
COX6C




cytochrome c oxidase subunit VIc




chr8_-_100905925 0.209 ENST00000518171.1
COX6C
cytochrome c oxidase subunit VIc
chr20_+_388791 0.164 ENST00000441733.1
ENST00000353660.3
RBCK1

RanBP-type and C3HC4-type zinc finger containing 1

chr20_+_388679 0.163 ENST00000356286.5
ENST00000475269.1
RBCK1

RanBP-type and C3HC4-type zinc finger containing 1

chrY_-_1461617 0.145 ENSTR0000381401.5
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chrX_-_1511617 0.145 ENST00000381401.5
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr15_-_35838348 0.144 ENST00000561411.1
ENST00000256538.4
ENST00000440392.2
DPH6


diphthamine biosynthesis 6


chr11_+_5617976 0.144 ENST00000445329.1
TRIM6
tripartite motif containing 6
chr6_-_99842041 0.138 ENST00000254759.3
ENST00000369242.1
COQ3

coenzyme Q3 methyltransferase

chr11_+_5617858 0.136 ENST00000380097.3
TRIM6
tripartite motif containing 6
chr12_-_21810726 0.134 ENST00000396076.1
LDHB
lactate dehydrogenase B
chr14_+_75761099 0.134 ENST00000561000.1
ENST00000558575.1
RP11-293M10.5

RP11-293M10.5

chr11_+_73498973 0.127 ENST00000537007.1
MRPL48
mitochondrial ribosomal protein L48
chr11_+_5618029 0.126 ENST00000515022.1
ENST00000506134.1
TRIM6

tripartite motif containing 6

chr12_-_21810765 0.124 ENST00000450584.1
ENST00000350669.1
LDHB

lactate dehydrogenase B

chr10_+_35456444 0.096 ENST00000361599.4
CREM
cAMP responsive element modulator
chr11_+_73498898 0.073 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48





mitochondrial ribosomal protein L48





chr1_+_32712815 0.072 ENST00000373582.3
FAM167B
family with sequence similarity 167, member B
chr7_+_102937869 0.066 ENST00000249269.4
ENST00000428154.1
ENST00000420236.2
PMPCB


peptidase (mitochondrial processing) beta


chr10_+_123970670 0.048 ENST00000496913.2
TACC2
transforming, acidic coiled-coil containing protein 2
chr11_-_117170403 0.048 ENST00000504995.1
BACE1
beta-site APP-cleaving enzyme 1
chr14_+_32414059 0.045 ENST00000553330.1
RP11-187E13.1
Uncharacterized protein
chr8_+_22102626 0.043 ENST00000519237.1
ENST00000397802.4
POLR3D

polymerase (RNA) III (DNA directed) polypeptide D, 44kDa

chr20_+_3024266 0.042 ENST00000245983.2
ENST00000359100.2
ENST00000359987.1
GNRH2


gonadotropin-releasing hormone 2


chr11_-_47400078 0.040 ENST00000378538.3
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr11_-_47399942 0.036 ENST00000227163.4
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr11_-_47400062 0.035 ENST00000533030.1
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr4_+_189321881 0.028 ENST00000512839.1
ENST00000513313.1
LINC01060

long intergenic non-protein coding RNA 1060

chr9_+_100069933 0.028 ENST00000529487.1
CCDC180
coiled-coil domain containing 180
chr7_-_38394118 0.026 ENST00000390345.2
TRGV4
T cell receptor gamma variable 4
chr6_+_77484663 0.025 ENST00000607287.1
RP11-354K4.2
RP11-354K4.2
chr1_+_3668962 0.022 ENST00000294600.2
CCDC27
coiled-coil domain containing 27
chr9_-_139268068 0.021 ENST00000371734.3
ENST00000371732.5
ENST00000315908.7
CARD9


caspase recruitment domain family, member 9


chr1_+_161190160 0.021 ENST00000594609.1
AL590714.1
Uncharacterized protein
chr20_+_61640711 0.020 ENST00000606208.1
ENST00000607802.1
RP11-305P22.9

RP11-305P22.9

chr11_+_5617952 0.019 ENST00000354852.5
TRIM6-TRIM34
TRIM6-TRIM34 readthrough
chr20_+_37434329 0.015 ENST00000299824.1
ENST00000373331.2
PPP1R16B

protein phosphatase 1, regulatory subunit 16B

chr15_-_101084446 0.015 ENST00000538112.2
ENST00000559639.1
ENST00000558884.2
CERS3


ceramide synthase 3


chr15_-_101084547 0.012 ENST00000394113.1
CERS3
ceramide synthase 3
chr10_+_62538248 0.012 ENST00000448257.2
CDK1
cyclin-dependent kinase 1
chr11_-_45307817 0.012 ENST00000020926.3
SYT13
synaptotagmin XIII
chr16_-_69368774 0.011 ENST00000562949.1
RP11-343C2.12
Conserved oligomeric Golgi complex subunit 8
chr10_+_62538089 0.010 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
CDK1


cyclin-dependent kinase 1


chr15_+_35838396 0.008 ENST00000501169.2
DPH6-AS1
DPH6 antisense RNA 1 (head to head)
chr2_+_200472779 0.008 ENST00000427045.1
ENST00000419243.1
AC093590.1

AC093590.1

chr15_+_35838446 0.007 ENST00000559210.1
DPH6-AS1
DPH6 antisense RNA 1 (head to head)
chr15_-_101084881 0.004 ENST00000284382.4
CERS3
ceramide synthase 3
chr1_+_77997785 0.003 ENST00000478255.1
AK5
adenylate kinase 5
chr19_+_55085248 0.003 ENST00000396321.2
ENST00000418536.2
ENST00000448689.1
ENST00000391738.3
ENST00000251376.3
ENST00000391737.1
LILRB1


LILRA2


leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1


leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2


chr11_+_46366799 0.002 ENST00000532868.2
DGKZ
diacylglycerol kinase, zeta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0052553 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
0.0 0.2 GO:0002034 regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072)
0.0 0.4 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.0 0.3 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.1 GO:0044026 DNA hypermethylation(GO:0044026) hypermethylation of CpG island(GO:0044027)
0.0 0.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.3 GO:0006089 lactate metabolic process(GO:0006089)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.3 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.0 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005471 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.0 0.1 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 0.3 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)