Motif ID: TFAP2E

Z-value: 0.403


Transcription factors associated with TFAP2E:

Gene SymbolEntrez IDGene Name
TFAP2E ENSG00000116819.6 TFAP2E

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TFAP2Ehg19_v2_chr1_+_36038971_36038971-0.029.6e-01Click!


Activity profile for motif TFAP2E.

activity profile for motif TFAP2E


Sorted Z-values histogram for motif TFAP2E

Sorted Z-values for motif TFAP2E



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2E

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_39769005 0.600 ENST00000301653.4
ENST00000593067.1
KRT16

keratin 16

chr19_+_36195429 0.542 ENST00000392197.2
ZBTB32
zinc finger and BTB domain containing 32
chr19_-_43969796 0.460 ENST00000244333.3
LYPD3
LY6/PLAUR domain containing 3
chr19_+_45504688 0.456 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB


v-rel avian reticuloendotheliosis viral oncogene homolog B


chr3_+_105086056 0.386 ENST00000472644.2
ALCAM
activated leukocyte cell adhesion molecule
chr19_+_36195467 0.313 ENST00000426659.2
ZBTB32
zinc finger and BTB domain containing 32
chr19_+_13228917 0.282 ENST00000586171.1
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr3_+_50192833 0.257 ENST00000426511.1
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr4_+_75480629 0.231 ENST00000380846.3
AREGB
amphiregulin B
chr11_-_66056596 0.169 ENST00000471387.2
ENST00000359461.6
ENST00000376901.4
YIF1A


Yip1 interacting factor homolog A (S. cerevisiae)


chr19_+_38794797 0.165 ENST00000301246.5
ENST00000588605.1
C19orf33

chromosome 19 open reading frame 33

chrX_+_49028265 0.152 ENST00000376322.3
ENST00000376327.5
PLP2

proteolipid protein 2 (colonic epithelium-enriched)

chrX_+_152990302 0.151 ENST00000218104.3
ABCD1
ATP-binding cassette, sub-family D (ALD), member 1
chr7_+_100464760 0.150 ENST00000200457.4
TRIP6
thyroid hormone receptor interactor 6
chr17_+_72428218 0.143 ENST00000392628.2
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr19_+_13229126 0.134 ENST00000292431.4
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr19_-_11039188 0.132 ENST00000588347.1
YIPF2
Yip1 domain family, member 2
chr1_+_233749739 0.127 ENST00000366621.3
KCNK1
potassium channel, subfamily K, member 1
chr17_-_42188598 0.127 ENST00000591714.1
HDAC5
histone deacetylase 5
chr6_+_7108210 0.121 ENST00000467782.1
ENST00000334984.6
ENST00000349384.6
RREB1


ras responsive element binding protein 1


chr2_+_241375069 0.115 ENST00000264039.2
GPC1
glypican 1
chr17_+_48423453 0.109 ENST00000017003.2
ENST00000509778.1
ENST00000507602.1
XYLT2


xylosyltransferase II


chr3_+_110790590 0.106 ENST00000485303.1
PVRL3
poliovirus receptor-related 3
chr19_-_46389359 0.105 ENST00000302165.3
IRF2BP1
interferon regulatory factor 2 binding protein 1
chr3_+_171757346 0.104 ENST00000421757.1
ENST00000415807.2
ENST00000392699.1
FNDC3B


fibronectin type III domain containing 3B


chr6_+_7107830 0.102 ENST00000379933.3
RREB1
ras responsive element binding protein 1
chr17_+_36584662 0.099 ENST00000431231.2
ENST00000437668.3
ARHGAP23

Rho GTPase activating protein 23

chr19_-_11039261 0.098 ENST00000590329.1
ENST00000587943.1
ENST00000585858.1
ENST00000586748.1
ENST00000586575.1
ENST00000253031.2
YIPF2





Yip1 domain family, member 2





chr19_-_10613862 0.095 ENST00000592055.1
KEAP1
kelch-like ECH-associated protein 1
chr6_+_7107999 0.091 ENST00000491191.1
ENST00000379938.2
ENST00000471433.1
RREB1


ras responsive element binding protein 1


chr7_-_140624499 0.089 ENST00000288602.6
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr17_-_47755338 0.089 ENST00000508805.1
ENST00000515508.2
ENST00000451526.2
ENST00000507970.1
SPOP



speckle-type POZ protein



chr3_-_128207349 0.088 ENST00000487848.1
GATA2
GATA binding protein 2
chr9_+_35605274 0.086 ENST00000336395.5
TESK1
testis-specific kinase 1
chr16_+_69599899 0.080 ENST00000567239.1
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chrX_+_54466829 0.079 ENST00000375151.4
TSR2
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chr2_-_133429091 0.079 ENST00000345008.6
LYPD1
LY6/PLAUR domain containing 1
chr5_+_176237478 0.076 ENST00000329542.4
UNC5A
unc-5 homolog A (C. elegans)
chr12_-_65153175 0.073 ENST00000543646.1
ENST00000542058.1
ENST00000258145.3
GNS


glucosamine (N-acetyl)-6-sulfatase


chr11_+_82612740 0.073 ENST00000524921.1
ENST00000528759.1
ENST00000525361.1
ENST00000430323.2
ENST00000533655.1
ENST00000532764.1
ENST00000532589.1
ENST00000525388.1
C11orf82







chromosome 11 open reading frame 82







chr12_+_53443963 0.073 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1


tensin like C1 domain containing phosphatase (tensin 2)


chr12_+_53773944 0.072 ENST00000551969.1
ENST00000327443.4
SP1

Sp1 transcription factor

chr17_+_3627185 0.072 ENST00000325418.4
GSG2
germ cell associated 2 (haspin)
chr4_+_154387480 0.069 ENST00000409663.3
ENST00000440693.1
ENST00000409959.3
KIAA0922


KIAA0922


chr1_+_901847 0.069 ENST00000379410.3
ENST00000379409.2
ENST00000379407.3
PLEKHN1


pleckstrin homology domain containing, family N member 1


chr16_-_28506840 0.068 ENST00000569430.1
CLN3
ceroid-lipofuscinosis, neuronal 3
chr12_-_48213568 0.067 ENST00000080059.7
ENST00000354334.3
ENST00000430670.1
ENST00000552960.1
ENST00000440293.1
HDAC7




histone deacetylase 7




chr11_-_66056478 0.067 ENST00000431556.2
ENST00000528575.1
YIF1A

Yip1 interacting factor homolog A (S. cerevisiae)

chr7_-_100065686 0.066 ENST00000423266.1
ENST00000456330.1
TSC22D4

TSC22 domain family, member 4

chr16_+_69599861 0.064 ENST00000354436.2
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr1_-_11865351 0.064 ENST00000413656.1
ENST00000376585.1
ENST00000423400.1
ENST00000431243.1
MTHFR



methylenetetrahydrofolate reductase (NAD(P)H)



chr8_+_22250334 0.059 ENST00000520832.1
SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr19_+_11039391 0.058 ENST00000270502.6
C19orf52
chromosome 19 open reading frame 52
chr22_-_39096661 0.057 ENST00000216039.5
JOSD1
Josephin domain containing 1
chr17_+_74070853 0.054 ENST00000329003.3
GALR2
galanin receptor 2
chr11_-_65624415 0.052 ENST00000524553.1
ENST00000527344.1
CFL1

cofilin 1 (non-muscle)

chr16_+_69600058 0.052 ENST00000393742.2
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr12_+_75784850 0.050 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLIPR1L2





GLI pathogenesis-related 1 like 2





chr12_+_57984965 0.049 ENST00000540759.2
ENST00000551772.1
ENST00000550465.1
ENST00000354947.5
PIP4K2C



phosphatidylinositol-5-phosphate 4-kinase, type II, gamma



chr2_-_241831424 0.047 ENST00000402775.2
ENST00000307486.8
C2orf54

chromosome 2 open reading frame 54

chrX_-_124097620 0.046 ENST00000371130.3
ENST00000422452.2
TENM1

teneurin transmembrane protein 1

chr12_-_48213735 0.046 ENST00000417902.1
ENST00000417107.1
HDAC7

histone deacetylase 7

chr2_-_24149918 0.046 ENST00000439915.1
ATAD2B
ATPase family, AAA domain containing 2B
chr19_+_3572925 0.044 ENST00000333651.6
ENST00000417382.1
ENST00000453933.1
ENST00000262949.7
HMG20B



high mobility group 20B



chr17_-_42992856 0.044 ENST00000588316.1
ENST00000435360.2
ENST00000586793.1
ENST00000588735.1
ENST00000588037.1
ENST00000592320.1
ENST00000253408.5
GFAP






glial fibrillary acidic protein






chr20_+_58508817 0.043 ENST00000358293.3
FAM217B
family with sequence similarity 217, member B
chr1_+_17248418 0.043 ENST00000375541.5
CROCC
ciliary rootlet coiled-coil, rootletin
chr11_-_65625014 0.043 ENST00000534784.1
CFL1
cofilin 1 (non-muscle)
chr1_-_63782888 0.042 ENST00000436475.2
LINC00466
long intergenic non-protein coding RNA 466
chr11_+_64009072 0.041 ENST00000535135.1
ENST00000394540.3
FKBP2

FK506 binding protein 2, 13kDa

chr19_+_49458107 0.041 ENST00000539787.1
ENST00000345358.7
ENST00000391871.3
ENST00000415969.2
ENST00000354470.3
ENST00000506183.1
ENST00000293288.8
BAX






BCL2-associated X protein






chr6_+_292253 0.040 ENST00000603453.1
ENST00000605315.1
ENST00000603881.1
DUSP22


dual specificity phosphatase 22


chr2_-_177502254 0.039 ENST00000339037.3
AC017048.3
long intergenic non-protein coding RNA 1116
chr10_+_99894380 0.036 ENST00000370584.3
R3HCC1L
R3H domain and coiled-coil containing 1-like
chr22_+_38146987 0.034 ENST00000418339.1
TRIOBP
TRIO and F-actin binding protein
chr6_+_42531798 0.033 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
UBR2


ubiquitin protein ligase E3 component n-recognin 2


chr10_-_108924284 0.031 ENST00000344440.6
ENST00000263054.6
SORCS1

sortilin-related VPS10 domain containing receptor 1

chr2_-_24149977 0.030 ENST00000238789.5
ATAD2B
ATPase family, AAA domain containing 2B
chr17_-_47755436 0.029 ENST00000505581.1
ENST00000514121.1
ENST00000393328.2
ENST00000509079.1
ENST00000393331.3
ENST00000347630.2
ENST00000504102.1
SPOP






speckle-type POZ protein






chr10_+_99894399 0.027 ENST00000298999.3
ENST00000314594.5
R3HCC1L

R3H domain and coiled-coil containing 1-like

chr3_+_51428704 0.024 ENST00000323686.4
RBM15B
RNA binding motif protein 15B
chr9_+_19230433 0.022 ENST00000434457.2
ENST00000602925.1
DENND4C

DENN/MADD domain containing 4C

chr7_-_23053693 0.020 ENST00000409763.1
ENST00000409923.1
FAM126A

family with sequence similarity 126, member A

chr12_-_68797580 0.019 ENST00000539404.1
RP11-81H14.2
RP11-81H14.2
chr2_-_174828892 0.019 ENST00000418194.2
SP3
Sp3 transcription factor
chr1_-_11866034 0.017 ENST00000376590.3
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr1_+_150122034 0.017 ENST00000025469.6
ENST00000369124.4
PLEKHO1

pleckstrin homology domain containing, family O member 1

chr11_-_71753188 0.016 ENST00000543009.1
NUMA1
nuclear mitotic apparatus protein 1
chr6_+_37787262 0.016 ENST00000287218.4
ZFAND3
zinc finger, AN1-type domain 3
chr6_+_292051 0.016 ENST00000344450.5
DUSP22
dual specificity phosphatase 22
chr11_-_65325430 0.014 ENST00000322147.4
LTBP3
latent transforming growth factor beta binding protein 3
chr19_+_4969116 0.014 ENST00000588337.1
ENST00000159111.4
ENST00000381759.4
KDM4B


lysine (K)-specific demethylase 4B


chr19_+_54960790 0.012 ENST00000443957.1
LENG8
leukocyte receptor cluster (LRC) member 8
chr1_-_9189144 0.012 ENST00000414642.2
GPR157
G protein-coupled receptor 157
chrX_-_118826784 0.012 ENST00000394616.4
SEPT6
septin 6
chr2_+_232573222 0.011 ENST00000341369.7
ENST00000409683.1
PTMA

prothymosin, alpha

chr2_+_232573208 0.010 ENST00000409115.3
PTMA
prothymosin, alpha
chr17_+_40932610 0.010 ENST00000246914.5
WNK4
WNK lysine deficient protein kinase 4
chr13_-_76056250 0.010 ENST00000377636.3
ENST00000431480.2
ENST00000377625.2
ENST00000425511.1
TBC1D4



TBC1 domain family, member 4



chr11_+_66045634 0.009 ENST00000528852.1
ENST00000311445.6
CNIH2

cornichon family AMPA receptor auxiliary protein 2

chr1_-_11865982 0.009 ENST00000418034.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr14_-_60952739 0.008 ENST00000555476.1
ENST00000321731.3
C14orf39

chromosome 14 open reading frame 39

chr12_-_15942309 0.006 ENST00000544064.1
ENST00000543523.1
ENST00000536793.1
EPS8


epidermal growth factor receptor pathway substrate 8


chr6_+_13272904 0.004 ENST00000379335.3
ENST00000379329.1
PHACTR1

phosphatase and actin regulator 1

chr2_-_45236540 0.004 ENST00000303077.6
SIX2
SIX homeobox 2
chr11_-_82612549 0.003 ENST00000528082.1
ENST00000533126.1
PRCP

prolylcarboxypeptidase (angiotensinase C)

chr2_+_75061108 0.003 ENST00000290573.2
HK2
hexokinase 2
chr1_-_114355083 0.001 ENST00000261441.5
RSBN1
round spermatid basic protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.0 0.2 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.6 GO:0051546 keratinocyte migration(GO:0051546)
0.0 0.2 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.1 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 0.1 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725) eosinophil fate commitment(GO:0035854)
0.0 0.3 GO:0036486 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) neural crest cell migration involved in autonomic nervous system development(GO:1901166)
0.0 0.5 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 0.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.1 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.0 0.1 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 0.1 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.1 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.1 GO:0002318 myeloid progenitor cell differentiation(GO:0002318) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.1 GO:2000782 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.0 GO:0048597 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597) positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.0 0.9 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.3 GO:1902284 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.0 0.0 GO:0032053 ciliary basal body organization(GO:0032053) positive regulation of protein localization to cilium(GO:1903566)
0.0 0.1 GO:0060075 regulation of resting membrane potential(GO:0060075)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.5 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.2 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.4 GO:0042101 T cell receptor complex(GO:0042101)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.0 0.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.1 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.1 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.3 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.6 GO:0043236 laminin binding(GO:0043236)
0.0 0.1 GO:0004966 galanin receptor activity(GO:0004966)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels