Motif ID: SREBF2

Z-value: 0.310


Transcription factors associated with SREBF2:

Gene SymbolEntrez IDGene Name
SREBF2 ENSG00000198911.7 SREBF2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SREBF2hg19_v2_chr22_+_42229100_422291460.854.0e-03Click!


Activity profile for motif SREBF2.

activity profile for motif SREBF2


Sorted Z-values histogram for motif SREBF2

Sorted Z-values for motif SREBF2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_171528227 0.321 ENST00000356327.5
ENST00000342215.6
ENST00000340989.4
ENST00000351298.4
 PLD1



phospholipase D1, phosphatidylcholine-specific



chr5_-_39425068 0.307 ENST00000515700.1
ENST00000339788.6
 DAB2

Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)

chr5_-_149535421 0.303 ENST00000261799.4
 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr5_-_39424961 0.243 ENST00000503513.1
 DAB2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr11_+_2923499 0.227 ENST00000449793.2
 SLC22A18
solute carrier family 22, member 18
chr5_-_149535190 0.225 ENST00000517488.1
 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr19_-_18392422 0.219 ENST00000252818.3
 JUND
jun D proto-oncogene
chr20_+_33464368 0.217 ENST00000484354.1
ENST00000493805.2
ENST00000473172.1
 ACSS2


acyl-CoA synthetase short-chain family member 2


chr1_+_197237352 0.201 ENST00000538660.1
ENST00000367400.3
ENST00000367399.2
 CRB1


crumbs homolog 1 (Drosophila)


chr11_+_2923619 0.194 ENST00000380574.1
 SLC22A18
solute carrier family 22, member 18
chr11_+_2923423 0.192 ENST00000312221.5
 SLC22A18
solute carrier family 22, member 18
chr5_+_159656437 0.183 ENST00000402432.3
 FABP6
fatty acid binding protein 6, ileal
chr22_+_42229100 0.173 ENST00000361204.4
 SREBF2
sterol regulatory element binding transcription factor 2
chr6_+_43968306 0.166 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
 C6orf223


chromosome 6 open reading frame 223


chr15_+_47476275 0.163 ENST00000558014.1
 SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr19_-_46285646 0.157 ENST00000458663.2
 DMPK
dystrophia myotonica-protein kinase
chr17_-_17726907 0.152 ENST00000423161.3
 SREBF1
sterol regulatory element binding transcription factor 1
chr19_-_46285736 0.143 ENST00000291270.4
ENST00000447742.2
ENST00000354227.5
 DMPK


dystrophia myotonica-protein kinase


chr1_+_55505184 0.124 ENST00000302118.5
 PCSK9
proprotein convertase subtilisin/kexin type 9
chr16_+_2083265 0.117 ENST00000565855.1
ENST00000566198.1
 SLC9A3R2

solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2

chr3_-_160117301 0.115 ENST00000326448.7
ENST00000498409.1
ENST00000475677.1
ENST00000478536.1
 IFT80



intraflagellar transport 80 homolog (Chlamydomonas)



chr11_-_73309228 0.108 ENST00000356467.4
ENST00000064778.4
 FAM168A

family with sequence similarity 168, member A

chr8_-_17579726 0.106 ENST00000381861.3
 MTUS1
microtubule associated tumor suppressor 1
chr3_-_98620500 0.096 ENST00000326840.6
 DCBLD2
discoidin, CUB and LCCL domain containing 2
chr20_+_33464407 0.093 ENST00000253382.5
 ACSS2
acyl-CoA synthetase short-chain family member 2
chr12_-_91505608 0.091 ENST00000266718.4
 LUM
lumican
chr14_-_35183886 0.076 ENST00000298159.6
 CFL2
cofilin 2 (muscle)
chr9_+_96928516 0.072 ENST00000602703.1
 RP11-2B6.3
RP11-2B6.3
chr20_+_33464238 0.071 ENST00000360596.2
 ACSS2
acyl-CoA synthetase short-chain family member 2
chr11_-_73309112 0.067 ENST00000450446.2
 FAM168A
family with sequence similarity 168, member A
chr17_-_15168624 0.063 ENST00000312280.3
ENST00000494511.1
ENST00000580584.1
 PMP22


peripheral myelin protein 22


chr6_-_32151999 0.059 ENST00000375069.3
ENST00000538695.1
ENST00000438221.2
ENST00000375065.5
ENST00000450110.1
ENST00000375067.3
ENST00000375056.2
 AGER






advanced glycosylation end product-specific receptor






chr17_-_41738931 0.058 ENST00000329168.3
ENST00000549132.1
 MEOX1

mesenchyme homeobox 1

chr6_-_31926208 0.056 ENST00000454913.1
ENST00000436289.2
 NELFE

negative elongation factor complex member E

chr2_+_27435734 0.055 ENST00000419744.1
 ATRAID
all-trans retinoic acid-induced differentiation factor
chr6_-_32152064 0.053 ENST00000375076.4
ENST00000375070.3
 AGER

advanced glycosylation end product-specific receptor

chr6_-_52860171 0.050 ENST00000370963.4
 GSTA4
glutathione S-transferase alpha 4
chr3_-_171527560 0.048 ENST00000331659.2
 PP13439
PP13439
chr19_-_11308190 0.048 ENST00000586659.1
ENST00000592903.1
ENST00000589359.1
ENST00000588724.1
ENST00000432929.2
 KANK2




KN motif and ankyrin repeat domains 2




chr3_+_46742823 0.046 ENST00000326431.3
 TMIE
transmembrane inner ear
chr6_+_79577189 0.046 ENST00000369940.2
 IRAK1BP1
interleukin-1 receptor-associated kinase 1 binding protein 1
chr8_+_26434578 0.043 ENST00000493789.2
 DPYSL2
dihydropyrimidinase-like 2
chr17_-_40075219 0.035 ENST00000537919.1
ENST00000352035.2
ENST00000353196.1
ENST00000393896.2
 ACLY



ATP citrate lyase



chr6_-_32152020 0.035 ENST00000375055.2
 AGER
advanced glycosylation end product-specific receptor
chr19_+_36266417 0.033 ENST00000378944.5
ENST00000007510.4
 ARHGAP33

Rho GTPase activating protein 33

chr8_+_26435359 0.032 ENST00000311151.5
 DPYSL2
dihydropyrimidinase-like 2
chr20_+_58533471 0.030 ENST00000244047.5
ENST00000348616.4
 CDH26

cadherin 26

chr6_+_151561085 0.029 ENST00000402676.2
 AKAP12
A kinase (PRKA) anchor protein 12
chr8_+_104512976 0.028 ENST00000504942.2
 RIMS2
regulating synaptic membrane exocytosis 2
chr6_+_41604620 0.022 ENST00000432027.1
 MDFI
MyoD family inhibitor
chr14_+_74960423 0.021 ENST00000556816.1
ENST00000298818.8
ENST00000554924.1
 ISCA2


iron-sulfur cluster assembly 2


chr17_-_40075197 0.021 ENST00000590770.1
ENST00000590151.1
 ACLY

ATP citrate lyase

chr6_-_53213780 0.020 ENST00000304434.6
ENST00000370918.4
 ELOVL5

ELOVL fatty acid elongase 5

chr5_+_137774706 0.020 ENST00000378339.2
ENST00000254901.5
ENST00000506158.1
 REEP2


receptor accessory protein 2


chr8_+_104513086 0.018 ENST00000406091.3
 RIMS2
regulating synaptic membrane exocytosis 2
chr7_-_44580861 0.017 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
 NPC1L1



NPC1-like 1



chr6_-_52859968 0.017 ENST00000370959.1
 GSTA4
glutathione S-transferase alpha 4
chrX_+_27826107 0.016 ENST00000356790.2
 MAGEB10
melanoma antigen family B, 10
chr6_+_41604747 0.015 ENST00000419164.1
ENST00000373051.2
 MDFI

MyoD family inhibitor

chr13_+_24844979 0.014 ENST00000454083.1
 SPATA13
spermatogenesis associated 13
chrX_+_47229982 0.013 ENST00000377073.3
 ZNF157
zinc finger protein 157
chr5_-_149669612 0.013 ENST00000510347.1
 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr5_-_139283982 0.012 ENST00000340391.3
 NRG2
neuregulin 2
chr9_+_126131131 0.010 ENST00000373629.2
 CRB2
crumbs homolog 2 (Drosophila)
chr16_+_31225337 0.009 ENST00000322122.3
 TRIM72
tripartite motif containing 72
chrX_-_112084043 0.008 ENST00000304758.1
 AMOT
angiomotin
chr19_+_36266433 0.006 ENST00000314737.5
 ARHGAP33
Rho GTPase activating protein 33
chr16_+_22103828 0.006 ENST00000567131.1
ENST00000568328.1
ENST00000389398.5
ENST00000389397.4
 VWA3A



von Willebrand factor A domain containing 3A



chrX_-_103087136 0.005 ENST00000243298.2
 RAB9B
RAB9B, member RAS oncogene family
chr1_-_155232221 0.005 ENST00000355379.3
 SCAMP3
secretory carrier membrane protein 3
chr12_-_48398104 0.004 ENST00000337299.6
ENST00000380518.3
 COL2A1

collagen, type II, alpha 1

chr4_-_54930790 0.004 ENST00000263921.3
 CHIC2
cysteine-rich hydrophobic domain 2
chr17_+_73257742 0.003 ENST00000579761.1
ENST00000245539.6
 MRPS7

mitochondrial ribosomal protein S7

chr3_+_188889737 0.003 ENST00000345063.3
 TPRG1
tumor protein p63 regulated 1
chr10_-_74856608 0.003 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
 P4HA1





prolyl 4-hydroxylase, alpha polypeptide I





chr1_-_155232047 0.001 ENST00000302631.3
 SCAMP3
secretory carrier membrane protein 3
chr5_+_173416162 0.001 ENST00000340147.6
 C5orf47
chromosome 5 open reading frame 47
chr11_+_65383227 0.000 ENST00000355703.3
 PCNXL3
pecanex-like 3 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0060981 cell migration involved in coronary angiogenesis(GO:0060981)
0.1 0.5 GO:0035026 leading edge cell differentiation(GO:0035026)
0.1 0.6 GO:0046618 drug export(GO:0046618)
0.1 0.4 GO:0019427 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.1 0.2 GO:1905051 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.0 0.1 GO:1904604 regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
0.0 0.1 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.0 0.2 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.3 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.3 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0 0.1 GO:0061056 sclerotome development(GO:0061056)
0.0 0.0 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.1 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.2 GO:0035976 AP1 complex(GO:0035976)
0.0 0.1 GO:0009346 citrate lyase complex(GO:0009346)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0005019 platelet-derived growth factor beta-receptor activity(GO:0005019)
0.1 0.6 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.1 0.4 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:1904599 advanced glycation end-product binding(GO:1904599)
0.0 0.1 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 0.3 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0003878 ATP citrate synthase activity(GO:0003878)
0.0 0.5 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.2 GO:0032810 sterol response element binding(GO:0032810)
0.0 0.2 GO:0032052 bile acid binding(GO:0032052)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 0.3 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.4 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.5 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.2 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts