Motif ID: SOX6
Z-value: 1.017
Transcription factors associated with SOX6:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| SOX6 | ENSG00000110693.11 | SOX6 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX6 | hg19_v2_chr11_-_16403910_16403944 | 0.71 | 3.3e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.4 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 0.6 | 3.5 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
| 0.4 | 1.8 | GO:0072709 | cellular response to sorbitol(GO:0072709) |
| 0.3 | 0.8 | GO:0060129 | negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) regulation of calcium-independent cell-cell adhesion(GO:0051040) thyroid-stimulating hormone-secreting cell differentiation(GO:0060129) |
| 0.3 | 0.8 | GO:0021538 | epithalamus development(GO:0021538) habenula development(GO:0021986) |
| 0.2 | 0.7 | GO:1901069 | guanosine-containing compound catabolic process(GO:1901069) |
| 0.2 | 1.0 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
| 0.2 | 8.8 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 0.4 | GO:0035283 | central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284) |
| 0.1 | 0.9 | GO:0009256 | 10-formyltetrahydrofolate metabolic process(GO:0009256) |
| 0.1 | 0.9 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.1 | 6.5 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.1 | 2.2 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.1 | 1.5 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.1 | 0.3 | GO:0016260 | selenocysteine biosynthetic process(GO:0016260) |
| 0.1 | 0.9 | GO:0070235 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.1 | 0.4 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
| 0.1 | 0.3 | GO:0098582 | innate vocalization behavior(GO:0098582) |
| 0.1 | 0.5 | GO:1900220 | semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220) |
| 0.1 | 1.7 | GO:0071786 | endoplasmic reticulum tubular network organization(GO:0071786) |
| 0.1 | 0.4 | GO:0008204 | ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204) |
| 0.1 | 0.9 | GO:0034201 | response to oleic acid(GO:0034201) |
| 0.1 | 0.2 | GO:0001543 | ovarian follicle rupture(GO:0001543) |
| 0.1 | 0.5 | GO:0003025 | regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564) |
| 0.0 | 0.2 | GO:0061763 | multivesicular body-lysosome fusion(GO:0061763) |
| 0.0 | 0.1 | GO:0033024 | mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668) |
| 0.0 | 0.2 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.0 | 0.7 | GO:0098828 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
| 0.0 | 0.2 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
| 0.0 | 0.6 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.0 | 0.4 | GO:0048505 | regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505) |
| 0.0 | 0.4 | GO:0015871 | choline transport(GO:0015871) |
| 0.0 | 0.1 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.0 | 0.1 | GO:0009236 | cobalamin biosynthetic process(GO:0009236) |
| 0.0 | 0.1 | GO:0072658 | maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.0 | 0.2 | GO:0010710 | regulation of collagen catabolic process(GO:0010710) |
| 0.0 | 0.1 | GO:0060392 | negative regulation of SMAD protein import into nucleus(GO:0060392) |
| 0.0 | 0.1 | GO:1902683 | regulation of receptor localization to synapse(GO:1902683) |
| 0.0 | 0.4 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
| 0.0 | 0.6 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.0 | 0.6 | GO:0045109 | intermediate filament organization(GO:0045109) |
| 0.0 | 0.1 | GO:0000432 | regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) |
| 0.0 | 0.2 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.0 | 0.2 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.0 | 0.1 | GO:0016240 | autophagosome docking(GO:0016240) |
| 0.0 | 0.1 | GO:0008291 | acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581) acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619) |
| 0.0 | 0.1 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.0 | 0.1 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.0 | 0.0 | GO:0034164 | negative regulation of toll-like receptor 9 signaling pathway(GO:0034164) |
| 0.0 | 0.1 | GO:0030421 | defecation(GO:0030421) |
| 0.0 | 0.1 | GO:0007210 | serotonin receptor signaling pathway(GO:0007210) positive regulation of phosphatidylinositol biosynthetic process(GO:0010513) |
| 0.0 | 0.2 | GO:1903608 | protein localization to cytoplasmic stress granule(GO:1903608) |
| 0.0 | 0.1 | GO:0060040 | retinal bipolar neuron differentiation(GO:0060040) |
| 0.0 | 0.0 | GO:0019417 | sulfur oxidation(GO:0019417) |
| 0.0 | 0.3 | GO:1903071 | positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071) |
| 0.0 | 0.1 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 0.0 | 0.3 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.0 | 0.5 | GO:0097503 | sialylation(GO:0097503) |
| 0.0 | 0.4 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 0.0 | 0.1 | GO:0015811 | L-cystine transport(GO:0015811) proline transmembrane transport(GO:0035524) |
| 0.0 | 0.2 | GO:0036148 | phosphatidylglycerol acyl-chain remodeling(GO:0036148) |
| 0.0 | 0.5 | GO:0010644 | cell communication by electrical coupling(GO:0010644) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.3 | GO:0005594 | collagen type IX trimer(GO:0005594) |
| 0.3 | 3.5 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.3 | 6.5 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 2.2 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.1 | 0.4 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.1 | 1.0 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.1 | 0.2 | GO:0034677 | integrin alpha7-beta1 complex(GO:0034677) |
| 0.0 | 0.3 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.0 | 0.4 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.0 | 1.7 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 0.5 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.0 | 8.1 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 0.1 | GO:0070288 | intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288) |
| 0.0 | 0.4 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 0.1 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
| 0.0 | 0.2 | GO:0097165 | nuclear stress granule(GO:0097165) |
| 0.0 | 0.4 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.0 | 0.5 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.5 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 0.2 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 0.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.7 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 0.3 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 0.1 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.0 | 0.2 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.4 | GO:0016211 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.3 | 1.9 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 0.3 | 0.9 | GO:0072591 | citrate-L-glutamate ligase activity(GO:0072591) |
| 0.2 | 8.7 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 0.4 | GO:0047389 | glycerophosphocholine phosphodiesterase activity(GO:0047389) |
| 0.1 | 1.3 | GO:0030020 | extracellular matrix structural constituent conferring tensile strength(GO:0030020) |
| 0.1 | 1.0 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 0.1 | 3.5 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.1 | 0.3 | GO:0016781 | selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781) |
| 0.1 | 0.9 | GO:0043426 | MRF binding(GO:0043426) |
| 0.1 | 0.4 | GO:0051996 | farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996) |
| 0.1 | 0.4 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
| 0.1 | 6.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 0.8 | GO:0019211 | phosphatase activator activity(GO:0019211) |
| 0.1 | 0.7 | GO:0090599 | alpha-glucosidase activity(GO:0090599) |
| 0.0 | 1.6 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.0 | 0.9 | GO:0016742 | hydroxymethyl-, formyl- and related transferase activity(GO:0016742) |
| 0.0 | 0.4 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.0 | 0.5 | GO:1903763 | gap junction channel activity involved in cell communication by electrical coupling(GO:1903763) |
| 0.0 | 1.8 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 0.4 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.0 | 0.4 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.0 | 0.9 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.0 | 0.9 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 0.3 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.0 | 0.5 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 0.2 | GO:0047288 | monosialoganglioside sialyltransferase activity(GO:0047288) |
| 0.0 | 0.1 | GO:0004803 | transposase activity(GO:0004803) |
| 0.0 | 0.2 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
| 0.0 | 0.2 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.0 | 0.1 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 0.0 | 0.1 | GO:0008199 | ferric iron binding(GO:0008199) |
| 0.0 | 0.2 | GO:0047144 | 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144) |
| 0.0 | 0.1 | GO:0015186 | L-cystine transmembrane transporter activity(GO:0015184) L-glutamine transmembrane transporter activity(GO:0015186) L-proline transmembrane transporter activity(GO:0015193) |
| 0.0 | 0.1 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.0 | 0.0 | GO:0004113 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 6.3 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 3.4 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.8 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
| 0.0 | 1.5 | PID_INSULIN_PATHWAY | Insulin Pathway |
| 0.0 | 0.8 | PID_BMP_PATHWAY | BMP receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 1.8 | REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.0 | 0.7 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 2.0 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.7 | REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.0 | 0.9 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.0 | 0.4 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 0.8 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.4 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.4 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 0.2 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PG | Genes involved in Acyl chain remodelling of PG |
